Anaphase-promoting complex subunit 11

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

anaphase promoting complex subunit protein, putative

Species:

Leishmania major

UniProt:

E9AFS7_LEIMA

TriTrypDb:

LmjF.35.4500 , LMJLV39_350053200 , LMJSD75_350052600

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	9
GO:0000152	nuclear ubiquitin ligase complex	3	9
GO:0005634	nucleus	5	2
GO:0005680	anaphase-promoting complex	4	9
GO:0031461	cullin-RING ubiquitin ligase complex	4	9
GO:0032991	protein-containing complex	1	9
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	9
GO:0140535	intracellular protein-containing complex	2	9
GO:1902494	catalytic complex	2	9
GO:1990234	transferase complex	3	9

Expansion

Sequence features

E9AFS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFS7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	9
GO:0006511	ubiquitin-dependent protein catabolic process	7	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0007088	regulation of mitotic nuclear division	6	2
GO:0007346	regulation of mitotic cell cycle	5	2
GO:0008152	metabolic process	1	9
GO:0009056	catabolic process	2	9
GO:0009057	macromolecule catabolic process	4	9
GO:0009987	cellular process	1	9
GO:0010498	proteasomal protein catabolic process	5	9
GO:0010564	regulation of cell cycle process	5	2
GO:0010638	positive regulation of organelle organization	6	2
GO:0010965	regulation of mitotic sister chromatid separation	6	2
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	9
GO:0019941	modification-dependent protein catabolic process	6	9
GO:0030071	regulation of mitotic metaphase/anaphase transition	7	2
GO:0030163	protein catabolic process	4	9
GO:0031145	anaphase-promoting complex-dependent catabolic process	7	9
GO:0032446	protein modification by small protein conjugation	6	2
GO:0033043	regulation of organelle organization	5	2
GO:0033044	regulation of chromosome organization	6	2
GO:0033045	regulation of sister chromatid segregation	5	2
GO:0036211	protein modification process	4	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	2
GO:0043632	modification-dependent macromolecule catabolic process	5	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044248	cellular catabolic process	3	9
GO:0044260	obsolete cellular macromolecule metabolic process	3	9
GO:0044265	obsolete cellular macromolecule catabolic process	4	9
GO:0045787	positive regulation of cell cycle	5	2
GO:0045840	positive regulation of mitotic nuclear division	7	2
GO:0045842	positive regulation of mitotic metaphase/anaphase transition	8	2
GO:0045931	positive regulation of mitotic cell cycle	6	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051128	regulation of cellular component organization	4	2
GO:0051130	positive regulation of cellular component organization	5	2
GO:0051301	cell division	2	8
GO:0051603	proteolysis involved in protein catabolic process	5	9
GO:0051726	regulation of cell cycle	4	2
GO:0051783	regulation of nuclear division	6	2
GO:0051785	positive regulation of nuclear division	7	2
GO:0051983	regulation of chromosome segregation	4	2
GO:0065007	biological regulation	1	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	9
GO:0090068	positive regulation of cell cycle process	6	2
GO:1901564	organonitrogen compound metabolic process	3	9
GO:1901565	organonitrogen compound catabolic process	4	9
GO:1901575	organic substance catabolic process	3	9
GO:1901970	positive regulation of mitotic sister chromatid separation	7	2
GO:1901987	regulation of cell cycle phase transition	6	2
GO:1901989	positive regulation of cell cycle phase transition	7	2
GO:1901990	regulation of mitotic cell cycle phase transition	6	2
GO:1901992	positive regulation of mitotic cell cycle phase transition	7	2
GO:1902099	regulation of metaphase/anaphase transition of cell cycle	6	2
GO:1902101	positive regulation of metaphase/anaphase transition of cell cycle	7	2
GO:1905818	regulation of chromosome separation	5	2
GO:1905820	positive regulation of chromosome separation	6	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004842	ubiquitin-protein transferase activity	4	9
GO:0005488	binding	1	9
GO:0005515	protein binding	2	9
GO:0008270	zinc ion binding	6	9
GO:0016740	transferase activity	2	9
GO:0019787	ubiquitin-like protein transferase activity	3	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9
GO:0061630	ubiquitin protein ligase activity	5	9
GO:0061659	ubiquitin-like protein ligase activity	4	9
GO:0097602	cullin family protein binding	3	9
GO:0140096	catalytic activity, acting on a protein	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_UBRbox_2	1	3	PF02207	0.496
DOC_WW_Pin1_4	46	51	PF00397	0.530
LIG_FHA_1	20	26	PF00498	0.461
LIG_FHA_1	34	40	PF00498	0.541
LIG_FHA_1	52	58	PF00498	0.496
LIG_FHA_1	59	65	PF00498	0.496
LIG_SH3_3	68	74	PF00018	0.530
MOD_NEK2_2	51	56	PF00069	0.472
MOD_OFUCOSY	18	23	PF10250	0.296
MOD_PK_1	4	10	PF00069	0.541
MOD_ProDKin_1	46	52	PF00069	0.530
TRG_Pf-PMV_PEXEL_1	62	67	PF00026	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P965	Leptomonas seymouri	91%	100%
A0A0N1I1Q1	Leptomonas seymouri	35%	80%
A0A0S4JR26	Bodo saltans	54%	88%
A0A0S4KL27	Bodo saltans	34%	75%
A0A1X0NXY1	Trypanosomatidae	37%	77%
A0A3S7WW78	Leishmania donovani	36%	77%
A0A3S7X9W9	Leishmania donovani	100%	100%
A4H8I7	Leishmania braziliensis	39%	78%
A4HBJ7	Leishmania braziliensis	34%	80%
A4HNB7	Leishmania braziliensis	96%	100%
A4HZL7	Leishmania infantum	36%	77%
A4IBZ0	Leishmania infantum	100%	100%
C9ZYL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
D0A1J4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	77%
E9AUW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	77%
E9B6X9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O13959	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	77%
P62877	Homo sapiens	29%	76%
P62878	Mus musculus	29%	76%
Q08273	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	68%
Q23457	Caenorhabditis elegans	31%	75%
Q3ZCF6	Bos taurus	48%	98%
Q4QCL6	Leishmania major	36%	77%
Q4QEV4	Leishmania major	37%	78%
Q54K33	Dictyostelium discoideum	29%	79%
Q54L48	Dictyostelium discoideum	46%	94%
Q5R8A2	Pongo abelii	48%	98%
Q8QG64	Salmo salar	29%	76%
Q940X7	Arabidopsis thaliana	31%	69%
Q9CPX9	Mus musculus	48%	98%
Q9M2B0	Arabidopsis thaliana	31%	71%
Q9M9L0	Arabidopsis thaliana	50%	98%
Q9NHX0	Drosophila melanogaster	36%	67%
Q9NYG5	Homo sapiens	48%	98%
Q9UBF6	Homo sapiens	32%	73%
Q9UT86	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	87%
Q9W5E1	Drosophila melanogaster	29%	76%
Q9WTZ1	Mus musculus	32%	73%