C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger protein family member, putative

Species:

Leishmania major

UniProt:

E9AFW9_LEIMA

TriTrypDb:

LmjF.35.4950 , LMJLV39_350057500 , LMJSD75_350056800

Length:

1029

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AFW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFW9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.522
CLV_C14_Caspase3-7	641	645	PF00656	0.644
CLV_MEL_PAP_1	771	777	PF00089	0.752
CLV_NRD_NRD_1	517	519	PF00675	0.831
CLV_NRD_NRD_1	66	68	PF00675	0.632
CLV_NRD_NRD_1	842	844	PF00675	0.858
CLV_NRD_NRD_1	863	865	PF00675	0.708
CLV_NRD_NRD_1	984	986	PF00675	0.720
CLV_NRD_NRD_1	989	991	PF00675	0.672
CLV_PCSK_KEX2_1	517	519	PF00082	0.831
CLV_PCSK_KEX2_1	863	865	PF00082	0.708
CLV_PCSK_KEX2_1	932	934	PF00082	0.857
CLV_PCSK_KEX2_1	984	986	PF00082	0.715
CLV_PCSK_KEX2_1	989	991	PF00082	0.677
CLV_PCSK_KEX2_1	993	995	PF00082	0.666
CLV_PCSK_PC1ET2_1	932	934	PF00082	0.857
CLV_PCSK_PC1ET2_1	993	995	PF00082	0.852
CLV_PCSK_PC7_1	985	991	PF00082	0.853
CLV_PCSK_SKI1_1	161	165	PF00082	0.612
CLV_PCSK_SKI1_1	293	297	PF00082	0.850
CLV_PCSK_SKI1_1	469	473	PF00082	0.772
CLV_PCSK_SKI1_1	634	638	PF00082	0.772
CLV_PCSK_SKI1_1	736	740	PF00082	0.871
CLV_PCSK_SKI1_1	767	771	PF00082	0.744
CLV_PCSK_SKI1_1	793	797	PF00082	0.759
CLV_PCSK_SKI1_1	818	822	PF00082	0.625
CLV_PCSK_SKI1_1	844	848	PF00082	0.769
DEG_COP1_1	394	402	PF00400	0.678
DEG_SCF_FBW7_1	954	961	PF00400	0.846
DEG_SPOP_SBC_1	410	414	PF00917	0.773
DEG_SPOP_SBC_1	549	553	PF00917	0.756
DEG_SPOP_SBC_1	673	677	PF00917	0.779
DEG_SPOP_SBC_1	820	824	PF00917	0.695
DEG_SPOP_SBC_1	953	957	PF00917	0.643
DOC_CKS1_1	399	404	PF01111	0.812
DOC_CKS1_1	473	478	PF01111	0.771
DOC_CYCLIN_yCln2_LP_2	385	388	PF00134	0.751
DOC_MAPK_DCC_7	505	515	PF00069	0.852
DOC_MAPK_gen_1	802	812	PF00069	0.739
DOC_MAPK_MEF2A_6	421	428	PF00069	0.801
DOC_MAPK_MEF2A_6	803	812	PF00069	0.739
DOC_MAPK_NFAT4_5	805	813	PF00069	0.704
DOC_PP1_RVXF_1	109	116	PF00149	0.614
DOC_PP1_RVXF_1	794	801	PF00149	0.743
DOC_PP2B_LxvP_1	385	388	PF13499	0.839
DOC_PP2B_LxvP_1	471	474	PF13499	0.854
DOC_PP4_FxxP_1	923	926	PF00568	0.804
DOC_USP7_MATH_1	246	250	PF00917	0.829
DOC_USP7_MATH_1	254	258	PF00917	0.724
DOC_USP7_MATH_1	392	396	PF00917	0.776
DOC_USP7_MATH_1	405	409	PF00917	0.733
DOC_USP7_MATH_1	441	445	PF00917	0.775
DOC_USP7_MATH_1	452	456	PF00917	0.667
DOC_USP7_MATH_1	543	547	PF00917	0.860
DOC_USP7_MATH_1	548	552	PF00917	0.767
DOC_USP7_MATH_1	554	558	PF00917	0.659
DOC_USP7_MATH_1	659	663	PF00917	0.734
DOC_USP7_MATH_1	669	673	PF00917	0.645
DOC_USP7_MATH_1	773	777	PF00917	0.744
DOC_USP7_MATH_1	826	830	PF00917	0.729
DOC_USP7_MATH_1	838	842	PF00917	0.615
DOC_USP7_MATH_1	856	860	PF00917	0.765
DOC_USP7_MATH_1	875	879	PF00917	0.677
DOC_USP7_MATH_1	919	923	PF00917	0.845
DOC_USP7_MATH_1	962	966	PF00917	0.859
DOC_USP7_MATH_1	975	979	PF00917	0.641
DOC_USP7_UBL2_3	928	932	PF12436	0.865
DOC_WW_Pin1_4	231	236	PF00397	0.670
DOC_WW_Pin1_4	239	244	PF00397	0.711
DOC_WW_Pin1_4	29	34	PF00397	0.785
DOC_WW_Pin1_4	388	393	PF00397	0.766
DOC_WW_Pin1_4	398	403	PF00397	0.815
DOC_WW_Pin1_4	411	416	PF00397	0.630
DOC_WW_Pin1_4	46	51	PF00397	0.530
DOC_WW_Pin1_4	469	474	PF00397	0.805
DOC_WW_Pin1_4	550	555	PF00397	0.625
DOC_WW_Pin1_4	608	613	PF00397	0.729
DOC_WW_Pin1_4	642	647	PF00397	0.659
DOC_WW_Pin1_4	664	669	PF00397	0.787
DOC_WW_Pin1_4	871	876	PF00397	0.694
DOC_WW_Pin1_4	879	884	PF00397	0.692
DOC_WW_Pin1_4	914	919	PF00397	0.853
DOC_WW_Pin1_4	922	927	PF00397	0.718
DOC_WW_Pin1_4	938	943	PF00397	0.598
DOC_WW_Pin1_4	948	953	PF00397	0.780
DOC_WW_Pin1_4	954	959	PF00397	0.662
DOC_WW_Pin1_4	964	969	PF00397	0.588
LIG_14-3-3_CanoR_1	18	25	PF00244	0.776
LIG_14-3-3_CanoR_1	227	232	PF00244	0.737
LIG_14-3-3_CanoR_1	269	275	PF00244	0.796
LIG_14-3-3_CanoR_1	293	298	PF00244	0.851
LIG_14-3-3_CanoR_1	347	353	PF00244	0.675
LIG_14-3-3_CanoR_1	568	573	PF00244	0.792
LIG_14-3-3_CanoR_1	584	590	PF00244	0.642
LIG_14-3-3_CanoR_1	736	743	PF00244	0.863
LIG_14-3-3_CanoR_1	774	782	PF00244	0.730
LIG_14-3-3_CanoR_1	843	850	PF00244	0.857
LIG_14-3-3_CanoR_1	999	1007	PF00244	0.620
LIG_Actin_WH2_2	780	798	PF00022	0.739
LIG_BIR_II_1	1	5	PF00653	0.813
LIG_BRCT_BRCA1_1	130	134	PF00533	0.638
LIG_EH1_1	139	147	PF00400	0.609
LIG_EH1_1	695	703	PF00400	0.850
LIG_FHA_1	125	131	PF00498	0.613
LIG_FHA_1	136	142	PF00498	0.560
LIG_FHA_1	195	201	PF00498	0.661
LIG_FHA_1	20	26	PF00498	0.603
LIG_FHA_1	269	275	PF00498	0.673
LIG_FHA_1	296	302	PF00498	0.766
LIG_FHA_1	458	464	PF00498	0.815
LIG_FHA_1	504	510	PF00498	0.744
LIG_FHA_1	614	620	PF00498	0.850
LIG_FHA_1	770	776	PF00498	0.751
LIG_FHA_1	779	785	PF00498	0.573
LIG_FHA_1	845	851	PF00498	0.839
LIG_FHA_2	147	153	PF00498	0.617
LIG_FHA_2	737	743	PF00498	0.860
LIG_FHA_2	968	974	PF00498	0.864
LIG_Integrin_isoDGR_2	756	758	PF01839	0.848
LIG_LIR_Apic_2	920	926	PF02991	0.801
LIG_LIR_Gen_1	152	163	PF02991	0.599
LIG_LIR_Gen_1	93	103	PF02991	0.607
LIG_LIR_Nem_3	152	158	PF02991	0.588
LIG_LIR_Nem_3	93	98	PF02991	0.596
LIG_LIR_Nem_3	99	105	PF02991	0.512
LIG_PCNA_yPIPBox_3	83	95	PF02747	0.622
LIG_PTAP_UEV_1	707	712	PF05743	0.629
LIG_PTB_Apo_2	199	206	PF02174	0.698
LIG_PTB_Phospho_1	199	205	PF10480	0.698
LIG_SH2_CRK	214	218	PF00017	0.758
LIG_SH2_CRK	606	610	PF00017	0.637
LIG_SH2_CRK	95	99	PF00017	0.593
LIG_SH2_PTP2	102	105	PF00017	0.604
LIG_SH2_STAP1	170	174	PF00017	0.615
LIG_SH2_STAT3	184	187	PF00017	0.801
LIG_SH2_STAT5	102	105	PF00017	0.604
LIG_SH2_STAT5	140	143	PF00017	0.607
LIG_SH2_STAT5	148	151	PF00017	0.477
LIG_SH2_STAT5	782	785	PF00017	0.651
LIG_SH2_STAT5	797	800	PF00017	0.740
LIG_SH3_1	421	427	PF00018	0.818
LIG_SH3_2	243	248	PF14604	0.793
LIG_SH3_2	708	713	PF14604	0.633
LIG_SH3_3	240	246	PF00018	0.710
LIG_SH3_3	394	400	PF00018	0.768
LIG_SH3_3	421	427	PF00018	0.751
LIG_SH3_3	470	476	PF00018	0.767
LIG_SH3_3	577	583	PF00018	0.851
LIG_SH3_3	606	612	PF00018	0.801
LIG_SH3_3	616	622	PF00018	0.721
LIG_SH3_3	662	668	PF00018	0.684
LIG_SH3_3	69	75	PF00018	0.603
LIG_SH3_3	702	708	PF00018	0.804
LIG_SH3_3	725	731	PF00018	0.767
LIG_SH3_3	859	865	PF00018	0.744
LIG_SH3_3	869	875	PF00018	0.617
LIG_SH3_3	886	892	PF00018	0.725
LIG_SH3_3	912	918	PF00018	0.770
LIG_SH3_3	946	952	PF00018	0.852
LIG_SUMO_SIM_par_1	808	813	PF11976	0.699
LIG_TRAF2_1	630	633	PF00917	0.808
LIG_TRAF2_1	852	855	PF00917	0.855
LIG_TRAF2_1	978	981	PF00917	0.770
LIG_UBA3_1	154	161	PF00899	0.587
LIG_WW_3	290	294	PF00397	0.702
LIG_WW_3	386	390	PF00397	0.760
MOD_CDC14_SPxK_1	925	928	PF00782	0.856
MOD_CDK_SPxK_1	239	245	PF00069	0.631
MOD_CDK_SPxK_1	922	928	PF00069	0.853
MOD_CDK_SPxxK_3	879	886	PF00069	0.766
MOD_CDK_SPxxK_3	964	971	PF00069	0.742
MOD_CK1_1	157	163	PF00069	0.470
MOD_CK1_1	173	179	PF00069	0.433
MOD_CK1_1	194	200	PF00069	0.617
MOD_CK1_1	21	27	PF00069	0.822
MOD_CK1_1	391	397	PF00069	0.740
MOD_CK1_1	408	414	PF00069	0.773
MOD_CK1_1	445	451	PF00069	0.688
MOD_CK1_1	457	463	PF00069	0.747
MOD_CK1_1	639	645	PF00069	0.847
MOD_CK1_1	658	664	PF00069	0.627
MOD_CK1_1	672	678	PF00069	0.621
MOD_CK1_1	778	784	PF00069	0.723
MOD_CK1_1	829	835	PF00069	0.704
MOD_CK1_1	837	843	PF00069	0.699
MOD_CK1_1	874	880	PF00069	0.853
MOD_CK1_1	882	888	PF00069	0.695
MOD_CK1_1	922	928	PF00069	0.833
MOD_CK1_1	941	947	PF00069	0.552
MOD_CK1_1	961	967	PF00069	0.531
MOD_CK2_1	273	279	PF00069	0.751
MOD_CK2_1	322	328	PF00069	0.757
MOD_CK2_1	367	373	PF00069	0.647
MOD_CK2_1	921	927	PF00069	0.846
MOD_CK2_1	967	973	PF00069	0.862
MOD_CK2_1	975	981	PF00069	0.726
MOD_Cter_Amidation	987	990	PF01082	0.851
MOD_Cter_Amidation	991	994	PF01082	0.785
MOD_DYRK1A_RPxSP_1	398	402	PF00069	0.812
MOD_GlcNHglycan	1	4	PF01048	0.811
MOD_GlcNHglycan	175	178	PF01048	0.658
MOD_GlcNHglycan	187	190	PF01048	0.623
MOD_GlcNHglycan	249	252	PF01048	0.867
MOD_GlcNHglycan	316	319	PF01048	0.670
MOD_GlcNHglycan	339	342	PF01048	0.857
MOD_GlcNHglycan	354	357	PF01048	0.601
MOD_GlcNHglycan	444	447	PF01048	0.820
MOD_GlcNHglycan	456	459	PF01048	0.645
MOD_GlcNHglycan	465	468	PF01048	0.715
MOD_GlcNHglycan	477	480	PF01048	0.812
MOD_GlcNHglycan	545	548	PF01048	0.780
MOD_GlcNHglycan	557	560	PF01048	0.653
MOD_GlcNHglycan	570	573	PF01048	0.721
MOD_GlcNHglycan	576	579	PF01048	0.564
MOD_GlcNHglycan	622	625	PF01048	0.855
MOD_GlcNHglycan	638	641	PF01048	0.598
MOD_GlcNHglycan	657	660	PF01048	0.830
MOD_GlcNHglycan	661	664	PF01048	0.784
MOD_GlcNHglycan	671	674	PF01048	0.645
MOD_GlcNHglycan	676	679	PF01048	0.567
MOD_GlcNHglycan	708	711	PF01048	0.757
MOD_GlcNHglycan	777	780	PF01048	0.716
MOD_GlcNHglycan	823	826	PF01048	0.668
MOD_GlcNHglycan	83	86	PF01048	0.622
MOD_GlcNHglycan	835	839	PF01048	0.627
MOD_GlcNHglycan	847	850	PF01048	0.654
MOD_GlcNHglycan	858	861	PF01048	0.704
MOD_GlcNHglycan	912	915	PF01048	0.776
MOD_GlcNHglycan	934	937	PF01048	0.789
MOD_GlcNHglycan	945	948	PF01048	0.764
MOD_GlcNHglycan	986	989	PF01048	0.810
MOD_GSK3_1	124	131	PF00069	0.614
MOD_GSK3_1	146	153	PF00069	0.614
MOD_GSK3_1	166	173	PF00069	0.286
MOD_GSK3_1	19	26	PF00069	0.776
MOD_GSK3_1	227	234	PF00069	0.753
MOD_GSK3_1	269	276	PF00069	0.709
MOD_GSK3_1	329	336	PF00069	0.763
MOD_GSK3_1	388	395	PF00069	0.694
MOD_GSK3_1	405	412	PF00069	0.861
MOD_GSK3_1	441	448	PF00069	0.690
MOD_GSK3_1	450	457	PF00069	0.718
MOD_GSK3_1	463	470	PF00069	0.636
MOD_GSK3_1	550	557	PF00069	0.831
MOD_GSK3_1	636	643	PF00069	0.683
MOD_GSK3_1	654	661	PF00069	0.633
MOD_GSK3_1	664	671	PF00069	0.673
MOD_GSK3_1	769	776	PF00069	0.749
MOD_GSK3_1	778	785	PF00069	0.578
MOD_GSK3_1	834	841	PF00069	0.767
MOD_GSK3_1	867	874	PF00069	0.715
MOD_GSK3_1	875	882	PF00069	0.672
MOD_GSK3_1	910	917	PF00069	0.776
MOD_GSK3_1	932	939	PF00069	0.849
MOD_GSK3_1	948	955	PF00069	0.807
MOD_GSK3_1	958	965	PF00069	0.650
MOD_N-GLC_1	219	224	PF02516	0.844
MOD_N-GLC_1	442	447	PF02516	0.638
MOD_N-GLC_1	463	468	PF02516	0.665
MOD_N-GLC_1	543	548	PF02516	0.855
MOD_N-GLC_1	549	554	PF02516	0.748
MOD_N-GLC_1	555	560	PF02516	0.654
MOD_N-GLC_1	654	659	PF02516	0.650
MOD_N-GLC_1	87	92	PF02516	0.635
MOD_N-GLC_1	96	101	PF02516	0.459
MOD_N-GLC_1	962	967	PF02516	0.859
MOD_NEK2_1	1002	1007	PF00069	0.638
MOD_NEK2_1	141	146	PF00069	0.576
MOD_NEK2_1	154	159	PF00069	0.353
MOD_NEK2_1	20	25	PF00069	0.689
MOD_NEK2_1	226	231	PF00069	0.767
MOD_NEK2_1	335	340	PF00069	0.687
MOD_NEK2_1	574	579	PF00069	0.685
MOD_NEK2_1	769	774	PF00069	0.654
MOD_NEK2_1	821	826	PF00069	0.763
MOD_NEK2_1	87	92	PF00069	0.476
MOD_NEK2_2	150	155	PF00069	0.601
MOD_PIKK_1	124	130	PF00454	0.610
MOD_PIKK_1	273	279	PF00454	0.751
MOD_PIKK_1	392	398	PF00454	0.771
MOD_PIKK_1	405	411	PF00454	0.727
MOD_PIKK_1	490	496	PF00454	0.775
MOD_PIKK_1	826	832	PF00454	0.762
MOD_PIKK_1	902	908	PF00454	0.764
MOD_PK_1	227	233	PF00069	0.860
MOD_PKA_1	932	938	PF00069	0.729
MOD_PKA_1	984	990	PF00069	0.719
MOD_PKA_2	194	200	PF00069	0.748
MOD_PKA_2	226	232	PF00069	0.707
MOD_PKA_2	247	253	PF00069	0.796
MOD_PKA_2	262	268	PF00069	0.604
MOD_PKA_2	346	352	PF00069	0.647
MOD_PKA_2	516	522	PF00069	0.689
MOD_PKA_2	773	779	PF00069	0.687
MOD_PKA_2	842	848	PF00069	0.770
MOD_PKA_2	932	938	PF00069	0.729
MOD_PKA_2	984	990	PF00069	0.809
MOD_Plk_1	116	122	PF00069	0.600
MOD_Plk_1	303	309	PF00069	0.703
MOD_Plk_1	327	333	PF00069	0.691
MOD_Plk_1	87	93	PF00069	0.634
MOD_Plk_1	919	925	PF00069	0.848
MOD_Plk_1	962	968	PF00069	0.856
MOD_Plk_2-3	262	268	PF00069	0.850
MOD_Plk_4	141	147	PF00069	0.522
MOD_Plk_4	150	156	PF00069	0.407
MOD_Plk_4	159	165	PF00069	0.318
MOD_Plk_4	170	176	PF00069	0.289
MOD_Plk_4	200	206	PF00069	0.701
MOD_Plk_4	778	784	PF00069	0.522
MOD_Plk_4	87	93	PF00069	0.634
MOD_ProDKin_1	231	237	PF00069	0.671
MOD_ProDKin_1	239	245	PF00069	0.709
MOD_ProDKin_1	29	35	PF00069	0.781
MOD_ProDKin_1	388	394	PF00069	0.769
MOD_ProDKin_1	398	404	PF00069	0.817
MOD_ProDKin_1	411	417	PF00069	0.623
MOD_ProDKin_1	46	52	PF00069	0.530
MOD_ProDKin_1	469	475	PF00069	0.807
MOD_ProDKin_1	550	556	PF00069	0.626
MOD_ProDKin_1	608	614	PF00069	0.729
MOD_ProDKin_1	642	648	PF00069	0.655
MOD_ProDKin_1	664	670	PF00069	0.790
MOD_ProDKin_1	871	877	PF00069	0.695
MOD_ProDKin_1	879	885	PF00069	0.692
MOD_ProDKin_1	914	920	PF00069	0.854
MOD_ProDKin_1	922	928	PF00069	0.721
MOD_ProDKin_1	938	944	PF00069	0.600
MOD_ProDKin_1	948	954	PF00069	0.779
MOD_ProDKin_1	958	964	PF00069	0.575
MOD_SUMO_rev_2	799	804	PF00179	0.719
TRG_DiLeu_BaEn_3	764	770	PF01217	0.747
TRG_DiLeu_BaEn_4	790	796	PF01217	0.583
TRG_ENDOCYTIC_2	102	105	PF00928	0.489
TRG_ENDOCYTIC_2	214	217	PF00928	0.759
TRG_ENDOCYTIC_2	606	609	PF00928	0.640
TRG_ENDOCYTIC_2	797	800	PF00928	0.740
TRG_ENDOCYTIC_2	95	98	PF00928	0.593
TRG_ER_diArg_1	814	817	PF00400	0.621
TRG_ER_diArg_1	862	864	PF00400	0.716

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIU2	Leishmania donovani	94%	100%
A4HNF8	Leishmania braziliensis	76%	100%
E9AHX0	Leishmania infantum	93%	100%
E9B722	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%