PHD-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PHD-like zinc-binding domain containing protein, putative

Species:

Leishmania major

UniProt:

E9AFT3_LEIMA

TriTrypDb:

LmjF.35.4560 , LMJLV39_350053800 , LMJLV39_350053900 , LMJSD75_350053200

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFT3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	44	50	PF00089	0.622
CLV_PCSK_KEX2_1	447	449	PF00082	0.611
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.611
CLV_PCSK_SKI1_1	156	160	PF00082	0.631
CLV_PCSK_SKI1_1	271	275	PF00082	0.477
CLV_PCSK_SKI1_1	3	7	PF00082	0.593
CLV_PCSK_SKI1_1	375	379	PF00082	0.295
CLV_PCSK_SKI1_1	425	429	PF00082	0.519
CLV_PCSK_SKI1_1	50	54	PF00082	0.671
CLV_PCSK_SKI1_1	9	13	PF00082	0.552
DEG_SPOP_SBC_1	211	215	PF00917	0.659
DOC_CDC14_PxL_1	38	46	PF14671	0.555
DOC_CKS1_1	149	154	PF01111	0.649
DOC_CKS1_1	240	245	PF01111	0.627
DOC_MAPK_gen_1	3	13	PF00069	0.560
DOC_MAPK_gen_1	407	414	PF00069	0.491
DOC_MAPK_gen_1	47	56	PF00069	0.626
DOC_MAPK_MEF2A_6	80	89	PF00069	0.515
DOC_PP1_RVXF_1	7	14	PF00149	0.548
DOC_PP2B_LxvP_1	303	306	PF13499	0.607
DOC_PP2B_LxvP_1	437	440	PF13499	0.563
DOC_PP4_FxxP_1	19	22	PF00568	0.614
DOC_PP4_FxxP_1	400	403	PF00568	0.500
DOC_USP7_MATH_1	152	156	PF00917	0.633
DOC_USP7_MATH_1	211	215	PF00917	0.659
DOC_USP7_MATH_1	285	289	PF00917	0.601
DOC_USP7_MATH_1	33	37	PF00917	0.576
DOC_USP7_MATH_1	408	412	PF00917	0.537
DOC_USP7_MATH_1	423	427	PF00917	0.491
DOC_USP7_MATH_1	46	50	PF00917	0.530
DOC_USP7_MATH_1	99	103	PF00917	0.637
DOC_WW_Pin1_4	121	126	PF00397	0.671
DOC_WW_Pin1_4	133	138	PF00397	0.540
DOC_WW_Pin1_4	148	153	PF00397	0.647
DOC_WW_Pin1_4	182	187	PF00397	0.688
DOC_WW_Pin1_4	205	210	PF00397	0.631
DOC_WW_Pin1_4	239	244	PF00397	0.626
DOC_WW_Pin1_4	59	64	PF00397	0.547
LIG_14-3-3_CanoR_1	262	266	PF00244	0.444
LIG_14-3-3_CanoR_1	425	430	PF00244	0.489
LIG_14-3-3_CanoR_1	50	55	PF00244	0.631
LIG_Actin_WH2_2	352	367	PF00022	0.491
LIG_BIR_II_1	1	5	PF00653	0.600
LIG_BRCT_BRCA1_1	334	338	PF00533	0.314
LIG_FHA_1	133	139	PF00498	0.730
LIG_FHA_1	298	304	PF00498	0.686
LIG_FHA_1	331	337	PF00498	0.432
LIG_FHA_1	393	399	PF00498	0.467
LIG_FHA_1	51	57	PF00498	0.638
LIG_FHA_1	60	66	PF00498	0.547
LIG_FHA_1	73	79	PF00498	0.530
LIG_FHA_1	84	90	PF00498	0.592
LIG_FHA_2	149	155	PF00498	0.790
LIG_GSK3_LRP6_1	239	245	PF00069	0.524
LIG_LIR_Apic_2	146	152	PF02991	0.597
LIG_LIR_Apic_2	17	22	PF02991	0.604
LIG_LIR_Apic_2	399	403	PF02991	0.456
LIG_LIR_Gen_1	316	325	PF02991	0.482
LIG_LIR_Nem_3	12	16	PF02991	0.589
LIG_LIR_Nem_3	120	126	PF02991	0.537
LIG_LIR_Nem_3	316	320	PF02991	0.476
LIG_LIR_Nem_3	354	359	PF02991	0.491
LIG_MYND_1	42	46	PF01753	0.548
LIG_PCNA_yPIPBox_3	66	80	PF02747	0.640
LIG_Rb_LxCxE_1	346	360	PF01857	0.491
LIG_SH2_CRK	149	153	PF00017	0.817
LIG_SH2_STAP1	224	228	PF00017	0.604
LIG_SH2_STAP1	357	361	PF00017	0.491
LIG_SH2_STAT3	81	84	PF00017	0.617
LIG_SH2_STAT5	420	423	PF00017	0.560
LIG_SH3_2	243	248	PF14604	0.545
LIG_SH3_3	123	129	PF00018	0.796
LIG_SH3_3	237	243	PF00018	0.624
LIG_SH3_3	36	42	PF00018	0.669
LIG_SH3_3	433	439	PF00018	0.481
LIG_SH3_3	45	51	PF00018	0.725
LIG_SH3_3	90	96	PF00018	0.636
LIG_SH3_4	6	13	PF00018	0.493
LIG_SUMO_SIM_anti_2	53	59	PF11976	0.606
LIG_TRAF2_1	92	95	PF00917	0.515
MOD_CDC14_SPxK_1	245	248	PF00782	0.552
MOD_CDK_SPxK_1	242	248	PF00069	0.542
MOD_CDK_SPxxK_3	133	140	PF00069	0.570
MOD_CK1_1	222	228	PF00069	0.627
MOD_CK1_1	258	264	PF00069	0.489
MOD_CK1_1	27	33	PF00069	0.602
MOD_CK1_1	286	292	PF00069	0.532
MOD_CK1_1	59	65	PF00069	0.522
MOD_CK2_1	148	154	PF00069	0.653
MOD_CK2_1	177	183	PF00069	0.640
MOD_CK2_1	446	452	PF00069	0.676
MOD_CK2_1	88	94	PF00069	0.520
MOD_GlcNHglycan	19	22	PF01048	0.701
MOD_GlcNHglycan	192	195	PF01048	0.711
MOD_GlcNHglycan	214	217	PF01048	0.617
MOD_GlcNHglycan	285	288	PF01048	0.601
MOD_GlcNHglycan	425	428	PF01048	0.463
MOD_GlcNHglycan	431	434	PF01048	0.525
MOD_GlcNHglycan	58	61	PF01048	0.605
MOD_GlcNHglycan	90	93	PF01048	0.571
MOD_GSK3_1	117	124	PF00069	0.649
MOD_GSK3_1	141	148	PF00069	0.593
MOD_GSK3_1	152	159	PF00069	0.612
MOD_GSK3_1	182	189	PF00069	0.786
MOD_GSK3_1	219	226	PF00069	0.660
MOD_GSK3_1	235	242	PF00069	0.526
MOD_GSK3_1	254	261	PF00069	0.466
MOD_GSK3_1	279	286	PF00069	0.580
MOD_GSK3_1	290	297	PF00069	0.529
MOD_GSK3_1	332	339	PF00069	0.392
MOD_GSK3_1	392	399	PF00069	0.456
MOD_GSK3_1	423	430	PF00069	0.586
MOD_GSK3_1	46	53	PF00069	0.604
MOD_N-GLC_1	307	312	PF02516	0.568
MOD_N-GLC_2	237	239	PF02516	0.527
MOD_NEK2_1	210	215	PF00069	0.660
MOD_NEK2_1	219	224	PF00069	0.629
MOD_NEK2_1	233	238	PF00069	0.505
MOD_NEK2_1	446	451	PF00069	0.774
MOD_NEK2_1	88	93	PF00069	0.542
MOD_NEK2_2	396	401	PF00069	0.479
MOD_OFUCOSY	234	239	PF10250	0.522
MOD_OFUCOSY	391	396	PF10250	0.256
MOD_PIKK_1	117	123	PF00454	0.570
MOD_PIKK_1	186	192	PF00454	0.538
MOD_PIKK_1	24	30	PF00454	0.577
MOD_PIKK_1	290	296	PF00454	0.512
MOD_PKA_2	203	209	PF00069	0.558
MOD_PKA_2	219	225	PF00069	0.611
MOD_PKA_2	261	267	PF00069	0.447
MOD_PKA_2	290	296	PF00069	0.486
MOD_PKA_2	408	414	PF00069	0.498
MOD_PKA_2	46	52	PF00069	0.622
MOD_Plk_1	145	151	PF00069	0.576
MOD_Plk_1	279	285	PF00069	0.534
MOD_Plk_1	33	39	PF00069	0.637
MOD_Plk_1	330	336	PF00069	0.409
MOD_Plk_2-3	145	151	PF00069	0.576
MOD_Plk_4	177	183	PF00069	0.686
MOD_Plk_4	83	89	PF00069	0.728
MOD_ProDKin_1	121	127	PF00069	0.672
MOD_ProDKin_1	133	139	PF00069	0.542
MOD_ProDKin_1	148	154	PF00069	0.647
MOD_ProDKin_1	182	188	PF00069	0.689
MOD_ProDKin_1	205	211	PF00069	0.631
MOD_ProDKin_1	239	245	PF00069	0.628
MOD_ProDKin_1	59	65	PF00069	0.548
TRG_DiLeu_BaEn_1	68	73	PF01217	0.618
TRG_DiLeu_BaEn_2	33	39	PF01217	0.533
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.620
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.476
TRG_DiLeu_BaLyEn_6	372	377	PF01217	0.491
TRG_ER_diArg_1	373	376	PF00400	0.491
TRG_ER_diArg_1	44	47	PF00400	0.625
TRG_NLS_MonoExtC_3	446	452	PF00514	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I986	Leptomonas seymouri	32%	93%
A0A3S7X9X5	Leishmania donovani	81%	100%
A4IBZ6	Leishmania infantum	82%	100%
E9B6Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%