Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFZ1_LEIMA

TriTrypDb:

LmjF.35.5180 , LMJLV39_350059900 , LMJSD75_350059200

Length:

604

Annotations

LeishMANIAdb annotations

Putative transporter, with little homology outside Kinetoplastida

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AFZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFZ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	215	221	PF00089	0.385
CLV_NRD_NRD_1	27	29	PF00675	0.388
CLV_NRD_NRD_1	33	35	PF00675	0.364
CLV_NRD_NRD_1	473	475	PF00675	0.373
CLV_NRD_NRD_1	557	559	PF00675	0.301
CLV_PCSK_KEX2_1	35	37	PF00082	0.392
CLV_PCSK_KEX2_1	473	475	PF00082	0.408
CLV_PCSK_KEX2_1	557	559	PF00082	0.301
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.392
CLV_PCSK_SKI1_1	279	283	PF00082	0.491
CLV_PCSK_SKI1_1	53	57	PF00082	0.418
DEG_COP1_1	500	510	PF00400	0.382
DEG_Nend_Nbox_1	1	3	PF02207	0.587
DEG_SPOP_SBC_1	300	304	PF00917	0.563
DOC_CKS1_1	100	105	PF01111	0.686
DOC_CYCLIN_yCln2_LP_2	466	472	PF00134	0.617
DOC_CYCLIN_yCln2_LP_2	481	487	PF00134	0.198
DOC_MAPK_DCC_7	333	342	PF00069	0.604
DOC_MAPK_gen_1	473	482	PF00069	0.518
DOC_MAPK_gen_1	581	590	PF00069	0.537
DOC_MAPK_MEF2A_6	130	138	PF00069	0.596
DOC_MAPK_MEF2A_6	333	342	PF00069	0.604
DOC_PP1_RVXF_1	291	297	PF00149	0.545
DOC_PP1_RVXF_1	387	394	PF00149	0.360
DOC_PP4_FxxP_1	244	247	PF00568	0.615
DOC_PP4_FxxP_1	505	508	PF00568	0.414
DOC_USP7_MATH_1	227	231	PF00917	0.494
DOC_USP7_MATH_1	308	312	PF00917	0.598
DOC_USP7_MATH_1	315	319	PF00917	0.444
DOC_USP7_MATH_1	321	325	PF00917	0.552
DOC_USP7_MATH_1	73	77	PF00917	0.564
DOC_WW_Pin1_4	114	119	PF00397	0.487
DOC_WW_Pin1_4	178	183	PF00397	0.624
DOC_WW_Pin1_4	243	248	PF00397	0.629
DOC_WW_Pin1_4	38	43	PF00397	0.530
DOC_WW_Pin1_4	448	453	PF00397	0.500
DOC_WW_Pin1_4	480	485	PF00397	0.486
DOC_WW_Pin1_4	99	104	PF00397	0.644
LIG_14-3-3_CanoR_1	218	224	PF00244	0.575
LIG_14-3-3_CanoR_1	343	351	PF00244	0.420
LIG_14-3-3_CanoR_1	389	394	PF00244	0.483
LIG_14-3-3_CanoR_1	53	58	PF00244	0.560
LIG_14-3-3_CanoR_1	557	566	PF00244	0.548
LIG_14-3-3_CanoR_1	63	72	PF00244	0.515
LIG_Actin_WH2_2	363	378	PF00022	0.323
LIG_Actin_WH2_2	438	456	PF00022	0.552
LIG_BRCT_BRCA1_1	170	174	PF00533	0.586
LIG_BRCT_BRCA1_1	458	462	PF00533	0.559
LIG_CtBP_PxDLS_1	469	473	PF00389	0.616
LIG_DLG_GKlike_1	568	576	PF00625	0.600
LIG_eIF4E_1	439	445	PF01652	0.554
LIG_eIF4E_1	529	535	PF01652	0.346
LIG_FHA_1	131	137	PF00498	0.596
LIG_FHA_1	181	187	PF00498	0.597
LIG_FHA_1	381	387	PF00498	0.292
LIG_FHA_1	43	49	PF00498	0.530
LIG_FHA_1	433	439	PF00498	0.540
LIG_FHA_1	448	454	PF00498	0.450
LIG_FHA_1	542	548	PF00498	0.302
LIG_FHA_1	593	599	PF00498	0.316
LIG_FHA_2	100	106	PF00498	0.597
LIG_FHA_2	330	336	PF00498	0.606
LIG_FHA_2	66	72	PF00498	0.669
LIG_IRF3_LxIS_1	16	23	PF10401	0.548
LIG_LIR_Apic_2	504	508	PF02991	0.385
LIG_LIR_Apic_2	97	103	PF02991	0.624
LIG_LIR_Gen_1	10	20	PF02991	0.524
LIG_LIR_Gen_1	107	115	PF02991	0.596
LIG_LIR_Gen_1	240	248	PF02991	0.564
LIG_LIR_Gen_1	392	401	PF02991	0.450
LIG_LIR_Nem_3	10	16	PF02991	0.529
LIG_LIR_Nem_3	107	112	PF02991	0.621
LIG_LIR_Nem_3	153	158	PF02991	0.632
LIG_LIR_Nem_3	171	177	PF02991	0.414
LIG_LIR_Nem_3	240	245	PF02991	0.577
LIG_LIR_Nem_3	260	266	PF02991	0.631
LIG_LIR_Nem_3	392	396	PF02991	0.450
LIG_LIR_Nem_3	459	465	PF02991	0.559
LIG_LIR_Nem_3	525	529	PF02991	0.340
LIG_LIR_Nem_3	545	551	PF02991	0.150
LIG_LIR_Nem_3	575	580	PF02991	0.551
LIG_MLH1_MIPbox_1	170	174	PF16413	0.583
LIG_Pex14_1	341	345	PF04695	0.554
LIG_Pex14_1	495	499	PF04695	0.339
LIG_Pex14_2	491	495	PF04695	0.370
LIG_PTB_Apo_2	103	110	PF02174	0.593
LIG_PTB_Apo_2	236	243	PF02174	0.615
LIG_PTB_Apo_2	295	302	PF02174	0.540
LIG_PTB_Apo_2	336	343	PF02174	0.595
LIG_SH2_CRK	100	104	PF00017	0.640
LIG_SH2_CRK	155	159	PF00017	0.596
LIG_SH2_CRK	433	437	PF00017	0.592
LIG_SH2_CRK	582	586	PF00017	0.507
LIG_SH2_GRB2like	104	107	PF00017	0.589
LIG_SH2_NCK_1	100	104	PF00017	0.640
LIG_SH2_NCK_1	297	301	PF00017	0.532
LIG_SH2_NCK_1	499	503	PF00017	0.325
LIG_SH2_SRC	162	165	PF00017	0.506
LIG_SH2_SRC	225	228	PF00017	0.554
LIG_SH2_SRC	597	600	PF00017	0.402
LIG_SH2_STAP1	104	108	PF00017	0.592
LIG_SH2_STAP1	263	267	PF00017	0.611
LIG_SH2_STAT3	564	567	PF00017	0.581
LIG_SH2_STAT5	173	176	PF00017	0.513
LIG_SH2_STAT5	225	228	PF00017	0.554
LIG_SH2_STAT5	433	436	PF00017	0.510
LIG_SH2_STAT5	46	49	PF00017	0.491
LIG_SH2_STAT5	597	600	PF00017	0.374
LIG_SH3_3	354	360	PF00018	0.335
LIG_SH3_3	36	42	PF00018	0.536
LIG_SH3_3	461	467	PF00018	0.515
LIG_SH3_3	484	490	PF00018	0.420
LIG_SH3_3	510	516	PF00018	0.384
LIG_SH3_3	521	527	PF00018	0.411
LIG_SH3_3	563	569	PF00018	0.607
LIG_SUMO_SIM_anti_2	586	592	PF11976	0.412
LIG_SUMO_SIM_par_1	586	592	PF11976	0.412
LIG_TRAF2_1	23	26	PF00917	0.565
LIG_TRFH_1	109	113	PF08558	0.577
LIG_UBA3_1	2	8	PF00899	0.585
MOD_CDK_SPxK_1	448	454	PF00069	0.556
MOD_CDK_SPxxK_3	114	121	PF00069	0.546
MOD_CK1_1	114	120	PF00069	0.527
MOD_CK1_1	246	252	PF00069	0.664
MOD_CK1_1	378	384	PF00069	0.330
MOD_CK1_1	592	598	PF00069	0.320
MOD_CK1_1	65	71	PF00069	0.550
MOD_CK2_1	147	153	PF00069	0.626
MOD_CK2_1	20	26	PF00069	0.565
MOD_CK2_1	4	10	PF00069	0.605
MOD_CK2_1	408	414	PF00069	0.621
MOD_CK2_1	494	500	PF00069	0.360
MOD_CK2_1	65	71	PF00069	0.626
MOD_CK2_1	99	105	PF00069	0.684
MOD_CMANNOS	495	498	PF00535	0.339
MOD_GlcNHglycan	270	273	PF01048	0.530
MOD_GlcNHglycan	279	282	PF01048	0.576
MOD_GlcNHglycan	303	306	PF01048	0.394
MOD_GlcNHglycan	346	349	PF01048	0.420
MOD_GlcNHglycan	410	413	PF01048	0.430
MOD_GlcNHglycan	42	45	PF01048	0.331
MOD_GlcNHglycan	441	444	PF01048	0.353
MOD_GlcNHglycan	591	594	PF01048	0.301
MOD_GSK3_1	164	171	PF00069	0.625
MOD_GSK3_1	176	183	PF00069	0.508
MOD_GSK3_1	277	284	PF00069	0.677
MOD_GSK3_1	327	334	PF00069	0.588
MOD_GSK3_1	38	45	PF00069	0.548
MOD_GSK3_1	416	423	PF00069	0.680
MOD_GSK3_1	494	501	PF00069	0.353
MOD_GSK3_1	568	575	PF00069	0.662
MOD_GSK3_1	95	102	PF00069	0.638
MOD_N-GLC_1	389	394	PF02516	0.388
MOD_N-GLC_1	408	413	PF02516	0.260
MOD_N-GLC_1	456	461	PF02516	0.362
MOD_NEK2_1	144	149	PF00069	0.620
MOD_NEK2_1	168	173	PF00069	0.515
MOD_NEK2_1	177	182	PF00069	0.551
MOD_NEK2_1	301	306	PF00069	0.555
MOD_NEK2_1	375	380	PF00069	0.345
MOD_NEK2_1	425	430	PF00069	0.528
MOD_NEK2_1	538	543	PF00069	0.308
MOD_NEK2_1	572	577	PF00069	0.584
MOD_NEK2_1	591	596	PF00069	0.166
MOD_NEK2_2	227	232	PF00069	0.508
MOD_NEK2_2	308	313	PF00069	0.602
MOD_NEK2_2	402	407	PF00069	0.422
MOD_PIKK_1	147	153	PF00454	0.590
MOD_PIKK_1	281	287	PF00454	0.758
MOD_PKA_2	257	263	PF00069	0.557
MOD_PKA_2	375	381	PF00069	0.333
MOD_PKA_2	62	68	PF00069	0.549
MOD_PKB_1	581	589	PF00069	0.543
MOD_Plk_1	389	395	PF00069	0.388
MOD_Plk_1	456	462	PF00069	0.550
MOD_Plk_4	164	170	PF00069	0.520
MOD_Plk_4	375	381	PF00069	0.352
MOD_Plk_4	42	48	PF00069	0.522
MOD_Plk_4	432	438	PF00069	0.636
MOD_Plk_4	494	500	PF00069	0.481
MOD_Plk_4	501	507	PF00069	0.348
MOD_Plk_4	509	515	PF00069	0.249
MOD_Plk_4	538	544	PF00069	0.344
MOD_Plk_4	95	101	PF00069	0.589
MOD_ProDKin_1	114	120	PF00069	0.484
MOD_ProDKin_1	178	184	PF00069	0.624
MOD_ProDKin_1	243	249	PF00069	0.626
MOD_ProDKin_1	38	44	PF00069	0.525
MOD_ProDKin_1	448	454	PF00069	0.499
MOD_ProDKin_1	480	486	PF00069	0.486
MOD_ProDKin_1	99	105	PF00069	0.646
TRG_DiLeu_BaEn_1	107	112	PF01217	0.590
TRG_DiLeu_BaEn_2	239	245	PF01217	0.590
TRG_DiLeu_BaLyEn_6	580	585	PF01217	0.541
TRG_ENDOCYTIC_2	155	158	PF00928	0.597
TRG_ENDOCYTIC_2	297	300	PF00928	0.546
TRG_ENDOCYTIC_2	433	436	PF00928	0.529
TRG_ENDOCYTIC_2	582	585	PF00928	0.542
TRG_ER_diArg_1	34	37	PF00400	0.576
TRG_ER_diArg_1	472	474	PF00400	0.648
TRG_ER_diArg_1	514	517	PF00400	0.336
TRG_ER_diArg_1	557	559	PF00400	0.525
TRG_NLS_MonoExtN_4	31	38	PF00514	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7A6	Leptomonas seymouri	67%	94%
A0A0S4JQH1	Bodo saltans	27%	93%
A0A1X0P4Y6	Trypanosomatidae	38%	93%
A0A3Q8IK04	Leishmania donovani	95%	100%
A0A3R7MCC1	Trypanosoma rangeli	41%	95%
A4HNI0	Leishmania braziliensis	80%	99%
A4IC36	Leishmania infantum	95%	100%
C9ZYD5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	98%
E9B744	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%