Lon protease

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Lon protease

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFY9_LEIMA

TriTrypDb:

LmjF.35.5160 , LMJLV39_350059700 , LMJSD75_350059000

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFY9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.555
CLV_C14_Caspase3-7	276	280	PF00656	0.467
CLV_NRD_NRD_1	301	303	PF00675	0.503
CLV_PCSK_KEX2_1	293	295	PF00082	0.400
CLV_PCSK_KEX2_1	300	302	PF00082	0.400
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.400
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.400
CLV_PCSK_SKI1_1	24	28	PF00082	0.347
CLV_Separin_Metazoa	131	135	PF03568	0.460
DEG_APCC_DBOX_1	23	31	PF00400	0.335
DEG_SPOP_SBC_1	150	154	PF00917	0.494
DOC_CYCLIN_RxL_1	18	28	PF00134	0.463
DOC_MAPK_DCC_7	261	271	PF00069	0.491
DOC_MAPK_gen_1	177	187	PF00069	0.497
DOC_MAPK_gen_1	261	271	PF00069	0.371
DOC_MAPK_MEF2A_6	264	271	PF00069	0.431
DOC_MAPK_MEF2A_6	4	12	PF00069	0.360
DOC_MAPK_MEF2A_6	96	103	PF00069	0.344
DOC_MAPK_RevD_3	281	294	PF00069	0.360
DOC_PP1_RVXF_1	27	34	PF00149	0.339
DOC_PP4_FxxP_1	147	150	PF00568	0.479
DOC_PP4_FxxP_1	200	203	PF00568	0.470
DOC_USP7_MATH_1	150	154	PF00917	0.630
DOC_USP7_MATH_1	165	169	PF00917	0.439
DOC_WW_Pin1_4	151	156	PF00397	0.703
LIG_14-3-3_CanoR_1	108	118	PF00244	0.503
LIG_14-3-3_CanoR_1	248	252	PF00244	0.480
LIG_14-3-3_CanoR_1	273	278	PF00244	0.547
LIG_14-3-3_CanoR_1	43	47	PF00244	0.460
LIG_14-3-3_CanoR_1	57	65	PF00244	0.486
LIG_14-3-3_CanoR_1	70	74	PF00244	0.291
LIG_BIR_II_1	1	5	PF00653	0.434
LIG_FHA_1	207	213	PF00498	0.369
LIG_FHA_1	244	250	PF00498	0.509
LIG_FHA_1	266	272	PF00498	0.448
LIG_FHA_2	274	280	PF00498	0.485
LIG_FHA_2	59	65	PF00498	0.480
LIG_GBD_Chelix_1	291	299	PF00786	0.407
LIG_LIR_Gen_1	2	12	PF02991	0.372
LIG_LIR_Nem_3	16	22	PF02991	0.367
LIG_LIR_Nem_3	193	197	PF02991	0.440
LIG_LIR_Nem_3	2	8	PF02991	0.392
LIG_MYND_1	238	242	PF01753	0.453
LIG_NRBOX	113	119	PF00104	0.439
LIG_PCNA_yPIPBox_3	57	69	PF02747	0.439
LIG_RPA_C_Insects	289	304	PF08784	0.354
LIG_SH2_CRK	274	278	PF00017	0.316
LIG_SH2_CRK	5	9	PF00017	0.377
LIG_SH2_NCK_1	274	278	PF00017	0.316
LIG_SH2_STAP1	274	278	PF00017	0.316
LIG_SH2_STAT5	20	23	PF00017	0.339
LIG_SH2_STAT5	233	236	PF00017	0.614
LIG_SH2_STAT5	270	273	PF00017	0.449
LIG_SH2_STAT5	274	277	PF00017	0.494
LIG_SH2_STAT5	68	71	PF00017	0.462
LIG_SUMO_SIM_anti_2	245	253	PF11976	0.302
LIG_TYR_ITIM	17	22	PF00017	0.436
LIG_UBA3_1	295	300	PF00899	0.333
MOD_CK1_1	154	160	PF00069	0.645
MOD_CK1_1	87	93	PF00069	0.533
MOD_CK2_1	58	64	PF00069	0.399
MOD_GlcNHglycan	135	139	PF01048	0.552
MOD_GlcNHglycan	166	170	PF01048	0.468
MOD_GSK3_1	136	143	PF00069	0.540
MOD_GSK3_1	150	157	PF00069	0.608
MOD_GSK3_1	201	208	PF00069	0.490
MOD_GSK3_1	243	250	PF00069	0.435
MOD_GSK3_1	52	59	PF00069	0.536
MOD_N-GLC_1	122	127	PF02516	0.472
MOD_N-GLC_1	190	195	PF02516	0.473
MOD_N-GLC_2	280	282	PF02516	0.384
MOD_NEK2_1	205	210	PF00069	0.433
MOD_NEK2_1	25	30	PF00069	0.337
MOD_PIKK_1	58	64	PF00454	0.399
MOD_PIKK_1	87	93	PF00454	0.456
MOD_PKA_2	247	253	PF00069	0.440
MOD_PKA_2	272	278	PF00069	0.514
MOD_PKA_2	42	48	PF00069	0.458
MOD_PKA_2	56	62	PF00069	0.503
MOD_PKA_2	69	75	PF00069	0.377
MOD_Plk_1	122	128	PF00069	0.467
MOD_Plk_1	140	146	PF00069	0.599
MOD_Plk_1	165	171	PF00069	0.335
MOD_Plk_1	190	196	PF00069	0.524
MOD_Plk_1	37	43	PF00069	0.567
MOD_Plk_1	55	61	PF00069	0.304
MOD_Plk_4	123	129	PF00069	0.440
MOD_Plk_4	157	163	PF00069	0.540
MOD_Plk_4	247	253	PF00069	0.551
MOD_Plk_4	265	271	PF00069	0.476
MOD_Plk_4	281	287	PF00069	0.454
MOD_Plk_4	69	75	PF00069	0.452
MOD_ProDKin_1	151	157	PF00069	0.700
TRG_ENDOCYTIC_2	19	22	PF00928	0.344
TRG_ENDOCYTIC_2	274	277	PF00928	0.308
TRG_ENDOCYTIC_2	5	8	PF00928	0.375
TRG_ER_diArg_1	301	304	PF00400	0.404
TRG_NLS_MonoExtC_3	299	304	PF00514	0.383
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P619	Leptomonas seymouri	57%	94%
A0A3S7XA31	Leishmania donovani	93%	100%
A0A422P2U5	Trypanosoma rangeli	38%	77%
A4HNH8	Leishmania braziliensis	77%	100%
A4IC34	Leishmania infantum	93%	100%
C9ZZ55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	74%
E9B742	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BTH5	Trypanosoma cruzi	38%	76%