LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AFX1_LEIMA
TriTrypDb:
LmjF.35.4970 , LMJLV39_350057700 * , LMJSD75_350057000 *
Length:
342

Annotations

LeishMANIAdb annotations

A Kinetoplastid-specific signal-anchored protein. Might be part of a bigger complex.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

E9AFX1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFX1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 150 154 PF00656 0.581
CLV_NRD_NRD_1 217 219 PF00675 0.625
CLV_NRD_NRD_1 275 277 PF00675 0.645
CLV_NRD_NRD_1 292 294 PF00675 0.566
CLV_NRD_NRD_1 335 337 PF00675 0.671
CLV_PCSK_KEX2_1 217 219 PF00082 0.625
CLV_PCSK_KEX2_1 275 277 PF00082 0.650
CLV_PCSK_SKI1_1 255 259 PF00082 0.553
CLV_PCSK_SKI1_1 6 10 PF00082 0.413
CLV_Separin_Metazoa 97 101 PF03568 0.434
DEG_SCF_FBW7_1 307 312 PF00400 0.449
DEG_SPOP_SBC_1 154 158 PF00917 0.558
DOC_CYCLIN_yClb5_NLxxxL_5 43 52 PF00134 0.370
DOC_MAPK_DCC_7 10 19 PF00069 0.520
DOC_MAPK_gen_1 72 79 PF00069 0.395
DOC_MAPK_HePTP_8 7 19 PF00069 0.482
DOC_MAPK_MEF2A_6 10 19 PF00069 0.522
DOC_PP1_RVXF_1 4 10 PF00149 0.581
DOC_USP7_MATH_1 154 158 PF00917 0.573
DOC_USP7_MATH_1 160 164 PF00917 0.542
DOC_USP7_MATH_1 177 181 PF00917 0.319
DOC_USP7_MATH_1 220 224 PF00917 0.437
DOC_USP7_UBL2_3 6 10 PF12436 0.615
DOC_WW_Pin1_4 143 148 PF00397 0.529
DOC_WW_Pin1_4 164 169 PF00397 0.517
DOC_WW_Pin1_4 221 226 PF00397 0.405
DOC_WW_Pin1_4 250 255 PF00397 0.459
DOC_WW_Pin1_4 293 298 PF00397 0.412
DOC_WW_Pin1_4 305 310 PF00397 0.444
LIG_14-3-3_CanoR_1 221 225 PF00244 0.400
LIG_14-3-3_CanoR_1 92 96 PF00244 0.391
LIG_Actin_WH2_2 318 333 PF00022 0.417
LIG_APCC_ABBA_1 229 234 PF00400 0.362
LIG_BIR_II_1 1 5 PF00653 0.616
LIG_deltaCOP1_diTrp_1 298 304 PF00928 0.406
LIG_FHA_1 156 162 PF00498 0.517
LIG_FHA_1 234 240 PF00498 0.422
LIG_FHA_1 306 312 PF00498 0.411
LIG_FHA_1 316 322 PF00498 0.352
LIG_FHA_1 52 58 PF00498 0.410
LIG_FHA_2 148 154 PF00498 0.578
LIG_FHA_2 25 31 PF00498 0.450
LIG_FHA_2 92 98 PF00498 0.476
LIG_GBD_Chelix_1 322 330 PF00786 0.461
LIG_LIR_Apic_2 64 69 PF02991 0.414
LIG_LIR_Gen_1 130 139 PF02991 0.308
LIG_LIR_Gen_1 185 196 PF02991 0.394
LIG_LIR_Gen_1 94 103 PF02991 0.361
LIG_LIR_Nem_3 118 124 PF02991 0.353
LIG_LIR_Nem_3 130 134 PF02991 0.297
LIG_LIR_Nem_3 230 235 PF02991 0.373
LIG_LIR_Nem_3 94 98 PF02991 0.368
LIG_PCNA_yPIPBox_3 133 141 PF02747 0.427
LIG_Pex14_1 300 304 PF04695 0.376
LIG_Pex14_2 19 23 PF04695 0.337
LIG_Rb_LxCxE_1 328 342 PF01857 0.459
LIG_REV1ctd_RIR_1 261 270 PF16727 0.381
LIG_REV1ctd_RIR_1 6 14 PF16727 0.617
LIG_SH2_STAP1 235 239 PF00017 0.369
LIG_SH2_STAP1 53 57 PF00017 0.456
LIG_SH2_STAT5 110 113 PF00017 0.364
LIG_SH2_STAT5 121 124 PF00017 0.285
LIG_SH2_STAT5 235 238 PF00017 0.370
LIG_SH2_STAT5 53 56 PF00017 0.448
LIG_SH3_1 141 147 PF00018 0.477
LIG_SH3_3 141 147 PF00018 0.528
LIG_SH3_3 248 254 PF00018 0.505
LIG_SH3_3 9 15 PF00018 0.512
LIG_SUMO_SIM_par_1 226 234 PF11976 0.399
LIG_TRAF2_1 115 118 PF00917 0.438
LIG_TYR_ITIM 119 124 PF00017 0.350
LIG_UBA3_1 76 82 PF00899 0.442
LIG_WRC_WIRS_1 136 141 PF05994 0.419
MOD_CDC14_SPxK_1 224 227 PF00782 0.433
MOD_CDK_SPK_2 250 255 PF00069 0.324
MOD_CDK_SPxK_1 221 227 PF00069 0.440
MOD_CK1_1 163 169 PF00069 0.529
MOD_CK1_1 233 239 PF00069 0.419
MOD_CK2_1 143 149 PF00069 0.521
MOD_CK2_1 183 189 PF00069 0.340
MOD_CK2_1 220 226 PF00069 0.443
MOD_CK2_1 24 30 PF00069 0.391
MOD_CK2_1 250 256 PF00069 0.430
MOD_CK2_1 58 64 PF00069 0.403
MOD_CK2_1 72 78 PF00069 0.358
MOD_CK2_1 91 97 PF00069 0.488
MOD_GlcNHglycan 1 4 PF01048 0.424
MOD_GlcNHglycan 158 161 PF01048 0.781
MOD_GlcNHglycan 162 165 PF01048 0.776
MOD_GlcNHglycan 30 34 PF01048 0.641
MOD_GSK3_1 143 150 PF00069 0.531
MOD_GSK3_1 152 159 PF00069 0.534
MOD_GSK3_1 160 167 PF00069 0.544
MOD_GSK3_1 29 36 PF00069 0.474
MOD_GSK3_1 305 312 PF00069 0.414
MOD_N-GLC_1 305 310 PF02516 0.615
MOD_N-GLC_1 84 89 PF02516 0.695
MOD_N-GLC_2 211 213 PF02516 0.440
MOD_NEK2_1 183 188 PF00069 0.403
MOD_PIKK_1 51 57 PF00454 0.435
MOD_PK_1 72 78 PF00069 0.395
MOD_PKA_2 220 226 PF00069 0.439
MOD_PKA_2 91 97 PF00069 0.389
MOD_Plk_1 269 275 PF00069 0.422
MOD_Plk_2-3 113 119 PF00069 0.352
MOD_Plk_2-3 91 97 PF00069 0.412
MOD_Plk_4 135 141 PF00069 0.407
MOD_Plk_4 183 189 PF00069 0.399
MOD_Plk_4 258 264 PF00069 0.377
MOD_Plk_4 58 64 PF00069 0.418
MOD_ProDKin_1 143 149 PF00069 0.531
MOD_ProDKin_1 164 170 PF00069 0.504
MOD_ProDKin_1 221 227 PF00069 0.403
MOD_ProDKin_1 250 256 PF00069 0.450
MOD_ProDKin_1 293 299 PF00069 0.409
MOD_ProDKin_1 305 311 PF00069 0.439
TRG_DiLeu_BaEn_1 30 35 PF01217 0.380
TRG_DiLeu_BaLyEn_6 276 281 PF01217 0.519
TRG_ENDOCYTIC_2 121 124 PF00928 0.348
TRG_ER_diArg_1 217 219 PF00400 0.425
TRG_ER_diArg_1 275 277 PF00400 0.445
TRG_NES_CRM1_1 324 339 PF08389 0.353
TRG_Pf-PMV_PEXEL_1 74 78 PF00026 0.655

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2I6 Leptomonas seymouri 62% 97%
A0A0S4J6X6 Bodo saltans 34% 100%
A0A0S4J7W0 Bodo saltans 32% 100%
A0A1X0P4T2 Trypanosomatidae 38% 100%
A0A3R7MCD3 Trypanosoma rangeli 42% 100%
A0A3S7XA27 Leishmania donovani 94% 100%
A4HNG0 Leishmania braziliensis 79% 99%
A4IC71 Leishmania infantum 94% 100%
C9ZYG3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
E9B724 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 98%
V5B4K6 Trypanosoma cruzi 40% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS