C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

predicted zinc finger protein

Species:

Leishmania major

UniProt:

E9AFS2_LEIMA

TriTrypDb:

LmjF.35.4450 , LMJLV39_350052700 , LMJSD75_350052100

Length:

264

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFS2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	196	198	PF00675	0.483
CLV_PCSK_KEX2_1	196	198	PF00082	0.483
CLV_PCSK_SKI1_1	168	172	PF00082	0.580
DEG_Nend_Nbox_1	1	3	PF02207	0.660
DEG_SCF_FBW7_1	215	222	PF00400	0.534
DEG_SCF_FBW7_1	236	242	PF00400	0.684
DEG_SPOP_SBC_1	179	183	PF00917	0.475
DOC_CKS1_1	236	241	PF01111	0.684
DOC_CKS1_1	5	10	PF01111	0.636
DOC_CYCLIN_yCln2_LP_2	206	212	PF00134	0.565
DOC_PP4_FxxP_1	201	204	PF00568	0.458
DOC_PP4_FxxP_1	251	254	PF00568	0.672
DOC_USP7_MATH_1	166	170	PF00917	0.629
DOC_USP7_MATH_1	219	223	PF00917	0.600
DOC_USP7_MATH_1	239	243	PF00917	0.570
DOC_WW_Pin1_4	109	114	PF00397	0.636
DOC_WW_Pin1_4	140	145	PF00397	0.671
DOC_WW_Pin1_4	205	210	PF00397	0.690
DOC_WW_Pin1_4	215	220	PF00397	0.557
DOC_WW_Pin1_4	232	237	PF00397	0.559
DOC_WW_Pin1_4	4	9	PF00397	0.677
DOC_WW_Pin1_4	78	83	PF00397	0.717
LIG_14-3-3_CanoR_1	49	53	PF00244	0.528
LIG_14-3-3_CanoR_1	94	104	PF00244	0.527
LIG_FHA_1	243	249	PF00498	0.683
LIG_FHA_1	95	101	PF00498	0.747
LIG_FHA_2	216	222	PF00498	0.619
LIG_FHA_2	255	261	PF00498	0.669
LIG_Integrin_isoDGR_2	191	193	PF01839	0.452
LIG_LIR_Apic_2	249	254	PF02991	0.672
LIG_LIR_Gen_1	152	163	PF02991	0.643
LIG_LIR_Gen_1	230	239	PF02991	0.613
LIG_LIR_Nem_3	152	158	PF02991	0.634
LIG_LIR_Nem_3	230	234	PF02991	0.660
LIG_LIR_Nem_3	238	243	PF02991	0.597
LIG_LIR_Nem_3	81	86	PF02991	0.579
LIG_PTB_Apo_2	225	232	PF02174	0.584
LIG_SH2_CRK	155	159	PF00017	0.637
LIG_SH2_CRK	2	6	PF00017	0.608
LIG_SH2_CRK	240	244	PF00017	0.609
LIG_SH2_GRB2like	189	192	PF00017	0.446
LIG_SH2_SRC	189	192	PF00017	0.446
LIG_SH2_SRC	19	22	PF00017	0.600
LIG_SH2_SRC	86	89	PF00017	0.648
LIG_SH2_STAT3	84	87	PF00017	0.659
LIG_SH2_STAT5	189	192	PF00017	0.446
LIG_SH2_STAT5	19	22	PF00017	0.563
LIG_SH2_STAT5	217	220	PF00017	0.557
LIG_SH3_2	163	168	PF14604	0.554
LIG_SH3_3	110	116	PF00018	0.628
LIG_SH3_3	15	21	PF00018	0.672
LIG_SH3_3	160	166	PF00018	0.538
LIG_SH3_3	2	8	PF00018	0.690
LIG_SH3_3	206	212	PF00018	0.601
LIG_SH3_3	233	239	PF00018	0.738
LIG_SH3_3	33	39	PF00018	0.431
LIG_SH3_3	67	73	PF00018	0.579
LIG_TYR_ITSM	151	158	PF00017	0.568
LIG_WRC_WIRS_1	248	253	PF05994	0.553
MOD_CK1_1	121	127	PF00069	0.626
MOD_CK1_1	213	219	PF00069	0.677
MOD_CK1_1	235	241	PF00069	0.605
MOD_CK1_1	242	248	PF00069	0.635
MOD_CK1_1	249	255	PF00069	0.511
MOD_CK1_1	75	81	PF00069	0.627
MOD_CK1_1	96	102	PF00069	0.653
MOD_CK2_1	178	184	PF00069	0.536
MOD_CK2_1	254	260	PF00069	0.666
MOD_GlcNHglycan	168	171	PF01048	0.733
MOD_GlcNHglycan	221	224	PF01048	0.625
MOD_GSK3_1	105	112	PF00069	0.666
MOD_GSK3_1	118	125	PF00069	0.541
MOD_GSK3_1	164	171	PF00069	0.620
MOD_GSK3_1	174	181	PF00069	0.499
MOD_GSK3_1	215	222	PF00069	0.585
MOD_GSK3_1	235	242	PF00069	0.685
MOD_GSK3_1	249	256	PF00069	0.529
MOD_GSK3_1	74	81	PF00069	0.554
MOD_GSK3_1	90	97	PF00069	0.526
MOD_N-GLC_1	109	114	PF02516	0.583
MOD_NEK2_1	118	123	PF00069	0.721
MOD_PIKK_1	134	140	PF00454	0.769
MOD_PIKK_1	20	26	PF00454	0.651
MOD_PIKK_1	254	260	PF00454	0.566
MOD_PKA_2	258	264	PF00069	0.511
MOD_PKA_2	48	54	PF00069	0.550
MOD_PKA_2	93	99	PF00069	0.523
MOD_Plk_4	13	19	PF00069	0.609
MOD_Plk_4	258	264	PF00069	0.611
MOD_Plk_4	48	54	PF00069	0.581
MOD_Plk_4	96	102	PF00069	0.627
MOD_ProDKin_1	109	115	PF00069	0.640
MOD_ProDKin_1	140	146	PF00069	0.669
MOD_ProDKin_1	205	211	PF00069	0.695
MOD_ProDKin_1	215	221	PF00069	0.560
MOD_ProDKin_1	232	238	PF00069	0.557
MOD_ProDKin_1	4	10	PF00069	0.675
MOD_ProDKin_1	78	84	PF00069	0.722
TRG_ENDOCYTIC_2	155	158	PF00928	0.572
TRG_ENDOCYTIC_2	2	5	PF00928	0.614
TRG_ENDOCYTIC_2	240	243	PF00928	0.678
TRG_NLS_MonoExtN_4	196	201	PF00514	0.466
TRG_Pf-PMV_PEXEL_1	200	205	PF00026	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I468	Leptomonas seymouri	31%	100%
A0A3S7X9W1	Leishmania donovani	89%	100%
A4HNB3	Leishmania braziliensis	63%	100%
A4IBY5	Leishmania infantum	89%	100%
E9B6X4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%