LeishMANIAdb
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Secreted protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Secreted protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania major
UniProt:
E9AFV3_LEIMA
TriTrypDb:
LmjF.35.4780 , LMJLV39_350055900 * , LMJSD75_350055200
Length:
102

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 3
NetGPI no yes: 0, no: 3
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AFV3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFV3

Putative motif mimicry

Leishmania From To Domain/Motif Score
DEG_SCF_FBW7_1 66 72 PF00400 0.554
DEG_SPOP_SBC_1 18 22 PF00917 0.412
DOC_CKS1_1 66 71 PF01111 0.555
DOC_USP7_MATH_1 17 21 PF00917 0.621
DOC_USP7_MATH_1 2 6 PF00917 0.387
DOC_USP7_MATH_1 44 48 PF00917 0.280
DOC_USP7_MATH_1 51 55 PF00917 0.269
DOC_USP7_MATH_1 69 73 PF00917 0.523
DOC_WW_Pin1_4 42 47 PF00397 0.336
DOC_WW_Pin1_4 65 70 PF00397 0.592
LIG_14-3-3_CanoR_1 82 86 PF00244 0.260
LIG_FHA_1 24 30 PF00498 0.402
LIG_FHA_1 85 91 PF00498 0.299
LIG_LIR_Apic_2 42 46 PF02991 0.428
LIG_LIR_Gen_1 49 60 PF02991 0.332
LIG_LIR_Nem_3 49 55 PF02991 0.332
LIG_SH2_STAP1 31 35 PF00017 0.384
LIG_SH2_STAT5 95 98 PF00017 0.424
LIG_TRAF2_1 98 101 PF00917 0.395
LIG_WRC_WIRS_1 6 11 PF05994 0.291
MOD_CK1_1 20 26 PF00069 0.364
MOD_CK1_1 42 48 PF00069 0.291
MOD_CK1_1 5 11 PF00069 0.373
MOD_CK2_1 13 19 PF00069 0.299
MOD_CK2_1 95 101 PF00069 0.465
MOD_GlcNHglycan 11 14 PF01048 0.321
MOD_GlcNHglycan 15 18 PF01048 0.324
MOD_GlcNHglycan 76 79 PF01048 0.386
MOD_GlcNHglycan 97 100 PF01048 0.593
MOD_GSK3_1 1 8 PF00069 0.475
MOD_GSK3_1 18 25 PF00069 0.405
MOD_GSK3_1 42 49 PF00069 0.314
MOD_GSK3_1 65 72 PF00069 0.556
MOD_GSK3_1 81 88 PF00069 0.294
MOD_GSK3_1 9 16 PF00069 0.293
MOD_NEK2_1 85 90 PF00069 0.320
MOD_NEK2_1 9 14 PF00069 0.275
MOD_PKA_2 81 87 PF00069 0.260
MOD_Plk_4 2 8 PF00069 0.291
MOD_Plk_4 69 75 PF00069 0.568
MOD_Plk_4 81 87 PF00069 0.260
MOD_ProDKin_1 42 48 PF00069 0.336
MOD_ProDKin_1 65 71 PF00069 0.589

Homologs

Protein Taxonomy Sequence identity Coverage
A4HNE2 Leishmania braziliensis 51% 99%
E9B706 Leishmania mexicana (strain MHOM/GT/2001/U1103) 76% 68%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS