G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFZ0_LEIMA

TriTrypDb:

LmjF.35.5170 , LMJLV39_350059800 , LMJSD75_350059100

Length:

315

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFZ0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0005488	binding	1	2
GO:0005525	GTP binding	5	2
GO:0017076	purine nucleotide binding	4	2
GO:0019001	guanyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032561	guanyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	29	31	PF00675	0.656
CLV_PCSK_KEX2_1	29	31	PF00082	0.656
CLV_PCSK_SKI1_1	162	166	PF00082	0.419
CLV_PCSK_SKI1_1	276	280	PF00082	0.567
CLV_PCSK_SKI1_1	77	81	PF00082	0.454
DEG_Nend_Nbox_1	1	3	PF02207	0.463
DOC_CKS1_1	125	130	PF01111	0.343
DOC_CKS1_1	36	41	PF01111	0.707
DOC_CYCLIN_RxL_1	74	83	PF00134	0.479
DOC_MAPK_gen_1	152	161	PF00069	0.549
DOC_MAPK_MEF2A_6	297	306	PF00069	0.409
DOC_MAPK_MEF2A_6	61	69	PF00069	0.481
DOC_PP2B_LxvP_1	70	73	PF13499	0.482
DOC_USP7_MATH_1	245	249	PF00917	0.437
DOC_USP7_MATH_1	253	257	PF00917	0.348
DOC_USP7_UBL2_3	150	154	PF12436	0.451
DOC_WW_Pin1_4	124	129	PF00397	0.347
DOC_WW_Pin1_4	165	170	PF00397	0.443
DOC_WW_Pin1_4	228	233	PF00397	0.393
DOC_WW_Pin1_4	35	40	PF00397	0.726
DOC_WW_Pin1_4	5	10	PF00397	0.689
LIG_14-3-3_CanoR_1	19	28	PF00244	0.729
LIG_14-3-3_CanoR_1	246	255	PF00244	0.366
LIG_14-3-3_CanoR_1	40	45	PF00244	0.626
LIG_14-3-3_CanoR_1	5	9	PF00244	0.586
LIG_APCC_ABBA_1	296	301	PF00400	0.370
LIG_BIR_III_2	229	233	PF00653	0.406
LIG_BRCT_BRCA1_1	50	54	PF00533	0.677
LIG_DCNL_PONY_1	1	4	PF03556	0.463
LIG_FHA_1	105	111	PF00498	0.411
LIG_FHA_1	183	189	PF00498	0.374
LIG_FHA_1	268	274	PF00498	0.453
LIG_FHA_1	282	288	PF00498	0.455
LIG_FHA_1	62	68	PF00498	0.430
LIG_FHA_2	223	229	PF00498	0.456
LIG_FHA_2	235	241	PF00498	0.405
LIG_LIR_Gen_1	121	128	PF02991	0.376
LIG_LIR_Gen_1	231	239	PF02991	0.318
LIG_LIR_Gen_1	60	70	PF02991	0.494
LIG_LIR_Nem_3	121	125	PF02991	0.385
LIG_LIR_Nem_3	231	236	PF02991	0.335
LIG_Pex14_1	199	203	PF04695	0.459
LIG_RPA_C_Fungi	241	253	PF08784	0.450
LIG_SH2_STAP1	32	36	PF00017	0.521
LIG_SH2_STAT5	132	135	PF00017	0.534
LIG_SH2_STAT5	215	218	PF00017	0.420
LIG_SH2_STAT5	268	271	PF00017	0.333
LIG_SH3_3	33	39	PF00018	0.705
LIG_SH3_3	92	98	PF00018	0.470
LIG_TRAF2_1	22	25	PF00917	0.673
LIG_UBA3_1	212	217	PF00899	0.399
MOD_CDK_SPK_2	35	40	PF00069	0.709
MOD_CK1_1	130	136	PF00069	0.516
MOD_CK1_1	222	228	PF00069	0.422
MOD_CK1_1	43	49	PF00069	0.707
MOD_CK2_1	19	25	PF00069	0.736
MOD_DYRK1A_RPxSP_1	5	9	PF00069	0.619
MOD_GlcNHglycan	101	104	PF01048	0.620
MOD_GlcNHglycan	21	24	PF01048	0.684
MOD_GlcNHglycan	248	251	PF01048	0.470
MOD_GSK3_1	218	225	PF00069	0.399
MOD_GSK3_1	31	38	PF00069	0.747
MOD_GSK3_1	40	47	PF00069	0.593
MOD_GSK3_1	5	12	PF00069	0.702
MOD_LATS_1	116	122	PF00433	0.504
MOD_LATS_1	17	23	PF00433	0.703
MOD_N-GLC_1	246	251	PF02516	0.417
MOD_N-GLC_1	89	94	PF02516	0.558
MOD_NEK2_1	104	109	PF00069	0.476
MOD_NEK2_1	193	198	PF00069	0.483
MOD_NEK2_1	219	224	PF00069	0.340
MOD_NEK2_1	278	283	PF00069	0.605
MOD_NEK2_1	287	292	PF00069	0.460
MOD_NEK2_1	3	8	PF00069	0.575
MOD_NEK2_1	80	85	PF00069	0.407
MOD_PK_1	40	46	PF00069	0.628
MOD_PKA_2	245	251	PF00069	0.314
MOD_PKA_2	4	10	PF00069	0.680
MOD_PKA_2	44	50	PF00069	0.646
MOD_Plk_1	89	95	PF00069	0.603
MOD_Plk_4	118	124	PF00069	0.409
MOD_Plk_4	127	133	PF00069	0.387
MOD_Plk_4	193	199	PF00069	0.542
MOD_Plk_4	253	259	PF00069	0.390
MOD_Plk_4	75	81	PF00069	0.350
MOD_ProDKin_1	124	130	PF00069	0.347
MOD_ProDKin_1	165	171	PF00069	0.445
MOD_ProDKin_1	228	234	PF00069	0.388
MOD_ProDKin_1	35	41	PF00069	0.726
MOD_ProDKin_1	5	11	PF00069	0.689
TRG_DiLeu_BaEn_1	189	194	PF01217	0.325
TRG_DiLeu_BaEn_1	274	279	PF01217	0.536
TRG_ENDOCYTIC_2	62	65	PF00928	0.587
TRG_ER_diArg_1	199	202	PF00400	0.566
TRG_ER_diArg_1	28	30	PF00400	0.719
TRG_Pf-PMV_PEXEL_1	162	166	PF00026	0.329
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5M5	Leptomonas seymouri	68%	76%
A0A0S4JLN7	Bodo saltans	36%	78%
A0A1X0P4S5	Trypanosomatidae	55%	79%
A0A3Q8IFN6	Leishmania donovani	94%	76%
A0A422NCK5	Trypanosoma rangeli	50%	100%
A4HNH9	Leishmania braziliensis	79%	85%
A4IC35	Leishmania infantum	94%	100%
C9ZYD6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	83%
E9B743	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	76%
V5B8T8	Trypanosoma cruzi	51%	81%