FAM184 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFW2_LEIMA

TriTrypDb:

LmjF.35.4870 , LMJLV39_350056800 , LMJSD75_350056100

Length:

1000

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0097542	ciliary tip	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AFW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFW2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.502
CLV_C14_Caspase3-7	190	194	PF00656	0.517
CLV_C14_Caspase3-7	695	699	PF00656	0.643
CLV_NRD_NRD_1	263	265	PF00675	0.562
CLV_NRD_NRD_1	407	409	PF00675	0.508
CLV_NRD_NRD_1	504	506	PF00675	0.476
CLV_NRD_NRD_1	521	523	PF00675	0.437
CLV_NRD_NRD_1	617	619	PF00675	0.580
CLV_NRD_NRD_1	703	705	PF00675	0.616
CLV_NRD_NRD_1	854	856	PF00675	0.604
CLV_NRD_NRD_1	892	894	PF00675	0.643
CLV_PCSK_KEX2_1	145	147	PF00082	0.511
CLV_PCSK_KEX2_1	185	187	PF00082	0.583
CLV_PCSK_KEX2_1	263	265	PF00082	0.665
CLV_PCSK_KEX2_1	286	288	PF00082	0.613
CLV_PCSK_KEX2_1	437	439	PF00082	0.556
CLV_PCSK_KEX2_1	504	506	PF00082	0.475
CLV_PCSK_KEX2_1	617	619	PF00082	0.580
CLV_PCSK_KEX2_1	703	705	PF00082	0.616
CLV_PCSK_KEX2_1	841	843	PF00082	0.522
CLV_PCSK_KEX2_1	854	856	PF00082	0.517
CLV_PCSK_KEX2_1	892	894	PF00082	0.643
CLV_PCSK_KEX2_1	983	985	PF00082	0.734
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.511
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.583
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.568
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.671
CLV_PCSK_PC1ET2_1	841	843	PF00082	0.658
CLV_PCSK_PC1ET2_1	983	985	PF00082	0.587
CLV_PCSK_SKI1_1	167	171	PF00082	0.492
CLV_PCSK_SKI1_1	177	181	PF00082	0.501
CLV_PCSK_SKI1_1	223	227	PF00082	0.590
CLV_PCSK_SKI1_1	287	291	PF00082	0.615
CLV_PCSK_SKI1_1	305	309	PF00082	0.473
CLV_PCSK_SKI1_1	340	344	PF00082	0.665
CLV_PCSK_SKI1_1	384	388	PF00082	0.698
CLV_PCSK_SKI1_1	458	462	PF00082	0.600
CLV_PCSK_SKI1_1	467	471	PF00082	0.623
CLV_PCSK_SKI1_1	650	654	PF00082	0.586
CLV_PCSK_SKI1_1	785	789	PF00082	0.652
CLV_PCSK_SKI1_1	868	872	PF00082	0.569
CLV_Separin_Metazoa	443	447	PF03568	0.613
DOC_CYCLIN_RxL_1	933	941	PF00134	0.571
DOC_MAPK_gen_1	145	155	PF00069	0.643
DOC_MAPK_gen_1	916	925	PF00069	0.509
DOC_MIT_MIM_1	275	283	PF04212	0.580
DOC_USP7_MATH_1	202	206	PF00917	0.617
DOC_USP7_MATH_1	297	301	PF00917	0.527
DOC_USP7_MATH_1	3	7	PF00917	0.646
DOC_USP7_MATH_1	410	414	PF00917	0.572
DOC_USP7_MATH_1	497	501	PF00917	0.612
DOC_USP7_UBL2_3	16	20	PF12436	0.581
DOC_USP7_UBL2_3	23	27	PF12436	0.467
LIG_14-3-3_CanoR_1	223	228	PF00244	0.727
LIG_14-3-3_CanoR_1	279	284	PF00244	0.574
LIG_14-3-3_CanoR_1	411	415	PF00244	0.660
LIG_14-3-3_CanoR_1	446	454	PF00244	0.573
LIG_14-3-3_CanoR_1	458	465	PF00244	0.528
LIG_14-3-3_CanoR_1	623	628	PF00244	0.451
LIG_14-3-3_CanoR_1	650	659	PF00244	0.597
LIG_14-3-3_CanoR_1	903	907	PF00244	0.583
LIG_14-3-3_CanoR_1	984	989	PF00244	0.688
LIG_14-3-3_CterR_2	995	1000	PF00244	0.650
LIG_Actin_WH2_2	634	652	PF00022	0.649
LIG_BIR_II_1	1	5	PF00653	0.692
LIG_CaM_IQ_9	71	87	PF13499	0.549
LIG_Clathr_ClatBox_1	280	284	PF01394	0.468
LIG_FHA_1	142	148	PF00498	0.637
LIG_FHA_1	30	36	PF00498	0.471
LIG_FHA_1	327	333	PF00498	0.487
LIG_FHA_1	47	53	PF00498	0.512
LIG_FHA_1	654	660	PF00498	0.603
LIG_FHA_1	802	808	PF00498	0.516
LIG_FHA_2	126	132	PF00498	0.451
LIG_FHA_2	253	259	PF00498	0.552
LIG_FHA_2	272	278	PF00498	0.472
LIG_FHA_2	325	331	PF00498	0.644
LIG_FHA_2	693	699	PF00498	0.664
LIG_FHA_2	874	880	PF00498	0.565
LIG_FHA_2	903	909	PF00498	0.583
LIG_LIR_Gen_1	941	952	PF02991	0.616
LIG_LIR_Gen_1	958	969	PF02991	0.478
LIG_LIR_Gen_1	973	981	PF02991	0.625
LIG_LIR_Nem_3	958	964	PF02991	0.539
LIG_LIR_Nem_3	973	977	PF02991	0.623
LIG_NRBOX	822	828	PF00104	0.628
LIG_SH2_CRK	961	965	PF00017	0.554
LIG_SH2_CRK	974	978	PF00017	0.623
LIG_SH2_NCK_1	961	965	PF00017	0.554
LIG_SH2_NCK_1	974	978	PF00017	0.623
LIG_SH2_STAP1	125	129	PF00017	0.647
LIG_SH2_STAP1	620	624	PF00017	0.650
LIG_SH2_STAP1	67	71	PF00017	0.479
LIG_SH2_STAP1	725	729	PF00017	0.526
LIG_SH2_STAP1	974	978	PF00017	0.690
LIG_SH2_STAT5	36	39	PF00017	0.483
LIG_SUMO_SIM_anti_2	673	678	PF11976	0.603
LIG_SUMO_SIM_anti_2	921	927	PF11976	0.509
LIG_SUMO_SIM_par_1	279	285	PF11976	0.469
LIG_TRAF2_1	102	105	PF00917	0.631
LIG_TRAF2_1	119	122	PF00917	0.385
LIG_TRAF2_1	179	182	PF00917	0.531
LIG_TRAF2_1	255	258	PF00917	0.603
LIG_TRAF2_1	548	551	PF00917	0.538
LIG_TRAF2_1	818	821	PF00917	0.609
LIG_TRAF2_1	905	908	PF00917	0.617
LIG_UBA3_1	812	819	PF00899	0.620
LIG_UBA3_1	925	934	PF00899	0.502
MOD_CK1_1	234	240	PF00069	0.715
MOD_CK1_1	282	288	PF00069	0.611
MOD_CK1_1	324	330	PF00069	0.619
MOD_CK1_1	362	368	PF00069	0.592
MOD_CK1_1	369	375	PF00069	0.559
MOD_CK1_1	413	419	PF00069	0.562
MOD_CK1_1	626	632	PF00069	0.450
MOD_CK1_1	815	821	PF00069	0.480
MOD_CK2_1	116	122	PF00069	0.637
MOD_CK2_1	125	131	PF00069	0.529
MOD_CK2_1	234	240	PF00069	0.715
MOD_CK2_1	252	258	PF00069	0.452
MOD_CK2_1	271	277	PF00069	0.472
MOD_CK2_1	324	330	PF00069	0.646
MOD_CK2_1	415	421	PF00069	0.546
MOD_CK2_1	492	498	PF00069	0.692
MOD_CK2_1	66	72	PF00069	0.618
MOD_CK2_1	815	821	PF00069	0.618
MOD_CK2_1	873	879	PF00069	0.566
MOD_CK2_1	901	907	PF00069	0.571
MOD_CK2_1	915	921	PF00069	0.425
MOD_CK2_1	92	98	PF00069	0.520
MOD_Cter_Amidation	981	984	PF01082	0.694
MOD_GlcNHglycan	1	4	PF01048	0.685
MOD_GlcNHglycan	204	207	PF01048	0.658
MOD_GlcNHglycan	232	236	PF01048	0.720
MOD_GlcNHglycan	498	502	PF01048	0.613
MOD_GlcNHglycan	563	567	PF01048	0.693
MOD_GlcNHglycan	587	590	PF01048	0.498
MOD_GlcNHglycan	973	977	PF01048	0.623
MOD_GSK3_1	112	119	PF00069	0.583
MOD_GSK3_1	120	127	PF00069	0.513
MOD_GSK3_1	240	247	PF00069	0.546
MOD_GSK3_1	321	328	PF00069	0.647
MOD_GSK3_1	359	366	PF00069	0.540
MOD_GSK3_1	369	376	PF00069	0.608
MOD_GSK3_1	413	420	PF00069	0.558
MOD_GSK3_1	461	468	PF00069	0.636
MOD_GSK3_1	797	804	PF00069	0.490
MOD_GSK3_1	811	818	PF00069	0.559
MOD_GSK3_1	88	95	PF00069	0.503
MOD_GSK3_1	991	998	PF00069	0.743
MOD_N-GLC_1	416	421	PF02516	0.713
MOD_N-GLC_2	40	42	PF02516	0.640
MOD_NEK2_1	343	348	PF00069	0.686
MOD_NEK2_1	360	365	PF00069	0.441
MOD_NEK2_1	465	470	PF00069	0.695
MOD_NEK2_1	492	497	PF00069	0.678
MOD_NEK2_1	52	57	PF00069	0.457
MOD_NEK2_1	653	658	PF00069	0.634
MOD_NEK2_1	659	664	PF00069	0.600
MOD_NEK2_1	692	697	PF00069	0.654
MOD_NEK2_1	754	759	PF00069	0.639
MOD_NEK2_1	798	803	PF00069	0.589
MOD_NEK2_1	812	817	PF00069	0.401
MOD_NEK2_1	873	878	PF00069	0.517
MOD_NEK2_1	92	97	PF00069	0.566
MOD_NEK2_1	938	943	PF00069	0.535
MOD_PIKK_1	240	246	PF00454	0.548
MOD_PIKK_1	330	336	PF00454	0.502
MOD_PIKK_1	373	379	PF00454	0.705
MOD_PIKK_1	396	402	PF00454	0.655
MOD_PIKK_1	92	98	PF00454	0.567
MOD_PK_1	623	629	PF00069	0.446
MOD_PKA_1	430	436	PF00069	0.583
MOD_PKA_1	983	989	PF00069	0.686
MOD_PKA_2	396	402	PF00069	0.707
MOD_PKA_2	410	416	PF00069	0.516
MOD_PKA_2	902	908	PF00069	0.570
MOD_PKA_2	915	921	PF00069	0.432
MOD_PKA_2	983	989	PF00069	0.686
MOD_PKB_1	264	272	PF00069	0.610
MOD_PKB_1	783	791	PF00069	0.580
MOD_Plk_1	125	131	PF00069	0.465
MOD_Plk_1	972	978	PF00069	0.686
MOD_Plk_2-3	116	122	PF00069	0.564
MOD_Plk_2-3	271	277	PF00069	0.613
MOD_Plk_4	125	131	PF00069	0.469
MOD_Plk_4	321	327	PF00069	0.438
MOD_Plk_4	366	372	PF00069	0.645
MOD_Plk_4	637	643	PF00069	0.584
MOD_SUMO_for_1	184	187	PF00179	0.650
MOD_SUMO_for_1	272	275	PF00179	0.587
MOD_SUMO_for_1	401	404	PF00179	0.673
MOD_SUMO_for_1	737	740	PF00179	0.444
MOD_SUMO_rev_2	105	109	PF00179	0.557
MOD_SUMO_rev_2	138	147	PF00179	0.525
MOD_SUMO_rev_2	175	184	PF00179	0.465
MOD_SUMO_rev_2	269	274	PF00179	0.595
MOD_SUMO_rev_2	800	809	PF00179	0.552
MOD_SUMO_rev_2	814	823	PF00179	0.391
MOD_SUMO_rev_2	865	873	PF00179	0.569
TRG_DiLeu_BaEn_1	154	159	PF01217	0.494
TRG_DiLeu_BaEn_1	421	426	PF01217	0.591
TRG_DiLeu_BaEn_1	488	493	PF01217	0.688
TRG_DiLeu_BaEn_1	921	926	PF01217	0.509
TRG_DiLeu_BaLyEn_6	212	217	PF01217	0.630
TRG_DiLeu_BaLyEn_6	822	827	PF01217	0.558
TRG_ENDOCYTIC_2	166	169	PF00928	0.497
TRG_ENDOCYTIC_2	944	947	PF00928	0.480
TRG_ENDOCYTIC_2	961	964	PF00928	0.554
TRG_ENDOCYTIC_2	974	977	PF00928	0.624
TRG_ER_diArg_1	263	266	PF00400	0.661
TRG_ER_diArg_1	493	496	PF00400	0.557
TRG_ER_diArg_1	616	618	PF00400	0.584
TRG_ER_diArg_1	722	725	PF00400	0.514
TRG_ER_diArg_1	782	785	PF00400	0.580
TRG_NES_CRM1_1	768	781	PF08389	0.473
TRG_NES_CRM1_1	797	811	PF08389	0.487
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	505	509	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	556	560	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	79	84	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	825	829	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I973	Leptomonas seymouri	46%	99%
A0A3S7XA02	Leishmania donovani	92%	100%
A4HNF1	Leishmania braziliensis	68%	99%
A4IC23	Leishmania infantum	93%	100%
E9B715	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%