LeishMANIAdb
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Augmin complex subunit msd5

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Augmin complex subunit msd5
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AFY1_LEIMA
TriTrypDb:
LmjF.35.5080 , LMJLV39_350058900 , LMJSD75_350058200
Length:
171

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 2
GO:0005930 axoneme 2 2
GO:0043226 organelle 2 2
GO:0043228 non-membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043232 intracellular non-membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

E9AFY1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFY1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 130 134 PF00082 0.486
CLV_PCSK_SKI1_1 85 89 PF00082 0.527
CLV_Separin_Metazoa 164 168 PF03568 0.389
CLV_Separin_Metazoa 41 45 PF03568 0.461
DEG_APCC_DBOX_1 100 108 PF00400 0.502
DEG_APCC_DBOX_1 38 46 PF00400 0.451
DOC_MAPK_gen_1 130 139 PF00069 0.538
DOC_MAPK_gen_1 37 45 PF00069 0.464
DOC_MAPK_MEF2A_6 162 170 PF00069 0.486
DOC_PP1_RVXF_1 165 171 PF00149 0.445
DOC_PP4_FxxP_1 4 7 PF00568 0.434
LIG_14-3-3_CanoR_1 167 171 PF00244 0.506
LIG_14-3-3_CanoR_1 9 14 PF00244 0.538
LIG_Actin_WH2_2 10 28 PF00022 0.552
LIG_APCC_ABBA_1 43 48 PF00400 0.523
LIG_BIR_II_1 1 5 PF00653 0.511
LIG_FHA_1 72 78 PF00498 0.497
LIG_FHA_1 89 95 PF00498 0.338
LIG_FHA_2 22 28 PF00498 0.553
LIG_LIR_Apic_2 2 7 PF02991 0.470
LIG_LIR_Gen_1 75 86 PF02991 0.430
LIG_LIR_Nem_3 75 81 PF02991 0.419
LIG_LIR_Nem_3 83 87 PF02991 0.467
LIG_PDZ_Class_1 166 171 PF00595 0.499
LIG_SH2_CRK 84 88 PF00017 0.569
LIG_SH2_STAP1 31 35 PF00017 0.522
LIG_SH2_STAT3 46 49 PF00017 0.557
LIG_UBA3_1 77 85 PF00899 0.503
MOD_CK1_1 110 116 PF00069 0.632
MOD_CK1_1 12 18 PF00069 0.500
MOD_CK1_1 53 59 PF00069 0.592
MOD_CK1_1 71 77 PF00069 0.374
MOD_CK2_1 21 27 PF00069 0.567
MOD_GSK3_1 151 158 PF00069 0.517
MOD_GSK3_1 56 63 PF00069 0.462
MOD_GSK3_1 67 74 PF00069 0.453
MOD_NEK2_1 107 112 PF00069 0.607
MOD_NEK2_1 11 16 PF00069 0.494
MOD_PIKK_1 110 116 PF00454 0.607
MOD_PIKK_1 151 157 PF00454 0.519
MOD_PK_1 9 15 PF00069 0.603
MOD_Plk_1 108 114 PF00069 0.448
MOD_Plk_1 56 62 PF00069 0.536
MOD_Plk_4 12 18 PF00069 0.507
MOD_Plk_4 132 138 PF00069 0.484
MOD_SUMO_for_1 161 164 PF00179 0.415
MOD_SUMO_for_1 20 23 PF00179 0.555
TRG_DiLeu_BaEn_1 103 108 PF01217 0.542
TRG_ENDOCYTIC_2 84 87 PF00928 0.534
TRG_Pf-PMV_PEXEL_1 96 100 PF00026 0.571

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHH3 Leptomonas seymouri 51% 100%
A0A0S4JTH6 Bodo saltans 23% 97%
A0A1X0P528 Trypanosomatidae 28% 100%
A0A422NCM8 Trypanosoma rangeli 28% 100%
A4HNH0 Leishmania braziliensis 71% 100%
C9ZYE2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 22% 100%
E9B734 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q25302 Leishmania infantum 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS