C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFT7_LEIMA

TriTrypDb:

LmjF.35.4600 , LMJLV39_350054300 , LMJSD75_350053600

Length:

511

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFT7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.678
CLV_C14_Caspase3-7	395	399	PF00656	0.635
CLV_C14_Caspase3-7	454	458	PF00656	0.471
CLV_NRD_NRD_1	138	140	PF00675	0.605
CLV_NRD_NRD_1	21	23	PF00675	0.578
CLV_NRD_NRD_1	425	427	PF00675	0.545
CLV_NRD_NRD_1	461	463	PF00675	0.562
CLV_PCSK_KEX2_1	137	139	PF00082	0.688
CLV_PCSK_KEX2_1	23	25	PF00082	0.430
CLV_PCSK_KEX2_1	325	327	PF00082	0.474
CLV_PCSK_KEX2_1	461	463	PF00082	0.600
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.688
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.430
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.474
CLV_PCSK_SKI1_1	110	114	PF00082	0.705
CLV_PCSK_SKI1_1	127	131	PF00082	0.437
CLV_PCSK_SKI1_1	200	204	PF00082	0.505
CLV_PCSK_SKI1_1	263	267	PF00082	0.604
CLV_PCSK_SKI1_1	333	337	PF00082	0.460
CLV_PCSK_SKI1_1	461	465	PF00082	0.537
CLV_PCSK_SKI1_1	75	79	PF00082	0.590
DEG_APCC_DBOX_1	74	82	PF00400	0.495
DEG_SPOP_SBC_1	345	349	PF00917	0.481
DEG_SPOP_SBC_1	505	509	PF00917	0.655
DOC_CYCLIN_RxL_1	197	207	PF00134	0.512
DOC_CYCLIN_yCln2_LP_2	336	342	PF00134	0.457
DOC_MAPK_gen_1	261	270	PF00069	0.519
DOC_USP7_MATH_1	255	259	PF00917	0.555
DOC_USP7_MATH_1	281	285	PF00917	0.647
DOC_USP7_MATH_1	292	296	PF00917	0.675
DOC_USP7_MATH_1	344	348	PF00917	0.513
DOC_USP7_MATH_1	392	396	PF00917	0.450
DOC_USP7_MATH_1	404	408	PF00917	0.607
DOC_USP7_MATH_1	505	509	PF00917	0.676
DOC_USP7_MATH_1	86	90	PF00917	0.614
DOC_USP7_MATH_2	123	129	PF00917	0.438
DOC_USP7_UBL2_3	371	375	PF12436	0.484
DOC_USP7_UBL2_3	393	397	PF12436	0.587
DOC_WW_Pin1_4	152	157	PF00397	0.678
DOC_WW_Pin1_4	335	340	PF00397	0.625
DOC_WW_Pin1_4	402	407	PF00397	0.595
DOC_WW_Pin1_4	411	416	PF00397	0.636
DOC_WW_Pin1_4	95	100	PF00397	0.594
LIG_14-3-3_CanoR_1	142	150	PF00244	0.550
LIG_14-3-3_CanoR_1	326	334	PF00244	0.553
LIG_14-3-3_CanoR_1	497	503	PF00244	0.548
LIG_Actin_WH2_2	70	85	PF00022	0.617
LIG_APCC_ABBA_1	71	76	PF00400	0.566
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_eIF4E_1	26	32	PF01652	0.545
LIG_FHA_1	124	130	PF00498	0.557
LIG_FHA_2	130	136	PF00498	0.512
LIG_FHA_2	349	355	PF00498	0.674
LIG_FHA_2	55	61	PF00498	0.544
LIG_LIR_Apic_2	154	160	PF02991	0.531
LIG_LIR_Nem_3	41	46	PF02991	0.539
LIG_NRBOX	112	118	PF00104	0.630
LIG_NRBOX	16	22	PF00104	0.556
LIG_NRBOX	187	193	PF00104	0.608
LIG_SH2_CRK	43	47	PF00017	0.520
LIG_SH2_STAT3	309	312	PF00017	0.548
LIG_SH2_STAT5	19	22	PF00017	0.456
LIG_SH3_3	117	123	PF00018	0.566
LIG_SH3_3	286	292	PF00018	0.613
LIG_SH3_3	336	342	PF00018	0.641
LIG_SH3_3	416	422	PF00018	0.651
LIG_SH3_3	74	80	PF00018	0.501
LIG_TRAF2_1	251	254	PF00917	0.615
LIG_TRAF2_1	38	41	PF00917	0.567
LIG_TRAF2_1	45	48	PF00917	0.577
LIG_UBA3_1	112	119	PF00899	0.516
LIG_UBA3_1	191	200	PF00899	0.596
LIG_UBA3_1	78	83	PF00899	0.532
MOD_CDC14_SPxK_1	155	158	PF00782	0.525
MOD_CDK_SPxK_1	152	158	PF00069	0.682
MOD_CDK_SPxK_1	411	417	PF00069	0.594
MOD_CK1_1	194	200	PF00069	0.568
MOD_CK1_1	221	227	PF00069	0.675
MOD_CK1_1	348	354	PF00069	0.627
MOD_CK1_1	400	406	PF00069	0.547
MOD_CK1_1	496	502	PF00069	0.550
MOD_CK2_1	129	135	PF00069	0.529
MOD_CK2_1	292	298	PF00069	0.648
MOD_CK2_1	326	332	PF00069	0.516
MOD_CK2_1	348	354	PF00069	0.533
MOD_CK2_1	54	60	PF00069	0.588
MOD_CK2_1	95	101	PF00069	0.683
MOD_GlcNHglycan	144	147	PF01048	0.699
MOD_GlcNHglycan	177	180	PF01048	0.540
MOD_GlcNHglycan	283	286	PF01048	0.552
MOD_GlcNHglycan	342	345	PF01048	0.614
MOD_GlcNHglycan	402	405	PF01048	0.666
MOD_GlcNHglycan	500	503	PF01048	0.512
MOD_GlcNHglycan	84	87	PF01048	0.690
MOD_GlcNHglycan	88	91	PF01048	0.722
MOD_GSK3_1	101	108	PF00069	0.621
MOD_GSK3_1	121	128	PF00069	0.380
MOD_GSK3_1	217	224	PF00069	0.641
MOD_GSK3_1	340	347	PF00069	0.484
MOD_GSK3_1	400	407	PF00069	0.595
MOD_GSK3_1	417	424	PF00069	0.728
MOD_GSK3_1	493	500	PF00069	0.562
MOD_GSK3_1	82	89	PF00069	0.653
MOD_GSK3_1	91	98	PF00069	0.642
MOD_N-GLC_1	101	106	PF02516	0.670
MOD_N-GLC_1	152	157	PF02516	0.767
MOD_NEK2_1	129	134	PF00069	0.621
MOD_NEK2_1	177	182	PF00069	0.617
MOD_NEK2_1	191	196	PF00069	0.598
MOD_NEK2_1	498	503	PF00069	0.553
MOD_NEK2_1	82	87	PF00069	0.613
MOD_NEK2_2	392	397	PF00069	0.471
MOD_NEK2_2	69	74	PF00069	0.523
MOD_PIKK_1	194	200	PF00454	0.490
MOD_PIKK_1	316	322	PF00454	0.495
MOD_PIKK_1	326	332	PF00454	0.540
MOD_PKA_2	141	147	PF00069	0.685
MOD_PKA_2	496	502	PF00069	0.595
MOD_Plk_1	292	298	PF00069	0.709
MOD_Plk_1	397	403	PF00069	0.571
MOD_Plk_4	125	131	PF00069	0.445
MOD_Plk_4	177	183	PF00069	0.635
MOD_Plk_4	292	298	PF00069	0.536
MOD_Plk_4	397	403	PF00069	0.442
MOD_ProDKin_1	152	158	PF00069	0.682
MOD_ProDKin_1	335	341	PF00069	0.631
MOD_ProDKin_1	402	408	PF00069	0.597
MOD_ProDKin_1	411	417	PF00069	0.637
MOD_ProDKin_1	95	101	PF00069	0.595
MOD_SUMO_rev_2	124	129	PF00179	0.582
MOD_SUMO_rev_2	420	428	PF00179	0.634
TRG_DiLeu_BaEn_1	125	130	PF01217	0.627
TRG_DiLeu_BaEn_4	298	304	PF01217	0.573
TRG_ENDOCYTIC_2	43	46	PF00928	0.622
TRG_ER_diArg_1	21	24	PF00400	0.457
TRG_ER_diArg_1	461	463	PF00400	0.556
TRG_ER_diArg_1	471	474	PF00400	0.464
TRG_NES_CRM1_1	379	394	PF08389	0.446
TRG_NES_CRM1_1	441	455	PF08389	0.565
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	426	430	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P962	Leptomonas seymouri	47%	91%
A0A1X0P582	Trypanosomatidae	25%	100%
A0A3R7P212	Trypanosoma rangeli	26%	100%
A0A3S7X9X8	Leishmania donovani	91%	100%
A4HNC7	Leishmania braziliensis	68%	98%
A4IC00	Leishmania infantum	92%	100%
E9B6Y9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5C2K9	Trypanosoma cruzi	26%	100%