BRCT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

BRCA1 C Terminus (BRCT) domain containing protein, putative

Species:

Leishmania major

UniProt:

E9AFV6_LEIMA

TriTrypDb:

LmjF.35.4810 , LMJLV39_350056200 , LMJSD75_350055500

Length:

369

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFV6

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0006357	regulation of transcription by RNA polymerase II	7	2
GO:0006470	protein dephosphorylation	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0016311	dephosphorylation	5	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0019538	protein metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0070940	obsolete dephosphorylation of RNA polymerase II C-terminal domain	6	2
GO:0071704	organic substance metabolic process	2	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004721	phosphoprotein phosphatase activity	3	2
GO:0004722	protein serine/threonine phosphatase activity	4	2
GO:0008420	RNA polymerase II CTD heptapeptide repeat phosphatase activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:0005488	binding	1	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.534
CLV_C14_Caspase3-7	220	224	PF00656	0.522
CLV_NRD_NRD_1	18	20	PF00675	0.564
CLV_NRD_NRD_1	227	229	PF00675	0.665
CLV_PCSK_KEX2_1	18	20	PF00082	0.564
CLV_PCSK_KEX2_1	282	284	PF00082	0.642
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.642
CLV_PCSK_PC7_1	14	20	PF00082	0.584
CLV_PCSK_SKI1_1	248	252	PF00082	0.458
DOC_CKS1_1	257	262	PF01111	0.390
DOC_CKS1_1	346	351	PF01111	0.521
DOC_MAPK_gen_1	228	236	PF00069	0.606
DOC_MAPK_gen_1	304	310	PF00069	0.423
DOC_MAPK_gen_1	79	87	PF00069	0.462
DOC_MAPK_MEF2A_6	228	236	PF00069	0.653
DOC_MAPK_RevD_3	267	283	PF00069	0.452
DOC_PP1_RVXF_1	27	33	PF00149	0.341
DOC_PP2B_LxvP_1	91	94	PF13499	0.325
DOC_PP4_FxxP_1	12	15	PF00568	0.546
DOC_USP7_MATH_1	157	161	PF00917	0.710
DOC_USP7_MATH_1	43	47	PF00917	0.450
DOC_USP7_MATH_1	66	70	PF00917	0.455
DOC_USP7_UBL2_3	161	165	PF12436	0.729
DOC_USP7_UBL2_3	278	282	PF12436	0.580
DOC_USP7_UBL2_3	359	363	PF12436	0.530
DOC_WW_Pin1_4	256	261	PF00397	0.409
DOC_WW_Pin1_4	345	350	PF00397	0.517
LIG_14-3-3_CanoR_1	196	203	PF00244	0.623
LIG_14-3-3_CanoR_1	291	299	PF00244	0.472
LIG_14-3-3_CanoR_1	54	63	PF00244	0.456
LIG_APCC_ABBA_1	186	191	PF00400	0.647
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_BIR_III_3	1	5	PF00653	0.401
LIG_eIF4E_1	116	122	PF01652	0.487
LIG_FHA_1	117	123	PF00498	0.597
LIG_FHA_1	208	214	PF00498	0.654
LIG_FHA_1	220	226	PF00498	0.755
LIG_FHA_1	257	263	PF00498	0.396
LIG_FHA_1	264	270	PF00498	0.426
LIG_FHA_1	293	299	PF00498	0.418
LIG_FHA_1	348	354	PF00498	0.472
LIG_FHA_2	213	219	PF00498	0.578
LIG_FHA_2	59	65	PF00498	0.508
LIG_GBD_Chelix_1	98	106	PF00786	0.439
LIG_LIR_Apic_2	148	152	PF02991	0.510
LIG_LIR_Gen_1	3	13	PF02991	0.509
LIG_NRBOX	101	107	PF00104	0.386
LIG_SH2_CRK	149	153	PF00017	0.512
LIG_SH2_NCK_1	149	153	PF00017	0.479
LIG_SH2_STAT5	347	350	PF00017	0.449
LIG_SH2_STAT5	6	9	PF00017	0.513
LIG_SH3_3	121	127	PF00018	0.502
LIG_SH3_3	69	75	PF00018	0.411
LIG_SH3_3	91	97	PF00018	0.391
LIG_UBA3_1	353	360	PF00899	0.464
MOD_CDK_SPxxK_3	345	352	PF00069	0.561
MOD_CK1_1	150	156	PF00069	0.612
MOD_CK1_1	160	166	PF00069	0.718
MOD_CK1_1	292	298	PF00069	0.468
MOD_GlcNHglycan	165	168	PF01048	0.733
MOD_GlcNHglycan	177	181	PF01048	0.638
MOD_GlcNHglycan	25	28	PF01048	0.544
MOD_GlcNHglycan	251	254	PF01048	0.439
MOD_GlcNHglycan	291	294	PF01048	0.565
MOD_GSK3_1	101	108	PF00069	0.479
MOD_GSK3_1	125	132	PF00069	0.652
MOD_GSK3_1	147	154	PF00069	0.543
MOD_GSK3_1	208	215	PF00069	0.651
MOD_GSK3_1	282	289	PF00069	0.517
MOD_GSK3_1	359	366	PF00069	0.526
MOD_GSK3_1	55	62	PF00069	0.516
MOD_LATS_1	361	367	PF00433	0.396
MOD_NEK2_1	101	106	PF00069	0.407
MOD_NEK2_1	147	152	PF00069	0.469
MOD_NEK2_1	195	200	PF00069	0.551
MOD_NEK2_1	286	291	PF00069	0.494
MOD_NEK2_1	315	320	PF00069	0.538
MOD_NEK2_1	325	330	PF00069	0.445
MOD_NEK2_1	353	358	PF00069	0.442
MOD_PKA_1	282	288	PF00069	0.528
MOD_PKA_1	359	365	PF00069	0.519
MOD_PKA_2	116	122	PF00069	0.549
MOD_PKA_2	195	201	PF00069	0.610
MOD_PKA_2	227	233	PF00069	0.643
MOD_PKA_2	282	288	PF00069	0.577
MOD_Plk_1	147	153	PF00069	0.533
MOD_Plk_1	2	8	PF00069	0.585
MOD_Plk_1	286	292	PF00069	0.490
MOD_Plk_4	101	107	PF00069	0.433
MOD_Plk_4	111	117	PF00069	0.457
MOD_Plk_4	198	204	PF00069	0.634
MOD_Plk_4	66	72	PF00069	0.514
MOD_ProDKin_1	256	262	PF00069	0.407
MOD_ProDKin_1	345	351	PF00069	0.524
MOD_SUMO_for_1	213	216	PF00179	0.667
TRG_DiLeu_BaLyEn_6	117	122	PF01217	0.553
TRG_ENDOCYTIC_2	6	9	PF00928	0.497
TRG_NLS_MonoExtC_3	227	232	PF00514	0.665

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9H3	Leptomonas seymouri	68%	95%
A0A0S4J3S6	Bodo saltans	45%	94%
A0A1X0P4V1	Trypanosomatidae	52%	97%
A0A3R7RRN6	Trypanosoma rangeli	52%	96%
A0A3S7XA18	Leishmania donovani	90%	100%
A4HNE5	Leishmania braziliensis	64%	100%
C9ZYI4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	92%
E9AHW9	Leishmania infantum	90%	100%
E9B709	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	97%
V5B718	Trypanosoma cruzi	50%	96%