Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFX6_LEIMA

TriTrypDb:

LmjF.35.5030 , LMJLV39_350058400 , LMJSD75_350057700

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFX6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	506	510	PF00656	0.342
CLV_NRD_NRD_1	135	137	PF00675	0.509
CLV_NRD_NRD_1	149	151	PF00675	0.479
CLV_NRD_NRD_1	306	308	PF00675	0.436
CLV_NRD_NRD_1	42	44	PF00675	0.514
CLV_NRD_NRD_1	63	65	PF00675	0.552
CLV_PCSK_FUR_1	304	308	PF00082	0.417
CLV_PCSK_KEX2_1	135	137	PF00082	0.517
CLV_PCSK_KEX2_1	149	151	PF00082	0.479
CLV_PCSK_KEX2_1	306	308	PF00082	0.436
CLV_PCSK_SKI1_1	185	189	PF00082	0.386
CLV_PCSK_SKI1_1	203	207	PF00082	0.492
CLV_PCSK_SKI1_1	279	283	PF00082	0.523
CLV_PCSK_SKI1_1	339	343	PF00082	0.522
DEG_APCC_DBOX_1	306	314	PF00400	0.598
DEG_Nend_Nbox_1	1	3	PF02207	0.661
DEG_SPOP_SBC_1	163	167	PF00917	0.639
DOC_CKS1_1	364	369	PF01111	0.720
DOC_CKS1_1	375	380	PF01111	0.589
DOC_CYCLIN_RxL_1	200	207	PF00134	0.674
DOC_CYCLIN_yCln2_LP_2	50	56	PF00134	0.652
DOC_MAPK_gen_1	451	459	PF00069	0.283
DOC_MAPK_MEF2A_6	164	172	PF00069	0.690
DOC_PP1_RVXF_1	329	335	PF00149	0.658
DOC_PP1_RVXF_1	42	49	PF00149	0.708
DOC_PP1_RVXF_1	456	462	PF00149	0.299
DOC_PP2B_LxvP_1	206	209	PF13499	0.709
DOC_PP2B_LxvP_1	50	53	PF13499	0.668
DOC_PP4_FxxP_1	211	214	PF00568	0.642
DOC_PP4_FxxP_1	384	387	PF00568	0.603
DOC_USP7_MATH_1	128	132	PF00917	0.760
DOC_USP7_MATH_1	274	278	PF00917	0.597
DOC_USP7_MATH_1	291	295	PF00917	0.725
DOC_USP7_MATH_1	387	391	PF00917	0.664
DOC_USP7_MATH_1	490	494	PF00917	0.401
DOC_USP7_MATH_1	510	514	PF00917	0.337
DOC_USP7_MATH_1	515	519	PF00917	0.304
DOC_USP7_UBL2_3	177	181	PF12436	0.693
DOC_WW_Pin1_4	122	127	PF00397	0.740
DOC_WW_Pin1_4	164	169	PF00397	0.679
DOC_WW_Pin1_4	284	289	PF00397	0.653
DOC_WW_Pin1_4	356	361	PF00397	0.745
DOC_WW_Pin1_4	363	368	PF00397	0.703
DOC_WW_Pin1_4	374	379	PF00397	0.553
DOC_WW_Pin1_4	397	402	PF00397	0.662
DOC_WW_Pin1_4	83	88	PF00397	0.642
LIG_14-3-3_CanoR_1	135	141	PF00244	0.747
LIG_14-3-3_CanoR_1	159	164	PF00244	0.758
LIG_14-3-3_CanoR_1	236	244	PF00244	0.721
LIG_14-3-3_CanoR_1	312	318	PF00244	0.592
LIG_14-3-3_CanoR_1	64	72	PF00244	0.744
LIG_14-3-3_CanoR_1	73	82	PF00244	0.682
LIG_BIR_III_2	509	513	PF00653	0.341
LIG_CSL_BTD_1	460	463	PF09270	0.358
LIG_FHA_1	165	171	PF00498	0.637
LIG_FHA_1	186	192	PF00498	0.630
LIG_FHA_1	375	381	PF00498	0.644
LIG_FHA_1	454	460	PF00498	0.346
LIG_FHA_1	490	496	PF00498	0.508
LIG_FHA_1	75	81	PF00498	0.719
LIG_FHA_2	100	106	PF00498	0.672
LIG_FHA_2	33	39	PF00498	0.717
LIG_LIR_Apic_2	382	387	PF02991	0.595
LIG_LIR_Gen_1	478	488	PF02991	0.347
LIG_LIR_Nem_3	233	238	PF02991	0.659
LIG_LIR_Nem_3	277	281	PF02991	0.621
LIG_LIR_Nem_3	478	483	PF02991	0.346
LIG_LIR_Nem_3	516	522	PF02991	0.332
LIG_NRBOX	427	433	PF00104	0.315
LIG_REV1ctd_RIR_1	1	10	PF16727	0.674
LIG_SH2_CRK	278	282	PF00017	0.664
LIG_SH2_STAP1	404	408	PF00017	0.631
LIG_SH2_STAP1	522	526	PF00017	0.326
LIG_SH2_STAT5	106	109	PF00017	0.729
LIG_SH3_3	145	151	PF00018	0.700
LIG_SH3_3	241	247	PF00018	0.696
LIG_SH3_3	282	288	PF00018	0.702
LIG_SH3_3	361	367	PF00018	0.682
LIG_SH3_3	395	401	PF00018	0.697
LIG_SH3_3	457	463	PF00018	0.353
LIG_SH3_3	68	74	PF00018	0.650
LIG_SUMO_SIM_par_1	503	509	PF11976	0.454
LIG_WRC_WIRS_1	432	437	PF05994	0.395
MOD_CDC14_SPxK_1	287	290	PF00782	0.677
MOD_CDK_SPK_2	83	88	PF00069	0.642
MOD_CDK_SPxK_1	284	290	PF00069	0.674
MOD_CK1_1	122	128	PF00069	0.746
MOD_CK1_1	14	20	PF00069	0.687
MOD_CK1_1	162	168	PF00069	0.825
MOD_CK1_1	204	210	PF00069	0.703
MOD_CK1_1	222	228	PF00069	0.611
MOD_CK1_1	359	365	PF00069	0.694
MOD_CK1_1	410	416	PF00069	0.717
MOD_CK1_1	83	89	PF00069	0.697
MOD_CK1_1	96	102	PF00069	0.612
MOD_CK2_1	510	516	PF00069	0.327
MOD_CK2_1	526	532	PF00069	0.364
MOD_DYRK1A_RPxSP_1	164	168	PF00069	0.652
MOD_GlcNHglycan	111	114	PF01048	0.393
MOD_GlcNHglycan	155	158	PF01048	0.576
MOD_GlcNHglycan	238	241	PF01048	0.535
MOD_GlcNHglycan	250	253	PF01048	0.491
MOD_GlcNHglycan	301	304	PF01048	0.513
MOD_GlcNHglycan	339	342	PF01048	0.441
MOD_GlcNHglycan	346	349	PF01048	0.405
MOD_GlcNHglycan	387	390	PF01048	0.448
MOD_GlcNHglycan	439	442	PF01048	0.491
MOD_GlcNHglycan	464	469	PF01048	0.555
MOD_GlcNHglycan	492	495	PF01048	0.582
MOD_GSK3_1	105	112	PF00069	0.729
MOD_GSK3_1	159	166	PF00069	0.803
MOD_GSK3_1	16	23	PF00069	0.634
MOD_GSK3_1	190	197	PF00069	0.643
MOD_GSK3_1	32	39	PF00069	0.596
MOD_GSK3_1	358	365	PF00069	0.753
MOD_GSK3_1	431	438	PF00069	0.454
MOD_GSK3_1	60	67	PF00069	0.718
MOD_GSK3_1	74	81	PF00069	0.756
MOD_GSK3_1	93	100	PF00069	0.650
MOD_LATS_1	134	140	PF00433	0.716
MOD_N-GLC_2	115	117	PF02516	0.443
MOD_N-GLC_2	336	338	PF02516	0.459
MOD_NEK2_1	11	16	PF00069	0.663
MOD_NEK2_1	170	175	PF00069	0.674
MOD_NEK2_1	2	7	PF00069	0.708
MOD_NEK2_1	201	206	PF00069	0.695
MOD_NEK2_1	230	235	PF00069	0.668
MOD_NEK2_1	32	37	PF00069	0.684
MOD_NEK2_1	407	412	PF00069	0.600
MOD_NEK2_1	431	436	PF00069	0.395
MOD_NEK2_1	59	64	PF00069	0.681
MOD_NEK2_2	498	503	PF00069	0.430
MOD_PIKK_1	117	123	PF00454	0.711
MOD_PIKK_1	510	516	PF00454	0.384
MOD_PK_1	159	165	PF00069	0.714
MOD_PKA_1	185	191	PF00069	0.589
MOD_PKA_1	64	70	PF00069	0.726
MOD_PKA_2	153	159	PF00069	0.683
MOD_PKA_2	163	169	PF00069	0.709
MOD_PKA_2	313	319	PF00069	0.629
MOD_PKA_2	78	84	PF00069	0.697
MOD_PKA_2	96	102	PF00069	0.604
MOD_PKB_1	335	343	PF00069	0.658
MOD_PKB_1	95	103	PF00069	0.731
MOD_Plk_1	201	207	PF00069	0.710
MOD_Plk_1	423	429	PF00069	0.541
MOD_Plk_1	515	521	PF00069	0.367
MOD_Plk_1	97	103	PF00069	0.706
MOD_Plk_4	171	177	PF00069	0.663
MOD_Plk_4	201	207	PF00069	0.728
MOD_Plk_4	238	244	PF00069	0.620
MOD_Plk_4	292	298	PF00069	0.737
MOD_Plk_4	402	408	PF00069	0.657
MOD_Plk_4	431	437	PF00069	0.384
MOD_ProDKin_1	122	128	PF00069	0.740
MOD_ProDKin_1	164	170	PF00069	0.677
MOD_ProDKin_1	284	290	PF00069	0.655
MOD_ProDKin_1	356	362	PF00069	0.746
MOD_ProDKin_1	363	369	PF00069	0.704
MOD_ProDKin_1	374	380	PF00069	0.552
MOD_ProDKin_1	397	403	PF00069	0.658
MOD_ProDKin_1	83	89	PF00069	0.643
MOD_SUMO_rev_2	178	188	PF00179	0.687
MOD_SUMO_rev_2	327	332	PF00179	0.658
MOD_SUMO_rev_2	38	46	PF00179	0.635
TRG_AP2beta_CARGO_1	478	487	PF09066	0.329
TRG_DiLeu_BaEn_1	424	429	PF01217	0.570
TRG_DiLeu_BaEn_1	455	460	PF01217	0.286
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.592
TRG_DiLeu_BaLyEn_6	266	271	PF01217	0.636
TRG_DiLeu_BaLyEn_6	276	281	PF01217	0.636
TRG_DiLeu_BaLyEn_6	375	380	PF01217	0.665
TRG_ENDOCYTIC_2	278	281	PF00928	0.626
TRG_ENDOCYTIC_2	404	407	PF00928	0.646
TRG_ENDOCYTIC_2	524	527	PF00928	0.351
TRG_ER_diArg_1	135	137	PF00400	0.720
TRG_ER_diArg_1	148	150	PF00400	0.741
TRG_ER_diArg_1	266	269	PF00400	0.637
TRG_ER_diArg_1	304	307	PF00400	0.631
TRG_ER_diArg_1	334	337	PF00400	0.705
TRG_Pf-PMV_PEXEL_1	269	273	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	279	283	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3L4	Leptomonas seymouri	34%	92%
A0A3S7XA13	Leishmania donovani	85%	100%
A4HNG5	Leishmania braziliensis	56%	100%
A4IC56	Leishmania infantum	85%	100%
E9B729	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%