HECT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFX5_LEIMA

TriTrypDb:

LmjF.35.5020 , LMJLV39_350058300 , LMJSD75_350057600

Length:

896

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFX5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.637
CLV_C14_Caspase3-7	155	159	PF00656	0.517
CLV_C14_Caspase3-7	201	205	PF00656	0.448
CLV_C14_Caspase3-7	292	296	PF00656	0.578
CLV_C14_Caspase3-7	574	578	PF00656	0.455
CLV_NRD_NRD_1	148	150	PF00675	0.457
CLV_NRD_NRD_1	369	371	PF00675	0.584
CLV_NRD_NRD_1	69	71	PF00675	0.458
CLV_NRD_NRD_1	75	77	PF00675	0.408
CLV_NRD_NRD_1	795	797	PF00675	0.607
CLV_PCSK_FUR_1	73	77	PF00082	0.428
CLV_PCSK_KEX2_1	369	371	PF00082	0.572
CLV_PCSK_KEX2_1	73	75	PF00082	0.432
CLV_PCSK_KEX2_1	795	797	PF00082	0.607
CLV_PCSK_PC7_1	70	76	PF00082	0.435
CLV_PCSK_SKI1_1	300	304	PF00082	0.478
CLV_PCSK_SKI1_1	335	339	PF00082	0.447
CLV_PCSK_SKI1_1	362	366	PF00082	0.600
CLV_PCSK_SKI1_1	369	373	PF00082	0.492
CLV_PCSK_SKI1_1	377	381	PF00082	0.255
CLV_PCSK_SKI1_1	384	388	PF00082	0.260
CLV_PCSK_SKI1_1	480	484	PF00082	0.625
CLV_PCSK_SKI1_1	518	522	PF00082	0.541
CLV_PCSK_SKI1_1	570	574	PF00082	0.475
CLV_PCSK_SKI1_1	693	697	PF00082	0.503
CLV_PCSK_SKI1_1	796	800	PF00082	0.578
CLV_PCSK_SKI1_1	808	812	PF00082	0.331
CLV_PCSK_SKI1_1	886	890	PF00082	0.568
CLV_PCSK_SKI1_1	89	93	PF00082	0.526
CLV_Separin_Metazoa	287	291	PF03568	0.540
DEG_SPOP_SBC_1	522	526	PF00917	0.482
DEG_SPOP_SBC_1	685	689	PF00917	0.460
DOC_CDC14_PxL_1	254	262	PF14671	0.524
DOC_CKS1_1	755	760	PF01111	0.552
DOC_CYCLIN_RxL_1	381	391	PF00134	0.453
DOC_CYCLIN_RxL_1	690	699	PF00134	0.502
DOC_CYCLIN_RxL_1	793	802	PF00134	0.629
DOC_CYCLIN_yCln2_LP_2	755	761	PF00134	0.504
DOC_MAPK_gen_1	262	269	PF00069	0.492
DOC_MAPK_gen_1	691	698	PF00069	0.511
DOC_MAPK_gen_1	70	81	PF00069	0.414
DOC_MAPK_MEF2A_6	558	567	PF00069	0.460
DOC_MAPK_MEF2A_6	691	698	PF00069	0.562
DOC_MAPK_NFAT4_5	691	699	PF00069	0.561
DOC_PP1_RVXF_1	87	94	PF00149	0.434
DOC_USP7_MATH_1	10	14	PF00917	0.533
DOC_USP7_MATH_1	121	125	PF00917	0.677
DOC_USP7_MATH_1	230	234	PF00917	0.619
DOC_USP7_MATH_1	238	242	PF00917	0.628
DOC_USP7_MATH_1	246	250	PF00917	0.421
DOC_USP7_MATH_1	751	755	PF00917	0.599
DOC_WW_Pin1_4	160	165	PF00397	0.399
DOC_WW_Pin1_4	550	555	PF00397	0.513
DOC_WW_Pin1_4	643	648	PF00397	0.557
DOC_WW_Pin1_4	696	701	PF00397	0.652
DOC_WW_Pin1_4	708	713	PF00397	0.541
DOC_WW_Pin1_4	730	735	PF00397	0.551
DOC_WW_Pin1_4	754	759	PF00397	0.520
LIG_14-3-3_CanoR_1	209	214	PF00244	0.442
LIG_14-3-3_CanoR_1	290	298	PF00244	0.561
LIG_14-3-3_CanoR_1	362	372	PF00244	0.593
LIG_14-3-3_CanoR_1	518	527	PF00244	0.485
LIG_14-3-3_CanoR_1	570	576	PF00244	0.445
LIG_14-3-3_CanoR_1	629	636	PF00244	0.507
LIG_14-3-3_CanoR_1	750	756	PF00244	0.547
LIG_14-3-3_CanoR_1	777	786	PF00244	0.567
LIG_14-3-3_CanoR_1	821	826	PF00244	0.513
LIG_Actin_WH2_2	420	438	PF00022	0.519
LIG_APCC_ABBA_1	410	415	PF00400	0.392
LIG_BIR_III_2	748	752	PF00653	0.536
LIG_BIR_III_4	293	297	PF00653	0.519
LIG_BRCT_BRCA1_1	224	228	PF00533	0.432
LIG_CaM_IQ_9	878	894	PF13499	0.432
LIG_CtBP_PxDLS_1	164	168	PF00389	0.524
LIG_DLG_GKlike_1	209	216	PF00625	0.488
LIG_FHA_1	374	380	PF00498	0.535
LIG_FHA_1	492	498	PF00498	0.483
LIG_FHA_1	524	530	PF00498	0.522
LIG_FHA_1	755	761	PF00498	0.522
LIG_FHA_1	778	784	PF00498	0.481
LIG_FHA_1	785	791	PF00498	0.399
LIG_FHA_1	870	876	PF00498	0.431
LIG_FHA_2	136	142	PF00498	0.519
LIG_FHA_2	161	167	PF00498	0.348
LIG_FHA_2	232	238	PF00498	0.664
LIG_FHA_2	445	451	PF00498	0.513
LIG_FHA_2	487	493	PF00498	0.455
LIG_FHA_2	572	578	PF00498	0.541
LIG_FHA_2	615	621	PF00498	0.540
LIG_FHA_2	687	693	PF00498	0.563
LIG_LIR_Gen_1	41	50	PF02991	0.464
LIG_LIR_Gen_1	514	523	PF02991	0.446
LIG_LIR_Gen_1	53	63	PF02991	0.576
LIG_LIR_Gen_1	631	640	PF02991	0.483
LIG_LIR_Gen_1	64	69	PF02991	0.438
LIG_LIR_Nem_3	160	165	PF02991	0.467
LIG_LIR_Nem_3	514	519	PF02991	0.488
LIG_LIR_Nem_3	53	59	PF02991	0.581
LIG_LIR_Nem_3	555	560	PF02991	0.455
LIG_LIR_Nem_3	631	636	PF02991	0.456
LIG_LIR_Nem_3	64	68	PF02991	0.424
LIG_LIR_Nem_3	776	782	PF02991	0.519
LIG_NRBOX	182	188	PF00104	0.491
LIG_NRBOX	329	335	PF00104	0.445
LIG_Pex14_1	778	782	PF04695	0.517
LIG_RPA_C_Fungi	204	216	PF08784	0.322
LIG_SH2_CRK	437	441	PF00017	0.559
LIG_SH2_CRK	663	667	PF00017	0.383
LIG_SH2_GRB2like	782	785	PF00017	0.341
LIG_SH2_SRC	413	416	PF00017	0.544
LIG_SH2_SRC	85	88	PF00017	0.550
LIG_SH2_STAP1	336	340	PF00017	0.292
LIG_SH2_STAP1	516	520	PF00017	0.579
LIG_SH2_STAP1	633	637	PF00017	0.546
LIG_SH2_STAP1	663	667	PF00017	0.383
LIG_SH2_STAP1	779	783	PF00017	0.485
LIG_SH2_STAT5	42	45	PF00017	0.406
LIG_SH2_STAT5	552	555	PF00017	0.517
LIG_SH2_STAT5	779	782	PF00017	0.458
LIG_SH2_STAT5	785	788	PF00017	0.514
LIG_SH2_STAT5	877	880	PF00017	0.435
LIG_SH3_3	123	129	PF00018	0.645
LIG_SH3_3	531	537	PF00018	0.578
LIG_SH3_3	585	591	PF00018	0.546
LIG_SH3_3	697	703	PF00018	0.680
LIG_SH3_3	706	712	PF00018	0.594
LIG_SH3_3	731	737	PF00018	0.518
LIG_SUMO_SIM_anti_2	620	626	PF11976	0.533
LIG_SUMO_SIM_par_1	163	168	PF11976	0.525
LIG_SUMO_SIM_par_1	539	545	PF11976	0.396
LIG_SxIP_EBH_1	250	264	PF03271	0.556
LIG_TRAF2_1	719	722	PF00917	0.512
LIG_TYR_ITIM	435	440	PF00017	0.563
LIG_TYR_ITIM	661	666	PF00017	0.494
LIG_WRC_WIRS_1	633	638	PF05994	0.508
LIG_WRC_WIRS_1	853	858	PF05994	0.625
MOD_CK1_1	105	111	PF00069	0.648
MOD_CK1_1	157	163	PF00069	0.518
MOD_CK1_1	231	237	PF00069	0.646
MOD_CK1_1	241	247	PF00069	0.536
MOD_CK1_1	283	289	PF00069	0.418
MOD_CK1_1	314	320	PF00069	0.575
MOD_CK1_1	442	448	PF00069	0.513
MOD_CK1_1	486	492	PF00069	0.504
MOD_CK1_1	614	620	PF00069	0.566
MOD_CK1_1	631	637	PF00069	0.516
MOD_CK1_1	754	760	PF00069	0.481
MOD_CK1_1	890	896	PF00069	0.693
MOD_CK2_1	135	141	PF00069	0.450
MOD_CK2_1	355	361	PF00069	0.639
MOD_CK2_1	444	450	PF00069	0.491
MOD_CK2_1	511	517	PF00069	0.522
MOD_CK2_1	686	692	PF00069	0.562
MOD_CK2_1	760	766	PF00069	0.470
MOD_CK2_1	863	869	PF00069	0.578
MOD_Cter_Amidation	367	370	PF01082	0.612
MOD_GlcNHglycan	103	107	PF01048	0.660
MOD_GlcNHglycan	241	244	PF01048	0.632
MOD_GlcNHglycan	282	285	PF01048	0.567
MOD_GlcNHglycan	398	401	PF01048	0.576
MOD_GlcNHglycan	456	459	PF01048	0.523
MOD_GlcNHglycan	46	50	PF01048	0.538
MOD_GlcNHglycan	704	707	PF01048	0.667
MOD_GlcNHglycan	892	895	PF01048	0.683
MOD_GSK3_1	105	112	PF00069	0.752
MOD_GSK3_1	153	160	PF00069	0.560
MOD_GSK3_1	351	358	PF00069	0.556
MOD_GSK3_1	439	446	PF00069	0.572
MOD_GSK3_1	45	52	PF00069	0.551
MOD_GSK3_1	450	457	PF00069	0.438
MOD_GSK3_1	518	525	PF00069	0.501
MOD_GSK3_1	628	635	PF00069	0.502
MOD_GSK3_1	673	680	PF00069	0.590
MOD_GSK3_1	698	705	PF00069	0.719
MOD_GSK3_1	769	776	PF00069	0.507
MOD_GSK3_1	817	824	PF00069	0.569
MOD_GSK3_1	863	870	PF00069	0.645
MOD_NEK2_1	44	49	PF00069	0.448
MOD_NEK2_1	440	445	PF00069	0.468
MOD_NEK2_1	483	488	PF00069	0.586
MOD_NEK2_1	50	55	PF00069	0.481
MOD_NEK2_1	523	528	PF00069	0.506
MOD_NEK2_1	628	633	PF00069	0.495
MOD_NEK2_1	649	654	PF00069	0.576
MOD_NEK2_1	760	765	PF00069	0.453
MOD_NEK2_1	834	839	PF00069	0.494
MOD_NEK2_1	888	893	PF00069	0.547
MOD_PIKK_1	592	598	PF00454	0.456
MOD_PK_1	821	827	PF00069	0.587
MOD_PKA_2	289	295	PF00069	0.536
MOD_PKA_2	628	634	PF00069	0.504
MOD_PKA_2	69	75	PF00069	0.575
MOD_PKA_2	862	868	PF00069	0.601
MOD_Plk_1	121	127	PF00069	0.638
MOD_Plk_1	834	840	PF00069	0.504
MOD_Plk_2-3	135	141	PF00069	0.497
MOD_Plk_4	135	141	PF00069	0.497
MOD_Plk_4	182	188	PF00069	0.520
MOD_Plk_4	311	317	PF00069	0.509
MOD_Plk_4	393	399	PF00069	0.610
MOD_Plk_4	50	56	PF00069	0.587
MOD_Plk_4	635	641	PF00069	0.431
MOD_Plk_4	821	827	PF00069	0.532
MOD_ProDKin_1	160	166	PF00069	0.402
MOD_ProDKin_1	550	556	PF00069	0.508
MOD_ProDKin_1	643	649	PF00069	0.554
MOD_ProDKin_1	696	702	PF00069	0.664
MOD_ProDKin_1	708	714	PF00069	0.536
MOD_ProDKin_1	730	736	PF00069	0.545
MOD_ProDKin_1	754	760	PF00069	0.516
MOD_SUMO_rev_2	64	72	PF00179	0.564
MOD_SUMO_rev_2	86	91	PF00179	0.491
TRG_DiLeu_BaEn_1	329	334	PF01217	0.465
TRG_DiLeu_BaEn_2	402	408	PF01217	0.545
TRG_DiLeu_BaLyEn_6	495	500	PF01217	0.438
TRG_DiLeu_BaLyEn_6	515	520	PF01217	0.257
TRG_DiLeu_BaLyEn_6	690	695	PF01217	0.394
TRG_DiLeu_BaLyEn_6	794	799	PF01217	0.623
TRG_DiLeu_BaLyEn_6	870	875	PF01217	0.573
TRG_ENDOCYTIC_2	42	45	PF00928	0.406
TRG_ENDOCYTIC_2	437	440	PF00928	0.557
TRG_ENDOCYTIC_2	516	519	PF00928	0.590
TRG_ENDOCYTIC_2	557	560	PF00928	0.505
TRG_ENDOCYTIC_2	56	59	PF00928	0.476
TRG_ENDOCYTIC_2	633	636	PF00928	0.411
TRG_ENDOCYTIC_2	65	68	PF00928	0.537
TRG_ENDOCYTIC_2	663	666	PF00928	0.384
TRG_ENDOCYTIC_2	85	88	PF00928	0.221
TRG_ER_diArg_1	369	371	PF00400	0.569
TRG_ER_diArg_1	73	76	PF00400	0.440
TRG_ER_diArg_1	795	797	PF00400	0.656
TRG_ER_diArg_1	81	84	PF00400	0.428
TRG_NLS_MonoExtC_3	148	153	PF00514	0.561
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	467	472	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	796	800	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	808	813	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	859	864	PF00026	0.657

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ19	Leptomonas seymouri	52%	85%
A0A1X0P5W4	Trypanosomatidae	33%	90%
A0A3Q8IJL5	Leishmania donovani	93%	100%
A0A3R7KBK5	Trypanosoma rangeli	32%	97%
A4HNG4	Leishmania braziliensis	77%	99%
A4IC55	Leishmania infantum	93%	100%
C9ZYE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	93%
E9B728	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%