A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 2 |
| Forrest at al. (procyclic) | no | yes: 2 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | yes | yes: 24 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 6 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 14 |
| NetGPI | no | yes: 0, no: 14 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005737 | cytoplasm | 2 | 2 |
| GO:0110165 | cellular anatomical entity | 1 | 4 |
| GO:0016020 | membrane | 2 | 2 |
Related structures:
AlphaFold database: E9AFV2
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0000413 | protein peptidyl-prolyl isomerization | 7 | 15 |
| GO:0006457 | protein folding | 2 | 15 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 15 |
| GO:0008152 | metabolic process | 1 | 15 |
| GO:0009987 | cellular process | 1 | 15 |
| GO:0018193 | peptidyl-amino acid modification | 5 | 15 |
| GO:0018208 | peptidyl-proline modification | 6 | 15 |
| GO:0019538 | protein metabolic process | 3 | 15 |
| GO:0036211 | protein modification process | 4 | 15 |
| GO:0043170 | macromolecule metabolic process | 3 | 15 |
| GO:0043412 | macromolecule modification | 4 | 15 |
| GO:0044238 | primary metabolic process | 2 | 15 |
| GO:0071704 | organic substance metabolic process | 2 | 15 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 15 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003755 | peptidyl-prolyl cis-trans isomerase activity | 3 | 15 |
| GO:0003824 | catalytic activity | 1 | 15 |
| GO:0005488 | binding | 1 | 2 |
| GO:0016018 | cyclosporin A binding | 4 | 2 |
| GO:0016853 | isomerase activity | 2 | 15 |
| GO:0016859 | cis-trans isomerase activity | 3 | 15 |
| GO:0033218 | amide binding | 2 | 2 |
| GO:0042277 | peptide binding | 3 | 2 |
| GO:0140096 | catalytic activity, acting on a protein | 2 | 15 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 296 | 298 | PF00675 | 0.409 |
| CLV_PCSK_KEX2_1 | 17 | 19 | PF00082 | 0.346 |
| CLV_PCSK_KEX2_1 | 296 | 298 | PF00082 | 0.390 |
| CLV_PCSK_PC1ET2_1 | 17 | 19 | PF00082 | 0.317 |
| CLV_PCSK_SKI1_1 | 20 | 24 | PF00082 | 0.316 |
| CLV_PCSK_SKI1_1 | 232 | 236 | PF00082 | 0.427 |
| CLV_PCSK_SKI1_1 | 289 | 293 | PF00082 | 0.401 |
| CLV_PCSK_SKI1_1 | 350 | 354 | PF00082 | 0.492 |
| DOC_MAPK_gen_1 | 15 | 25 | PF00069 | 0.330 |
| DOC_MAPK_MEF2A_6 | 17 | 25 | PF00069 | 0.375 |
| DOC_MAPK_MEF2A_6 | 277 | 286 | PF00069 | 0.531 |
| DOC_PP1_RVXF_1 | 133 | 140 | PF00149 | 0.337 |
| DOC_PP4_FxxP_1 | 98 | 101 | PF00568 | 0.315 |
| DOC_USP7_MATH_1 | 209 | 213 | PF00917 | 0.544 |
| DOC_USP7_MATH_1 | 225 | 229 | PF00917 | 0.423 |
| DOC_USP7_UBL2_3 | 335 | 339 | PF12436 | 0.447 |
| DOC_WW_Pin1_4 | 152 | 157 | PF00397 | 0.400 |
| DOC_WW_Pin1_4 | 181 | 186 | PF00397 | 0.581 |
| DOC_WW_Pin1_4 | 196 | 201 | PF00397 | 0.469 |
| DOC_WW_Pin1_4 | 27 | 32 | PF00397 | 0.315 |
| LIG_14-3-3_CanoR_1 | 144 | 150 | PF00244 | 0.330 |
| LIG_14-3-3_CanoR_1 | 277 | 283 | PF00244 | 0.526 |
| LIG_APCC_ABBA_1 | 23 | 28 | PF00400 | 0.337 |
| LIG_APCC_ABBA_1 | 86 | 91 | PF00400 | 0.315 |
| LIG_BIR_III_2 | 176 | 180 | PF00653 | 0.599 |
| LIG_BIR_III_4 | 306 | 310 | PF00653 | 0.519 |
| LIG_BRCT_BRCA1_1 | 119 | 123 | PF00533 | 0.337 |
| LIG_FHA_1 | 277 | 283 | PF00498 | 0.492 |
| LIG_FHA_1 | 297 | 303 | PF00498 | 0.215 |
| LIG_FHA_1 | 326 | 332 | PF00498 | 0.480 |
| LIG_FHA_1 | 81 | 87 | PF00498 | 0.315 |
| LIG_LIR_Apic_2 | 95 | 101 | PF02991 | 0.315 |
| LIG_LIR_Gen_1 | 24 | 31 | PF02991 | 0.247 |
| LIG_LIR_Gen_1 | 4 | 12 | PF02991 | 0.433 |
| LIG_LIR_Gen_1 | 61 | 71 | PF02991 | 0.335 |
| LIG_LIR_Nem_3 | 188 | 193 | PF02991 | 0.500 |
| LIG_LIR_Nem_3 | 24 | 29 | PF02991 | 0.293 |
| LIG_LIR_Nem_3 | 35 | 40 | PF02991 | 0.337 |
| LIG_LIR_Nem_3 | 4 | 10 | PF02991 | 0.434 |
| LIG_LIR_Nem_3 | 61 | 66 | PF02991 | 0.335 |
| LIG_MLH1_MIPbox_1 | 119 | 123 | PF16413 | 0.337 |
| LIG_PTB_Apo_2 | 215 | 222 | PF02174 | 0.402 |
| LIG_PTB_Phospho_1 | 220 | 226 | PF10480 | 0.531 |
| LIG_REV1ctd_RIR_1 | 292 | 301 | PF16727 | 0.402 |
| LIG_SH2_GRB2like | 239 | 242 | PF00017 | 0.520 |
| LIG_SH2_SRC | 7 | 10 | PF00017 | 0.361 |
| LIG_SH2_STAP1 | 226 | 230 | PF00017 | 0.411 |
| LIG_SH2_STAP1 | 233 | 237 | PF00017 | 0.363 |
| LIG_SH2_STAT3 | 239 | 242 | PF00017 | 0.493 |
| LIG_SH2_STAT5 | 239 | 242 | PF00017 | 0.462 |
| LIG_SH2_STAT5 | 5 | 8 | PF00017 | 0.441 |
| LIG_SH3_3 | 188 | 194 | PF00018 | 0.466 |
| LIG_TRAF2_1 | 179 | 182 | PF00917 | 0.536 |
| MOD_CDK_SPK_2 | 27 | 32 | PF00069 | 0.330 |
| MOD_CK2_1 | 225 | 231 | PF00069 | 0.480 |
| MOD_Cter_Amidation | 45 | 48 | PF01082 | 0.404 |
| MOD_GlcNHglycan | 103 | 107 | PF01048 | 0.448 |
| MOD_GlcNHglycan | 227 | 230 | PF01048 | 0.507 |
| MOD_GSK3_1 | 123 | 130 | PF00069 | 0.503 |
| MOD_GSK3_1 | 54 | 61 | PF00069 | 0.233 |
| MOD_GSK3_1 | 80 | 87 | PF00069 | 0.328 |
| MOD_N-GLC_1 | 117 | 122 | PF02516 | 0.337 |
| MOD_N-GLC_1 | 80 | 85 | PF02516 | 0.337 |
| MOD_N-GLC_1 | 96 | 101 | PF02516 | 0.337 |
| MOD_NEK2_1 | 122 | 127 | PF00069 | 0.352 |
| MOD_NEK2_2 | 145 | 150 | PF00069 | 0.330 |
| MOD_NEK2_2 | 209 | 214 | PF00069 | 0.376 |
| MOD_NEK2_2 | 84 | 89 | PF00069 | 0.337 |
| MOD_PIKK_1 | 117 | 123 | PF00454 | 0.337 |
| MOD_PIKK_1 | 312 | 318 | PF00454 | 0.448 |
| MOD_PKA_1 | 296 | 302 | PF00069 | 0.437 |
| MOD_PKA_2 | 276 | 282 | PF00069 | 0.498 |
| MOD_PKA_2 | 296 | 302 | PF00069 | 0.208 |
| MOD_Plk_1 | 96 | 102 | PF00069 | 0.470 |
| MOD_Plk_4 | 84 | 90 | PF00069 | 0.337 |
| MOD_ProDKin_1 | 152 | 158 | PF00069 | 0.400 |
| MOD_ProDKin_1 | 181 | 187 | PF00069 | 0.579 |
| MOD_ProDKin_1 | 196 | 202 | PF00069 | 0.469 |
| MOD_ProDKin_1 | 27 | 33 | PF00069 | 0.315 |
| MOD_SUMO_for_1 | 16 | 19 | PF00179 | 0.317 |
| MOD_SUMO_rev_2 | 198 | 207 | PF00179 | 0.568 |
| MOD_SUMO_rev_2 | 247 | 257 | PF00179 | 0.512 |
| MOD_SUMO_rev_2 | 281 | 291 | PF00179 | 0.534 |
| TRG_ENDOCYTIC_2 | 5 | 8 | PF00928 | 0.441 |
| TRG_ER_diArg_1 | 295 | 297 | PF00400 | 0.378 |
| TRG_ER_diLys_1 | 350 | 354 | PF00400 | 0.461 |
| TRG_Pf-PMV_PEXEL_1 | 238 | 242 | PF00026 | 0.537 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1IAQ4 | Leptomonas seymouri | 82% | 100% |
| A0A0S4JAB5 | Bodo saltans | 58% | 99% |
| A0A1X0P563 | Trypanosomatidae | 65% | 100% |
| A0A3Q8IIG9 | Leishmania donovani | 96% | 100% |
| A0A3S5H7U6 | Leishmania donovani | 53% | 100% |
| A0A3S7X325 | Leishmania donovani | 30% | 100% |
| A0A3S7XB52 | Leishmania donovani | 40% | 100% |
| A0A422P185 | Trypanosoma rangeli | 65% | 100% |
| A4HHU7 | Leishmania braziliensis | 33% | 100% |
| A4HNE1 | Leishmania braziliensis | 85% | 100% |
| A4I4Z7 | Leishmania infantum | 30% | 100% |
| A4I935 | Leishmania infantum | 53% | 100% |
| A4IC14 | Leishmania infantum | 96% | 100% |
| A4IDA1 | Leishmania infantum | 40% | 100% |
| C9ZYI8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 63% | 100% |
| E9B0C7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 32% | 100% |
| E9B400 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 52% | 100% |
| E9B705 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 95% | 100% |
| P0C1I1 | Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880) | 48% | 97% |
| P0CP80 | Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) | 39% | 94% |
| P0CP81 | Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) | 39% | 94% |
| P26882 | Bos taurus | 45% | 96% |
| P47103 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 34% | 90% |
| P53691 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 43% | 95% |
| Q08752 | Homo sapiens | 44% | 96% |
| Q11004 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 40% | 99% |
| Q2U0E0 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | 44% | 95% |
| Q4HXF6 | Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) | 45% | 95% |
| Q4P0V4 | Ustilago maydis (strain 521 / FGSC 9021) | 41% | 89% |
| Q4Q1A6 | Leishmania major | 40% | 100% |
| Q4Q7V7 | Leishmania major | 30% | 100% |
| Q4WIF3 | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) | 43% | 94% |
| Q5ACI8 | Candida albicans (strain SC5314 / ATCC MYA-2876) | 42% | 96% |
| Q5B4E7 | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) | 43% | 95% |
| Q5U8Z7 | Amanita muscaria | 42% | 95% |
| Q6BXZ7 | Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) | 44% | 96% |
| Q6CBP4 | Yarrowia lipolytica (strain CLIB 122 / E 150) | 41% | 96% |
| Q6CL78 | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) | 42% | 95% |
| Q6DGG0 | Rattus norvegicus | 45% | 96% |
| Q6FNU6 | Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) | 42% | 95% |
| Q75A33 | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) | 45% | 96% |
| Q9C566 | Arabidopsis thaliana | 42% | 98% |
| Q9CR16 | Mus musculus | 44% | 96% |
| Q9P3X9 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | 44% | 94% |
| V5D7H4 | Trypanosoma cruzi | 64% | 100% |