Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MICOS complex subunit MIC60, putative

Species:

Leishmania major

UniProt:

E9AFS8_LEIMA

TriTrypDb:

LmjF.35.4510 , LMJLV39_350053300 , LMJSD75_350052700

Length:

231

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0016020	membrane	2	6
GO:0020023	kinetoplast	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AFS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFS8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.336
CLV_NRD_NRD_1	2	4	PF00675	0.441
CLV_NRD_NRD_1	80	82	PF00675	0.433
CLV_PCSK_KEX2_1	2	4	PF00082	0.422
CLV_PCSK_KEX2_1	80	82	PF00082	0.389
DEG_Nend_UBRbox_1	1	4	PF02207	0.703
DOC_PP4_FxxP_1	139	142	PF00568	0.382
DOC_PP4_FxxP_1	56	59	PF00568	0.672
DOC_USP7_MATH_1	32	36	PF00917	0.763
DOC_USP7_UBL2_3	151	155	PF12436	0.397
DOC_USP7_UBL2_3	40	44	PF12436	0.598
DOC_WW_Pin1_4	49	54	PF00397	0.672
LIG_14-3-3_CanoR_1	187	196	PF00244	0.285
LIG_14-3-3_CanoR_1	66	71	PF00244	0.705
LIG_Actin_WH2_2	171	189	PF00022	0.391
LIG_APCC_ABBAyCdc20_2	167	173	PF00400	0.453
LIG_eIF4E_1	218	224	PF01652	0.444
LIG_FHA_1	84	90	PF00498	0.444
LIG_FHA_1	91	97	PF00498	0.418
LIG_FHA_2	142	148	PF00498	0.406
LIG_FHA_2	37	43	PF00498	0.748
LIG_LIR_Apic_2	54	59	PF02991	0.668
LIG_LIR_Apic_2	69	73	PF02991	0.650
LIG_LIR_Gen_1	143	153	PF02991	0.348
LIG_LIR_Gen_1	219	229	PF02991	0.404
LIG_LIR_Nem_3	143	148	PF02991	0.351
LIG_LIR_Nem_3	215	221	PF02991	0.361
LIG_LIR_Nem_3	41	46	PF02991	0.694
LIG_PDZ_Class_2	226	231	PF00595	0.443
LIG_SH2_NCK_1	221	225	PF00017	0.413
LIG_SH2_PTP2	70	73	PF00017	0.625
LIG_SH2_SRC	70	73	PF00017	0.625
LIG_SH2_STAP1	145	149	PF00017	0.446
LIG_SH2_STAT5	100	103	PF00017	0.281
LIG_SH2_STAT5	70	73	PF00017	0.607
LIG_SUMO_SIM_anti_2	131	137	PF11976	0.444
LIG_SUMO_SIM_anti_2	95	100	PF11976	0.453
LIG_TYR_ITIM	98	103	PF00017	0.357
LIG_TYR_ITSM	39	46	PF00017	0.700
MOD_CK1_1	27	33	PF00069	0.750
MOD_CK1_1	34	40	PF00069	0.642
MOD_CK2_1	141	147	PF00069	0.355
MOD_CK2_1	216	222	PF00069	0.430
MOD_CK2_1	36	42	PF00069	0.732
MOD_CK2_1	66	72	PF00069	0.699
MOD_GlcNHglycan	190	193	PF01048	0.610
MOD_GlcNHglycan	218	221	PF01048	0.664
MOD_GlcNHglycan	34	37	PF01048	0.495
MOD_GSK3_1	137	144	PF00069	0.342
MOD_GSK3_1	16	23	PF00069	0.764
MOD_GSK3_1	161	168	PF00069	0.470
MOD_GSK3_1	212	219	PF00069	0.354
MOD_GSK3_1	27	34	PF00069	0.695
MOD_GSK3_1	45	52	PF00069	0.649
MOD_N-GLC_2	183	185	PF02516	0.549
MOD_NEK2_1	101	106	PF00069	0.376
MOD_NEK2_1	216	221	PF00069	0.395
MOD_NEK2_1	85	90	PF00069	0.292
MOD_NEK2_2	166	171	PF00069	0.424
MOD_NEK2_2	75	80	PF00069	0.634
MOD_PIKK_1	158	164	PF00454	0.423
MOD_PKA_2	131	137	PF00069	0.504
MOD_Plk_4	171	177	PF00069	0.367
MOD_Plk_4	66	72	PF00069	0.699
MOD_ProDKin_1	49	55	PF00069	0.671
MOD_SUMO_rev_2	69	76	PF00179	0.664
TRG_DiLeu_BaEn_2	71	77	PF01217	0.582
TRG_ENDOCYTIC_2	100	103	PF00928	0.279
TRG_ENDOCYTIC_2	145	148	PF00928	0.446
TRG_ENDOCYTIC_2	149	152	PF00928	0.442
TRG_ENDOCYTIC_2	221	224	PF00928	0.368
TRG_ENDOCYTIC_2	43	46	PF00928	0.699
TRG_ER_diArg_1	1	3	PF00400	0.645
TRG_ER_diArg_1	124	127	PF00400	0.338
TRG_ER_diArg_1	79	81	PF00400	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMV6	Leptomonas seymouri	62%	97%
A0A0S4JR13	Bodo saltans	32%	97%
A0A1X0P4Y8	Trypanosomatidae	44%	100%
A0A3S7XA10	Leishmania donovani	95%	100%
A0A422P1A7	Trypanosoma rangeli	43%	100%
A4HNB8	Leishmania braziliensis	83%	100%
A4IBZ1	Leishmania infantum	95%	100%
C9ZYL3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B6Y0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%