CUE domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFW8_LEIMA

TriTrypDb:

LmjF.35.4940 , LMJLV39_350057400 , LMJSD75_350056700

Length:

210

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AFW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFW8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	87	91	PF00656	0.650
CLV_NRD_NRD_1	163	165	PF00675	0.415
CLV_NRD_NRD_1	175	177	PF00675	0.420
CLV_NRD_NRD_1	38	40	PF00675	0.531
CLV_NRD_NRD_1	95	97	PF00675	0.456
CLV_PCSK_FUR_1	42	46	PF00082	0.562
CLV_PCSK_FUR_1	93	97	PF00082	0.517
CLV_PCSK_KEX2_1	44	46	PF00082	0.561
CLV_PCSK_KEX2_1	82	84	PF00082	0.515
CLV_PCSK_KEX2_1	95	97	PF00082	0.459
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.561
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.528
CLV_PCSK_SKI1_1	176	180	PF00082	0.509
DEG_Nend_Nbox_1	1	3	PF02207	0.393
DOC_MAPK_gen_1	164	170	PF00069	0.651
DOC_MAPK_gen_1	179	189	PF00069	0.772
DOC_USP7_MATH_1	109	113	PF00917	0.768
DOC_USP7_UBL2_3	116	120	PF12436	0.699
DOC_USP7_UBL2_3	40	44	PF12436	0.744
DOC_WW_Pin1_4	126	131	PF00397	0.764
LIG_14-3-3_CanoR_1	114	124	PF00244	0.754
LIG_14-3-3_CanoR_1	164	169	PF00244	0.684
LIG_BRCT_BRCA1_1	166	170	PF00533	0.676
LIG_FHA_1	52	58	PF00498	0.697
LIG_FHA_1	60	66	PF00498	0.616
LIG_FHA_2	155	161	PF00498	0.673
LIG_LIR_Apic_2	3	7	PF02991	0.362
LIG_LIR_Nem_3	121	127	PF02991	0.655
LIG_MLH1_MIPbox_1	166	170	PF16413	0.685
LIG_REV1ctd_RIR_1	167	175	PF16727	0.683
LIG_SH2_SRC	4	7	PF00017	0.447
LIG_SH2_STAP1	53	57	PF00017	0.689
LIG_SH2_STAT5	4	7	PF00017	0.372
LIG_SH2_STAT5	53	56	PF00017	0.705
LIG_SH3_3	124	130	PF00018	0.716
LIG_SH3_4	40	47	PF00018	0.766
LIG_SUMO_SIM_par_1	54	63	PF11976	0.678
LIG_TRAF2_1	158	161	PF00917	0.671
LIG_TRAF2_1	183	186	PF00917	0.747
LIG_TRAF2_1	98	101	PF00917	0.710
LIG_UBA3_1	21	27	PF00899	0.522
MOD_CDK_SPK_2	126	131	PF00069	0.720
MOD_CK1_1	172	178	PF00069	0.761
MOD_CK2_1	154	160	PF00069	0.668
MOD_CK2_1	23	29	PF00069	0.678
MOD_GlcNHglycan	117	120	PF01048	0.526
MOD_GlcNHglycan	190	193	PF01048	0.534
MOD_GlcNHglycan	74	77	PF01048	0.482
MOD_GSK3_1	150	157	PF00069	0.780
MOD_GSK3_1	202	209	PF00069	0.666
MOD_GSK3_1	21	28	PF00069	0.539
MOD_GSK3_1	43	50	PF00069	0.738
MOD_GSK3_1	72	79	PF00069	0.677
MOD_NEK2_1	169	174	PF00069	0.654
MOD_PIKK_1	102	108	PF00454	0.697
MOD_PIKK_1	43	49	PF00454	0.785
MOD_PKA_1	164	170	PF00069	0.684
MOD_PKA_2	150	156	PF00069	0.792
MOD_PKA_2	47	53	PF00069	0.717
MOD_Plk_4	164	170	PF00069	0.657
MOD_ProDKin_1	126	132	PF00069	0.767
MOD_SUMO_for_1	183	186	PF00179	0.767
MOD_SUMO_rev_2	158	167	PF00179	0.624
MOD_SUMO_rev_2	174	183	PF00179	0.755
MOD_SUMO_rev_2	75	84	PF00179	0.737
TRG_ER_diArg_1	92	95	PF00400	0.686
TRG_ER_diLys_1	206	210	PF00400	0.750
TRG_NLS_MonoCore_2	38	43	PF00514	0.769
TRG_NLS_MonoExtN_4	37	43	PF00514	0.793

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICF1	Leptomonas seymouri	57%	96%
A0A0S4J7Q9	Bodo saltans	28%	100%
A0A1X0P5X3	Trypanosomatidae	37%	100%
A0A3Q8IN24	Leishmania donovani	91%	100%
A0A3R7KQ70	Trypanosoma rangeli	39%	100%
A4HNF7	Leishmania braziliensis	76%	100%
A4IC29	Leishmania infantum	91%	100%
C9ZYH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	99%
E9B721	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%