Putative phosphatidylcholine:ceramide cholinephosphotransferase 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFW5_LEIMA

TriTrypDb:

LmjF.35.4900 , LMJLV39_350057100 , LMJSD75_350056400

Length:

153

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFW5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	52	56	PF00656	0.602
CLV_NRD_NRD_1	39	41	PF00675	0.537
CLV_NRD_NRD_1	44	46	PF00675	0.570
CLV_PCSK_FUR_1	37	41	PF00082	0.478
CLV_PCSK_KEX2_1	39	41	PF00082	0.560
CLV_PCSK_PC7_1	35	41	PF00082	0.529
CLV_PCSK_SKI1_1	149	153	PF00082	0.475
DEG_SPOP_SBC_1	72	76	PF00917	0.650
DOC_CKS1_1	62	67	PF01111	0.507
DOC_PP2B_LxvP_1	92	95	PF13499	0.490
DOC_USP7_MATH_1	88	92	PF00917	0.466
DOC_WW_Pin1_4	61	66	PF00397	0.510
LIG_14-3-3_CanoR_1	3	11	PF00244	0.590
LIG_14-3-3_CterR_2	149	153	PF00244	0.475
LIG_BIR_III_4	55	59	PF00653	0.601
LIG_BRCT_MDC1_1	149	153	PF00533	0.378
LIG_Clathr_ClatBox_1	120	124	PF01394	0.376
LIG_CSL_BTD_1	62	65	PF09270	0.511
LIG_deltaCOP1_diTrp_1	143	148	PF00928	0.533
LIG_deltaCOP1_diTrp_1	99	107	PF00928	0.463
LIG_FHA_2	50	56	PF00498	0.642
LIG_LIR_Gen_1	99	107	PF02991	0.408
LIG_LIR_Nem_3	130	136	PF02991	0.469
LIG_LIR_Nem_3	143	147	PF02991	0.416
LIG_LIR_Nem_3	99	103	PF02991	0.408
LIG_PCNA_PIPBox_1	129	138	PF02747	0.404
LIG_PCNA_yPIPBox_3	128	136	PF02747	0.356
LIG_Pex14_1	144	148	PF04695	0.456
LIG_SH2_STAT5	119	122	PF00017	0.462
LIG_SH2_STAT5	147	150	PF00017	0.520
LIG_SUMO_SIM_anti_2	113	118	PF11976	0.392
LIG_SUMO_SIM_par_1	119	126	PF11976	0.357
LIG_TRAF2_1	122	125	PF00917	0.422
MOD_CK1_1	74	80	PF00069	0.582
MOD_GlcNHglycan	41	44	PF01048	0.547
MOD_GlcNHglycan	51	55	PF01048	0.677
MOD_GSK3_1	50	57	PF00069	0.597
MOD_PKA_1	39	45	PF00069	0.496
MOD_PKA_2	2	8	PF00069	0.616
MOD_PKA_2	39	45	PF00069	0.498
MOD_PKB_1	37	45	PF00069	0.490
MOD_ProDKin_1	61	67	PF00069	0.507
TRG_ER_diArg_1	33	36	PF00400	0.617
TRG_ER_diArg_1	39	41	PF00400	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I444	Leptomonas seymouri	56%	98%
A0A1X0P5P2	Trypanosomatidae	25%	100%
A0A3S5H809	Leishmania donovani	91%	100%
A4HNF4	Leishmania braziliensis	76%	100%
A4IC26	Leishmania infantum	91%	100%
E9B718	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%