C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

predicted zinc finger protein

Species:

Leishmania major

UniProt:

E9AFS2_LEIMA

TriTrypDb:

LmjF.35.4450 , LMJLV39_350052700 , LMJSD75_350052100

Length:

264

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFS2

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	196	198	PF00675	0.483
CLV_PCSK_KEX2_1	196	198	PF00082	0.483
CLV_PCSK_SKI1_1	168	172	PF00082	0.580
DEG_Nend_Nbox_1	1	3	PF02207	0.660
DEG_SCF_FBW7_1	215	222	PF00400	0.534
DEG_SCF_FBW7_1	236	242	PF00400	0.684
DEG_SPOP_SBC_1	179	183	PF00917	0.475
DOC_CKS1_1	236	241	PF01111	0.684
DOC_CKS1_1	5	10	PF01111	0.636
DOC_CYCLIN_yCln2_LP_2	206	212	PF00134	0.565

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I468	Leptomonas seymouri	31%	100%
A0A3S7X9W1	Leishmania donovani	89%	100%
A4HNB3	Leishmania braziliensis	63%	100%
A4IBY5	Leishmania infantum	89%	100%
E9B6X4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%

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