Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFT0_LEIMA

TriTrypDb:

LmjF.35.4530 , LMJLV39_350053500 , LMJSD75_350052900

Length:

716

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFT0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.565
CLV_C14_Caspase3-7	636	640	PF00656	0.427
CLV_MEL_PAP_1	402	408	PF00089	0.382
CLV_NRD_NRD_1	307	309	PF00675	0.609
CLV_NRD_NRD_1	543	545	PF00675	0.606
CLV_NRD_NRD_1	556	558	PF00675	0.699
CLV_NRD_NRD_1	76	78	PF00675	0.536
CLV_PCSK_KEX2_1	306	308	PF00082	0.497
CLV_PCSK_KEX2_1	419	421	PF00082	0.637
CLV_PCSK_KEX2_1	543	545	PF00082	0.611
CLV_PCSK_KEX2_1	76	78	PF00082	0.488
CLV_PCSK_PC1ET2_1	419	421	PF00082	0.517
CLV_PCSK_SKI1_1	183	187	PF00082	0.432
CLV_PCSK_SKI1_1	401	405	PF00082	0.487
CLV_PCSK_SKI1_1	537	541	PF00082	0.560
CLV_PCSK_SKI1_1	604	608	PF00082	0.433
CLV_PCSK_SKI1_1	676	680	PF00082	0.467
CLV_PCSK_SKI1_1	82	86	PF00082	0.427
DEG_APCC_DBOX_1	307	315	PF00400	0.486
DEG_APCC_DBOX_1	390	398	PF00400	0.458
DEG_APCC_DBOX_1	543	551	PF00400	0.576
DEG_SPOP_SBC_1	374	378	PF00917	0.429
DEG_SPOP_SBC_1	634	638	PF00917	0.313
DOC_CYCLIN_RxL_1	600	610	PF00134	0.434
DOC_MAPK_gen_1	306	314	PF00069	0.503
DOC_MAPK_gen_1	689	698	PF00069	0.486
DOC_MAPK_MEF2A_6	172	179	PF00069	0.265
DOC_MAPK_MEF2A_6	307	316	PF00069	0.407
DOC_MAPK_MEF2A_6	689	698	PF00069	0.469
DOC_MAPK_NFAT4_5	691	699	PF00069	0.458
DOC_MAPK_RevD_3	404	420	PF00069	0.424
DOC_PP1_RVXF_1	84	90	PF00149	0.416
DOC_PP4_FxxP_1	226	229	PF00568	0.340
DOC_USP7_MATH_1	112	116	PF00917	0.756
DOC_USP7_MATH_1	251	255	PF00917	0.433
DOC_USP7_MATH_1	267	271	PF00917	0.587
DOC_USP7_MATH_1	301	305	PF00917	0.732
DOC_USP7_MATH_1	348	352	PF00917	0.497
DOC_USP7_MATH_1	373	377	PF00917	0.498
DOC_USP7_MATH_1	482	486	PF00917	0.531
DOC_USP7_MATH_1	524	528	PF00917	0.621
DOC_USP7_MATH_1	559	563	PF00917	0.718
DOC_USP7_MATH_1	570	574	PF00917	0.764
DOC_USP7_MATH_1	634	638	PF00917	0.313
DOC_USP7_MATH_1	91	95	PF00917	0.532
DOC_WW_Pin1_4	247	252	PF00397	0.536
DOC_WW_Pin1_4	314	319	PF00397	0.304
DOC_WW_Pin1_4	329	334	PF00397	0.730
DOC_WW_Pin1_4	562	567	PF00397	0.756
DOC_WW_Pin1_4	576	581	PF00397	0.527
DOC_WW_Pin1_4	647	652	PF00397	0.459
LIG_14-3-3_CanoR_1	172	178	PF00244	0.443
LIG_14-3-3_CanoR_1	537	547	PF00244	0.626
LIG_14-3-3_CanoR_1	90	96	PF00244	0.461
LIG_Actin_WH2_2	168	185	PF00022	0.485
LIG_Actin_WH2_2	390	407	PF00022	0.401
LIG_Actin_WH2_2	433	448	PF00022	0.451
LIG_AP2alpha_1	659	663	PF02296	0.388
LIG_BIR_III_2	212	216	PF00653	0.490
LIG_BRCT_BRCA1_1	526	530	PF00533	0.611
LIG_BRCT_BRCA1_1	631	635	PF00533	0.385
LIG_BRCT_BRCA1_1	651	655	PF00533	0.423
LIG_Clathr_ClatBox_1	468	472	PF01394	0.318
LIG_CtBP_PxDLS_1	70	76	PF00389	0.489
LIG_EH1_1	172	180	PF00400	0.447
LIG_eIF4E_1	78	84	PF01652	0.502
LIG_FHA_1	117	123	PF00498	0.745
LIG_FHA_1	134	140	PF00498	0.291
LIG_FHA_1	157	163	PF00498	0.479
LIG_FHA_1	297	303	PF00498	0.491
LIG_FHA_1	326	332	PF00498	0.461
LIG_FHA_1	376	382	PF00498	0.505
LIG_FHA_1	488	494	PF00498	0.504
LIG_FHA_1	576	582	PF00498	0.628
LIG_FHA_1	83	89	PF00498	0.482
LIG_FHA_2	1	7	PF00498	0.661
LIG_FHA_2	103	109	PF00498	0.681
LIG_FHA_2	152	158	PF00498	0.582
LIG_FHA_2	24	30	PF00498	0.591
LIG_FHA_2	350	356	PF00498	0.320
LIG_FHA_2	416	422	PF00498	0.378
LIG_FHA_2	685	691	PF00498	0.611
LIG_LIR_Gen_1	310	318	PF02991	0.357
LIG_LIR_Gen_1	464	471	PF02991	0.418
LIG_LIR_Gen_1	509	518	PF02991	0.605
LIG_LIR_Gen_1	527	536	PF02991	0.665
LIG_LIR_LC3C_4	620	623	PF02991	0.401
LIG_LIR_Nem_3	247	252	PF02991	0.489
LIG_LIR_Nem_3	310	316	PF02991	0.355
LIG_LIR_Nem_3	464	468	PF02991	0.438
LIG_LIR_Nem_3	509	513	PF02991	0.708
LIG_LIR_Nem_3	527	533	PF02991	0.619
LIG_NRBOX	694	700	PF00104	0.441
LIG_NRBOX	83	89	PF00104	0.412
LIG_PCNA_yPIPBox_3	424	436	PF02747	0.648
LIG_Pex14_1	359	363	PF04695	0.483
LIG_Pex14_2	655	659	PF04695	0.400
LIG_PTB_Apo_2	444	451	PF02174	0.589
LIG_REV1ctd_RIR_1	537	545	PF16727	0.540
LIG_SH2_CRK	249	253	PF00017	0.454
LIG_SH2_NCK_1	147	151	PF00017	0.480
LIG_SH2_SRC	147	150	PF00017	0.482
LIG_SH2_STAP1	147	151	PF00017	0.480
LIG_SH2_STAT5	393	396	PF00017	0.413
LIG_SH2_STAT5	656	659	PF00017	0.482
LIG_SH3_3	212	218	PF00018	0.500
LIG_SH3_3	245	251	PF00018	0.369
LIG_SH3_3	31	37	PF00018	0.527
LIG_SH3_3	403	409	PF00018	0.474
LIG_SH3_3	563	569	PF00018	0.642
LIG_SH3_3	628	634	PF00018	0.403
LIG_Sin3_3	619	626	PF02671	0.493
LIG_SUMO_SIM_anti_2	156	164	PF11976	0.446
LIG_SUMO_SIM_anti_2	64	70	PF11976	0.470
LIG_SUMO_SIM_par_1	131	136	PF11976	0.472
LIG_SUMO_SIM_par_1	467	473	PF11976	0.331
LIG_TRAF2_1	150	153	PF00917	0.614
LIG_UBA3_1	694	702	PF00899	0.457
MOD_CDK_SPxxK_3	576	583	PF00069	0.508
MOD_CK1_1	102	108	PF00069	0.754
MOD_CK1_1	128	134	PF00069	0.580
MOD_CK1_1	167	173	PF00069	0.552
MOD_CK1_1	190	196	PF00069	0.682
MOD_CK1_1	247	253	PF00069	0.561
MOD_CK1_1	270	276	PF00069	0.644
MOD_CK1_1	283	289	PF00069	0.544
MOD_CK1_1	376	382	PF00069	0.484
MOD_CK1_1	449	455	PF00069	0.570
MOD_CK1_1	516	522	PF00069	0.591
MOD_CK1_1	562	568	PF00069	0.743
MOD_CK1_1	574	580	PF00069	0.698
MOD_CK1_1	7	13	PF00069	0.678
MOD_CK2_1	102	108	PF00069	0.766
MOD_CK2_1	23	29	PF00069	0.591
MOD_CK2_1	349	355	PF00069	0.438
MOD_CK2_1	415	421	PF00069	0.359
MOD_CK2_1	684	690	PF00069	0.450
MOD_CK2_1	90	96	PF00069	0.556
MOD_Cter_Amidation	699	702	PF01082	0.349
MOD_GlcNHglycan	110	113	PF01048	0.732
MOD_GlcNHglycan	116	119	PF01048	0.747
MOD_GlcNHglycan	189	192	PF01048	0.624
MOD_GlcNHglycan	196	199	PF01048	0.710
MOD_GlcNHglycan	257	260	PF01048	0.642
MOD_GlcNHglycan	272	275	PF01048	0.581
MOD_GlcNHglycan	299	302	PF01048	0.562
MOD_GlcNHglycan	303	306	PF01048	0.468
MOD_GlcNHglycan	336	339	PF01048	0.701
MOD_GlcNHglycan	406	409	PF01048	0.509
MOD_GlcNHglycan	472	475	PF01048	0.451
MOD_GlcNHglycan	484	487	PF01048	0.450
MOD_GlcNHglycan	55	58	PF01048	0.389
MOD_GlcNHglycan	710	713	PF01048	0.530
MOD_GlcNHglycan	9	12	PF01048	0.733
MOD_GSK3_1	108	115	PF00069	0.766
MOD_GSK3_1	18	25	PF00069	0.604
MOD_GSK3_1	186	193	PF00069	0.532
MOD_GSK3_1	231	238	PF00069	0.497
MOD_GSK3_1	247	254	PF00069	0.575
MOD_GSK3_1	297	304	PF00069	0.680
MOD_GSK3_1	314	321	PF00069	0.341
MOD_GSK3_1	325	332	PF00069	0.634
MOD_GSK3_1	373	380	PF00069	0.477
MOD_GSK3_1	570	577	PF00069	0.687
MOD_GSK3_1	629	636	PF00069	0.418
MOD_GSK3_1	645	652	PF00069	0.365
MOD_N-GLC_1	102	107	PF02516	0.679
MOD_N-GLC_1	235	240	PF02516	0.594
MOD_N-GLC_1	446	451	PF02516	0.575
MOD_N-GLC_1	513	518	PF02516	0.703
MOD_N-GLC_1	581	586	PF02516	0.722
MOD_N-GLC_2	341	343	PF02516	0.556
MOD_NEK2_1	252	257	PF00069	0.649
MOD_NEK2_1	296	301	PF00069	0.739
MOD_NEK2_1	312	317	PF00069	0.354
MOD_NEK2_1	395	400	PF00069	0.452
MOD_NEK2_1	4	9	PF00069	0.679
MOD_NEK2_1	404	409	PF00069	0.427
MOD_NEK2_1	415	420	PF00069	0.283
MOD_NEK2_1	571	576	PF00069	0.721
MOD_NEK2_1	607	612	PF00069	0.375
MOD_NEK2_1	621	626	PF00069	0.313
MOD_NEK2_1	679	684	PF00069	0.517
MOD_NEK2_2	441	446	PF00069	0.429
MOD_PIKK_1	396	402	PF00454	0.592
MOD_PIKK_1	422	428	PF00454	0.667
MOD_PIKK_1	449	455	PF00454	0.694
MOD_PIKK_1	487	493	PF00454	0.543
MOD_PIKK_1	538	544	PF00454	0.530
MOD_PIKK_1	545	551	PF00454	0.584
MOD_PIKK_1	71	77	PF00454	0.550
MOD_PK_1	5	11	PF00069	0.573
MOD_PKA_2	404	410	PF00069	0.463
MOD_PKB_1	80	88	PF00069	0.322
MOD_Plk_1	156	162	PF00069	0.464
MOD_Plk_1	167	173	PF00069	0.513
MOD_Plk_1	441	447	PF00069	0.591
MOD_Plk_1	5	11	PF00069	0.655
MOD_Plk_1	513	519	PF00069	0.578
MOD_Plk_1	581	587	PF00069	0.692
MOD_Plk_1	592	598	PF00069	0.564
MOD_Plk_4	128	134	PF00069	0.405
MOD_Plk_4	18	24	PF00069	0.665
MOD_Plk_4	244	250	PF00069	0.474
MOD_Plk_4	275	281	PF00069	0.732
MOD_Plk_4	377	383	PF00069	0.466
MOD_Plk_4	666	672	PF00069	0.553
MOD_ProDKin_1	247	253	PF00069	0.547
MOD_ProDKin_1	314	320	PF00069	0.315
MOD_ProDKin_1	329	335	PF00069	0.728
MOD_ProDKin_1	562	568	PF00069	0.756
MOD_ProDKin_1	576	582	PF00069	0.526
MOD_ProDKin_1	647	653	PF00069	0.459
MOD_SUMO_rev_2	234	239	PF00179	0.495
TRG_DiLeu_BaEn_1	690	695	PF01217	0.507
TRG_DiLeu_BaLyEn_6	694	699	PF01217	0.494
TRG_DiLeu_BaLyEn_6	79	84	PF01217	0.427
TRG_ENDOCYTIC_2	249	252	PF00928	0.560
TRG_ENDOCYTIC_2	656	659	PF00928	0.482
TRG_ER_diArg_1	306	308	PF00400	0.575
TRG_ER_diArg_1	543	545	PF00400	0.550
TRG_ER_diArg_1	76	78	PF00400	0.539
TRG_ER_diArg_1	80	83	PF00400	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMN1	Leptomonas seymouri	52%	98%
A0A1X0P552	Trypanosomatidae	28%	100%
A0A3Q8IIF7	Leishmania donovani	90%	100%
A0A3R7KX70	Trypanosoma rangeli	30%	100%
A4HNC0	Leishmania braziliensis	70%	100%
A4IBZ3	Leishmania infantum	91%	100%
C9ZYL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B6Y2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5C2M3	Trypanosoma cruzi	31%	100%