DHC_N1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFY5_LEIMA

TriTrypDb:

LmjF.35.5120 , LMJLV39_350059300 , LMJSD75_350058600

Length:

720

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFY5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	388	392	PF00656	0.453
CLV_C14_Caspase3-7	399	403	PF00656	0.459
CLV_NRD_NRD_1	211	213	PF00675	0.588
CLV_NRD_NRD_1	215	217	PF00675	0.536
CLV_NRD_NRD_1	314	316	PF00675	0.557
CLV_NRD_NRD_1	424	426	PF00675	0.572
CLV_NRD_NRD_1	548	550	PF00675	0.464
CLV_NRD_NRD_1	573	575	PF00675	0.725
CLV_NRD_NRD_1	633	635	PF00675	0.529
CLV_NRD_NRD_1	646	648	PF00675	0.316
CLV_PCSK_KEX2_1	314	316	PF00082	0.557
CLV_PCSK_KEX2_1	424	426	PF00082	0.633
CLV_PCSK_KEX2_1	511	513	PF00082	0.666
CLV_PCSK_KEX2_1	548	550	PF00082	0.503
CLV_PCSK_KEX2_1	646	648	PF00082	0.478
CLV_PCSK_PC1ET2_1	511	513	PF00082	0.683
CLV_PCSK_SKI1_1	136	140	PF00082	0.475
CLV_PCSK_SKI1_1	216	220	PF00082	0.444
CLV_PCSK_SKI1_1	285	289	PF00082	0.483
CLV_PCSK_SKI1_1	315	319	PF00082	0.517
CLV_PCSK_SKI1_1	398	402	PF00082	0.418
CLV_PCSK_SKI1_1	408	412	PF00082	0.446
CLV_PCSK_SKI1_1	44	48	PF00082	0.637
CLV_PCSK_SKI1_1	448	452	PF00082	0.404
CLV_PCSK_SKI1_1	459	463	PF00082	0.395
DEG_APCC_DBOX_1	247	255	PF00400	0.685
DEG_APCC_DBOX_1	284	292	PF00400	0.503
DEG_APCC_DBOX_1	669	677	PF00400	0.554
DEG_Nend_Nbox_1	1	3	PF02207	0.678
DEG_SPOP_SBC_1	29	33	PF00917	0.669
DOC_ANK_TNKS_1	337	344	PF00023	0.473
DOC_CKS1_1	287	292	PF01111	0.467
DOC_CKS1_1	345	350	PF01111	0.593
DOC_CYCLIN_RxL_1	395	402	PF00134	0.453
DOC_CYCLIN_RxL_1	445	453	PF00134	0.408
DOC_CYCLIN_yClb1_LxF_4	537	543	PF00134	0.499
DOC_MAPK_gen_1	314	322	PF00069	0.507
DOC_MAPK_gen_1	349	359	PF00069	0.441
DOC_MAPK_gen_1	634	641	PF00069	0.546
DOC_MAPK_MEF2A_6	352	361	PF00069	0.408
DOC_MAPK_MEF2A_6	529	536	PF00069	0.487
DOC_PP2B_LxvP_1	176	179	PF13499	0.638
DOC_PP4_FxxP_1	327	330	PF00568	0.519
DOC_PP4_FxxP_1	345	348	PF00568	0.548
DOC_USP7_MATH_1	155	159	PF00917	0.721
DOC_USP7_MATH_1	162	166	PF00917	0.675
DOC_USP7_MATH_1	24	28	PF00917	0.563
DOC_USP7_MATH_1	244	248	PF00917	0.748
DOC_USP7_MATH_1	29	33	PF00917	0.515
DOC_USP7_MATH_1	564	568	PF00917	0.757
DOC_USP7_UBL2_3	213	217	PF12436	0.498
DOC_USP7_UBL2_3	369	373	PF12436	0.531
DOC_USP7_UBL2_3	413	417	PF12436	0.514
DOC_WW_Pin1_4	146	151	PF00397	0.700
DOC_WW_Pin1_4	286	291	PF00397	0.450
DOC_WW_Pin1_4	344	349	PF00397	0.593
DOC_WW_Pin1_4	705	710	PF00397	0.516
LIG_14-3-3_CanoR_1	129	135	PF00244	0.544
LIG_14-3-3_CanoR_1	19	25	PF00244	0.631
LIG_14-3-3_CanoR_1	242	252	PF00244	0.692
LIG_14-3-3_CanoR_1	267	276	PF00244	0.488
LIG_14-3-3_CanoR_1	424	432	PF00244	0.547
LIG_14-3-3_CanoR_1	529	533	PF00244	0.527
LIG_14-3-3_CanoR_1	556	562	PF00244	0.524
LIG_14-3-3_CanoR_1	634	641	PF00244	0.526
LIG_14-3-3_CanoR_1	695	701	PF00244	0.498
LIG_Actin_WH2_2	443	461	PF00022	0.518
LIG_Actin_WH2_2	618	636	PF00022	0.550
LIG_BRCT_BRCA1_1	130	134	PF00533	0.563
LIG_BRCT_BRCA1_1	587	591	PF00533	0.594
LIG_BRCT_BRCA1_2	130	136	PF00533	0.561
LIG_Clathr_ClatBox_1	622	626	PF01394	0.618
LIG_deltaCOP1_diTrp_1	363	368	PF00928	0.400
LIG_EH1_1	394	402	PF00400	0.436
LIG_eIF4E_1	395	401	PF01652	0.525
LIG_eIF4E_1	445	451	PF01652	0.433
LIG_FHA_1	206	212	PF00498	0.487
LIG_FHA_1	438	444	PF00498	0.485
LIG_FHA_1	482	488	PF00498	0.548
LIG_FHA_1	523	529	PF00498	0.596
LIG_FHA_1	55	61	PF00498	0.630
LIG_FHA_1	552	558	PF00498	0.561
LIG_FHA_1	628	634	PF00498	0.627
LIG_FHA_2	112	118	PF00498	0.562
LIG_FHA_2	287	293	PF00498	0.535
LIG_FHA_2	433	439	PF00498	0.508
LIG_FHA_2	57	63	PF00498	0.539
LIG_FHA_2	706	712	PF00498	0.611
LIG_FHA_2	79	85	PF00498	0.550
LIG_Integrin_isoDGR_2	693	695	PF01839	0.538
LIG_LIR_Apic_2	324	330	PF02991	0.531
LIG_LIR_Gen_1	306	317	PF02991	0.469
LIG_LIR_Gen_1	353	362	PF02991	0.466
LIG_LIR_Gen_1	588	597	PF02991	0.569
LIG_LIR_Gen_1	683	692	PF02991	0.448
LIG_LIR_Gen_1	84	94	PF02991	0.495
LIG_LIR_Nem_3	306	312	PF02991	0.462
LIG_LIR_Nem_3	353	359	PF02991	0.393
LIG_LIR_Nem_3	426	432	PF02991	0.503
LIG_LIR_Nem_3	452	458	PF02991	0.476
LIG_LIR_Nem_3	588	594	PF02991	0.579
LIG_LIR_Nem_3	84	90	PF02991	0.501
LIG_LIR_Nem_3	95	99	PF02991	0.388
LIG_Pex14_1	609	613	PF04695	0.422
LIG_Pex14_2	361	365	PF04695	0.385
LIG_Pex14_2	605	609	PF04695	0.426
LIG_PTB_Apo_2	389	396	PF02174	0.525
LIG_PTB_Apo_2	536	543	PF02174	0.393
LIG_PTB_Phospho_1	389	395	PF10480	0.521
LIG_Rb_pABgroove_1	585	593	PF01858	0.601
LIG_SH2_CRK	455	459	PF00017	0.480
LIG_SH2_CRK	463	467	PF00017	0.555
LIG_SH2_CRK	70	74	PF00017	0.494
LIG_SH2_GRB2like	404	407	PF00017	0.514
LIG_SH2_NCK_1	295	299	PF00017	0.552
LIG_SH2_PTP2	354	357	PF00017	0.494
LIG_SH2_SRC	258	261	PF00017	0.587
LIG_SH2_SRC	404	407	PF00017	0.521
LIG_SH2_SRC	601	604	PF00017	0.477
LIG_SH2_STAP1	419	423	PF00017	0.468
LIG_SH2_STAP1	99	103	PF00017	0.496
LIG_SH2_STAT5	103	106	PF00017	0.455
LIG_SH2_STAT5	286	289	PF00017	0.415
LIG_SH2_STAT5	350	353	PF00017	0.510
LIG_SH2_STAT5	354	357	PF00017	0.494
LIG_SH2_STAT5	404	407	PF00017	0.470
LIG_SH2_STAT5	445	448	PF00017	0.439
LIG_SH2_STAT5	482	485	PF00017	0.531
LIG_SH2_STAT5	601	604	PF00017	0.441
LIG_SH2_STAT5	658	661	PF00017	0.531
LIG_SH2_STAT5	96	99	PF00017	0.414
LIG_SH3_3	284	290	PF00018	0.413
LIG_SH3_3	577	583	PF00018	0.665
LIG_SH3_3	71	77	PF00018	0.568
LIG_SUMO_SIM_par_1	56	62	PF11976	0.660
LIG_SUMO_SIM_par_1	620	626	PF11976	0.531
LIG_TRAF2_1	475	478	PF00917	0.444
LIG_TRAF2_1	59	62	PF00917	0.545
LIG_TRFH_1	286	290	PF08558	0.415
LIG_TYR_ITIM	461	466	PF00017	0.570
LIG_UBA3_1	251	256	PF00899	0.679
LIG_UBA3_1	652	660	PF00899	0.477
LIG_WRC_WIRS_1	25	30	PF05994	0.582
LIG_WRC_WIRS_1	451	456	PF05994	0.504
MOD_CDK_SPK_2	344	349	PF00069	0.593
MOD_CK1_1	146	152	PF00069	0.722
MOD_CK1_1	174	180	PF00069	0.629
MOD_CK1_1	247	253	PF00069	0.725
MOD_CK1_1	33	39	PF00069	0.640
MOD_CK2_1	111	117	PF00069	0.540
MOD_CK2_1	268	274	PF00069	0.524
MOD_CK2_1	286	292	PF00069	0.518
MOD_CK2_1	412	418	PF00069	0.585
MOD_CK2_1	432	438	PF00069	0.417
MOD_CK2_1	472	478	PF00069	0.468
MOD_CK2_1	56	62	PF00069	0.533
MOD_CK2_1	563	569	PF00069	0.724
MOD_CK2_1	593	599	PF00069	0.577
MOD_CK2_1	626	632	PF00069	0.592
MOD_CK2_1	705	711	PF00069	0.594
MOD_CK2_1	78	84	PF00069	0.583
MOD_GlcNHglycan	136	139	PF01048	0.539
MOD_GlcNHglycan	150	153	PF01048	0.637
MOD_GlcNHglycan	173	176	PF01048	0.739
MOD_GlcNHglycan	20	23	PF01048	0.591
MOD_GlcNHglycan	270	273	PF01048	0.444
MOD_GlcNHglycan	32	35	PF01048	0.565
MOD_GlcNHglycan	571	574	PF01048	0.675
MOD_GSK3_1	151	158	PF00069	0.720
MOD_GSK3_1	24	31	PF00069	0.562
MOD_GSK3_1	243	250	PF00069	0.748
MOD_GSK3_1	299	306	PF00069	0.508
MOD_GSK3_1	419	426	PF00069	0.492
MOD_GSK3_1	428	435	PF00069	0.410
MOD_GSK3_1	446	453	PF00069	0.518
MOD_GSK3_1	513	520	PF00069	0.660
MOD_GSK3_1	617	624	PF00069	0.619
MOD_GSK3_1	703	710	PF00069	0.573
MOD_GSK3_1	78	85	PF00069	0.585
MOD_LATS_1	515	521	PF00433	0.701
MOD_N-GLC_1	205	210	PF02516	0.520
MOD_N-GLC_1	54	59	PF02516	0.667
MOD_N-GLC_1	627	632	PF02516	0.614
MOD_N-GLC_2	539	541	PF02516	0.494
MOD_NEK2_1	134	139	PF00069	0.478
MOD_NEK2_1	266	271	PF00069	0.391
MOD_NEK2_1	28	33	PF00069	0.559
MOD_NEK2_1	322	327	PF00069	0.508
MOD_NEK2_1	334	339	PF00069	0.370
MOD_NEK2_1	371	376	PF00069	0.510
MOD_NEK2_1	446	451	PF00069	0.456
MOD_NEK2_1	454	459	PF00069	0.411
MOD_NEK2_1	462	467	PF00069	0.316
MOD_NEK2_1	605	610	PF00069	0.469
MOD_NEK2_1	633	638	PF00069	0.510
MOD_NEK2_1	674	679	PF00069	0.467
MOD_NEK2_2	419	424	PF00069	0.545
MOD_PIKK_1	585	591	PF00454	0.609
MOD_PIKK_1	633	639	PF00454	0.530
MOD_PIKK_1	668	674	PF00454	0.441
MOD_PIKK_1	696	702	PF00454	0.593
MOD_PKA_1	574	580	PF00069	0.686
MOD_PKA_2	128	134	PF00069	0.547
MOD_PKA_2	18	24	PF00069	0.631
MOD_PKA_2	247	253	PF00069	0.708
MOD_PKA_2	266	272	PF00069	0.513
MOD_PKA_2	423	429	PF00069	0.553
MOD_PKA_2	528	534	PF00069	0.529
MOD_PKA_2	633	639	PF00069	0.518
MOD_Plk_1	322	328	PF00069	0.518
MOD_Plk_1	386	392	PF00069	0.546
MOD_Plk_1	432	438	PF00069	0.517
MOD_Plk_1	54	60	PF00069	0.657
MOD_Plk_1	627	633	PF00069	0.437
MOD_Plk_1	674	680	PF00069	0.440
MOD_Plk_1	83	89	PF00069	0.597
MOD_Plk_2-3	412	418	PF00069	0.466
MOD_Plk_2-3	621	627	PF00069	0.600
MOD_Plk_4	247	253	PF00069	0.744
MOD_Plk_4	303	309	PF00069	0.441
MOD_Plk_4	322	328	PF00069	0.368
MOD_Plk_4	446	452	PF00069	0.484
MOD_Plk_4	462	468	PF00069	0.312
MOD_ProDKin_1	146	152	PF00069	0.707
MOD_ProDKin_1	286	292	PF00069	0.463
MOD_ProDKin_1	344	350	PF00069	0.587
MOD_ProDKin_1	705	711	PF00069	0.515
MOD_SUMO_rev_2	214	224	PF00179	0.534
MOD_SUMO_rev_2	41	48	PF00179	0.686
MOD_SUMO_rev_2	662	669	PF00179	0.539
TRG_DiLeu_BaEn_2	377	383	PF01217	0.501
TRG_DiLeu_BaLyEn_6	180	185	PF01217	0.598
TRG_DiLeu_BaLyEn_6	261	266	PF01217	0.512
TRG_ENDOCYTIC_2	354	357	PF00928	0.465
TRG_ENDOCYTIC_2	455	458	PF00928	0.450
TRG_ENDOCYTIC_2	463	466	PF00928	0.509
TRG_ER_diArg_1	313	315	PF00400	0.559
TRG_ER_diArg_1	395	398	PF00400	0.560
TRG_ER_diArg_1	423	425	PF00400	0.580
TRG_ER_diArg_1	547	549	PF00400	0.500
TRG_ER_diArg_1	646	648	PF00400	0.514
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	273	278	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	398	402	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2N5	Leptomonas seymouri	69%	100%
A0A0S4JQA4	Bodo saltans	35%	98%
A0A1X0P526	Trypanosomatidae	44%	100%
A0A3Q8IIV4	Leishmania donovani	95%	100%
A0A422NCN3	Trypanosoma rangeli	44%	100%
A4HNH4	Leishmania braziliensis	82%	100%
C9ZYD8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B738	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BYQ9	Trypanosoma cruzi	44%	100%