CS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Co-chaperone protein P23

Species:

Leishmania major

UniProt:

E9AFS4_LEIMA

TriTrypDb:

LmjF.35.4470 , LMJLV39_350052900 , LMJSD75_350052300

Length:

199

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AFS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFS4

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0043933	protein-containing complex organization	4	2
GO:0051131	chaperone-mediated protein complex assembly	6	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0031072	heat shock protein binding	3	11
GO:0051087	protein-folding chaperone binding	3	2
GO:0051879	Hsp90 protein binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.754
CLV_NRD_NRD_1	10	12	PF00675	0.254
DOC_MAPK_gen_1	11	19	PF00069	0.440
DOC_MAPK_MEF2A_6	11	19	PF00069	0.440
DOC_MAPK_MEF2A_6	71	79	PF00069	0.440
DOC_USP7_MATH_1	122	126	PF00917	0.582
DOC_USP7_MATH_1	45	49	PF00917	0.471
DOC_USP7_MATH_1	65	69	PF00917	0.354
DOC_USP7_MATH_1	99	103	PF00917	0.516
DOC_WW_Pin1_4	20	25	PF00397	0.598
LIG_14-3-3_CanoR_1	14	20	PF00244	0.487
LIG_BIR_II_1	1	5	PF00653	0.480
LIG_deltaCOP1_diTrp_1	107	111	PF00928	0.409
LIG_FHA_1	33	39	PF00498	0.558
LIG_FHA_1	67	73	PF00498	0.496
LIG_FHA_2	21	27	PF00498	0.484
LIG_LIR_Gen_1	13	24	PF02991	0.464
LIG_LIR_Nem_3	125	130	PF02991	0.560
LIG_LIR_Nem_3	13	19	PF02991	0.464
LIG_LIR_Nem_3	68	73	PF02991	0.451
LIG_PDZ_Class_2	194	199	PF00595	0.627
LIG_SH2_GRB2like	88	91	PF00017	0.415
LIG_SH3_3	90	96	PF00018	0.400
LIG_SUMO_SIM_par_1	33	39	PF11976	0.474
LIG_UBA3_1	156	162	PF00899	0.580
MOD_CK1_1	102	108	PF00069	0.449
MOD_CK1_1	22	28	PF00069	0.473
MOD_CK2_1	165	171	PF00069	0.671
MOD_CMANNOS	108	111	PF00535	0.424
MOD_GlcNHglycan	104	107	PF01048	0.541
MOD_GlcNHglycan	38	41	PF01048	0.312
MOD_GSK3_1	15	22	PF00069	0.438
MOD_GSK3_1	152	159	PF00069	0.567
MOD_GSK3_1	32	39	PF00069	0.446
MOD_GSK3_1	41	48	PF00069	0.440
MOD_N-GLC_1	45	50	PF02516	0.334
MOD_NEK2_1	156	161	PF00069	0.733
MOD_PIKK_1	45	51	PF00454	0.533
MOD_PK_1	34	40	PF00069	0.535
MOD_Plk_1	32	38	PF00069	0.443
MOD_Plk_1	65	71	PF00069	0.471
MOD_Plk_4	140	146	PF00069	0.558
MOD_Plk_4	152	158	PF00069	0.512
MOD_Plk_4	99	105	PF00069	0.520
MOD_ProDKin_1	20	26	PF00069	0.598
MOD_SUMO_for_1	53	56	PF00179	0.496
MOD_SUMO_for_1	82	85	PF00179	0.569
TRG_ENDOCYTIC_2	130	133	PF00928	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JTH1	Bodo saltans	51%	100%
A0A1X0P6F3	Trypanosomatidae	66%	100%
A0A3Q8II57	Leishmania donovani	26%	95%
A0A3R7NTN0	Trypanosoma rangeli	59%	100%
A0A3S5H807	Leishmania donovani	91%	100%
A4HNB5	Leishmania braziliensis	81%	99%
A4I9J1	Leishmania infantum	26%	95%
A4IBY7	Leishmania infantum	91%	100%
C9ZYL8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9B4I9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	95%
E9B6X6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
G1TGF1	Oryctolagus cuniculus	38%	100%
P83868	Rattus norvegicus	35%	100%
Q11118	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
Q15185	Homo sapiens	38%	100%
Q3ZBF7	Bos taurus	38%	100%
Q4Q3I7	Leishmania major	25%	95%
Q5NVM4	Pongo abelii	38%	100%
Q6PWL5	Macaca fascicularis	38%	100%
Q9FR62	Brassica napus	29%	100%
Q9R0Q7	Mus musculus	35%	100%
Q9VH95	Drosophila melanogaster	29%	100%
V5BCP6	Trypanosoma cruzi	56%	100%