Mitochondrial inner membrane protein OXA1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60Kd inner membrane protein, putative

Species:

Leishmania major

UniProt:

E9AFT5_LEIMA

TriTrypDb:

LmjF.35.4580 , LMJLV39_350054100 , LMJSD75_350053400

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AFT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFT5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006839	mitochondrial transport	4	2
GO:0006886	intracellular protein transport	4	2
GO:0006996	organelle organization	4	2
GO:0007005	mitochondrion organization	5	2
GO:0007006	mitochondrial membrane organization	5	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	2
GO:0032978	protein insertion into membrane from inner side	6	2
GO:0032979	protein insertion into mitochondrial inner membrane from matrix	5	2
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051205	protein insertion into membrane	5	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0061024	membrane organization	4	2
GO:0070585	protein localization to mitochondrion	6	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0072594	establishment of protein localization to organelle	4	2
GO:0072655	establishment of protein localization to mitochondrion	5	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2
GO:0090151	establishment of protein localization to mitochondrial membrane	4	2

Molecular functions
Term	Name	Level	Count
GO:0032977	membrane insertase activity	3	11
GO:0140104	molecular carrier activity	1	11
GO:0140597	protein carrier chaperone	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.309
CLV_NRD_NRD_1	293	295	PF00675	0.362
CLV_NRD_NRD_1	310	312	PF00675	0.522
CLV_PCSK_KEX2_1	157	159	PF00082	0.307
CLV_PCSK_KEX2_1	293	295	PF00082	0.362
CLV_PCSK_KEX2_1	310	312	PF00082	0.504
CLV_PCSK_KEX2_1	484	486	PF00082	0.567
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.567
CLV_PCSK_SKI1_1	119	123	PF00082	0.357
CLV_PCSK_SKI1_1	158	162	PF00082	0.295
CLV_PCSK_SKI1_1	237	241	PF00082	0.350
CLV_PCSK_SKI1_1	311	315	PF00082	0.530
CLV_PCSK_SKI1_1	323	327	PF00082	0.450
DEG_APCC_DBOX_1	118	126	PF00400	0.610
DEG_ODPH_VHL_1	28	41	PF01847	0.385
DEG_SCF_FBW7_1	1	8	PF00400	0.453
DEG_SPOP_SBC_1	199	203	PF00917	0.367
DEG_SPOP_SBC_1	447	451	PF00917	0.695
DOC_CDC14_PxL_1	216	224	PF14671	0.335
DOC_CDC14_PxL_1	256	264	PF14671	0.292
DOC_CKS1_1	439	444	PF01111	0.683
DOC_CYCLIN_yCln2_LP_2	212	218	PF00134	0.292
DOC_CYCLIN_yCln2_LP_2	281	287	PF00134	0.271
DOC_MAPK_FxFP_2	296	299	PF00069	0.446
DOC_MAPK_gen_1	328	337	PF00069	0.546
DOC_MAPK_MEF2A_6	113	122	PF00069	0.593
DOC_MAPK_MEF2A_6	266	273	PF00069	0.236
DOC_PP1_RVXF_1	132	138	PF00149	0.555
DOC_PP1_RVXF_1	243	250	PF00149	0.472
DOC_PP2B_LxvP_1	120	123	PF13499	0.542
DOC_PP2B_LxvP_1	210	213	PF13499	0.314
DOC_PP2B_LxvP_1	217	220	PF13499	0.314
DOC_PP2B_LxvP_1	28	31	PF13499	0.435
DOC_PP4_FxxP_1	296	299	PF00568	0.463
DOC_USP7_MATH_1	16	20	PF00917	0.528
DOC_USP7_MATH_1	309	313	PF00917	0.707
DOC_USP7_MATH_1	403	407	PF00917	0.743
DOC_USP7_MATH_1	425	429	PF00917	0.686
DOC_USP7_MATH_1	448	452	PF00917	0.727
DOC_USP7_MATH_1	467	471	PF00917	0.617
DOC_USP7_MATH_1	489	493	PF00917	0.751
DOC_USP7_MATH_1	69	73	PF00917	0.444
DOC_USP7_UBL2_3	386	390	PF12436	0.726
DOC_USP7_UBL2_3	484	488	PF12436	0.799
DOC_WW_Pin1_4	1	6	PF00397	0.398
DOC_WW_Pin1_4	305	310	PF00397	0.679
DOC_WW_Pin1_4	438	443	PF00397	0.741
DOC_WW_Pin1_4	451	456	PF00397	0.694
DOC_WW_Pin1_4	516	521	PF00397	0.763
DOC_WW_Pin1_4	522	527	PF00397	0.736
LIG_14-3-3_CanoR_1	10	16	PF00244	0.432
LIG_14-3-3_CanoR_1	101	106	PF00244	0.271
LIG_14-3-3_CanoR_1	310	316	PF00244	0.650
LIG_14-3-3_CanoR_1	323	328	PF00244	0.649
LIG_14-3-3_CanoR_1	359	369	PF00244	0.582
LIG_14-3-3_CanoR_1	432	438	PF00244	0.785
LIG_Actin_WH2_2	272	290	PF00022	0.291
LIG_AP2alpha_2	214	216	PF02296	0.317
LIG_APCC_ABBA_1	107	112	PF00400	0.333
LIG_BRCT_BRCA1_1	47	51	PF00533	0.373
LIG_Clathr_ClatBox_1	228	232	PF01394	0.289
LIG_deltaCOP1_diTrp_1	43	51	PF00928	0.334
LIG_FHA_1	164	170	PF00498	0.557
LIG_FHA_1	2	8	PF00498	0.435
LIG_FHA_1	221	227	PF00498	0.389
LIG_FHA_2	188	194	PF00498	0.222
LIG_FHA_2	209	215	PF00498	0.293
LIG_FHA_2	324	330	PF00498	0.641
LIG_FHA_2	51	57	PF00498	0.445
LIG_IRF3_LxIS_1	73	80	PF10401	0.233
LIG_LIR_Gen_1	130	140	PF02991	0.514
LIG_LIR_Gen_1	214	222	PF02991	0.269
LIG_LIR_Gen_1	378	388	PF02991	0.717
LIG_LIR_Gen_1	72	79	PF02991	0.297
LIG_LIR_Nem_3	104	110	PF02991	0.271
LIG_LIR_Nem_3	130	135	PF02991	0.508
LIG_LIR_Nem_3	214	219	PF02991	0.223
LIG_LIR_Nem_3	363	369	PF02991	0.621
LIG_LIR_Nem_3	378	383	PF02991	0.640
LIG_LIR_Nem_3	48	54	PF02991	0.377
LIG_LIR_Nem_3	72	77	PF02991	0.271
LIG_NRBOX	368	374	PF00104	0.648
LIG_Pex14_2	74	78	PF04695	0.302
LIG_SH2_GRB2like	136	139	PF00017	0.615
LIG_SH2_GRB2like	515	518	PF00017	0.609
LIG_SH2_STAT5	136	139	PF00017	0.566
LIG_SH2_STAT5	204	207	PF00017	0.400
LIG_SH2_STAT5	272	275	PF00017	0.271
LIG_SH2_STAT5	368	371	PF00017	0.595
LIG_SH2_STAT5	38	41	PF00017	0.352
LIG_SH3_3	24	30	PF00018	0.508
LIG_SH3_3	483	489	PF00018	0.683
LIG_SH3_3	517	523	PF00018	0.768
LIG_SUMO_SIM_par_1	283	289	PF11976	0.289
LIG_WRC_WIRS_1	262	267	PF05994	0.379
MOD_CDK_SPK_2	305	310	PF00069	0.591
MOD_CDK_SPxK_1	305	311	PF00069	0.606
MOD_CDK_SPxxK_3	438	445	PF00069	0.761
MOD_CDK_SPxxK_3	522	529	PF00069	0.630
MOD_CK1_1	264	270	PF00069	0.305
MOD_CK1_1	451	457	PF00069	0.704
MOD_CK1_1	516	522	PF00069	0.738
MOD_CK1_1	524	530	PF00069	0.713
MOD_CK1_1	72	78	PF00069	0.399
MOD_CK2_1	139	145	PF00069	0.595
MOD_CK2_1	187	193	PF00069	0.290
MOD_CK2_1	323	329	PF00069	0.646
MOD_CK2_1	451	457	PF00069	0.724
MOD_CK2_1	467	473	PF00069	0.609
MOD_CK2_1	50	56	PF00069	0.398
MOD_CK2_1	502	508	PF00069	0.640
MOD_GlcNHglycan	141	144	PF01048	0.317
MOD_GlcNHglycan	18	21	PF01048	0.696
MOD_GlcNHglycan	266	269	PF01048	0.509
MOD_GlcNHglycan	288	291	PF01048	0.324
MOD_GlcNHglycan	299	302	PF01048	0.282
MOD_GlcNHglycan	311	314	PF01048	0.541
MOD_GlcNHglycan	320	323	PF01048	0.524
MOD_GlcNHglycan	419	422	PF01048	0.523
MOD_GlcNHglycan	463	467	PF01048	0.568
MOD_GlcNHglycan	469	472	PF01048	0.512
MOD_GlcNHglycan	473	477	PF01048	0.462
MOD_GlcNHglycan	491	494	PF01048	0.473
MOD_GlcNHglycan	496	499	PF01048	0.578
MOD_GlcNHglycan	55	59	PF01048	0.588
MOD_GlcNHglycan	67	70	PF01048	0.558
MOD_GSK3_1	1	8	PF00069	0.445
MOD_GSK3_1	148	155	PF00069	0.565
MOD_GSK3_1	16	23	PF00069	0.425
MOD_GSK3_1	220	227	PF00069	0.397
MOD_GSK3_1	260	267	PF00069	0.390
MOD_GSK3_1	305	312	PF00069	0.649
MOD_GSK3_1	344	351	PF00069	0.626
MOD_GSK3_1	447	454	PF00069	0.686
MOD_GSK3_1	467	474	PF00069	0.582
MOD_GSK3_1	489	496	PF00069	0.728
MOD_GSK3_1	498	505	PF00069	0.714
MOD_GSK3_1	50	57	PF00069	0.407
MOD_GSK3_1	518	525	PF00069	0.583
MOD_GSK3_1	65	72	PF00069	0.427
MOD_GSK3_1	97	104	PF00069	0.278
MOD_N-GLC_1	193	198	PF02516	0.532
MOD_N-GLC_1	348	353	PF02516	0.366
MOD_N-GLC_1	516	521	PF02516	0.414
MOD_NEK2_1	105	110	PF00069	0.259
MOD_NEK2_1	205	210	PF00069	0.320
MOD_NEK2_1	231	236	PF00069	0.481
MOD_NEK2_1	286	291	PF00069	0.385
MOD_NEK2_1	358	363	PF00069	0.680
MOD_NEK2_1	417	422	PF00069	0.661
MOD_NEK2_1	45	50	PF00069	0.374
MOD_NEK2_1	494	499	PF00069	0.701
MOD_NEK2_1	77	82	PF00069	0.334
MOD_NEK2_2	5	10	PF00069	0.408
MOD_PIKK_1	499	505	PF00454	0.645
MOD_PIKK_1	72	78	PF00454	0.434
MOD_PKA_2	309	315	PF00069	0.645
MOD_PKA_2	358	364	PF00069	0.588
MOD_Plk_1	192	198	PF00069	0.407
MOD_Plk_1	231	237	PF00069	0.491
MOD_Plk_2-3	193	199	PF00069	0.324
MOD_Plk_4	101	107	PF00069	0.232
MOD_Plk_4	148	154	PF00069	0.597
MOD_Plk_4	200	206	PF00069	0.304
MOD_Plk_4	433	439	PF00069	0.657
MOD_Plk_4	69	75	PF00069	0.417
MOD_Plk_4	88	94	PF00069	0.187
MOD_ProDKin_1	1	7	PF00069	0.400
MOD_ProDKin_1	305	311	PF00069	0.687
MOD_ProDKin_1	438	444	PF00069	0.743
MOD_ProDKin_1	451	457	PF00069	0.693
MOD_ProDKin_1	516	522	PF00069	0.766
MOD_SUMO_rev_2	232	241	PF00179	0.555
TRG_DiLeu_BaEn_1	88	93	PF01217	0.289
TRG_DiLeu_BaLyEn_6	281	286	PF01217	0.289
TRG_ENDOCYTIC_2	38	41	PF00928	0.425
TRG_ENDOCYTIC_2	380	383	PF00928	0.614
TRG_ER_diArg_1	117	120	PF00400	0.532
TRG_ER_diArg_1	292	294	PF00400	0.550
TRG_ER_diArg_1	309	311	PF00400	0.702

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFR8	Leptomonas seymouri	56%	96%
A0A1X0P4X1	Trypanosomatidae	39%	100%
A0A3S7XA08	Leishmania donovani	91%	95%
A0A422P166	Trypanosoma rangeli	38%	100%
A4HNC5	Leishmania braziliensis	76%	95%
A4IBZ8	Leishmania infantum	91%	95%
C9ZYK6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B6Y7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	95%
V5BT14	Trypanosoma cruzi	39%	100%