Putative katanin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative katanin

Gene product:

katanin, putative

Species:

Leishmania major

UniProt:

E9AFU4_LEIMA

TriTrypDb:

LmjF.35.4670 , LMJLV39_350055000 , LMJSD75_350054300

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	8
GO:0005875	microtubule associated complex	2	2
GO:0008352	katanin complex	3	2
GO:0032991	protein-containing complex	1	4
GO:0110165	cellular anatomical entity	1	8
GO:0005856	cytoskeleton	5	6
GO:0043226	organelle	2	6
GO:0043228	non-membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043232	intracellular non-membrane-bounded organelle	4	6
GO:0005840	ribosome	5	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

E9AFU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFU4

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0007019	microtubule depolymerization	5	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022411	cellular component disassembly	4	2
GO:0031109	microtubule polymerization or depolymerization	4	2
GO:0032984	protein-containing complex disassembly	5	2
GO:0043933	protein-containing complex organization	4	2
GO:0051261	protein depolymerization	6	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0097435	supramolecular fiber organization	4	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004609	phosphatidylserine decarboxylase activity	5	5
GO:0005488	binding	1	9
GO:0005515	protein binding	2	9
GO:0008017	microtubule binding	5	9
GO:0008092	cytoskeletal protein binding	3	9
GO:0015631	tubulin binding	4	9
GO:0016829	lyase activity	2	5
GO:0016830	carbon-carbon lyase activity	3	5
GO:0016831	carboxy-lyase activity	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.362
CLV_NRD_NRD_1	126	128	PF00675	0.268
CLV_NRD_NRD_1	300	302	PF00675	0.531
CLV_NRD_NRD_1	342	344	PF00675	0.666
CLV_NRD_NRD_1	429	431	PF00675	0.283
CLV_NRD_NRD_1	528	530	PF00675	0.234
CLV_PCSK_KEX2_1	300	302	PF00082	0.531
CLV_PCSK_KEX2_1	429	431	PF00082	0.283
CLV_PCSK_KEX2_1	528	530	PF00082	0.234
CLV_PCSK_SKI1_1	136	140	PF00082	0.362
CLV_PCSK_SKI1_1	385	389	PF00082	0.647
CLV_PCSK_SKI1_1	480	484	PF00082	0.286
CLV_PCSK_SKI1_1	576	580	PF00082	0.256
CLV_PCSK_SKI1_1	90	94	PF00082	0.467
CLV_Separin_Metazoa	87	91	PF03568	0.459
DEG_APCC_DBOX_1	575	583	PF00400	0.440
DEG_Nend_Nbox_1	1	3	PF02207	0.496
DEG_ODPH_VHL_1	318	329	PF01847	0.534
DEG_SPOP_SBC_1	396	400	PF00917	0.614
DOC_CKS1_1	222	227	PF01111	0.374
DOC_CYCLIN_yCln2_LP_2	260	266	PF00134	0.481
DOC_CYCLIN_yCln2_LP_2	53	59	PF00134	0.430
DOC_MAPK_gen_1	22	29	PF00069	0.454
DOC_MAPK_HePTP_8	495	507	PF00069	0.486
DOC_MAPK_MEF2A_6	22	29	PF00069	0.454
DOC_MAPK_MEF2A_6	498	507	PF00069	0.486
DOC_PP2B_LxvP_1	260	263	PF13499	0.482
DOC_USP7_MATH_1	113	117	PF00917	0.288
DOC_USP7_MATH_1	183	187	PF00917	0.268
DOC_USP7_MATH_1	20	24	PF00917	0.484
DOC_USP7_MATH_1	271	275	PF00917	0.430
DOC_USP7_MATH_1	321	325	PF00917	0.616
DOC_USP7_MATH_1	347	351	PF00917	0.602
DOC_USP7_MATH_1	373	377	PF00917	0.750
DOC_USP7_MATH_1	387	391	PF00917	0.667
DOC_USP7_MATH_1	396	400	PF00917	0.651
DOC_USP7_MATH_1	405	409	PF00917	0.531
DOC_USP7_MATH_1	530	534	PF00917	0.534
DOC_USP7_UBL2_3	172	176	PF12436	0.272
DOC_WW_Pin1_4	145	150	PF00397	0.303
DOC_WW_Pin1_4	221	226	PF00397	0.380
DOC_WW_Pin1_4	319	324	PF00397	0.604
DOC_WW_Pin1_4	350	355	PF00397	0.707
DOC_WW_Pin1_4	397	402	PF00397	0.710
LIG_14-3-3_CanoR_1	127	135	PF00244	0.276
LIG_14-3-3_CanoR_1	17	25	PF00244	0.383
LIG_14-3-3_CanoR_1	216	226	PF00244	0.447
LIG_14-3-3_CanoR_1	235	244	PF00244	0.409
LIG_14-3-3_CanoR_1	255	261	PF00244	0.252
LIG_14-3-3_CanoR_1	385	395	PF00244	0.748
LIG_14-3-3_CanoR_1	429	435	PF00244	0.466
LIG_14-3-3_CanoR_1	529	538	PF00244	0.499
LIG_14-3-3_CanoR_1	94	103	PF00244	0.548
LIG_Actin_WH2_2	500	515	PF00022	0.499
LIG_BRCT_BRCA1_1	107	111	PF00533	0.442
LIG_BRCT_BRCA1_1	185	189	PF00533	0.268
LIG_BRCT_BRCA1_1	335	339	PF00533	0.594
LIG_eIF4E_1	501	507	PF01652	0.499
LIG_FHA_1	115	121	PF00498	0.331
LIG_FHA_1	137	143	PF00498	0.362
LIG_FHA_1	179	185	PF00498	0.338
LIG_FHA_1	202	208	PF00498	0.373
LIG_FHA_1	232	238	PF00498	0.418
LIG_FHA_1	247	253	PF00498	0.289
LIG_FHA_1	481	487	PF00498	0.570
LIG_FHA_1	549	555	PF00498	0.508
LIG_FHA_1	65	71	PF00498	0.310
LIG_FHA_2	222	228	PF00498	0.392
LIG_FHA_2	360	366	PF00498	0.688
LIG_FHA_2	486	492	PF00498	0.480
LIG_FHA_2	497	503	PF00498	0.449
LIG_FHA_2	97	103	PF00498	0.335
LIG_Integrin_isoDGR_2	150	152	PF01839	0.362
LIG_LIR_Apic_2	535	541	PF02991	0.486
LIG_LIR_Gen_1	12	20	PF02991	0.443
LIG_LIR_Gen_1	192	202	PF02991	0.351
LIG_LIR_Gen_1	261	272	PF02991	0.407
LIG_LIR_Gen_1	487	497	PF02991	0.431
LIG_LIR_Nem_3	12	18	PF02991	0.439
LIG_LIR_Nem_3	192	198	PF02991	0.350
LIG_LIR_Nem_3	461	465	PF02991	0.514
LIG_LIR_Nem_3	487	492	PF02991	0.524
LIG_LIR_Nem_3	499	504	PF02991	0.467
LIG_LYPXL_S_1	38	42	PF13949	0.406
LIG_LYPXL_yS_3	39	42	PF13949	0.415
LIG_Pex14_2	213	217	PF04695	0.365
LIG_Pex14_2	462	466	PF04695	0.499
LIG_Rb_pABgroove_1	160	168	PF01858	0.247
LIG_SH2_CRK	15	19	PF00017	0.421
LIG_SH2_CRK	166	170	PF00017	0.362
LIG_SH2_NCK_1	15	19	PF00017	0.421
LIG_SH2_NCK_1	166	170	PF00017	0.303
LIG_SH2_NCK_1	272	276	PF00017	0.460
LIG_SH2_STAP1	166	170	PF00017	0.362
LIG_SH2_STAP1	44	48	PF00017	0.361
LIG_SH2_STAT5	195	198	PF00017	0.325
LIG_SH2_STAT5	44	47	PF00017	0.428
LIG_SH3_3	317	323	PF00018	0.680
LIG_SH3_3	390	396	PF00018	0.745
LIG_SH3_3	577	583	PF00018	0.508
LIG_Sin3_3	575	582	PF02671	0.486
LIG_SUMO_SIM_anti_2	467	473	PF11976	0.486
LIG_SUMO_SIM_anti_2	487	494	PF11976	0.339
LIG_SUMO_SIM_anti_2	502	508	PF11976	0.399
LIG_SUMO_SIM_par_1	202	209	PF11976	0.376
LIG_TRAF2_1	302	305	PF00917	0.622
LIG_TYR_ITIM	193	198	PF00017	0.409
LIG_UBA3_1	120	128	PF00899	0.296
LIG_WRC_WIRS_1	210	215	PF05994	0.458
LIG_WRC_WIRS_1	486	491	PF05994	0.451
LIG_WW_3	584	588	PF00397	0.609
MOD_CDC14_SPxK_1	357	360	PF00782	0.682
MOD_CDK_SPxK_1	354	360	PF00069	0.701
MOD_CDK_SPxxK_3	145	152	PF00069	0.268
MOD_CDK_SPxxK_3	319	326	PF00069	0.607
MOD_CK1_1	16	22	PF00069	0.333
MOD_CK1_1	212	218	PF00069	0.454
MOD_CK1_1	221	227	PF00069	0.480
MOD_CK1_1	250	256	PF00069	0.436
MOD_CK1_1	334	340	PF00069	0.715
MOD_CK1_1	350	356	PF00069	0.629
MOD_CK1_1	376	382	PF00069	0.766
MOD_CK1_1	394	400	PF00069	0.617
MOD_CK1_1	485	491	PF00069	0.486
MOD_CK1_1	514	520	PF00069	0.432
MOD_CK1_1	533	539	PF00069	0.432
MOD_CK1_1	98	104	PF00069	0.315
MOD_CK2_1	496	502	PF00069	0.499
MOD_GlcNHglycan	107	110	PF01048	0.450
MOD_GlcNHglycan	129	132	PF01048	0.326
MOD_GlcNHglycan	18	21	PF01048	0.412
MOD_GlcNHglycan	199	202	PF01048	0.369
MOD_GlcNHglycan	231	234	PF01048	0.440
MOD_GlcNHglycan	273	276	PF01048	0.433
MOD_GlcNHglycan	315	318	PF01048	0.660
MOD_GlcNHglycan	374	378	PF01048	0.759
MOD_GlcNHglycan	379	382	PF01048	0.732
MOD_GlcNHglycan	389	392	PF01048	0.680
MOD_GlcNHglycan	46	49	PF01048	0.289
MOD_GSK3_1	127	134	PF00069	0.303
MOD_GSK3_1	16	23	PF00069	0.454
MOD_GSK3_1	178	185	PF00069	0.310
MOD_GSK3_1	197	204	PF00069	0.299
MOD_GSK3_1	212	219	PF00069	0.422
MOD_GSK3_1	246	253	PF00069	0.463
MOD_GSK3_1	281	288	PF00069	0.488
MOD_GSK3_1	350	357	PF00069	0.678
MOD_GSK3_1	372	379	PF00069	0.695
MOD_GSK3_1	387	394	PF00069	0.639
MOD_GSK3_1	396	403	PF00069	0.646
MOD_GSK3_1	419	426	PF00069	0.466
MOD_GSK3_1	480	487	PF00069	0.382
MOD_GSK3_1	51	58	PF00069	0.402
MOD_N-GLC_1	250	255	PF02516	0.496
MOD_N-GLC_1	334	339	PF02516	0.717
MOD_N-GLC_1	347	352	PF02516	0.635
MOD_N-GLC_2	556	558	PF02516	0.250
MOD_NEK2_1	111	116	PF00069	0.335
MOD_NEK2_1	217	222	PF00069	0.462
MOD_NEK2_1	231	236	PF00069	0.282
MOD_NEK2_1	247	252	PF00069	0.306
MOD_NEK2_1	281	286	PF00069	0.431
MOD_NEK2_1	42	47	PF00069	0.449
MOD_NEK2_1	472	477	PF00069	0.503
MOD_NEK2_1	482	487	PF00069	0.490
MOD_NEK2_1	542	547	PF00069	0.500
MOD_NEK2_2	183	188	PF00069	0.303
MOD_NEK2_2	292	297	PF00069	0.584
MOD_NEK2_2	508	513	PF00069	0.499
MOD_PIKK_1	218	224	PF00454	0.503
MOD_PIKK_1	321	327	PF00454	0.618
MOD_PIKK_1	530	536	PF00454	0.499
MOD_PIKK_1	542	548	PF00454	0.499
MOD_PK_1	32	38	PF00069	0.412
MOD_PKA_1	127	133	PF00069	0.268
MOD_PKA_2	126	132	PF00069	0.344
MOD_PKA_2	16	22	PF00069	0.365
MOD_PKA_2	530	536	PF00069	0.576
MOD_Plk_1	253	259	PF00069	0.453
MOD_Plk_1	32	38	PF00069	0.378
MOD_Plk_1	334	340	PF00069	0.591
MOD_Plk_1	64	70	PF00069	0.454
MOD_Plk_2-3	209	215	PF00069	0.452
MOD_Plk_2-3	82	88	PF00069	0.450
MOD_Plk_4	203	209	PF00069	0.298
MOD_Plk_4	334	340	PF00069	0.591
MOD_Plk_4	467	473	PF00069	0.568
MOD_Plk_4	485	491	PF00069	0.397
MOD_Plk_4	65	71	PF00069	0.408
MOD_ProDKin_1	145	151	PF00069	0.303
MOD_ProDKin_1	221	227	PF00069	0.377
MOD_ProDKin_1	319	325	PF00069	0.604
MOD_ProDKin_1	350	356	PF00069	0.709
MOD_ProDKin_1	397	403	PF00069	0.706
TRG_DiLeu_BaEn_1	502	507	PF01217	0.459
TRG_DiLeu_BaLyEn_6	232	237	PF01217	0.424
TRG_DiLeu_BaLyEn_6	500	505	PF01217	0.486
TRG_ENDOCYTIC_2	15	18	PF00928	0.425
TRG_ENDOCYTIC_2	166	169	PF00928	0.362
TRG_ENDOCYTIC_2	194	197	PF00928	0.314
TRG_ENDOCYTIC_2	39	42	PF00928	0.455
TRG_ENDOCYTIC_2	501	504	PF00928	0.499
TRG_ER_diArg_1	299	301	PF00400	0.485
TRG_ER_diArg_1	429	431	PF00400	0.483
TRG_ER_diArg_1	519	522	PF00400	0.486
TRG_ER_diArg_1	528	531	PF00400	0.481
TRG_Pf-PMV_PEXEL_1	438	443	PF00026	0.256
TRG_Pf-PMV_PEXEL_1	453	458	PF00026	0.256
TRG_Pf-PMV_PEXEL_1	480	484	PF00026	0.286

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P963	Leptomonas seymouri	67%	100%
A0A1X0P573	Trypanosomatidae	40%	100%
A0A3S7XA71	Leishmania donovani	96%	100%
A4HND4	Leishmania braziliensis	85%	100%
A4IC06	Leishmania infantum	96%	100%
C9ZYJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B6Z6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q9BVA0	Homo sapiens	23%	90%