DFDF domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFV9_LEIMA

TriTrypDb:

LmjF.35.4840 , LMJLV39_350056500 , LMJSD75_350055800

Length:

256

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AFV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFV9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	254	256	PF00675	0.813
CLV_PCSK_SKI1_1	83	87	PF00082	0.459
DEG_APCC_DBOX_1	82	90	PF00400	0.644
DEG_Nend_Nbox_1	1	3	PF02207	0.498
DOC_CKS1_1	7	12	PF01111	0.483
DOC_CYCLIN_yCln2_LP_2	43	49	PF00134	0.453
DOC_CYCLIN_yCln2_LP_2	85	91	PF00134	0.650
DOC_PP2B_LxvP_1	5	8	PF13499	0.423
DOC_PP2B_LxvP_1	85	88	PF13499	0.678
DOC_PP4_FxxP_1	221	224	PF00568	0.496
DOC_PP4_FxxP_1	228	231	PF00568	0.440
DOC_USP7_UBL2_3	133	137	PF12436	0.536
DOC_WW_Pin1_4	238	243	PF00397	0.511
DOC_WW_Pin1_4	3	8	PF00397	0.492
DOC_WW_Pin1_4	90	95	PF00397	0.664
LIG_14-3-3_CanoR_1	247	251	PF00244	0.642
LIG_APCC_ABBA_1	177	182	PF00400	0.371
LIG_BRCT_BRCA1_1	16	20	PF00533	0.471
LIG_BRCT_BRCA1_1	240	244	PF00533	0.520
LIG_BRCT_BRCA1_1	92	96	PF00533	0.381
LIG_EH_1	225	229	PF12763	0.487
LIG_FHA_1	189	195	PF00498	0.469
LIG_FHA_1	234	240	PF00498	0.503
LIG_FHA_1	72	78	PF00498	0.364
LIG_FHA_2	176	182	PF00498	0.450
LIG_FHA_2	247	253	PF00498	0.568
LIG_LIR_Apic_2	219	224	PF02991	0.504
LIG_LIR_Gen_1	17	27	PF02991	0.412
LIG_LIR_Gen_1	73	82	PF02991	0.359
LIG_LIR_Nem_3	17	23	PF02991	0.471
LIG_LIR_Nem_3	178	183	PF02991	0.445
LIG_LIR_Nem_3	73	79	PF02991	0.359
LIG_MLH1_MIPbox_1	16	20	PF16413	0.399
LIG_NRBOX	81	87	PF00104	0.635
LIG_Pex14_1	72	76	PF04695	0.354
LIG_Pex14_2	98	102	PF04695	0.364
LIG_PTB_Apo_2	215	222	PF02174	0.508
LIG_SH2_CRK	2	6	PF00017	0.592
LIG_SH2_STAP1	113	117	PF00017	0.462
LIG_SH2_STAP1	167	171	PF00017	0.545
LIG_SH2_STAT3	159	162	PF00017	0.457
LIG_SH2_STAT3	54	57	PF00017	0.354
LIG_SH2_STAT5	113	116	PF00017	0.440
LIG_SH2_STAT5	159	162	PF00017	0.476
LIG_SH2_STAT5	167	170	PF00017	0.445
LIG_SH2_STAT5	54	57	PF00017	0.381
LIG_SH3_3	221	227	PF00018	0.492
LIG_SH3_3	4	10	PF00018	0.447
LIG_SH3_3	43	49	PF00018	0.472
LIG_SH3_3	85	91	PF00018	0.756
LIG_SUMO_SIM_par_1	24	31	PF11976	0.451
LIG_TRAF2_1	139	142	PF00917	0.542
LIG_TRAF2_1	249	252	PF00917	0.524
MOD_CK1_1	132	138	PF00069	0.536
MOD_CK1_1	18	24	PF00069	0.444
MOD_CK1_1	28	34	PF00069	0.452
MOD_CK2_1	136	142	PF00069	0.641
MOD_CK2_1	150	156	PF00069	0.467
MOD_CK2_1	175	181	PF00069	0.457
MOD_CK2_1	246	252	PF00069	0.635
MOD_DYRK1A_RPxSP_1	90	94	PF00069	0.539
MOD_GlcNHglycan	134	137	PF01048	0.726
MOD_GlcNHglycan	30	33	PF01048	0.788
MOD_GSK3_1	107	114	PF00069	0.273
MOD_GSK3_1	132	139	PF00069	0.536
MOD_GSK3_1	14	21	PF00069	0.527
MOD_GSK3_1	188	195	PF00069	0.466
MOD_GSK3_1	233	240	PF00069	0.547
MOD_NEK2_1	1	6	PF00069	0.432
MOD_NEK2_1	129	134	PF00069	0.528
MOD_NEK2_1	186	191	PF00069	0.466
MOD_NEK2_1	30	35	PF00069	0.478
MOD_NEK2_1	61	66	PF00069	0.410
MOD_NEK2_1	71	76	PF00069	0.358
MOD_NEK2_2	175	180	PF00069	0.377
MOD_PIKK_1	21	27	PF00454	0.510
MOD_PK_1	140	146	PF00069	0.529
MOD_PKA_1	150	156	PF00069	0.448
MOD_PKA_2	246	252	PF00069	0.585
MOD_Plk_1	140	146	PF00069	0.529
MOD_Plk_2-3	246	252	PF00069	0.522
MOD_Plk_4	15	21	PF00069	0.428
MOD_Plk_4	175	181	PF00069	0.380
MOD_Plk_4	25	31	PF00069	0.435
MOD_Plk_4	61	67	PF00069	0.381
MOD_Plk_4	71	77	PF00069	0.307
MOD_ProDKin_1	238	244	PF00069	0.512
MOD_ProDKin_1	3	9	PF00069	0.491
MOD_ProDKin_1	90	96	PF00069	0.664
MOD_SUMO_rev_2	143	153	PF00179	0.535
TRG_ENDOCYTIC_2	183	186	PF00928	0.575
TRG_ENDOCYTIC_2	2	5	PF00928	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJX6	Leishmania donovani	91%	100%
A4IC20	Leishmania infantum	91%	100%
E9B712	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	73%