FPL domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised conserved protein, putative

Species:

Leishmania major

UniProt:

E9AFT1_LEIMA

TriTrypDb:

LmjF.35.4540 , LMJLV39_350053600 , LMJSD75_350053000

Length:

924

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005765	lysosomal membrane	7	2
GO:0005774	vacuolar membrane	5	2
GO:0010008	endosome membrane	5	2
GO:0012506	vesicle membrane	4	2
GO:0016020	membrane	2	2
GO:0030659	cytoplasmic vesicle membrane	5	2
GO:0031090	organelle membrane	3	2
GO:0036020	endolysosome membrane	6	2
GO:0098588	bounding membrane of organelle	4	2
GO:0098852	lytic vacuole membrane	6	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AFT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFT1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0007034	vacuolar transport	4	2
GO:0007041	lysosomal transport	5	2
GO:0008333	endosome to lysosome transport	5	2
GO:0009894	regulation of catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010506	regulation of autophagy	6	2
GO:0016192	vesicle-mediated transport	4	2
GO:0016197	endosomal transport	4	2
GO:0016241	regulation of macroautophagy	7	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031329	regulation of cellular catabolic process	5	2
GO:0033043	regulation of organelle organization	5	2
GO:0043244	regulation of protein-containing complex disassembly	5	2
GO:0046907	intracellular transport	3	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051128	regulation of cellular component organization	4	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0065007	biological regulation	1	2
GO:1901096	regulation of autophagosome maturation	6	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	335	339	PF00656	0.624
CLV_C14_Caspase3-7	36	40	PF00656	0.620
CLV_C14_Caspase3-7	586	590	PF00656	0.580
CLV_NRD_NRD_1	41	43	PF00675	0.528
CLV_NRD_NRD_1	735	737	PF00675	0.642
CLV_NRD_NRD_1	843	845	PF00675	0.515
CLV_PCSK_KEX2_1	735	737	PF00082	0.642
CLV_PCSK_KEX2_1	842	844	PF00082	0.548
CLV_PCSK_PC1ET2_1	842	844	PF00082	0.548
CLV_PCSK_SKI1_1	222	226	PF00082	0.480
CLV_PCSK_SKI1_1	286	290	PF00082	0.514
CLV_PCSK_SKI1_1	323	327	PF00082	0.498
CLV_PCSK_SKI1_1	433	437	PF00082	0.700
CLV_PCSK_SKI1_1	5	9	PF00082	0.709
CLV_PCSK_SKI1_1	55	59	PF00082	0.411
CLV_PCSK_SKI1_1	567	571	PF00082	0.609
CLV_PCSK_SKI1_1	735	739	PF00082	0.569
CLV_PCSK_SKI1_1	816	820	PF00082	0.489
CLV_PCSK_SKI1_1	843	847	PF00082	0.508
CLV_PCSK_SKI1_1	86	90	PF00082	0.411
CLV_PCSK_SKI1_1	865	869	PF00082	0.568
CLV_PCSK_SKI1_1	918	922	PF00082	0.630
DEG_APCC_DBOX_1	221	229	PF00400	0.470
DEG_APCC_DBOX_1	842	850	PF00400	0.503
DEG_MDM2_SWIB_1	376	383	PF02201	0.512
DEG_Nend_UBRbox_2	1	3	PF02207	0.637
DEG_ODPH_VHL_1	795	806	PF01847	0.631
DEG_SPOP_SBC_1	442	446	PF00917	0.647
DOC_CKS1_1	798	803	PF01111	0.541
DOC_CYCLIN_RxL_1	148	158	PF00134	0.411
DOC_CYCLIN_RxL_1	563	571	PF00134	0.548
DOC_CYCLIN_yCln2_LP_2	424	430	PF00134	0.558
DOC_CYCLIN_yCln2_LP_2	821	827	PF00134	0.648
DOC_MAPK_gen_1	52	62	PF00069	0.292
DOC_MAPK_gen_1	653	660	PF00069	0.736
DOC_MAPK_gen_1	842	851	PF00069	0.485
DOC_MAPK_MEF2A_6	253	262	PF00069	0.606
DOC_MAPK_MEF2A_6	55	64	PF00069	0.411
DOC_MAPK_MEF2A_6	653	660	PF00069	0.745
DOC_MAPK_MEF2A_6	816	825	PF00069	0.513
DOC_MAPK_MEF2A_6	844	853	PF00069	0.497
DOC_MAPK_NFAT4_5	653	661	PF00069	0.745
DOC_MAPK_NFAT4_5	816	824	PF00069	0.502
DOC_PIKK_1	297	305	PF02985	0.585
DOC_PP1_RVXF_1	321	327	PF00149	0.508
DOC_PP1_RVXF_1	549	555	PF00149	0.485
DOC_PP1_RVXF_1	596	602	PF00149	0.645
DOC_PP1_RVXF_1	814	821	PF00149	0.605
DOC_PP1_RVXF_1	841	848	PF00149	0.558
DOC_PP2B_LxvP_1	821	824	PF13499	0.619
DOC_PP4_FxxP_1	397	400	PF00568	0.636
DOC_PP4_FxxP_1	509	512	PF00568	0.401
DOC_SPAK_OSR1_1	409	413	PF12202	0.576
DOC_USP7_MATH_1	343	347	PF00917	0.607
DOC_USP7_MATH_1	361	365	PF00917	0.552
DOC_USP7_MATH_1	400	404	PF00917	0.592
DOC_USP7_MATH_1	443	447	PF00917	0.695
DOC_USP7_UBL2_3	490	494	PF12436	0.634
DOC_WW_Pin1_4	112	117	PF00397	0.183
DOC_WW_Pin1_4	155	160	PF00397	0.411
DOC_WW_Pin1_4	268	273	PF00397	0.672
DOC_WW_Pin1_4	305	310	PF00397	0.495
DOC_WW_Pin1_4	445	450	PF00397	0.803
DOC_WW_Pin1_4	464	469	PF00397	0.445
DOC_WW_Pin1_4	495	500	PF00397	0.649
DOC_WW_Pin1_4	608	613	PF00397	0.522
DOC_WW_Pin1_4	638	643	PF00397	0.628
DOC_WW_Pin1_4	713	718	PF00397	0.551
DOC_WW_Pin1_4	755	760	PF00397	0.571
DOC_WW_Pin1_4	797	802	PF00397	0.555
DOC_WW_Pin1_4	92	97	PF00397	0.292
LIG_14-3-3_CanoR_1	21	29	PF00244	0.507
LIG_14-3-3_CanoR_1	253	258	PF00244	0.650
LIG_14-3-3_CanoR_1	286	291	PF00244	0.502
LIG_14-3-3_CanoR_1	409	413	PF00244	0.576
LIG_14-3-3_CanoR_1	454	460	PF00244	0.717
LIG_14-3-3_CanoR_1	529	537	PF00244	0.535
LIG_14-3-3_CanoR_1	598	602	PF00244	0.641
LIG_14-3-3_CanoR_1	715	725	PF00244	0.608
LIG_14-3-3_CanoR_1	830	837	PF00244	0.684
LIG_14-3-3_CanoR_1	844	850	PF00244	0.388
LIG_14-3-3_CanoR_1	906	911	PF00244	0.512
LIG_Actin_WH2_2	140	158	PF00022	0.411
LIG_APCC_ABBA_1	135	140	PF00400	0.385
LIG_APCC_ABBA_1	162	167	PF00400	0.423
LIG_APCC_ABBAyCdc20_2	816	822	PF00400	0.593
LIG_BRCT_BRCA1_1	103	107	PF00533	0.415
LIG_BRCT_BRCA1_1	763	767	PF00533	0.675
LIG_BRCT_BRCA1_1	908	912	PF00533	0.576
LIG_Clathr_ClatBox_1	61	65	PF01394	0.411
LIG_Clathr_ClatBox_1	818	822	PF01394	0.486
LIG_CSL_BTD_1	677	680	PF09270	0.659
LIG_DLG_GKlike_1	114	121	PF00625	0.423
LIG_DLG_GKlike_1	906	914	PF00625	0.566
LIG_EH1_1	409	417	PF00400	0.656
LIG_eIF4E_1	728	734	PF01652	0.653
LIG_EVH1_2	451	455	PF00568	0.730
LIG_FHA_1	104	110	PF00498	0.411
LIG_FHA_1	113	119	PF00498	0.411
LIG_FHA_1	159	165	PF00498	0.433
LIG_FHA_1	283	289	PF00498	0.607
LIG_FHA_1	319	325	PF00498	0.418
LIG_FHA_1	442	448	PF00498	0.741
LIG_FHA_1	470	476	PF00498	0.661
LIG_FHA_1	532	538	PF00498	0.538
LIG_FHA_1	56	62	PF00498	0.411
LIG_FHA_1	771	777	PF00498	0.521
LIG_FHA_1	87	93	PF00498	0.411
LIG_FHA_2	22	28	PF00498	0.587
LIG_FHA_2	418	424	PF00498	0.677
LIG_FHA_2	581	587	PF00498	0.584
LIG_FHA_2	770	776	PF00498	0.427
LIG_FHA_2	892	898	PF00498	0.565
LIG_LIR_Apic_2	869	873	PF02991	0.521
LIG_LIR_Gen_1	139	150	PF02991	0.411
LIG_LIR_Gen_1	241	249	PF02991	0.728
LIG_LIR_Gen_1	553	562	PF02991	0.574
LIG_LIR_Gen_1	6	16	PF02991	0.573
LIG_LIR_Gen_1	600	607	PF02991	0.489
LIG_LIR_Gen_1	696	707	PF02991	0.635
LIG_LIR_Gen_1	70	80	PF02991	0.414
LIG_LIR_Gen_1	817	828	PF02991	0.629
LIG_LIR_Nem_3	139	145	PF02991	0.411
LIG_LIR_Nem_3	219	224	PF02991	0.431
LIG_LIR_Nem_3	241	245	PF02991	0.706
LIG_LIR_Nem_3	553	557	PF02991	0.590
LIG_LIR_Nem_3	6	11	PF02991	0.701
LIG_LIR_Nem_3	600	604	PF02991	0.538
LIG_LIR_Nem_3	662	666	PF02991	0.667
LIG_LIR_Nem_3	676	681	PF02991	0.560
LIG_LIR_Nem_3	696	702	PF02991	0.638
LIG_LIR_Nem_3	70	75	PF02991	0.414
LIG_LIR_Nem_3	817	823	PF02991	0.591
LIG_LIR_Nem_3	850	856	PF02991	0.463
LIG_MAD2	865	873	PF02301	0.503
LIG_MYND_1	679	683	PF01753	0.575
LIG_NRBOX	535	541	PF00104	0.614
LIG_NRBOX	728	734	PF00104	0.527
LIG_PALB2_WD40_1	67	75	PF16756	0.292
LIG_Pex14_1	247	251	PF04695	0.545
LIG_Pex14_1	554	558	PF04695	0.569
LIG_Pex14_1	695	699	PF04695	0.738
LIG_Pex14_2	376	380	PF04695	0.495
LIG_Pex14_2	397	401	PF04695	0.411
LIG_Pex14_2	659	663	PF04695	0.756
LIG_RPA_C_Fungi	731	743	PF08784	0.553
LIG_SH2_CRK	519	523	PF00017	0.648
LIG_SH2_CRK	576	580	PF00017	0.599
LIG_SH2_CRK	699	703	PF00017	0.591
LIG_SH2_CRK	870	874	PF00017	0.545
LIG_SH2_GRB2like	301	304	PF00017	0.480
LIG_SH2_SRC	367	370	PF00017	0.535
LIG_SH2_STAP1	576	580	PF00017	0.578
LIG_SH2_STAP1	761	765	PF00017	0.470
LIG_SH2_STAT3	379	382	PF00017	0.524
LIG_SH2_STAT5	120	123	PF00017	0.411
LIG_SH2_STAT5	146	149	PF00017	0.411
LIG_SH2_STAT5	301	304	PF00017	0.480
LIG_SH2_STAT5	367	370	PF00017	0.403
LIG_SH2_STAT5	519	522	PF00017	0.562
LIG_SH2_STAT5	524	527	PF00017	0.559
LIG_SH2_STAT5	558	561	PF00017	0.650
LIG_SH2_STAT5	657	660	PF00017	0.651
LIG_SH2_STAT5	728	731	PF00017	0.493
LIG_SH2_STAT5	761	764	PF00017	0.558
LIG_SH3_2	449	454	PF14604	0.689
LIG_SH3_2	860	865	PF14604	0.631
LIG_SH3_3	269	275	PF00018	0.691
LIG_SH3_3	321	327	PF00018	0.595
LIG_SH3_3	446	452	PF00018	0.752
LIG_SH3_3	615	621	PF00018	0.629
LIG_SH3_3	658	664	PF00018	0.653
LIG_SH3_3	677	683	PF00018	0.665
LIG_SH3_3	791	797	PF00018	0.660
LIG_SH3_3	857	863	PF00018	0.624
LIG_SUMO_SIM_par_1	129	134	PF11976	0.385
LIG_SUMO_SIM_par_1	279	285	PF11976	0.613
LIG_SUMO_SIM_par_1	662	670	PF11976	0.675
LIG_SUMO_SIM_par_1	822	829	PF11976	0.671
LIG_SxIP_EBH_1	477	488	PF03271	0.598
LIG_TRAF2_1	28	31	PF00917	0.384
LIG_TRAF2_1	583	586	PF00917	0.578
LIG_TRFH_1	396	400	PF08558	0.536
LIG_TYR_ITIM	697	702	PF00017	0.637
LIG_UBA3_1	622	627	PF00899	0.655
LIG_WRC_WIRS_1	146	151	PF05994	0.411
MOD_CDC14_SPxK_1	95	98	PF00782	0.292
MOD_CDK_SPK_2	495	500	PF00069	0.594
MOD_CDK_SPxK_1	92	98	PF00069	0.292
MOD_CDK_SPxxK_3	271	278	PF00069	0.667
MOD_CDK_SPxxK_3	447	454	PF00069	0.695
MOD_CK1_1	101	107	PF00069	0.411
MOD_CK1_1	241	247	PF00069	0.706
MOD_CK1_1	252	258	PF00069	0.581
MOD_CK1_1	274	280	PF00069	0.584
MOD_CK1_1	347	353	PF00069	0.667
MOD_CK1_1	404	410	PF00069	0.712
MOD_CK1_1	445	451	PF00069	0.700
MOD_CK1_1	498	504	PF00069	0.650
MOD_CK1_1	531	537	PF00069	0.532
MOD_CK1_1	597	603	PF00069	0.632
MOD_CK1_1	713	719	PF00069	0.546
MOD_CK2_1	21	27	PF00069	0.594
MOD_CK2_1	580	586	PF00069	0.579
MOD_CK2_1	603	609	PF00069	0.628
MOD_CK2_1	716	722	PF00069	0.563
MOD_CK2_1	769	775	PF00069	0.434
MOD_CK2_1	823	829	PF00069	0.676
MOD_CK2_1	891	897	PF00069	0.625
MOD_GlcNHglycan	209	212	PF01048	0.479
MOD_GlcNHglycan	228	231	PF01048	0.244
MOD_GlcNHglycan	338	341	PF01048	0.597
MOD_GlcNHglycan	346	349	PF01048	0.612
MOD_GlcNHglycan	404	407	PF01048	0.620
MOD_GlcNHglycan	545	548	PF01048	0.681
MOD_GlcNHglycan	675	678	PF01048	0.631
MOD_GlcNHglycan	807	810	PF01048	0.551
MOD_GlcNHglycan	918	921	PF01048	0.629
MOD_GSK3_1	110	117	PF00069	0.411
MOD_GSK3_1	141	148	PF00069	0.411
MOD_GSK3_1	21	28	PF00069	0.401
MOD_GSK3_1	241	248	PF00069	0.700
MOD_GSK3_1	249	256	PF00069	0.755
MOD_GSK3_1	282	289	PF00069	0.524
MOD_GSK3_1	343	350	PF00069	0.600
MOD_GSK3_1	378	385	PF00069	0.550
MOD_GSK3_1	400	407	PF00069	0.597
MOD_GSK3_1	441	448	PF00069	0.752
MOD_GSK3_1	531	538	PF00069	0.548
MOD_GSK3_1	665	672	PF00069	0.667
MOD_GSK3_1	755	762	PF00069	0.643
MOD_GSK3_1	767	774	PF00069	0.488
MOD_GSK3_1	781	788	PF00069	0.566
MOD_LATS_1	53	59	PF00433	0.423
MOD_N-GLC_1	110	115	PF02516	0.411
MOD_N-GLC_1	401	406	PF02516	0.653
MOD_N-GLC_1	770	775	PF02516	0.555
MOD_N-GLC_2	901	903	PF02516	0.553
MOD_NEK2_1	145	150	PF00069	0.411
MOD_NEK2_1	189	194	PF00069	0.411
MOD_NEK2_1	204	209	PF00069	0.486
MOD_NEK2_1	344	349	PF00069	0.577
MOD_NEK2_1	378	383	PF00069	0.555
MOD_NEK2_1	401	406	PF00069	0.657
MOD_NEK2_1	417	422	PF00069	0.618
MOD_NEK2_1	436	441	PF00069	0.431
MOD_NEK2_1	525	530	PF00069	0.544
MOD_NEK2_1	643	648	PF00069	0.723
MOD_NEK2_1	673	678	PF00069	0.721
MOD_NEK2_1	702	707	PF00069	0.677
MOD_NEK2_1	710	715	PF00069	0.677
MOD_NEK2_1	749	754	PF00069	0.574
MOD_NEK2_1	767	772	PF00069	0.544
MOD_NEK2_1	881	886	PF00069	0.513
MOD_NEK2_2	761	766	PF00069	0.469
MOD_PIKK_1	318	324	PF00454	0.456
MOD_PIKK_1	378	384	PF00454	0.619
MOD_PIKK_1	517	523	PF00454	0.539
MOD_PIKK_1	759	765	PF00454	0.587
MOD_PIKK_1	787	793	PF00454	0.635
MOD_PIKK_1	830	836	PF00454	0.705
MOD_PKA_2	252	258	PF00069	0.687
MOD_PKA_2	408	414	PF00069	0.576
MOD_PKA_2	528	534	PF00069	0.551
MOD_PKA_2	597	603	PF00069	0.714
MOD_PKB_1	904	912	PF00069	0.562
MOD_Plk_1	213	219	PF00069	0.520
MOD_Plk_1	417	423	PF00069	0.654
MOD_Plk_1	47	53	PF00069	0.376
MOD_Plk_1	669	675	PF00069	0.668
MOD_Plk_1	774	780	PF00069	0.492
MOD_Plk_2-3	12	18	PF00069	0.512
MOD_Plk_2-3	25	31	PF00069	0.499
MOD_Plk_2-3	603	609	PF00069	0.512
MOD_Plk_4	103	109	PF00069	0.465
MOD_Plk_4	114	120	PF00069	0.343
MOD_Plk_4	141	147	PF00069	0.411
MOD_Plk_4	238	244	PF00069	0.603
MOD_Plk_4	363	369	PF00069	0.537
MOD_Plk_4	411	417	PF00069	0.644
MOD_Plk_4	535	541	PF00069	0.507
MOD_Plk_4	575	581	PF00069	0.533
MOD_Plk_4	669	675	PF00069	0.668
MOD_Plk_4	702	708	PF00069	0.552
MOD_Plk_4	750	756	PF00069	0.492
MOD_ProDKin_1	112	118	PF00069	0.183
MOD_ProDKin_1	155	161	PF00069	0.411
MOD_ProDKin_1	268	274	PF00069	0.671
MOD_ProDKin_1	305	311	PF00069	0.504
MOD_ProDKin_1	445	451	PF00069	0.800
MOD_ProDKin_1	464	470	PF00069	0.532
MOD_ProDKin_1	495	501	PF00069	0.648
MOD_ProDKin_1	608	614	PF00069	0.522
MOD_ProDKin_1	638	644	PF00069	0.631
MOD_ProDKin_1	713	719	PF00069	0.546
MOD_ProDKin_1	755	761	PF00069	0.576
MOD_ProDKin_1	797	803	PF00069	0.547
MOD_ProDKin_1	92	98	PF00069	0.292
MOD_SUMO_rev_2	25	34	PF00179	0.453
TRG_DiLeu_BaEn_1	560	565	PF01217	0.537
TRG_DiLeu_BaEn_1	814	819	PF01217	0.615
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.411
TRG_DiLeu_BaLyEn_6	564	569	PF01217	0.641
TRG_DiLeu_BaLyEn_6	639	644	PF01217	0.707
TRG_DiLeu_BaLyEn_6	661	666	PF01217	0.753
TRG_DiLeu_BaLyEn_6	677	682	PF01217	0.503
TRG_DiLeu_BaLyEn_6	71	76	PF01217	0.292
TRG_ENDOCYTIC_2	146	149	PF00928	0.411
TRG_ENDOCYTIC_2	519	522	PF00928	0.562
TRG_ENDOCYTIC_2	558	561	PF00928	0.587
TRG_ENDOCYTIC_2	576	579	PF00928	0.597
TRG_ENDOCYTIC_2	619	622	PF00928	0.585
TRG_ENDOCYTIC_2	657	660	PF00928	0.651
TRG_ENDOCYTIC_2	699	702	PF00928	0.593
TRG_ENDOCYTIC_2	728	731	PF00928	0.532
TRG_ER_diArg_1	438	441	PF00400	0.635
TRG_ER_diArg_1	734	736	PF00400	0.646
TRG_ER_diArg_1	843	845	PF00400	0.515
TRG_NES_CRM1_1	560	571	PF08389	0.644
TRG_Pf-PMV_PEXEL_1	181	186	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	286	291	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	567	571	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	74	79	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2F5	Leptomonas seymouri	53%	95%
A0A3S7X9Y3	Leishmania donovani	93%	100%
A4HNC1	Leishmania braziliensis	73%	96%
A4IBZ4	Leishmania infantum	93%	86%
E9B6Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%