PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region, putative

Species:

Leishmania major

UniProt:

E9AFX3_LEIMA

TriTrypDb:

LmjF.35.5000 , LMJLV39_350058000 , LMJSD75_350057300

Length:

280

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AFX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFX3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	64	68	PF00656	0.603
CLV_NRD_NRD_1	108	110	PF00675	0.526
CLV_NRD_NRD_1	154	156	PF00675	0.372
CLV_NRD_NRD_1	166	168	PF00675	0.305
CLV_NRD_NRD_1	218	220	PF00675	0.399
CLV_NRD_NRD_1	253	255	PF00675	0.617
CLV_NRD_NRD_1	257	259	PF00675	0.639
CLV_PCSK_KEX2_1	154	156	PF00082	0.372
CLV_PCSK_KEX2_1	16	18	PF00082	0.583
CLV_PCSK_KEX2_1	166	168	PF00082	0.345
CLV_PCSK_KEX2_1	218	220	PF00082	0.311
CLV_PCSK_KEX2_1	253	255	PF00082	0.627
CLV_PCSK_KEX2_1	257	259	PF00082	0.637
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.658
CLV_PCSK_PC7_1	253	259	PF00082	0.741
CLV_PCSK_SKI1_1	148	152	PF00082	0.438
CLV_PCSK_SKI1_1	154	158	PF00082	0.287
CLV_PCSK_SKI1_1	16	20	PF00082	0.659
CLV_PCSK_SKI1_1	167	171	PF00082	0.246
CLV_PCSK_SKI1_1	201	205	PF00082	0.321
CLV_PCSK_SKI1_1	222	226	PF00082	0.297
CLV_PCSK_SKI1_1	268	272	PF00082	0.531
CLV_PCSK_SKI1_1	63	67	PF00082	0.703
DOC_CKS1_1	30	35	PF01111	0.577
DOC_CYCLIN_RxL_1	218	226	PF00134	0.419
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.700
DOC_CYCLIN_yCln2_LP_2	87	93	PF00134	0.446
DOC_MAPK_gen_1	201	207	PF00069	0.300
DOC_MAPK_gen_1	209	217	PF00069	0.286
DOC_PP1_RVXF_1	229	235	PF00149	0.390
DOC_PP2B_LxvP_1	87	90	PF13499	0.494
DOC_USP7_MATH_1	272	276	PF00917	0.477
DOC_USP7_MATH_1	4	8	PF00917	0.638
DOC_USP7_MATH_1	49	53	PF00917	0.607
DOC_USP7_MATH_1	61	65	PF00917	0.655
DOC_USP7_MATH_1	69	73	PF00917	0.626
DOC_USP7_MATH_1	77	81	PF00917	0.723
DOC_USP7_MATH_1	83	87	PF00917	0.715
DOC_USP7_UBL2_3	106	110	PF12436	0.410
DOC_USP7_UBL2_3	15	19	PF12436	0.612
DOC_WW_Pin1_4	140	145	PF00397	0.558
DOC_WW_Pin1_4	29	34	PF00397	0.554
DOC_WW_Pin1_4	45	50	PF00397	0.675
DOC_WW_Pin1_4	57	62	PF00397	0.606
LIG_14-3-3_CanoR_1	166	170	PF00244	0.384
LIG_14-3-3_CanoR_1	179	188	PF00244	0.331
LIG_14-3-3_CanoR_1	209	215	PF00244	0.323
LIG_14-3-3_CanoR_1	219	225	PF00244	0.302
LIG_14-3-3_CanoR_1	47	56	PF00244	0.592
LIG_Actin_WH2_2	237	255	PF00022	0.473
LIG_BRCT_BRCA1_1	210	214	PF00533	0.404
LIG_FHA_1	140	146	PF00498	0.553
LIG_FHA_1	202	208	PF00498	0.305
LIG_FHA_1	247	253	PF00498	0.655
LIG_FHA_2	155	161	PF00498	0.308
LIG_FHA_2	166	172	PF00498	0.271
LIG_FHA_2	187	193	PF00498	0.467
LIG_LIR_Gen_1	211	220	PF02991	0.316
LIG_LIR_Gen_1	99	107	PF02991	0.436
LIG_LIR_Nem_3	211	217	PF02991	0.318
LIG_LIR_Nem_3	223	228	PF02991	0.412
LIG_LIR_Nem_3	99	105	PF02991	0.371
LIG_PALB2_WD40_1	229	237	PF16756	0.370
LIG_PCNA_yPIPBox_3	110	124	PF02747	0.328
LIG_PCNA_yPIPBox_3	218	228	PF02747	0.419
LIG_Pex14_2	112	116	PF04695	0.381
LIG_PTAP_UEV_1	70	75	PF05743	0.456
LIG_SH2_STAP1	26	30	PF00017	0.626
LIG_SH2_STAT5	236	239	PF00017	0.370
LIG_SH3_3	182	188	PF00018	0.311
LIG_SH3_3	245	251	PF00018	0.677
LIG_SH3_3	30	36	PF00018	0.571
LIG_SH3_3	68	74	PF00018	0.641
LIG_SUMO_SIM_anti_2	147	153	PF11976	0.305
LIG_SUMO_SIM_par_1	122	127	PF11976	0.467
LIG_SUMO_SIM_par_1	203	208	PF11976	0.414
LIG_UBA3_1	195	202	PF00899	0.372
MOD_CDC14_SPxK_1	60	63	PF00782	0.674
MOD_CDK_SPK_2	45	50	PF00069	0.674
MOD_CDK_SPxK_1	57	63	PF00069	0.682
MOD_CK1_1	180	186	PF00069	0.405
MOD_CK1_1	208	214	PF00069	0.341
MOD_CK1_1	29	35	PF00069	0.623
MOD_CK1_1	3	9	PF00069	0.609
MOD_CK1_1	48	54	PF00069	0.637
MOD_CK1_1	55	61	PF00069	0.594
MOD_CK2_1	165	171	PF00069	0.390
MOD_CK2_1	186	192	PF00069	0.467
MOD_CK2_1	258	264	PF00069	0.703
MOD_Cter_Amidation	107	110	PF01082	0.498
MOD_Cter_Amidation	199	202	PF01082	0.360
MOD_GlcNHglycan	2	5	PF01048	0.688
MOD_GlcNHglycan	51	54	PF01048	0.742
MOD_GlcNHglycan	71	74	PF01048	0.591
MOD_GSK3_1	154	161	PF00069	0.417
MOD_GSK3_1	201	208	PF00069	0.300
MOD_GSK3_1	242	249	PF00069	0.539
MOD_GSK3_1	270	277	PF00069	0.525
MOD_GSK3_1	3	10	PF00069	0.607
MOD_GSK3_1	45	52	PF00069	0.643
MOD_GSK3_1	57	64	PF00069	0.512
MOD_NEK2_1	2	7	PF00069	0.619
MOD_NEK2_1	220	225	PF00069	0.306
MOD_NEK2_1	9	14	PF00069	0.609
MOD_NEK2_2	174	179	PF00069	0.392
MOD_PIKK_1	159	165	PF00454	0.420
MOD_PIKK_1	180	186	PF00454	0.242
MOD_PIKK_1	4	10	PF00454	0.521
MOD_PKA_1	154	160	PF00069	0.419
MOD_PKA_1	201	207	PF00069	0.332
MOD_PKA_1	257	263	PF00069	0.657
MOD_PKA_2	154	160	PF00069	0.419
MOD_PKA_2	165	171	PF00069	0.419
MOD_PKA_2	208	214	PF00069	0.357
MOD_PKA_2	257	263	PF00069	0.599
MOD_Plk_4	26	32	PF00069	0.609
MOD_ProDKin_1	140	146	PF00069	0.560
MOD_ProDKin_1	29	35	PF00069	0.551
MOD_ProDKin_1	45	51	PF00069	0.675
MOD_ProDKin_1	57	63	PF00069	0.608
MOD_SUMO_rev_2	193	203	PF00179	0.378
MOD_SUMO_rev_2	261	271	PF00179	0.499
TRG_DiLeu_BaEn_1	147	152	PF01217	0.304
TRG_ER_diArg_1	153	155	PF00400	0.374
TRG_ER_diArg_1	217	219	PF00400	0.311
TRG_ER_diArg_1	228	231	PF00400	0.143
TRG_ER_diArg_1	252	254	PF00400	0.635
TRG_NLS_MonoExtC_3	14	19	PF00514	0.492
TRG_NLS_MonoExtN_4	15	20	PF00514	0.650
TRG_Pf-PMV_PEXEL_1	179	184	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.375
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.669

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYT9	Leptomonas seymouri	26%	73%
A0A0N1PC14	Leptomonas seymouri	65%	97%
A0A1X0P536	Trypanosomatidae	43%	100%
A0A3Q8IJZ1	Leishmania donovani	95%	100%
A0A3R7KIC4	Trypanosoma rangeli	27%	71%
A0A3R7NIU7	Trypanosoma rangeli	39%	100%
A4HMC6	Leishmania braziliensis	24%	68%
A4HNG2	Leishmania braziliensis	82%	100%
A4IC69	Leishmania infantum	95%	100%
C9ZYF4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
D0A3S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AI38	Leishmania braziliensis	29%	74%
E9B726	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BJK0	Trypanosoma cruzi	27%	77%
V5DA19	Trypanosoma cruzi	29%	71%