Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania major

UniProt:

E9AFT9_LEIMA

TriTrypDb:

LmjF.35.4620 , LMJLV39_350054500 , LMJSD75_350053800

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AFT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFT9

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0106310	protein serine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.607
CLV_NRD_NRD_1	162	164	PF00675	0.232
CLV_NRD_NRD_1	22	24	PF00675	0.488
CLV_PCSK_KEX2_1	162	164	PF00082	0.194
CLV_PCSK_KEX2_1	22	24	PF00082	0.417
CLV_PCSK_SKI1_1	236	240	PF00082	0.386
CLV_Separin_Metazoa	168	172	PF03568	0.335
DEG_APCC_DBOX_1	235	243	PF00400	0.386
DEG_Nend_Nbox_1	1	3	PF02207	0.556
DOC_CKS1_1	2	7	PF01111	0.684
DOC_CKS1_1	63	68	PF01111	0.452
DOC_CYCLIN_RxL_1	230	241	PF00134	0.240
DOC_CYCLIN_yCln2_LP_2	243	249	PF00134	0.312
DOC_CYCLIN_yCln2_LP_2	82	88	PF00134	0.330
DOC_MAPK_JIP1_4	236	242	PF00069	0.306
DOC_PP2B_LxvP_1	82	85	PF13499	0.425
DOC_PP4_FxxP_1	224	227	PF00568	0.386
DOC_USP7_MATH_1	9	13	PF00917	0.568
DOC_WW_Pin1_4	1	6	PF00397	0.705
DOC_WW_Pin1_4	208	213	PF00397	0.251
DOC_WW_Pin1_4	62	67	PF00397	0.374
LIG_14-3-3_CanoR_1	138	148	PF00244	0.384
LIG_14-3-3_CanoR_1	23	31	PF00244	0.479
LIG_14-3-3_CanoR_1	90	94	PF00244	0.514
LIG_FHA_1	147	153	PF00498	0.479
LIG_FHA_1	19	25	PF00498	0.376
LIG_FHA_1	199	205	PF00498	0.256
LIG_FHA_1	58	64	PF00498	0.483
LIG_FHA_2	140	146	PF00498	0.322
LIG_Integrin_RGD_1	171	173	PF01839	0.306
LIG_LIR_Apic_2	223	227	PF02991	0.390
LIG_LIR_Gen_1	65	73	PF02991	0.344
LIG_LIR_Nem_3	65	71	PF02991	0.356
LIG_NRBOX	183	189	PF00104	0.335
LIG_SH2_CRK	154	158	PF00017	0.382
LIG_SH2_PTP2	55	58	PF00017	0.387
LIG_SH2_STAT5	55	58	PF00017	0.325
LIG_SH2_STAT5	68	71	PF00017	0.299
LIG_SH3_3	2	8	PF00018	0.695
LIG_SH3_3	60	66	PF00018	0.381
LIG_SUMO_SIM_par_1	236	241	PF11976	0.240
LIG_TYR_ITIM	152	157	PF00017	0.381
LIG_WW_2	8	11	PF00397	0.491
MOD_CK1_1	220	226	PF00069	0.247
MOD_CK1_1	265	271	PF00069	0.624
MOD_CK1_1	272	278	PF00069	0.719
MOD_CK2_1	139	145	PF00069	0.322
MOD_CK2_1	272	278	PF00069	0.660
MOD_CK2_1	29	35	PF00069	0.365
MOD_GlcNHglycan	12	15	PF01048	0.572
MOD_GlcNHglycan	219	222	PF01048	0.295
MOD_GlcNHglycan	249	252	PF01048	0.500
MOD_GlcNHglycan	91	94	PF01048	0.438
MOD_GSK3_1	204	211	PF00069	0.291
MOD_GSK3_1	213	220	PF00069	0.173
MOD_GSK3_1	262	269	PF00069	0.649
MOD_GSK3_1	280	287	PF00069	0.708
MOD_N-GLC_1	272	277	PF02516	0.685
MOD_NEK2_1	192	197	PF00069	0.405
MOD_NEK2_1	213	218	PF00069	0.321
MOD_NEK2_1	247	252	PF00069	0.417
MOD_PKA_2	24	30	PF00069	0.449
MOD_PKA_2	89	95	PF00069	0.558
MOD_Plk_1	73	79	PF00069	0.536
MOD_Plk_4	220	226	PF00069	0.266
MOD_ProDKin_1	1	7	PF00069	0.704
MOD_ProDKin_1	208	214	PF00069	0.251
MOD_ProDKin_1	62	68	PF00069	0.373
TRG_DiLeu_BaEn_1	205	210	PF01217	0.275
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.355
TRG_ENDOCYTIC_2	154	157	PF00928	0.532
TRG_ENDOCYTIC_2	68	71	PF00928	0.337
TRG_ER_diArg_1	22	25	PF00400	0.424
TRG_ER_diArg_1	37	40	PF00400	0.328
TRG_ER_diArg_1	44	47	PF00400	0.385
TRG_Pf-PMV_PEXEL_1	236	241	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAR1	Leptomonas seymouri	57%	97%
A0A1X0P5S2	Trypanosomatidae	35%	100%
A0A3Q8IFJ8	Leishmania donovani	94%	100%
A0A422P1C1	Trypanosoma rangeli	33%	100%
A4HNC9	Leishmania braziliensis	79%	100%
C9ZL78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	68%
C9ZYK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AHW8	Leishmania infantum	94%	100%
E9B6Z1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O70150	Rattus norvegicus	28%	84%
Q14012	Homo sapiens	25%	78%
Q6P2M8	Homo sapiens	27%	84%
Q9QYK9	Mus musculus	28%	84%
V5C2I6	Trypanosoma cruzi	33%	100%
W0LYS5	Macrobrachium nipponense	25%	83%