Putative mitochondrial phosphate transporter

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial phosphate transporter, putative

Species:

Leishmania major

UniProt:

E9AFR9_LEIMA

TriTrypDb:

LmjF.35.4420 , LMJLV39_000009500 , LMJSD75_350051900

Length:

337

Annotations

LeishMANIAdb annotations

Forms a well-defined channel with 6 helices. Some paralogs tend to have an additional hydrophobic segment that might be a transit or signal peptide. It is unclear if the N-peptide is a signal or transit peptide. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0005739	mitochondrion	5	3
GO:0020023	kinetoplast	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	16
GO:0005743	mitochondrial inner membrane	5	13
GO:0016020	membrane	2	13
GO:0019866	organelle inner membrane	4	13
GO:0031090	organelle membrane	3	13
GO:0031966	mitochondrial membrane	4	13

Expansion

Sequence features

E9AFR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFR9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	16
GO:0006811	monoatomic ion transport	4	16
GO:0006817	phosphate ion transport	7	16
GO:0006820	monoatomic anion transport	5	16
GO:0009987	cellular process	1	16
GO:0015698	inorganic anion transport	6	16
GO:0034220	monoatomic ion transmembrane transport	3	16
GO:0035435	phosphate ion transmembrane transport	6	16
GO:0051179	localization	1	16
GO:0051234	establishment of localization	2	16
GO:0055085	transmembrane transport	2	16
GO:0098656	monoatomic anion transmembrane transport	4	16
GO:0098660	inorganic ion transmembrane transport	4	16
GO:0098661	inorganic anion transmembrane transport	5	16
GO:1990542	mitochondrial transmembrane transport	3	16
GO:1990547	mitochondrial phosphate ion transmembrane transport	4	16

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	16
GO:0005315	inorganic phosphate transmembrane transporter activity	4	16
GO:0015291	secondary active transmembrane transporter activity	4	16
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	16
GO:0022804	active transmembrane transporter activity	3	16
GO:0022857	transmembrane transporter activity	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	221	225	PF00082	0.409
CLV_PCSK_SKI1_1	327	331	PF00082	0.494
DOC_AGCK_PIF_2	123	128	PF00069	0.472
DOC_MAPK_gen_1	143	151	PF00069	0.542
DOC_MAPK_MEF2A_6	246	254	PF00069	0.424
DOC_PP4_FxxP_1	237	240	PF00568	0.460
DOC_USP7_MATH_1	190	194	PF00917	0.462
DOC_USP7_MATH_1	196	200	PF00917	0.401
DOC_USP7_MATH_1	20	24	PF00917	0.430
DOC_USP7_MATH_1	203	207	PF00917	0.201
DOC_USP7_MATH_1	265	269	PF00917	0.400
DOC_USP7_MATH_1	284	288	PF00917	0.597
DOC_WW_Pin1_4	175	180	PF00397	0.341
DOC_WW_Pin1_4	2	7	PF00397	0.469
DOC_WW_Pin1_4	76	81	PF00397	0.366
LIG_14-3-3_CanoR_1	22	32	PF00244	0.565
LIG_14-3-3_CanoR_1	82	87	PF00244	0.492
LIG_BRCT_BRCA1_1	155	159	PF00533	0.366
LIG_BRCT_BRCA1_1	198	202	PF00533	0.443
LIG_BRCT_BRCA1_1	250	254	PF00533	0.426
LIG_DLG_GKlike_1	82	90	PF00625	0.492
LIG_FHA_1	14	20	PF00498	0.581
LIG_FHA_1	183	189	PF00498	0.470
LIG_FHA_1	305	311	PF00498	0.454
LIG_LIR_Apic_2	33	39	PF02991	0.472
LIG_LIR_Gen_1	131	137	PF02991	0.366
LIG_LIR_Gen_1	158	168	PF02991	0.351
LIG_LIR_Gen_1	294	305	PF02991	0.461
LIG_LIR_Nem_3	127	132	PF02991	0.365
LIG_LIR_Nem_3	287	291	PF02991	0.471
LIG_LIR_Nem_3	294	300	PF02991	0.416
LIG_LIR_Nem_3	81	86	PF02991	0.340
LIG_PCNA_yPIPBox_3	95	109	PF02747	0.425
LIG_Pex14_1	32	36	PF04695	0.455
LIG_REV1ctd_RIR_1	221	231	PF16727	0.353
LIG_SH2_CRK	204	208	PF00017	0.481
LIG_SH2_CRK	233	237	PF00017	0.336
LIG_SH2_CRK	288	292	PF00017	0.438
LIG_SH2_CRK	297	301	PF00017	0.441
LIG_SH2_GRB2like	133	136	PF00017	0.366
LIG_SH2_GRB2like	297	300	PF00017	0.482
LIG_SH2_GRB2like	36	39	PF00017	0.506
LIG_SH2_NCK_1	244	248	PF00017	0.502
LIG_SH2_PTP2	36	39	PF00017	0.579
LIG_SH2_SRC	233	236	PF00017	0.431
LIG_SH2_SRC	36	39	PF00017	0.506
LIG_SH2_STAP1	133	137	PF00017	0.366
LIG_SH2_STAT3	115	118	PF00017	0.351
LIG_SH2_STAT5	128	131	PF00017	0.483
LIG_SH2_STAT5	217	220	PF00017	0.337
LIG_SH2_STAT5	235	238	PF00017	0.444
LIG_SH2_STAT5	258	261	PF00017	0.397
LIG_SH2_STAT5	36	39	PF00017	0.525
LIG_SH3_1	36	42	PF00018	0.480
LIG_SH3_3	264	270	PF00018	0.395
LIG_SH3_3	36	42	PF00018	0.480
LIG_SH3_4	239	246	PF00018	0.582
LIG_SUMO_SIM_par_1	307	314	PF11976	0.419
LIG_TRAF2_1	137	140	PF00917	0.546
MOD_CDC14_SPxK_1	79	82	PF00782	0.366
MOD_CDK_SPK_2	175	180	PF00069	0.434
MOD_CDK_SPxK_1	76	82	PF00069	0.366
MOD_CK1_1	23	29	PF00069	0.446
MOD_CK1_1	5	11	PF00069	0.590
MOD_GlcNHglycan	115	118	PF01048	0.500
MOD_GlcNHglycan	153	156	PF01048	0.344
MOD_GlcNHglycan	199	202	PF01048	0.487
MOD_GlcNHglycan	22	25	PF01048	0.631
MOD_GlcNHglycan	255	258	PF01048	0.379
MOD_GlcNHglycan	275	278	PF01048	0.457
MOD_GSK3_1	175	182	PF00069	0.363
MOD_GSK3_1	20	27	PF00069	0.437
MOD_N-GLC_2	299	301	PF02516	0.464
MOD_NEK2_1	151	156	PF00069	0.339
MOD_NEK2_1	168	173	PF00069	0.299
MOD_NEK2_1	250	255	PF00069	0.494
MOD_NEK2_1	311	316	PF00069	0.418
MOD_NEK2_1	332	337	PF00069	0.469
MOD_NEK2_2	190	195	PF00069	0.453
MOD_PIKK_1	24	30	PF00454	0.450
MOD_PIKK_1	245	251	PF00454	0.442
MOD_Plk_1	43	49	PF00069	0.535
MOD_Plk_4	203	209	PF00069	0.324
MOD_Plk_4	270	276	PF00069	0.438
MOD_Plk_4	43	49	PF00069	0.454
MOD_ProDKin_1	175	181	PF00069	0.341
MOD_ProDKin_1	2	8	PF00069	0.466
MOD_ProDKin_1	76	82	PF00069	0.366
MOD_SUMO_for_1	94	97	PF00179	0.452
TRG_ENDOCYTIC_2	126	129	PF00928	0.341
TRG_ENDOCYTIC_2	133	136	PF00928	0.332
TRG_ENDOCYTIC_2	145	148	PF00928	0.359
TRG_ENDOCYTIC_2	204	207	PF00928	0.492
TRG_ENDOCYTIC_2	233	236	PF00928	0.342
TRG_ENDOCYTIC_2	288	291	PF00928	0.451
TRG_ENDOCYTIC_2	297	300	PF00928	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3H8	Leptomonas seymouri	31%	69%
A0A0N1I993	Leptomonas seymouri	83%	100%
A0A0S4JBC4	Bodo saltans	38%	87%
A0A0S4JNX4	Bodo saltans	70%	99%
A0A0S4KJX8	Bodo saltans	26%	96%
A0A1X0P0K9	Trypanosomatidae	38%	100%
A0A1X0P561	Trypanosomatidae	75%	100%
A0A3S5IRV4	Trypanosoma rangeli	77%	100%
A0A3S7WP13	Leishmania donovani	31%	69%
A0A3S7X9V4	Leishmania donovani	97%	100%
A0A3S7X9Y0	Leishmania donovani	97%	100%
A0A422NF39	Trypanosoma rangeli	26%	100%
A4H474	Leishmania braziliensis	31%	68%
A4HNB1	Leishmania braziliensis	94%	100%
A4HNB2	Leishmania braziliensis	93%	100%
A4HSE9	Leishmania infantum	31%	69%
A4IBY2	Leishmania infantum	93%	100%
A4IBY3	Leishmania infantum	97%	100%
B0G143	Dictyostelium discoideum	25%	100%
C9ZYM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	100%
D0A4I3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	89%
E9AFS0	Leishmania major	99%	100%
E9AKD5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	69%
E9B6X2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O04619	Arabidopsis thaliana	25%	96%
O61703	Choristoneura fumiferana	51%	97%
P12234	Bos taurus	51%	93%
P16036	Rattus norvegicus	50%	95%
P16260	Homo sapiens	25%	100%
P23641	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	100%
P40035	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	100%
P40614	Caenorhabditis elegans	56%	99%
Q00325	Homo sapiens	50%	93%
Q01888	Bos taurus	26%	100%
Q03829	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	92%
Q29RM1	Bos taurus	25%	100%
Q4QJH3	Leishmania major	31%	69%
Q54BF6	Dictyostelium discoideum	40%	100%
Q5R7W2	Pongo abelii	51%	93%
Q7DNC3	Arabidopsis thaliana	40%	100%
Q8C0K5	Mus musculus	25%	100%
Q8VEM8	Mus musculus	51%	94%
Q9FI43	Arabidopsis thaliana	23%	69%
Q9FMU6	Arabidopsis thaliana	51%	90%
Q9M2Z8	Arabidopsis thaliana	49%	93%
Q9P7V8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	100%
V5BT68	Trypanosoma cruzi	76%	100%