Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFX8_LEIMA

TriTrypDb:

LmjF.35.5050 , LMJLV39_350058600 , LMJSD75_350057900

Length:

648

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFX8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.638
CLV_NRD_NRD_1	19	21	PF00675	0.779
CLV_NRD_NRD_1	329	331	PF00675	0.579
CLV_NRD_NRD_1	373	375	PF00675	0.666
CLV_NRD_NRD_1	377	379	PF00675	0.637
CLV_NRD_NRD_1	412	414	PF00675	0.638
CLV_NRD_NRD_1	516	518	PF00675	0.712
CLV_NRD_NRD_1	520	522	PF00675	0.705
CLV_NRD_NRD_1	545	547	PF00675	0.700
CLV_NRD_NRD_1	583	585	PF00675	0.720
CLV_NRD_NRD_1	590	592	PF00675	0.649
CLV_PCSK_FUR_1	374	378	PF00082	0.625
CLV_PCSK_FUR_1	517	521	PF00082	0.679
CLV_PCSK_FUR_1	588	592	PF00082	0.714
CLV_PCSK_KEX2_1	19	21	PF00082	0.688
CLV_PCSK_KEX2_1	329	331	PF00082	0.579
CLV_PCSK_KEX2_1	373	375	PF00082	0.666
CLV_PCSK_KEX2_1	376	378	PF00082	0.649
CLV_PCSK_KEX2_1	412	414	PF00082	0.638
CLV_PCSK_KEX2_1	516	518	PF00082	0.713
CLV_PCSK_KEX2_1	519	521	PF00082	0.713
CLV_PCSK_KEX2_1	545	547	PF00082	0.700
CLV_PCSK_KEX2_1	583	585	PF00082	0.720
CLV_PCSK_KEX2_1	590	592	PF00082	0.649
CLV_PCSK_PC7_1	373	379	PF00082	0.623
CLV_PCSK_PC7_1	408	414	PF00082	0.552
CLV_PCSK_PC7_1	516	522	PF00082	0.704
CLV_PCSK_SKI1_1	190	194	PF00082	0.657
CLV_PCSK_SKI1_1	243	247	PF00082	0.620
CLV_PCSK_SKI1_1	36	40	PF00082	0.624
CLV_PCSK_SKI1_1	558	562	PF00082	0.638
CLV_PCSK_SKI1_1	90	94	PF00082	0.581
DEG_Nend_UBRbox_2	1	3	PF02207	0.640
DEG_SPOP_SBC_1	214	218	PF00917	0.655
DEG_SPOP_SBC_1	290	294	PF00917	0.647
DEG_SPOP_SBC_1	45	49	PF00917	0.682
DOC_ANK_TNKS_1	329	336	PF00023	0.548
DOC_ANK_TNKS_1	460	467	PF00023	0.617
DOC_CKS1_1	83	88	PF01111	0.729
DOC_CYCLIN_yCln2_LP_2	180	183	PF00134	0.644
DOC_CYCLIN_yCln2_LP_2	564	570	PF00134	0.639
DOC_CYCLIN_yCln2_LP_2	630	636	PF00134	0.581
DOC_MAPK_MEF2A_6	558	566	PF00069	0.640
DOC_MAPK_RevD_3	359	374	PF00069	0.639
DOC_MAPK_RevD_3	532	546	PF00069	0.624
DOC_PP2B_LxvP_1	180	183	PF13499	0.644
DOC_PP2B_LxvP_1	224	227	PF13499	0.703
DOC_PP2B_LxvP_1	265	268	PF13499	0.714
DOC_PP2B_LxvP_1	455	458	PF13499	0.667
DOC_PP2B_LxvP_1	564	567	PF13499	0.633
DOC_SPAK_OSR1_1	357	361	PF12202	0.660
DOC_USP7_MATH_1	127	131	PF00917	0.721
DOC_USP7_MATH_1	152	156	PF00917	0.668
DOC_USP7_MATH_1	164	168	PF00917	0.615
DOC_USP7_MATH_1	192	196	PF00917	0.683
DOC_USP7_MATH_1	200	204	PF00917	0.634
DOC_USP7_MATH_1	214	218	PF00917	0.576
DOC_USP7_MATH_1	227	231	PF00917	0.535
DOC_USP7_MATH_1	275	279	PF00917	0.748
DOC_USP7_MATH_1	290	294	PF00917	0.526
DOC_USP7_MATH_1	304	308	PF00917	0.569
DOC_USP7_MATH_1	313	317	PF00917	0.585
DOC_USP7_MATH_1	393	397	PF00917	0.657
DOC_USP7_MATH_1	418	422	PF00917	0.649
DOC_USP7_MATH_1	45	49	PF00917	0.635
DOC_USP7_MATH_1	464	468	PF00917	0.662
DOC_USP7_MATH_1	511	515	PF00917	0.726
DOC_USP7_MATH_1	640	644	PF00917	0.640
DOC_WW_Pin1_4	131	136	PF00397	0.587
DOC_WW_Pin1_4	202	207	PF00397	0.701
DOC_WW_Pin1_4	219	224	PF00397	0.540
DOC_WW_Pin1_4	293	298	PF00397	0.625
DOC_WW_Pin1_4	309	314	PF00397	0.643
DOC_WW_Pin1_4	335	340	PF00397	0.776
DOC_WW_Pin1_4	388	393	PF00397	0.654
DOC_WW_Pin1_4	441	446	PF00397	0.667
DOC_WW_Pin1_4	509	514	PF00397	0.662
DOC_WW_Pin1_4	528	533	PF00397	0.528
DOC_WW_Pin1_4	536	541	PF00397	0.624
DOC_WW_Pin1_4	558	563	PF00397	0.666
DOC_WW_Pin1_4	578	583	PF00397	0.535
DOC_WW_Pin1_4	58	63	PF00397	0.692
DOC_WW_Pin1_4	592	597	PF00397	0.560
DOC_WW_Pin1_4	621	626	PF00397	0.780
DOC_WW_Pin1_4	82	87	PF00397	0.826
LIG_14-3-3_CanoR_1	103	107	PF00244	0.684
LIG_14-3-3_CanoR_1	213	223	PF00244	0.701
LIG_14-3-3_CanoR_1	408	414	PF00244	0.654
LIG_14-3-3_CanoR_1	441	445	PF00244	0.617
LIG_BIR_III_2	639	643	PF00653	0.623
LIG_BRCT_BRCA1_1	337	341	PF00533	0.616
LIG_CtBP_PxDLS_1	206	210	PF00389	0.652
LIG_EVH1_1	265	269	PF00568	0.715
LIG_FHA_1	175	181	PF00498	0.617
LIG_FHA_1	26	32	PF00498	0.685
LIG_FHA_1	283	289	PF00498	0.653
LIG_FHA_1	559	565	PF00498	0.638
LIG_FHA_1	625	631	PF00498	0.685
LIG_FHA_2	574	580	PF00498	0.667
LIG_FHA_2	83	89	PF00498	0.583
LIG_LIR_Apic_2	595	601	PF02991	0.685
LIG_LIR_Gen_1	355	364	PF02991	0.650
LIG_LIR_Gen_1	493	500	PF02991	0.576
LIG_LIR_Gen_1	56	65	PF02991	0.625
LIG_LIR_Nem_3	218	224	PF02991	0.768
LIG_LIR_Nem_3	355	361	PF02991	0.654
LIG_LIR_Nem_3	493	497	PF02991	0.568
LIG_LIR_Nem_3	56	60	PF02991	0.676
LIG_MYND_1	476	480	PF01753	0.640
LIG_MYND_1	96	100	PF01753	0.694
LIG_RPA_C_Fungi	541	553	PF08784	0.702
LIG_SH2_CRK	57	61	PF00017	0.678
LIG_SH2_CRK	598	602	PF00017	0.686
LIG_SH2_NCK_1	598	602	PF00017	0.686
LIG_SH3_1	19	25	PF00018	0.668
LIG_SH3_1	263	269	PF00018	0.713
LIG_SH3_3	121	127	PF00018	0.639
LIG_SH3_3	19	25	PF00018	0.668
LIG_SH3_3	263	269	PF00018	0.779
LIG_SH3_3	28	34	PF00018	0.611
LIG_SH3_3	328	334	PF00018	0.713
LIG_SH3_3	347	353	PF00018	0.792
LIG_SH3_3	361	367	PF00018	0.639
LIG_SH3_3	619	625	PF00018	0.684
LIG_SH3_3	639	645	PF00018	0.522
LIG_SH3_3	77	83	PF00018	0.722
LIG_SH3_3	94	100	PF00018	0.597
LIG_SUMO_SIM_anti_2	155	162	PF11976	0.638
MOD_CDC14_SPxK_1	581	584	PF00782	0.708
MOD_CDC14_SPxK_1	628	631	PF00782	0.708
MOD_CDK_SPK_2	578	583	PF00069	0.709
MOD_CDK_SPxK_1	578	584	PF00069	0.711
MOD_CDK_SPxK_1	625	631	PF00069	0.704
MOD_CDK_SPxxK_3	509	516	PF00069	0.649
MOD_CK1_1	105	111	PF00069	0.621
MOD_CK1_1	130	136	PF00069	0.720
MOD_CK1_1	167	173	PF00069	0.711
MOD_CK1_1	175	181	PF00069	0.604
MOD_CK1_1	205	211	PF00069	0.763
MOD_CK1_1	217	223	PF00069	0.630
MOD_CK1_1	231	237	PF00069	0.519
MOD_CK1_1	256	262	PF00069	0.698
MOD_CK1_1	293	299	PF00069	0.642
MOD_CK1_1	365	371	PF00069	0.481
MOD_CK1_1	425	431	PF00069	0.665
MOD_CK1_1	493	499	PF00069	0.645
MOD_CK1_1	512	518	PF00069	0.552
MOD_CK1_1	548	554	PF00069	0.667
MOD_CK1_1	594	600	PF00069	0.691
MOD_CK1_1	604	610	PF00069	0.585
MOD_CK1_1	624	630	PF00069	0.513
MOD_CK1_1	91	97	PF00069	0.721
MOD_CK2_1	322	328	PF00069	0.652
MOD_DYRK1A_RPxSP_1	441	445	PF00069	0.726
MOD_DYRK1A_RPxSP_1	558	562	PF00069	0.638
MOD_DYRK1A_RPxSP_1	621	625	PF00069	0.648
MOD_DYRK1A_RPxSP_1	82	86	PF00069	0.729
MOD_GlcNHglycan	161	164	PF01048	0.708
MOD_GlcNHglycan	171	174	PF01048	0.603
MOD_GlcNHglycan	177	180	PF01048	0.544
MOD_GlcNHglycan	230	233	PF01048	0.598
MOD_GlcNHglycan	258	261	PF01048	0.596
MOD_GlcNHglycan	277	280	PF01048	0.748
MOD_GlcNHglycan	367	370	PF01048	0.703
MOD_GlcNHglycan	418	421	PF01048	0.637
MOD_GlcNHglycan	424	427	PF01048	0.618
MOD_GlcNHglycan	462	465	PF01048	0.600
MOD_GlcNHglycan	48	51	PF01048	0.608
MOD_GlcNHglycan	497	500	PF01048	0.777
MOD_GlcNHglycan	521	524	PF01048	0.668
MOD_GlcNHglycan	548	551	PF01048	0.661
MOD_GlcNHglycan	572	576	PF01048	0.649
MOD_GlcNHglycan	585	588	PF01048	0.571
MOD_GlcNHglycan	611	615	PF01048	0.679
MOD_GlcNHglycan	90	93	PF01048	0.671
MOD_GSK3_1	102	109	PF00069	0.759
MOD_GSK3_1	125	132	PF00069	0.738
MOD_GSK3_1	188	195	PF00069	0.714
MOD_GSK3_1	198	205	PF00069	0.651
MOD_GSK3_1	213	220	PF00069	0.569
MOD_GSK3_1	227	234	PF00069	0.530
MOD_GSK3_1	289	296	PF00069	0.673
MOD_GSK3_1	309	316	PF00069	0.552
MOD_GSK3_1	32	39	PF00069	0.777
MOD_GSK3_1	40	47	PF00069	0.629
MOD_GSK3_1	418	425	PF00069	0.690
MOD_GSK3_1	460	467	PF00069	0.660
MOD_GSK3_1	617	624	PF00069	0.707
MOD_GSK3_1	78	85	PF00069	0.731
MOD_N-GLC_1	128	133	PF02516	0.679
MOD_N-GLC_1	36	41	PF02516	0.631
MOD_NEK2_1	158	163	PF00069	0.723
MOD_NEK2_1	253	258	PF00069	0.654
MOD_NEK2_1	27	32	PF00069	0.698
MOD_NEK2_1	289	294	PF00069	0.599
MOD_NEK2_1	314	319	PF00069	0.680
MOD_NEK2_1	38	43	PF00069	0.533
MOD_NEK2_1	407	412	PF00069	0.596
MOD_NEK2_1	439	444	PF00069	0.682
MOD_NEK2_2	393	398	PF00069	0.639
MOD_PIKK_1	253	259	PF00454	0.509
MOD_PIKK_1	362	368	PF00454	0.488
MOD_PIKK_1	551	557	PF00454	0.711
MOD_PKA_1	519	525	PF00069	0.672
MOD_PKA_1	545	551	PF00069	0.704
MOD_PKA_1	583	589	PF00069	0.666
MOD_PKA_2	102	108	PF00069	0.743
MOD_PKA_2	114	120	PF00069	0.656
MOD_PKA_2	167	173	PF00069	0.697
MOD_PKA_2	32	38	PF00069	0.752
MOD_PKA_2	407	413	PF00069	0.653
MOD_PKA_2	440	446	PF00069	0.619
MOD_PKA_2	460	466	PF00069	0.568
MOD_PKA_2	519	525	PF00069	0.672
MOD_PKA_2	545	551	PF00069	0.704
MOD_PKA_2	583	589	PF00069	0.666
MOD_PKB_1	517	525	PF00069	0.671
MOD_Plk_1	253	259	PF00069	0.581
MOD_Plk_1	304	310	PF00069	0.704
MOD_Plk_1	353	359	PF00069	0.721
MOD_Plk_4	182	188	PF00069	0.541
MOD_Plk_4	27	33	PF00069	0.643
MOD_Plk_4	393	399	PF00069	0.687
MOD_Plk_4	474	480	PF00069	0.670
MOD_Plk_4	538	544	PF00069	0.642
MOD_Plk_4	601	607	PF00069	0.685
MOD_ProDKin_1	131	137	PF00069	0.587
MOD_ProDKin_1	202	208	PF00069	0.700
MOD_ProDKin_1	219	225	PF00069	0.539
MOD_ProDKin_1	293	299	PF00069	0.627
MOD_ProDKin_1	309	315	PF00069	0.639
MOD_ProDKin_1	335	341	PF00069	0.776
MOD_ProDKin_1	388	394	PF00069	0.650
MOD_ProDKin_1	441	447	PF00069	0.669
MOD_ProDKin_1	509	515	PF00069	0.662
MOD_ProDKin_1	528	534	PF00069	0.528
MOD_ProDKin_1	536	542	PF00069	0.622
MOD_ProDKin_1	558	564	PF00069	0.666
MOD_ProDKin_1	578	584	PF00069	0.538
MOD_ProDKin_1	58	64	PF00069	0.692
MOD_ProDKin_1	592	598	PF00069	0.561
MOD_ProDKin_1	621	627	PF00069	0.781
MOD_ProDKin_1	82	88	PF00069	0.827
TRG_DiLeu_BaEn_1	207	212	PF01217	0.638
TRG_DiLeu_BaEn_1	474	479	PF01217	0.620
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.702
TRG_ENDOCYTIC_2	57	60	PF00928	0.679
TRG_ER_diArg_1	18	20	PF00400	0.689
TRG_ER_diArg_1	240	243	PF00400	0.469
TRG_ER_diArg_1	329	331	PF00400	0.579
TRG_ER_diArg_1	373	376	PF00400	0.666
TRG_ER_diArg_1	412	414	PF00400	0.636
TRG_ER_diArg_1	516	519	PF00400	0.718
TRG_ER_diArg_1	582	584	PF00400	0.709
TRG_ER_diArg_1	588	591	PF00400	0.660
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.638
TRG_Pf-PMV_PEXEL_1	72	77	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H810	Leishmania donovani	86%	100%
A4HNG7	Leishmania braziliensis	59%	100%
A4IC58	Leishmania infantum	85%	100%
E9B731	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%