LeishMANIAdb
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Heat shock 70 kDa protein 14

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Heat shock 70 kDa protein 14
Gene product:
170 kDa glucose-regulated protein, putative
Species:
Leishmania major
UniProt:
E9AFU8_LEIMA
TriTrypDb:
LmjF.35.4710 , LMJLV39_350055400 , LMJSD75_350054700
Length:
723

Annotations

LeishMANIAdb annotations

Appears to be a secreted chaperone, related to mammalian HYOU1 proteins. Probably ER-localized as in other eukaryotes

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 11, no: 2
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0032991 protein-containing complex 1 2
GO:0034663 endoplasmic reticulum chaperone complex 3 2
GO:0140534 endoplasmic reticulum protein-containing complex 2 2
GO:0043226 organelle 2 12
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

E9AFU8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFU8

Function

Biological processes
Term Name Level Count
GO:0001666 response to hypoxia 3 2
GO:0006950 response to stress 2 2
GO:0009628 response to abiotic stimulus 2 2
GO:0009966 regulation of signal transduction 4 2
GO:0009968 negative regulation of signal transduction 5 2
GO:0009987 cellular process 1 2
GO:0010646 regulation of cell communication 4 2
GO:0010648 negative regulation of cell communication 5 2
GO:0010941 regulation of cell death 4 2
GO:0023051 regulation of signaling 3 2
GO:0023057 negative regulation of signaling 4 2
GO:0033554 cellular response to stress 3 2
GO:0036293 response to decreased oxygen levels 4 2
GO:0036294 cellular response to decreased oxygen levels 5 2
GO:0042221 response to chemical 2 2
GO:0042981 regulation of apoptotic process 6 2
GO:0043066 negative regulation of apoptotic process 7 2
GO:0043067 regulation of programmed cell death 5 2
GO:0043069 negative regulation of programmed cell death 6 2
GO:0048519 negative regulation of biological process 3 2
GO:0048523 negative regulation of cellular process 4 2
GO:0048583 regulation of response to stimulus 3 2
GO:0048585 negative regulation of response to stimulus 4 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0050896 response to stimulus 1 2
GO:0051716 cellular response to stimulus 2 2
GO:0060548 negative regulation of cell death 5 2
GO:0065007 biological regulation 1 2
GO:0070482 response to oxygen levels 3 2
GO:0070887 cellular response to chemical stimulus 3 2
GO:0071453 cellular response to oxygen levels 4 2
GO:0071456 cellular response to hypoxia 4 2
GO:0080134 regulation of response to stress 4 2
GO:0080135 regulation of cellular response to stress 4 2
GO:1900037 regulation of cellular response to hypoxia 5 2
GO:1900038 negative regulation of cellular response to hypoxia 5 2
GO:1902531 regulation of intracellular signal transduction 5 2
GO:1902532 negative regulation of intracellular signal transduction 6 2
GO:1903297 regulation of hypoxia-induced intrinsic apoptotic signaling pathway 7 2
GO:1903298 negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway 6 2
GO:2001233 regulation of apoptotic signaling pathway 5 2
GO:2001234 negative regulation of apoptotic signaling pathway 6 2
GO:2001242 regulation of intrinsic apoptotic signaling pathway 6 2
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 7 2
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 14
GO:0005488 binding 1 14
GO:0005524 ATP binding 5 14
GO:0017076 purine nucleotide binding 4 14
GO:0030554 adenyl nucleotide binding 5 14
GO:0032553 ribonucleotide binding 3 14
GO:0032555 purine ribonucleotide binding 4 14
GO:0032559 adenyl ribonucleotide binding 5 14
GO:0035639 purine ribonucleoside triphosphate binding 4 14
GO:0036094 small molecule binding 2 14
GO:0043167 ion binding 2 14
GO:0043168 anion binding 3 14
GO:0044183 protein folding chaperone 1 14
GO:0097159 organic cyclic compound binding 2 14
GO:0097367 carbohydrate derivative binding 2 14
GO:0140657 ATP-dependent activity 1 14
GO:0140662 ATP-dependent protein folding chaperone 2 14
GO:1901265 nucleoside phosphate binding 3 14
GO:1901363 heterocyclic compound binding 2 14

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 177 179 PF00675 0.409
CLV_NRD_NRD_1 455 457 PF00675 0.387
CLV_NRD_NRD_1 566 568 PF00675 0.438
CLV_NRD_NRD_1 57 59 PF00675 0.329
CLV_NRD_NRD_1 67 69 PF00675 0.329
CLV_NRD_NRD_1 98 100 PF00675 0.462
CLV_PCSK_KEX2_1 177 179 PF00082 0.372
CLV_PCSK_KEX2_1 455 457 PF00082 0.375
CLV_PCSK_KEX2_1 57 59 PF00082 0.462
CLV_PCSK_KEX2_1 67 69 PF00082 0.462
CLV_PCSK_SKI1_1 178 182 PF00082 0.433
CLV_PCSK_SKI1_1 427 431 PF00082 0.427
CLV_PCSK_SKI1_1 456 460 PF00082 0.345
CLV_PCSK_SKI1_1 502 506 PF00082 0.356
CLV_PCSK_SKI1_1 572 576 PF00082 0.463
DOC_CYCLIN_RxL_1 424 434 PF00134 0.462
DOC_MAPK_gen_1 2 10 PF00069 0.608
DOC_MAPK_gen_1 353 361 PF00069 0.370
DOC_MAPK_gen_1 57 66 PF00069 0.333
DOC_MAPK_gen_1 67 73 PF00069 0.322
DOC_MAPK_gen_1 97 107 PF00069 0.471
DOC_MAPK_MEF2A_6 162 170 PF00069 0.388
DOC_PP1_RVXF_1 216 223 PF00149 0.462
DOC_PP1_RVXF_1 436 442 PF00149 0.446
DOC_USP7_MATH_1 125 129 PF00917 0.476
DOC_USP7_MATH_1 244 248 PF00917 0.485
DOC_USP7_MATH_1 518 522 PF00917 0.432
DOC_USP7_MATH_1 584 588 PF00917 0.492
DOC_USP7_MATH_2 704 710 PF00917 0.549
DOC_USP7_UBL2_3 568 572 PF12436 0.437
DOC_WW_Pin1_4 170 175 PF00397 0.486
DOC_WW_Pin1_4 318 323 PF00397 0.369
DOC_WW_Pin1_4 381 386 PF00397 0.368
DOC_WW_Pin1_4 418 423 PF00397 0.387
DOC_WW_Pin1_4 488 493 PF00397 0.348
DOC_WW_Pin1_4 509 514 PF00397 0.452
DOC_WW_Pin1_4 596 601 PF00397 0.296
LIG_14-3-3_CanoR_1 340 344 PF00244 0.425
LIG_14-3-3_CanoR_1 425 430 PF00244 0.344
LIG_14-3-3_CanoR_1 456 466 PF00244 0.463
LIG_14-3-3_CanoR_1 567 571 PF00244 0.454
LIG_14-3-3_CanoR_1 57 66 PF00244 0.358
LIG_14-3-3_CanoR_1 623 630 PF00244 0.424
LIG_14-3-3_CanoR_1 67 73 PF00244 0.345
LIG_AP2alpha_2 134 136 PF02296 0.479
LIG_BRCT_BRCA1_1 245 249 PF00533 0.479
LIG_BRCT_BRCA1_1 470 474 PF00533 0.455
LIG_BRCT_BRCA1_1 480 484 PF00533 0.377
LIG_Clathr_ClatBox_1 535 539 PF01394 0.369
LIG_EVH1_1 237 241 PF00568 0.246
LIG_FHA_1 124 130 PF00498 0.407
LIG_FHA_1 149 155 PF00498 0.479
LIG_FHA_1 214 220 PF00498 0.318
LIG_FHA_1 252 258 PF00498 0.339
LIG_FHA_1 312 318 PF00498 0.462
LIG_FHA_1 360 366 PF00498 0.444
LIG_FHA_1 382 388 PF00498 0.366
LIG_FHA_1 489 495 PF00498 0.348
LIG_FHA_1 531 537 PF00498 0.449
LIG_FHA_1 550 556 PF00498 0.363
LIG_FHA_1 706 712 PF00498 0.764
LIG_FHA_2 135 141 PF00498 0.344
LIG_FHA_2 225 231 PF00498 0.341
LIG_FHA_2 597 603 PF00498 0.440
LIG_GBD_Chelix_1 24 32 PF00786 0.479
LIG_LIR_Apic_2 235 239 PF02991 0.246
LIG_LIR_Apic_2 589 595 PF02991 0.371
LIG_LIR_Gen_1 139 148 PF02991 0.369
LIG_LIR_Gen_1 300 308 PF02991 0.387
LIG_LIR_Gen_1 34 42 PF02991 0.348
LIG_LIR_Gen_1 374 381 PF02991 0.385
LIG_LIR_Gen_1 491 501 PF02991 0.483
LIG_LIR_Nem_3 139 145 PF02991 0.432
LIG_LIR_Nem_3 246 252 PF02991 0.357
LIG_LIR_Nem_3 300 305 PF02991 0.387
LIG_LIR_Nem_3 34 39 PF02991 0.348
LIG_LIR_Nem_3 368 372 PF02991 0.446
LIG_LIR_Nem_3 491 496 PF02991 0.431
LIG_LIR_Nem_3 60 66 PF02991 0.341
LIG_PCNA_TLS_4 627 634 PF02747 0.387
LIG_PDZ_Class_3 718 723 PF00595 0.792
LIG_Pex14_2 480 484 PF04695 0.479
LIG_PTB_Apo_2 363 370 PF02174 0.479
LIG_SH2_CRK 142 146 PF00017 0.446
LIG_SH2_PTP2 36 39 PF00017 0.369
LIG_SH2_SRC 113 116 PF00017 0.479
LIG_SH2_SRC 236 239 PF00017 0.367
LIG_SH2_STAP1 113 117 PF00017 0.479
LIG_SH2_STAP1 142 146 PF00017 0.374
LIG_SH2_STAP1 416 420 PF00017 0.387
LIG_SH2_STAP1 485 489 PF00017 0.246
LIG_SH2_STAP1 547 551 PF00017 0.368
LIG_SH2_STAP1 686 690 PF00017 0.407
LIG_SH2_STAT5 148 151 PF00017 0.390
LIG_SH2_STAT5 236 239 PF00017 0.431
LIG_SH2_STAT5 323 326 PF00017 0.462
LIG_SH2_STAT5 36 39 PF00017 0.387
LIG_SH2_STAT5 633 636 PF00017 0.369
LIG_SH2_STAT5 72 75 PF00017 0.462
LIG_SH3_3 155 161 PF00018 0.375
LIG_SH3_3 163 169 PF00018 0.387
LIG_SH3_3 235 241 PF00018 0.246
LIG_SH3_3 36 42 PF00018 0.354
LIG_SH3_3 440 446 PF00018 0.463
LIG_SH3_3 451 457 PF00018 0.263
LIG_SH3_5 330 334 PF00018 0.401
LIG_SUMO_SIM_anti_2 187 193 PF11976 0.401
LIG_SUMO_SIM_par_1 124 132 PF11976 0.479
LIG_SUMO_SIM_par_1 532 539 PF11976 0.325
LIG_TRAF2_1 137 140 PF00917 0.354
LIG_TRAF2_1 599 602 PF00917 0.462
LIG_TRAF2_1 666 669 PF00917 0.450
LIG_UBA3_1 377 386 PF00899 0.440
LIG_WRC_WIRS_1 372 377 PF05994 0.458
MOD_CDK_SPK_2 381 386 PF00069 0.369
MOD_CDK_SPxxK_3 170 177 PF00069 0.462
MOD_CDK_SPxxK_3 418 425 PF00069 0.388
MOD_CDK_SPxxK_3 509 516 PF00069 0.399
MOD_CK1_1 187 193 PF00069 0.401
MOD_CK1_1 226 232 PF00069 0.330
MOD_CK1_1 300 306 PF00069 0.362
MOD_CK1_1 316 322 PF00069 0.314
MOD_CK1_1 336 342 PF00069 0.424
MOD_CK1_1 709 715 PF00069 0.737
MOD_CK2_1 134 140 PF00069 0.341
MOD_CK2_1 170 176 PF00069 0.404
MOD_CK2_1 224 230 PF00069 0.341
MOD_CK2_1 596 602 PF00069 0.406
MOD_CK2_1 681 687 PF00069 0.374
MOD_GlcNHglycan 123 126 PF01048 0.432
MOD_GlcNHglycan 186 189 PF01048 0.468
MOD_GlcNHglycan 246 249 PF01048 0.446
MOD_GlcNHglycan 459 462 PF01048 0.479
MOD_GlcNHglycan 563 566 PF01048 0.442
MOD_GlcNHglycan 585 589 PF01048 0.341
MOD_GlcNHglycan 714 717 PF01048 0.752
MOD_GlcNHglycan 89 92 PF01048 0.444
MOD_GSK3_1 121 128 PF00069 0.410
MOD_GSK3_1 140 147 PF00069 0.424
MOD_GSK3_1 244 251 PF00069 0.464
MOD_GSK3_1 293 300 PF00069 0.440
MOD_GSK3_1 466 473 PF00069 0.353
MOD_GSK3_1 474 481 PF00069 0.303
MOD_GSK3_1 53 60 PF00069 0.341
MOD_GSK3_1 549 556 PF00069 0.398
MOD_GSK3_1 557 564 PF00069 0.364
MOD_GSK3_1 566 573 PF00069 0.276
MOD_GSK3_1 681 688 PF00069 0.467
MOD_GSK3_1 705 712 PF00069 0.712
MOD_N-GLC_1 213 218 PF02516 0.354
MOD_N-GLC_1 365 370 PF02516 0.433
MOD_N-GLC_1 474 479 PF02516 0.328
MOD_N-GLC_1 518 523 PF02516 0.356
MOD_N-GLC_1 530 535 PF02516 0.363
MOD_N-GLC_1 557 562 PF02516 0.363
MOD_NEK2_1 144 149 PF00069 0.462
MOD_NEK2_1 17 22 PF00069 0.539
MOD_NEK2_1 194 199 PF00069 0.341
MOD_NEK2_1 224 229 PF00069 0.430
MOD_NEK2_1 290 295 PF00069 0.372
MOD_NEK2_1 357 362 PF00069 0.418
MOD_NEK2_1 431 436 PF00069 0.405
MOD_NEK2_1 466 471 PF00069 0.437
MOD_NEK2_1 530 535 PF00069 0.429
MOD_NEK2_1 603 608 PF00069 0.386
MOD_NEK2_1 622 627 PF00069 0.149
MOD_NEK2_2 213 218 PF00069 0.424
MOD_NEK2_2 248 253 PF00069 0.452
MOD_PIKK_1 17 23 PF00454 0.456
MOD_PIKK_1 293 299 PF00454 0.364
MOD_PIKK_1 549 555 PF00454 0.485
MOD_PIKK_1 603 609 PF00454 0.485
MOD_PIKK_1 681 687 PF00454 0.491
MOD_PKA_1 57 63 PF00069 0.462
MOD_PKA_1 99 105 PF00069 0.462
MOD_PKA_2 184 190 PF00069 0.429
MOD_PKA_2 311 317 PF00069 0.412
MOD_PKA_2 339 345 PF00069 0.432
MOD_PKA_2 566 572 PF00069 0.486
MOD_PKA_2 57 63 PF00069 0.341
MOD_PKA_2 622 628 PF00069 0.420
MOD_PKA_2 66 72 PF00069 0.341
MOD_PKB_1 97 105 PF00069 0.401
MOD_Plk_1 100 106 PF00069 0.401
MOD_Plk_1 213 219 PF00069 0.354
MOD_Plk_1 259 265 PF00069 0.342
MOD_Plk_1 365 371 PF00069 0.397
MOD_Plk_1 399 405 PF00069 0.391
MOD_Plk_1 431 437 PF00069 0.455
MOD_Plk_1 478 484 PF00069 0.358
MOD_Plk_1 518 524 PF00069 0.348
MOD_Plk_1 570 576 PF00069 0.434
MOD_Plk_1 662 668 PF00069 0.477
MOD_Plk_2-3 371 377 PF00069 0.462
MOD_Plk_2-3 566 572 PF00069 0.388
MOD_Plk_4 100 106 PF00069 0.419
MOD_Plk_4 140 146 PF00069 0.481
MOD_Plk_4 187 193 PF00069 0.375
MOD_ProDKin_1 170 176 PF00069 0.486
MOD_ProDKin_1 318 324 PF00069 0.369
MOD_ProDKin_1 381 387 PF00069 0.368
MOD_ProDKin_1 418 424 PF00069 0.387
MOD_ProDKin_1 488 494 PF00069 0.348
MOD_ProDKin_1 509 515 PF00069 0.452
MOD_ProDKin_1 596 602 PF00069 0.296
MOD_SUMO_for_1 608 611 PF00179 0.285
MOD_SUMO_rev_2 128 135 PF00179 0.481
MOD_SUMO_rev_2 156 164 PF00179 0.419
MOD_SUMO_rev_2 561 570 PF00179 0.461
TRG_DiLeu_BaEn_3 139 145 PF01217 0.387
TRG_ENDOCYTIC_2 142 145 PF00928 0.377
TRG_ENDOCYTIC_2 204 207 PF00928 0.358
TRG_ENDOCYTIC_2 234 237 PF00928 0.497
TRG_ENDOCYTIC_2 36 39 PF00928 0.378
TRG_ER_diArg_1 207 210 PF00400 0.369
TRG_ER_diArg_1 454 456 PF00400 0.399
TRG_ER_diArg_1 579 582 PF00400 0.421
TRG_ER_diArg_1 66 68 PF00400 0.401
TRG_ER_diArg_1 96 99 PF00400 0.401
TRG_NES_CRM1_1 356 371 PF08389 0.452
TRG_NES_CRM1_1 393 407 PF08389 0.401
TRG_Pf-PMV_PEXEL_1 659 663 PF00026 0.452

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDD3 Leptomonas seymouri 24% 86%
A0A0N1PEF0 Leptomonas seymouri 68% 97%
A0A0S4IUD0 Bodo saltans 24% 100%
A0A0S4IUZ2 Bodo saltans 34% 82%
A0A0S4JJU2 Bodo saltans 39% 94%
A0A0S4JRV7 Bodo saltans 25% 87%
A0A1X0NER7 Trypanosomatidae 24% 100%
A0A1X0P2S1 Trypanosomatidae 30% 83%
A0A1X0P4V9 Trypanosomatidae 47% 100%
A0A1X0P8H2 Trypanosomatidae 24% 88%
A0A3R7L0X2 Trypanosoma rangeli 27% 87%
A0A3S5H744 Leishmania donovani 25% 88%
A0A3S5H808 Leishmania donovani 93% 100%
A0A422NGS3 Trypanosoma rangeli 33% 77%
A0A422P1B1 Trypanosoma rangeli 48% 100%
A2Q0Z1 Equus caballus 24% 100%
A4H9P0 Leishmania braziliensis 25% 88%
A4HGY1 Leishmania braziliensis 25% 100%
A4HND7 Leishmania braziliensis 81% 100%
A4IC10 Leishmania infantum 94% 100%
A5A8V7 Sus scrofa 25% 100%
C9ZXL9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 87%
C9ZYJ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
D0A590 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 89%
E9AGQ5 Leishmania infantum 25% 88%
E9ARS1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 88%
E9B700 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
F4HQD4 Arabidopsis thaliana 26% 87%
F4JMJ1 Arabidopsis thaliana 25% 83%
O59838 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 100%
O59855 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 100%
O74225 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 25% 100%
O88600 Rattus norvegicus 26% 86%
O93866 Trichophyton rubrum 24% 100%
O97125 Drosophila melanogaster 25% 100%
P02825 Drosophila melanogaster 25% 100%
P08418 Schistosoma mansoni 24% 100%
P0CB32 Bos taurus 26% 100%
P0DMV8 Homo sapiens 25% 100%
P0DMV9 Homo sapiens 25% 100%
P0DMW0 Rattus norvegicus 25% 100%
P0DMW1 Rattus norvegicus 25% 100%
P11142 Homo sapiens 24% 100%
P11145 Trypanosoma brucei brucei 25% 100%
P11147 Drosophila melanogaster 24% 100%
P16627 Mus musculus 25% 100%
P17066 Homo sapiens 25% 100%
P17879 Mus musculus 25% 100%
P18694 Ustilago maydis (strain 521 / FGSC 9021) 26% 100%
P19120 Bos taurus 24% 100%
P19378 Cricetulus griseus 23% 100%
P29843 Drosophila melanogaster 24% 100%
P32589 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 100%
P32590 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
P34930 Sus scrofa 25% 100%
P34931 Homo sapiens 25% 100%
P34932 Homo sapiens 26% 86%
P36415 Dictyostelium discoideum 26% 100%
P40918 Davidiella tassiana 24% 100%
P41753 Achlya klebsiana 23% 100%
P41825 Anopheles albimanus 24% 100%
P41826 Anopheles albimanus 24% 100%
P41827 Anopheles albimanus 24% 100%
P47773 Ictalurus punctatus 23% 100%
P48720 Blastocladiella emersonii 25% 100%
P55063 Rattus norvegicus 25% 100%
P63017 Mus musculus 24% 100%
P63018 Rattus norvegicus 24% 100%
P82910 Drosophila melanogaster 25% 100%
P87047 Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) 25% 100%
Q00043 Ajellomyces capsulatus 25% 100%
Q01233 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 25% 100%
Q04967 Sus scrofa 25% 100%
Q05036 Caenorhabditis elegans 25% 93%
Q0IIM3 Bos taurus 29% 84%
Q0VA61 Xenopus tropicalis 30% 100%
Q10265 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 24% 100%
Q24789 Echinococcus granulosus 24% 100%
Q27965 Bos taurus 25% 100%
Q27975 Bos taurus 25% 100%
Q2TFN9 Canis lupus familiaris 28% 86%
Q4QDQ2 Leishmania major 25% 88%
Q4R888 Macaca fascicularis 25% 100%
Q4U0F3 Bos mutus grunniens 25% 100%
Q53RJ5 Oryza sativa subsp. japonica 24% 100%
Q566I3 Xenopus laevis 31% 100%
Q5B2V1 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 25% 100%
Q5NVM9 Pongo abelii 24% 100%
Q5R7D3 Pongo abelii 25% 100%
Q5RDM4 Pongo abelii 26% 86%
Q5ZLK7 Gallus gallus 27% 72%
Q61316 Mus musculus 28% 86%
Q61696 Mus musculus 25% 100%
Q63617 Rattus norvegicus 31% 72%
Q6FJI3 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 25% 100%
Q6S4N2 Sus scrofa 25% 100%
Q6TMK3 Dictyostelium discoideum 24% 94%
Q71U34 Saguinus oedipus 24% 100%
Q74ZJ0 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 24% 100%
Q75C78 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 24% 100%
Q7YQC6 Canis lupus familiaris 25% 100%
Q7ZUW2 Danio rerio 28% 74%
Q875P5 Lachancea kluyveri (strain ATCC 58438 / CBS 3082 / BCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543 / NRRL Y-12651) 26% 100%
Q875V0 Naumovozyma castellii (strain ATCC 76901 / BCRC 22586 / CBS 4309 / NBRC 1992 / NRRL Y-12630) 25% 100%
Q8INI8 Drosophila melanogaster 25% 100%
Q90473 Danio rerio 24% 100%
Q91233 Oncorhynchus tshawytscha 24% 100%
Q96W30 Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) 25% 100%
Q9BIR7 Drosophila melanogaster 25% 100%
Q9BIS2 Drosophila melanogaster 25% 100%
Q9GSU4 Drosophila simulans 25% 100%
Q9GSU7 Drosophila simulans 25% 100%
Q9JKR6 Mus musculus 31% 72%
Q9N1U2 Saguinus oedipus 24% 100%
Q9S7C0 Arabidopsis thaliana 26% 87%
Q9SAB1 Arabidopsis thaliana 23% 95%
Q9U639 Manduca sexta 25% 100%
Q9VG58 Drosophila melanogaster 25% 100%
Q9Y4L1 Homo sapiens 32% 72%
V5ARL4 Trypanosoma cruzi 46% 100%
V5DD81 Trypanosoma cruzi 31% 89%
V5DFF3 Trypanosoma cruzi 26% 87%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS