Methyltransf_11 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AFY7_LEIMA

TriTrypDb:

LmjF.35.5140 , LMJLV39_350059500 , LMJSD75_350058800

Length:

286

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFY7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.309
CLV_NRD_NRD_1	34	36	PF00675	0.613
CLV_PCSK_SKI1_1	172	176	PF00082	0.398
DEG_Nend_UBRbox_3	1	3	PF02207	0.615
DEG_SPOP_SBC_1	106	110	PF00917	0.620
DOC_MAPK_gen_1	212	222	PF00069	0.339
DOC_MAPK_JIP1_4	215	221	PF00069	0.416
DOC_MAPK_MEF2A_6	112	121	PF00069	0.423
DOC_USP7_MATH_1	105	109	PF00917	0.623
DOC_USP7_MATH_1	155	159	PF00917	0.541
DOC_WW_Pin1_4	148	153	PF00397	0.453
DOC_WW_Pin1_4	229	234	PF00397	0.476
LIG_14-3-3_CanoR_1	112	119	PF00244	0.308
LIG_14-3-3_CanoR_1	271	279	PF00244	0.367
LIG_Actin_WH2_2	200	217	PF00022	0.359
LIG_BRCT_BRCA1_1	152	156	PF00533	0.501
LIG_deltaCOP1_diTrp_1	14	19	PF00928	0.443
LIG_FAT_LD_1	96	104	PF03623	0.441
LIG_FHA_1	248	254	PF00498	0.343
LIG_FHA_1	78	84	PF00498	0.479
LIG_HCF-1_HBM_1	17	20	PF13415	0.478
LIG_LIR_Gen_1	14	20	PF02991	0.479
LIG_LIR_Nem_3	14	19	PF02991	0.482
LIG_LIR_Nem_3	270	275	PF02991	0.359
LIG_LIR_Nem_3	51	56	PF02991	0.390
LIG_PCNA_yPIPBox_3	200	212	PF02747	0.366
LIG_Pex14_1	16	20	PF04695	0.401
LIG_Pex14_1	52	56	PF04695	0.375
LIG_Pex14_2	15	19	PF04695	0.402
LIG_SH2_CRK	277	281	PF00017	0.350
LIG_SH2_NCK_1	277	281	PF00017	0.368
LIG_SH2_STAP1	234	238	PF00017	0.345
LIG_SH2_STAP1	249	253	PF00017	0.400
LIG_SH2_STAP1	277	281	PF00017	0.426
LIG_SH2_STAP1	50	54	PF00017	0.377
LIG_SH2_STAP1	59	63	PF00017	0.352
LIG_SH2_STAT5	249	252	PF00017	0.452
LIG_SH3_3	149	155	PF00018	0.519
LIG_SH3_3	210	216	PF00018	0.412
LIG_SH3_3	227	233	PF00018	0.381
LIG_SUMO_SIM_anti_2	177	184	PF11976	0.341
LIG_SUMO_SIM_par_1	221	229	PF11976	0.451
LIG_TYR_ITIM	247	252	PF00017	0.449
LIG_WRC_WIRS_1	192	197	PF05994	0.481
LIG_WRC_WIRS_1	242	247	PF05994	0.441
MOD_CK1_1	108	114	PF00069	0.599
MOD_CK1_1	150	156	PF00069	0.527
MOD_CK1_1	224	230	PF00069	0.492
MOD_CK1_1	270	276	PF00069	0.435
MOD_GlcNHglycan	236	239	PF01048	0.395
MOD_GlcNHglycan	281	284	PF01048	0.449
MOD_GSK3_1	107	114	PF00069	0.637
MOD_GSK3_1	146	153	PF00069	0.458
MOD_LATS_1	262	268	PF00433	0.544
MOD_N-GLC_2	142	144	PF02516	0.330
MOD_NEK2_1	146	151	PF00069	0.402
MOD_NEK2_1	191	196	PF00069	0.510
MOD_NEK2_1	221	226	PF00069	0.452
MOD_NEK2_2	241	246	PF00069	0.304
MOD_PKA_2	111	117	PF00069	0.345
MOD_PKA_2	270	276	PF00069	0.417
MOD_PKA_2	42	48	PF00069	0.489
MOD_Plk_4	121	127	PF00069	0.361
MOD_Plk_4	42	48	PF00069	0.489
MOD_Plk_4	69	75	PF00069	0.455
MOD_ProDKin_1	148	154	PF00069	0.466
MOD_ProDKin_1	229	235	PF00069	0.469
TRG_DiLeu_BaEn_1	42	47	PF01217	0.473
TRG_ENDOCYTIC_2	249	252	PF00928	0.450
TRG_ENDOCYTIC_2	277	280	PF00928	0.337
TRG_ENDOCYTIC_2	50	53	PF00928	0.382
TRG_ER_diArg_1	169	172	PF00400	0.403
TRG_Pf-PMV_PEXEL_1	261	266	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTH2	Leptomonas seymouri	63%	100%
A0A3S7XA23	Leishmania donovani	92%	100%
A4HNH6	Leishmania braziliensis	76%	100%
A4IC32	Leishmania infantum	91%	100%
E9B740	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%