bVLRF1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFX9_LEIMA

TriTrypDb:

LmjF.35.5060 , LMJLV39_350058700 , LMJSD75_350058000

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AFX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFX9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010033	response to organic substance	3	2
GO:0010243	response to organonitrogen compound	4	2
GO:0010498	proteasomal protein catabolic process	5	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0030163	protein catabolic process	4	2
GO:0030433	ubiquitin-dependent ERAD pathway	6	2
GO:0033554	cellular response to stress	3	2
GO:0034976	response to endoplasmic reticulum stress	4	2
GO:0036503	ERAD pathway	5	2
GO:0042221	response to chemical	2	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0050896	response to stimulus	1	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0051716	cellular response to stimulus	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:1901698	response to nitrogen compound	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.693
CLV_NRD_NRD_1	114	116	PF00675	0.642
CLV_NRD_NRD_1	386	388	PF00675	0.260
CLV_NRD_NRD_1	467	469	PF00675	0.275
CLV_NRD_NRD_1	497	499	PF00675	0.323
CLV_PCSK_KEX2_1	114	116	PF00082	0.689
CLV_PCSK_KEX2_1	139	141	PF00082	0.657
CLV_PCSK_KEX2_1	278	280	PF00082	0.533
CLV_PCSK_KEX2_1	497	499	PF00082	0.323
CLV_PCSK_KEX2_1	70	72	PF00082	0.504
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.657
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.533
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.504
CLV_PCSK_SKI1_1	15	19	PF00082	0.498
CLV_PCSK_SKI1_1	210	214	PF00082	0.486
CLV_PCSK_SKI1_1	275	279	PF00082	0.574
CLV_PCSK_SKI1_1	42	46	PF00082	0.521
CLV_PCSK_SKI1_1	424	428	PF00082	0.240
CLV_PCSK_SKI1_1	450	454	PF00082	0.240
DEG_APCC_DBOX_1	41	49	PF00400	0.520
DEG_APCC_DBOX_1	504	512	PF00400	0.565
DEG_Nend_Nbox_1	1	3	PF02207	0.545
DEG_SCF_FBW7_1	17	24	PF00400	0.446
DEG_SPOP_SBC_1	191	195	PF00917	0.606
DEG_SPOP_SBC_1	285	289	PF00917	0.759
DOC_CKS1_1	18	23	PF01111	0.540
DOC_CKS1_1	204	209	PF01111	0.392
DOC_CYCLIN_RxL_1	9	20	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	147	153	PF00134	0.516
DOC_MAPK_DCC_7	468	476	PF00069	0.448
DOC_MAPK_gen_1	468	476	PF00069	0.557
DOC_MAPK_gen_1	477	486	PF00069	0.508
DOC_MAPK_RevD_3	456	469	PF00069	0.475
DOC_PP1_RVXF_1	208	214	PF00149	0.377
DOC_PP2B_LxvP_1	147	150	PF13499	0.513
DOC_PP2B_LxvP_1	333	336	PF13499	0.591
DOC_USP7_MATH_1	110	114	PF00917	0.722
DOC_USP7_MATH_1	116	120	PF00917	0.784
DOC_USP7_MATH_1	259	263	PF00917	0.590
DOC_USP7_MATH_1	285	289	PF00917	0.756
DOC_USP7_MATH_1	46	50	PF00917	0.530
DOC_USP7_MATH_1	461	465	PF00917	0.503
DOC_USP7_MATH_1	479	483	PF00917	0.546
DOC_USP7_UBL2_3	118	122	PF12436	0.650
DOC_USP7_UBL2_3	124	128	PF12436	0.660
DOC_USP7_UBL2_3	135	139	PF12436	0.543
DOC_USP7_UBL2_3	389	393	PF12436	0.440
DOC_WW_Pin1_4	166	171	PF00397	0.745
DOC_WW_Pin1_4	17	22	PF00397	0.501
DOC_WW_Pin1_4	203	208	PF00397	0.389
DOC_WW_Pin1_4	281	286	PF00397	0.704
DOC_WW_Pin1_4	469	474	PF00397	0.465
LIG_14-3-3_CanoR_1	22	26	PF00244	0.500
LIG_14-3-3_CanoR_1	450	460	PF00244	0.440
LIG_14-3-3_CanoR_1	483	493	PF00244	0.494
LIG_14-3-3_CanoR_1	505	509	PF00244	0.583
LIG_14-3-3_CterR_2	519	522	PF00244	0.501
LIG_BRCT_BRCA1_1	339	343	PF00533	0.571
LIG_BRCT_BRCA1_1	85	89	PF00533	0.679
LIG_FHA_1	170	176	PF00498	0.586
LIG_FHA_1	212	218	PF00498	0.443
LIG_FHA_1	22	28	PF00498	0.543
LIG_FHA_1	299	305	PF00498	0.531
LIG_FHA_1	330	336	PF00498	0.521
LIG_FHA_1	349	355	PF00498	0.525
LIG_FHA_1	9	15	PF00498	0.508
LIG_FHA_2	139	145	PF00498	0.770
LIG_FHA_2	182	188	PF00498	0.406
LIG_FHA_2	21	27	PF00498	0.482
LIG_FHA_2	264	270	PF00498	0.613
LIG_FHA_2	285	291	PF00498	0.666
LIG_FHA_2	306	312	PF00498	0.552
LIG_FHA_2	490	496	PF00498	0.471
LIG_LIR_Gen_1	171	181	PF02991	0.507
LIG_LIR_Gen_1	352	359	PF02991	0.346
LIG_LIR_Gen_1	403	411	PF02991	0.534
LIG_LIR_Gen_1	454	463	PF02991	0.472
LIG_LIR_Gen_1	492	500	PF02991	0.453
LIG_LIR_Nem_3	171	177	PF02991	0.524
LIG_LIR_Nem_3	229	234	PF02991	0.376
LIG_LIR_Nem_3	352	358	PF02991	0.363
LIG_LIR_Nem_3	403	407	PF02991	0.441
LIG_LIR_Nem_3	429	433	PF02991	0.471
LIG_LIR_Nem_3	438	442	PF02991	0.458
LIG_LIR_Nem_3	454	459	PF02991	0.377
LIG_LIR_Nem_3	492	496	PF02991	0.453
LIG_NRBOX	13	19	PF00104	0.389
LIG_PCNA_yPIPBox_3	199	212	PF02747	0.513
LIG_Pex14_2	85	89	PF04695	0.679
LIG_SH2_CRK	231	235	PF00017	0.376
LIG_SH2_CRK	404	408	PF00017	0.440
LIG_SH2_CRK	442	446	PF00017	0.535
LIG_SH2_NCK_1	317	321	PF00017	0.516
LIG_SH2_NCK_1	404	408	PF00017	0.535
LIG_SH2_NCK_1	442	446	PF00017	0.535
LIG_SH2_STAT3	510	513	PF00017	0.487
LIG_SH2_STAT3	52	55	PF00017	0.508
LIG_SH2_STAT5	364	367	PF00017	0.440
LIG_SH2_STAT5	384	387	PF00017	0.440
LIG_SH2_STAT5	433	436	PF00017	0.440
LIG_SH2_STAT5	510	513	PF00017	0.388
LIG_SH2_STAT5	52	55	PF00017	0.391
LIG_SH3_3	201	207	PF00018	0.451
LIG_TRAF2_1	323	326	PF00917	0.623
LIG_TRAF2_1	413	416	PF00917	0.535
LIG_TRAF2_1	492	495	PF00917	0.453
LIG_TRAF2_1	90	93	PF00917	0.634
LIG_TRAF2_2	473	478	PF00917	0.492
LIG_TRFH_1	456	460	PF08558	0.535
MOD_CDK_SPK_2	17	22	PF00069	0.540
MOD_CDK_SPK_2	281	286	PF00069	0.636
MOD_CDK_SPxxK_3	166	173	PF00069	0.544
MOD_CDK_SPxxK_3	203	210	PF00069	0.385
MOD_CK1_1	104	110	PF00069	0.638
MOD_CK1_1	168	174	PF00069	0.716
MOD_CK1_1	284	290	PF00069	0.765
MOD_CK1_1	403	409	PF00069	0.446
MOD_CK1_1	504	510	PF00069	0.498
MOD_CK2_1	1	7	PF00069	0.463
MOD_CK2_1	117	123	PF00069	0.756
MOD_CK2_1	181	187	PF00069	0.624
MOD_CK2_1	20	26	PF00069	0.363
MOD_CK2_1	243	249	PF00069	0.406
MOD_CK2_1	299	305	PF00069	0.716
MOD_CK2_1	489	495	PF00069	0.453
MOD_Cter_Amidation	466	469	PF01082	0.275
MOD_GlcNHglycan	103	106	PF01048	0.694
MOD_GlcNHglycan	119	122	PF01048	0.591
MOD_GlcNHglycan	275	278	PF01048	0.762
MOD_GlcNHglycan	47	51	PF01048	0.435
MOD_GSK3_1	13	20	PF00069	0.521
MOD_GSK3_1	164	171	PF00069	0.688
MOD_GSK3_1	211	218	PF00069	0.436
MOD_GSK3_1	259	266	PF00069	0.535
MOD_GSK3_1	281	288	PF00069	0.742
MOD_GSK3_1	485	492	PF00069	0.453
MOD_NEK2_1	253	258	PF00069	0.346
MOD_PIKK_1	253	259	PF00454	0.411
MOD_PIKK_1	406	412	PF00454	0.455
MOD_PKA_1	117	123	PF00069	0.704
MOD_PKA_2	21	27	PF00069	0.488
MOD_PKA_2	371	377	PF00069	0.538
MOD_PKA_2	479	485	PF00069	0.552
MOD_PKA_2	489	495	PF00069	0.375
MOD_PKA_2	504	510	PF00069	0.560
MOD_Plk_1	298	304	PF00069	0.655
MOD_Plk_1	305	311	PF00069	0.560
MOD_Plk_1	454	460	PF00069	0.479
MOD_Plk_2-3	138	144	PF00069	0.552
MOD_Plk_2-3	299	305	PF00069	0.635
MOD_Plk_4	13	19	PF00069	0.465
MOD_Plk_4	299	305	PF00069	0.682
MOD_Plk_4	435	441	PF00069	0.497
MOD_Plk_4	504	510	PF00069	0.575
MOD_ProDKin_1	166	172	PF00069	0.732
MOD_ProDKin_1	17	23	PF00069	0.501
MOD_ProDKin_1	203	209	PF00069	0.380
MOD_ProDKin_1	281	287	PF00069	0.706
MOD_ProDKin_1	469	475	PF00069	0.465
MOD_SUMO_for_1	198	201	PF00179	0.341
MOD_SUMO_rev_2	4	11	PF00179	0.428
TRG_ENDOCYTIC_2	231	234	PF00928	0.400
TRG_ENDOCYTIC_2	404	407	PF00928	0.440
TRG_ER_diArg_1	114	116	PF00400	0.670
TRG_ER_diArg_1	496	498	PF00400	0.456
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.627
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGL8	Leptomonas seymouri	63%	100%
A0A1X0P4S2	Trypanosomatidae	42%	100%
A0A3Q8IQ93	Leishmania donovani	91%	100%
A0A3S5IQY8	Trypanosoma rangeli	39%	100%
A4HNG8	Leishmania braziliensis	74%	100%
A4IC59	Leishmania infantum	92%	100%
C9ZYE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9B732	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5DQH4	Trypanosoma cruzi	42%	100%