C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFZ3_LEIMA

TriTrypDb:

LmjF.35.5200 , LMJLV39_350060100 , LMJSD75_350059400

Length:

257

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFZ3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.540
CLV_PCSK_KEX2_1	11	13	PF00082	0.540
CLV_PCSK_SKI1_1	27	31	PF00082	0.357
CLV_Separin_Metazoa	17	21	PF03568	0.489
DOC_CDC14_PxL_1	227	235	PF14671	0.558
DOC_CKS1_1	125	130	PF01111	0.536
DOC_CKS1_1	233	238	PF01111	0.591
DOC_CKS1_1	5	10	PF01111	0.472
DOC_MAPK_MEF2A_6	94	103	PF00069	0.447
DOC_PP1_RVXF_1	247	253	PF00149	0.457
DOC_USP7_MATH_1	111	115	PF00917	0.459
DOC_USP7_MATH_1	136	140	PF00917	0.626
DOC_USP7_MATH_1	143	147	PF00917	0.708
DOC_USP7_MATH_1	186	190	PF00917	0.542
DOC_USP7_MATH_1	192	196	PF00917	0.497
DOC_USP7_MATH_1	245	249	PF00917	0.609
DOC_WW_Pin1_4	124	129	PF00397	0.580
DOC_WW_Pin1_4	172	177	PF00397	0.731
DOC_WW_Pin1_4	232	237	PF00397	0.640
DOC_WW_Pin1_4	35	40	PF00397	0.389
DOC_WW_Pin1_4	4	9	PF00397	0.529
LIG_14-3-3_CanoR_1	170	176	PF00244	0.523
LIG_BIR_II_1	1	5	PF00653	0.706
LIG_FHA_1	125	131	PF00498	0.585
LIG_FHA_1	49	55	PF00498	0.426
LIG_LIR_Gen_1	40	47	PF02991	0.272
LIG_LIR_Gen_1	97	106	PF02991	0.412
LIG_LIR_Nem_3	146	150	PF02991	0.523
LIG_LIR_Nem_3	177	182	PF02991	0.569
LIG_LIR_Nem_3	248	254	PF02991	0.580
LIG_LIR_Nem_3	40	46	PF02991	0.278
LIG_LIR_Nem_3	97	101	PF02991	0.394
LIG_SH2_CRK	98	102	PF00017	0.383
LIG_SH2_GRB2like	108	111	PF00017	0.565
LIG_SH2_GRB2like	182	185	PF00017	0.608
LIG_SH2_NCK_1	182	186	PF00017	0.562
LIG_SH2_SRC	108	111	PF00017	0.506
LIG_SH2_SRC	182	185	PF00017	0.569
LIG_SH2_STAT3	93	96	PF00017	0.359
LIG_SH2_STAT5	108	111	PF00017	0.461
LIG_SH2_STAT5	251	254	PF00017	0.610
LIG_SH3_3	122	128	PF00018	0.577
LIG_SH3_3	130	136	PF00018	0.628
LIG_SH3_3	149	155	PF00018	0.432
LIG_SH3_3	196	202	PF00018	0.760
LIG_SH3_3	36	42	PF00018	0.365
LIG_SH3_3	89	95	PF00018	0.446
LIG_WRC_WIRS_1	144	149	PF05994	0.528
LIG_WRC_WIRS_1	58	63	PF05994	0.424
MOD_CDK_SPxxK_3	4	11	PF00069	0.539
MOD_CK1_1	114	120	PF00069	0.542
MOD_CK1_1	174	180	PF00069	0.694
MOD_CK1_1	195	201	PF00069	0.670
MOD_CK1_1	57	63	PF00069	0.416
MOD_GlcNHglycan	194	197	PF01048	0.575
MOD_GlcNHglycan	87	90	PF01048	0.476
MOD_GSK3_1	160	167	PF00069	0.598
MOD_GSK3_1	168	175	PF00069	0.558
MOD_GSK3_1	186	193	PF00069	0.625
MOD_GSK3_1	203	210	PF00069	0.438
MOD_GSK3_1	29	36	PF00069	0.392
MOD_NEK2_1	164	169	PF00069	0.633
MOD_NEK2_1	29	34	PF00069	0.325
MOD_NEK2_1	75	80	PF00069	0.355
MOD_NEK2_1	85	90	PF00069	0.422
MOD_OFUCOSY	35	41	PF10250	0.275
MOD_PIKK_1	154	160	PF00454	0.552
MOD_PIKK_1	164	170	PF00454	0.537
MOD_PIKK_1	186	192	PF00454	0.643
MOD_PIKK_1	239	245	PF00454	0.577
MOD_PIKK_1	60	66	PF00454	0.381
MOD_PIKK_1	75	81	PF00454	0.366
MOD_PKA_2	33	39	PF00069	0.382
MOD_Plk_4	160	166	PF00069	0.612
MOD_Plk_4	195	201	PF00069	0.600
MOD_Plk_4	208	214	PF00069	0.586
MOD_Plk_4	57	63	PF00069	0.416
MOD_Plk_4	70	76	PF00069	0.320
MOD_ProDKin_1	124	130	PF00069	0.583
MOD_ProDKin_1	172	178	PF00069	0.734
MOD_ProDKin_1	232	238	PF00069	0.639
MOD_ProDKin_1	35	41	PF00069	0.389
MOD_ProDKin_1	4	10	PF00069	0.526
TRG_ENDOCYTIC_2	251	254	PF00928	0.610
TRG_ENDOCYTIC_2	43	46	PF00928	0.298
TRG_ENDOCYTIC_2	98	101	PF00928	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL43	Leptomonas seymouri	54%	90%
A0A1X0P4Q8	Trypanosomatidae	47%	100%
A0A3S7XA28	Leishmania donovani	93%	100%
A4HNI2	Leishmania braziliensis	80%	100%
A4IC38	Leishmania infantum	93%	100%
E9B746	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%