Peroxin-13

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Peroxin-13

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFX0_LEIMA

TriTrypDb:

LmjF.35.4960 , LMJLV39_350057600 , LMJSD75_350056900

Length:

208

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AFX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFX0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.614
CLV_NRD_NRD_1	124	126	PF00675	0.618
CLV_NRD_NRD_1	144	146	PF00675	0.686
CLV_NRD_NRD_1	186	188	PF00675	0.437
CLV_PCSK_KEX2_1	140	142	PF00082	0.680
CLV_PCSK_KEX2_1	175	177	PF00082	0.429
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.668
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.429
CLV_PCSK_PC7_1	136	142	PF00082	0.713
CLV_PCSK_SKI1_1	125	129	PF00082	0.620
CLV_PCSK_SKI1_1	176	180	PF00082	0.408
CLV_PCSK_SKI1_1	187	191	PF00082	0.468
DEG_APCC_DBOX_1	124	132	PF00400	0.428
DEG_APCC_DBOX_1	175	183	PF00400	0.495
DOC_USP7_MATH_1	139	143	PF00917	0.449
DOC_USP7_MATH_1	197	201	PF00917	0.596
DOC_WW_Pin1_4	52	57	PF00397	0.654
LIG_deltaCOP1_diTrp_1	73	78	PF00928	0.487
LIG_FHA_1	66	72	PF00498	0.554
LIG_LIR_Nem_3	34	39	PF02991	0.202
LIG_LIR_Nem_3	73	78	PF02991	0.469
LIG_LIR_Nem_3	95	99	PF02991	0.347
LIG_PDZ_Class_2	203	208	PF00595	0.556
LIG_Pex14_2	152	156	PF04695	0.414
LIG_SH2_CRK	36	40	PF00017	0.415
LIG_SH2_PTP2	96	99	PF00017	0.346
LIG_SH2_STAT5	137	140	PF00017	0.465
LIG_SH2_STAT5	171	174	PF00017	0.279
LIG_SH2_STAT5	96	99	PF00017	0.346
LIG_SH3_3	141	147	PF00018	0.520
LIG_SxIP_EBH_1	124	133	PF03271	0.408
LIG_WRC_WIRS_1	153	158	PF05994	0.347
MOD_CK1_1	201	207	PF00069	0.561
MOD_CK2_1	190	196	PF00069	0.635
MOD_Cter_Amidation	185	188	PF01082	0.436
MOD_GlcNHglycan	184	187	PF01048	0.450
MOD_GlcNHglycan	191	195	PF01048	0.492
MOD_GlcNHglycan	8	11	PF01048	0.644
MOD_GlcNHglycan	87	90	PF01048	0.372
MOD_GSK3_1	148	155	PF00069	0.484
MOD_GSK3_1	197	204	PF00069	0.661
MOD_NEK2_1	152	157	PF00069	0.378
MOD_NEK2_1	189	194	PF00069	0.668
MOD_NEK2_1	65	70	PF00069	0.600
MOD_NEK2_1	82	87	PF00069	0.219
MOD_NEK2_2	31	36	PF00069	0.336
MOD_NMyristoyl	1	7	PF02799	0.415
MOD_PIKK_1	76	82	PF00454	0.279
MOD_Plk_1	201	207	PF00069	0.530
MOD_Plk_4	148	154	PF00069	0.437
MOD_Plk_4	31	37	PF00069	0.183
MOD_ProDKin_1	52	58	PF00069	0.649
TRG_DiLeu_BaLyEn_6	156	161	PF01217	0.312
TRG_ENDOCYTIC_2	27	30	PF00928	0.402
TRG_ENDOCYTIC_2	36	39	PF00928	0.321
TRG_ENDOCYTIC_2	96	99	PF00928	0.346
TRG_ER_diArg_1	141	144	PF00400	0.448
TRG_NLS_Bipartite_1	125	144	PF00514	0.405
TRG_NLS_MonoCore_2	144	149	PF00514	0.443
TRG_NLS_MonoExtN_4	139	144	PF00514	0.421
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2X3	Leptomonas seymouri	74%	72%
A0A0S4J7P3	Bodo saltans	31%	69%
A0A0S4J8A4	Bodo saltans	30%	69%
A0A3Q8IVL9	Leishmania donovani	93%	100%
A4HNF9	Leishmania braziliensis	79%	100%
A4IC72	Leishmania infantum	92%	100%
E9B723	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%