IQ calmodulin-binding motif domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFY6_LEIMA

TriTrypDb:

LmjF.35.5130 , LMJLV39_350059400 , LMJSD75_350058700

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFY6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	170	172	PF00675	0.482
CLV_NRD_NRD_1	245	247	PF00675	0.604
CLV_NRD_NRD_1	46	48	PF00675	0.585
CLV_PCSK_FUR_1	243	247	PF00082	0.495
CLV_PCSK_KEX2_1	170	172	PF00082	0.512
CLV_PCSK_KEX2_1	245	247	PF00082	0.687
CLV_PCSK_KEX2_1	46	48	PF00082	0.585
CLV_PCSK_SKI1_1	170	174	PF00082	0.479
CLV_PCSK_SKI1_1	180	184	PF00082	0.429
CLV_PCSK_SKI1_1	20	24	PF00082	0.636
DEG_Nend_UBRbox_2	1	3	PF02207	0.618
DEG_SPOP_SBC_1	205	209	PF00917	0.546
DOC_CYCLIN_RxL_1	308	319	PF00134	0.449
DOC_CYCLIN_yCln2_LP_2	123	129	PF00134	0.603
DOC_MAPK_gen_1	185	193	PF00069	0.450
DOC_MAPK_MEF2A_6	188	195	PF00069	0.438
DOC_PP1_RVXF_1	171	177	PF00149	0.565
DOC_PP1_RVXF_1	18	25	PF00149	0.539
DOC_PP1_RVXF_1	309	316	PF00149	0.440
DOC_USP7_MATH_1	105	109	PF00917	0.508
DOC_USP7_MATH_1	119	123	PF00917	0.693
DOC_USP7_MATH_1	222	226	PF00917	0.633
DOC_USP7_MATH_1	241	245	PF00917	0.435
DOC_USP7_MATH_1	283	287	PF00917	0.673
DOC_USP7_MATH_1	294	298	PF00917	0.498
DOC_USP7_MATH_1	328	332	PF00917	0.526
DOC_USP7_MATH_1	342	346	PF00917	0.509
DOC_WW_Pin1_4	127	132	PF00397	0.630
DOC_WW_Pin1_4	290	295	PF00397	0.596
DOC_WW_Pin1_4	348	353	PF00397	0.622
LIG_14-3-3_CanoR_1	206	211	PF00244	0.646
LIG_14-3-3_CanoR_1	223	227	PF00244	0.466
LIG_14-3-3_CanoR_1	270	276	PF00244	0.581
LIG_BRCT_BRCA1_1	267	271	PF00533	0.628
LIG_CaM_IQ_9	232	248	PF13499	0.426
LIG_FHA_1	10	16	PF00498	0.638
LIG_FHA_1	107	113	PF00498	0.719
LIG_FHA_1	122	128	PF00498	0.584
LIG_FHA_1	135	141	PF00498	0.567
LIG_FHA_1	216	222	PF00498	0.465
LIG_FHA_1	226	232	PF00498	0.397
LIG_FHA_1	270	276	PF00498	0.613
LIG_FHA_1	74	80	PF00498	0.571
LIG_FHA_2	79	85	PF00498	0.547
LIG_LIR_Apic_2	289	294	PF02991	0.596
LIG_LIR_Gen_1	21	31	PF02991	0.583
LIG_LIR_Nem_3	21	27	PF02991	0.585
LIG_PCNA_yPIPBox_3	295	309	PF02747	0.523
LIG_Pex14_2	194	198	PF04695	0.500
LIG_Pex14_2	238	242	PF04695	0.510
LIG_SH2_NCK_1	276	280	PF00017	0.573
LIG_SH2_NCK_1	340	344	PF00017	0.477
LIG_SH2_PTP2	291	294	PF00017	0.549
LIG_SH2_STAP1	56	60	PF00017	0.609
LIG_SH2_STAT5	291	294	PF00017	0.611
LIG_SH2_STAT5	301	304	PF00017	0.615
LIG_SH2_STAT5	314	317	PF00017	0.404
LIG_SH3_3	2	8	PF00018	0.763
LIG_SH3_3	346	352	PF00018	0.622
LIG_SUMO_SIM_par_1	271	278	PF11976	0.484
LIG_SxIP_EBH_1	127	138	PF03271	0.516
LIG_TRAF2_1	264	267	PF00917	0.549
LIG_WRC_WIRS_1	195	200	PF05994	0.512
LIG_WW_3	100	104	PF00397	0.500
MOD_CDK_SPxxK_3	348	355	PF00069	0.593
MOD_CK1_1	121	127	PF00069	0.645
MOD_CK1_1	133	139	PF00069	0.664
MOD_CK1_1	225	231	PF00069	0.509
MOD_CK1_1	274	280	PF00069	0.548
MOD_CK1_1	290	296	PF00069	0.576
MOD_CK1_1	324	330	PF00069	0.597
MOD_CK1_1	333	339	PF00069	0.447
MOD_CK1_1	341	347	PF00069	0.638
MOD_CK1_1	351	357	PF00069	0.632
MOD_CK1_1	360	366	PF00069	0.465
MOD_CK1_1	40	46	PF00069	0.672
MOD_CK1_1	78	84	PF00069	0.524
MOD_CK2_1	283	289	PF00069	0.607
MOD_CK2_1	78	84	PF00069	0.652
MOD_DYRK1A_RPxSP_1	348	352	PF00069	0.576
MOD_GlcNHglycan	155	158	PF01048	0.511
MOD_GlcNHglycan	254	257	PF01048	0.542
MOD_GlcNHglycan	277	280	PF01048	0.608
MOD_GlcNHglycan	326	329	PF01048	0.629
MOD_GlcNHglycan	330	333	PF01048	0.605
MOD_GlcNHglycan	340	343	PF01048	0.435
MOD_GlcNHglycan	39	42	PF01048	0.633
MOD_GSK3_1	129	136	PF00069	0.752
MOD_GSK3_1	153	160	PF00069	0.585
MOD_GSK3_1	200	207	PF00069	0.646
MOD_GSK3_1	227	234	PF00069	0.446
MOD_GSK3_1	265	272	PF00069	0.547
MOD_GSK3_1	283	290	PF00069	0.550
MOD_GSK3_1	324	331	PF00069	0.549
MOD_GSK3_1	338	345	PF00069	0.613
MOD_GSK3_1	347	354	PF00069	0.573
MOD_GSK3_1	360	367	PF00069	0.604
MOD_GSK3_1	60	67	PF00069	0.784
MOD_N-GLC_1	287	292	PF02516	0.582
MOD_N-GLC_1	294	299	PF02516	0.490
MOD_NEK2_1	194	199	PF00069	0.522
MOD_NEK2_1	204	209	PF00069	0.639
MOD_NEK2_1	215	220	PF00069	0.556
MOD_NEK2_1	231	236	PF00069	0.359
MOD_NEK2_1	271	276	PF00069	0.633
MOD_NEK2_1	338	343	PF00069	0.554
MOD_NEK2_1	75	80	PF00069	0.601
MOD_NEK2_1	9	14	PF00069	0.727
MOD_PK_1	206	212	PF00069	0.540
MOD_PKA_2	200	206	PF00069	0.641
MOD_PKA_2	222	228	PF00069	0.634
MOD_PKA_2	269	275	PF00069	0.593
MOD_PKA_2	347	353	PF00069	0.634
MOD_PKB_1	62	70	PF00069	0.660
MOD_Plk_1	20	26	PF00069	0.597
MOD_Plk_1	283	289	PF00069	0.689
MOD_Plk_1	294	300	PF00069	0.667
MOD_Plk_1	305	311	PF00069	0.528
MOD_Plk_1	333	339	PF00069	0.684
MOD_Plk_1	357	363	PF00069	0.635
MOD_Plk_4	143	149	PF00069	0.713
MOD_Plk_4	194	200	PF00069	0.560
MOD_Plk_4	222	228	PF00069	0.462
MOD_Plk_4	271	277	PF00069	0.625
MOD_Plk_4	287	293	PF00069	0.582
MOD_Plk_4	333	339	PF00069	0.688
MOD_ProDKin_1	127	133	PF00069	0.627
MOD_ProDKin_1	290	296	PF00069	0.597
MOD_ProDKin_1	348	354	PF00069	0.623
MOD_SUMO_for_1	172	175	PF00179	0.445
MOD_SUMO_rev_2	84	92	PF00179	0.638
TRG_ER_diArg_1	170	172	PF00400	0.513
TRG_ER_diArg_1	242	245	PF00400	0.582
TRG_ER_diArg_1	97	100	PF00400	0.626
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I004	Leptomonas seymouri	42%	96%
A0A3S7XA50	Leishmania donovani	93%	100%
A4HNH5	Leishmania braziliensis	58%	100%
A4IC31	Leishmania infantum	94%	100%
C9ZYD7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B739	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BTY5	Trypanosoma cruzi	29%	100%