DUF962-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF962), putative

Species:

Leishmania major

UniProt:

E9AFS9_LEIMA

TriTrypDb:

LmjF.35.4520 , LMJLV39_350053400 , LMJSD75_350052800

Length:

263

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	5
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AFS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFS9

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	2
GO:0006643	membrane lipid metabolic process	4	2
GO:0006665	sphingolipid metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	2
GO:0016042	lipid catabolic process	4	2
GO:0030149	sphingolipid catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044242	cellular lipid catabolic process	4	2
GO:0044248	cellular catabolic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0046466	membrane lipid catabolic process	5	2
GO:0046519	sphingoid metabolic process	5	2
GO:0046521	sphingoid catabolic process	6	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	251	253	PF00675	0.484
CLV_NRD_NRD_1	56	58	PF00675	0.408
CLV_PCSK_KEX2_1	251	253	PF00082	0.484
CLV_PCSK_KEX2_1	69	71	PF00082	0.387
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.387
CLV_PCSK_SKI1_1	207	211	PF00082	0.443
CLV_PCSK_SKI1_1	44	48	PF00082	0.290
DEG_SPOP_SBC_1	26	30	PF00917	0.549
DOC_CYCLIN_yCln2_LP_2	124	130	PF00134	0.420
DOC_MAPK_gen_1	69	77	PF00069	0.447
DOC_MAPK_MEF2A_6	142	150	PF00069	0.447
DOC_MAPK_MEF2A_6	70	79	PF00069	0.447
DOC_PP2B_LxvP_1	124	127	PF13499	0.400
DOC_USP7_MATH_1	235	239	PF00917	0.673
DOC_USP7_MATH_1	27	31	PF00917	0.547
DOC_USP7_UBL2_3	220	224	PF12436	0.659
LIG_14-3-3_CanoR_1	25	34	PF00244	0.550
LIG_14-3-3_CanoR_1	57	61	PF00244	0.608
LIG_Actin_WH2_2	43	59	PF00022	0.470
LIG_BRCT_BRCA1_1	58	62	PF00533	0.608
LIG_FHA_1	17	23	PF00498	0.550
LIG_FHA_1	2	8	PF00498	0.559
LIG_FHA_1	239	245	PF00498	0.678
LIG_FHA_1	95	101	PF00498	0.362
LIG_LIR_Gen_1	111	121	PF02991	0.488
LIG_LIR_Nem_3	107	112	PF02991	0.275
LIG_LIR_Nem_3	51	56	PF02991	0.647
LIG_LIR_Nem_3	59	63	PF02991	0.514
LIG_PAM2_1	25	37	PF00658	0.549
LIG_SH2_STAP1	110	114	PF00017	0.502
LIG_SH2_STAT5	110	113	PF00017	0.303
LIG_SH2_STAT5	134	137	PF00017	0.564
LIG_SH2_STAT5	49	52	PF00017	0.558
LIG_SH2_STAT5	53	56	PF00017	0.494
MOD_CK1_1	120	126	PF00069	0.379
MOD_CK1_1	16	22	PF00069	0.555
MOD_CK1_1	238	244	PF00069	0.635
MOD_CK1_1	9	15	PF00069	0.579
MOD_GlcNHglycan	118	122	PF01048	0.407
MOD_GlcNHglycan	235	238	PF01048	0.431
MOD_GlcNHglycan	29	32	PF01048	0.345
MOD_GlcNHglycan	8	11	PF01048	0.372
MOD_GSK3_1	100	107	PF00069	0.228
MOD_GSK3_1	233	240	PF00069	0.668
MOD_GSK3_1	25	32	PF00069	0.529
MOD_GSK3_1	82	89	PF00069	0.357
MOD_GSK3_1	9	16	PF00069	0.568
MOD_N-GLC_1	100	105	PF02516	0.420
MOD_NEK2_1	56	61	PF00069	0.608
MOD_NEK2_1	8	13	PF00069	0.588
MOD_PKA_1	233	239	PF00069	0.636
MOD_PKA_2	56	62	PF00069	0.608
MOD_Plk_1	100	106	PF00069	0.420
MOD_Plk_4	110	116	PF00069	0.446
MOD_Plk_4	120	126	PF00069	0.277
MOD_Plk_4	17	23	PF00069	0.575
MOD_Plk_4	56	62	PF00069	0.537
MOD_Plk_4	86	92	PF00069	0.502
MOD_SUMO_for_1	115	118	PF00179	0.502
MOD_SUMO_for_1	201	204	PF00179	0.654
TRG_DiLeu_BaEn_2	189	195	PF01217	0.502
TRG_ENDOCYTIC_2	125	128	PF00928	0.475
TRG_ENDOCYTIC_2	53	56	PF00928	0.608
TRG_ER_diArg_1	250	252	PF00400	0.680
TRG_NES_CRM1_1	178	190	PF08389	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X9Y4	Leishmania donovani	92%	100%
A4HNB9	Leishmania braziliensis	77%	100%
A4IBZ2	Leishmania infantum	89%	100%
E9B6Y1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O13737	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%