Putative amino acid permease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amino acid permease, putative

Species:

Leishmania major

UniProt:

E9AFR8_LEIMA

TriTrypDb:

LmjF.35.4410 , LMJLV39_350052200 , LMJSD75_350051700

Length:

517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0000323	lytic vacuole	6	2
GO:0005764	lysosome	7	2
GO:0005773	vacuole	5	2
GO:0016020	membrane	2	24
GO:0020022	acidocalcisome	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	24

Expansion

Sequence features

E9AFR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFR8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0005215	transporter activity	1	24
GO:0015203	polyamine transmembrane transporter activity	3	24
GO:0016787	hydrolase activity	2	6
GO:0022857	transmembrane transporter activity	2	24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	201	203	PF00082	0.330
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.330
CLV_PCSK_SKI1_1	153	157	PF00082	0.327
CLV_PCSK_SKI1_1	201	205	PF00082	0.205
CLV_PCSK_SKI1_1	32	36	PF00082	0.232
DEG_Nend_UBRbox_3	1	3	PF02207	0.608
DEG_SCF_FBW7_1	1	8	PF00400	0.604
DOC_CKS1_1	2	7	PF01111	0.606
DOC_CKS1_1	347	352	PF01111	0.417
DOC_CYCLIN_yCln2_LP_2	402	408	PF00134	0.425
DOC_MAPK_MEF2A_6	12	20	PF00069	0.558
DOC_MAPK_MEF2A_6	60	68	PF00069	0.205
DOC_MAPK_RevD_3	186	202	PF00069	0.210
DOC_PP1_RVXF_1	151	157	PF00149	0.282
DOC_PP2B_LxvP_1	192	195	PF13499	0.321
DOC_PP2B_PxIxI_1	507	513	PF00149	0.672
DOC_PP4_FxxP_1	20	23	PF00568	0.538
DOC_USP7_MATH_1	106	110	PF00917	0.271
DOC_USP7_MATH_1	264	268	PF00917	0.339
DOC_USP7_MATH_1	317	321	PF00917	0.448
DOC_USP7_MATH_1	331	335	PF00917	0.421
DOC_USP7_MATH_1	452	456	PF00917	0.366
DOC_USP7_MATH_1	478	482	PF00917	0.652
DOC_USP7_MATH_1	5	9	PF00917	0.703
DOC_USP7_MATH_1	92	96	PF00917	0.428
DOC_USP7_UBL2_3	338	342	PF12436	0.405
DOC_WW_Pin1_4	1	6	PF00397	0.669
DOC_WW_Pin1_4	12	17	PF00397	0.517
DOC_WW_Pin1_4	19	24	PF00397	0.422
DOC_WW_Pin1_4	291	296	PF00397	0.321
DOC_WW_Pin1_4	346	351	PF00397	0.417
LIG_14-3-3_CanoR_1	19	23	PF00244	0.525
LIG_14-3-3_CanoR_1	202	206	PF00244	0.473
LIG_14-3-3_CanoR_1	396	400	PF00244	0.521
LIG_14-3-3_CanoR_1	500	504	PF00244	0.575
LIG_Actin_WH2_2	369	386	PF00022	0.256
LIG_BRCT_BRCA1_1	463	467	PF00533	0.478
LIG_Clathr_ClatBox_1	373	377	PF01394	0.313
LIG_deltaCOP1_diTrp_1	211	216	PF00928	0.444
LIG_deltaCOP1_diTrp_1	277	284	PF00928	0.201
LIG_eIF4E_1	442	448	PF01652	0.401
LIG_FHA_1	117	123	PF00498	0.235
LIG_FHA_1	2	8	PF00498	0.644
LIG_FHA_1	297	303	PF00498	0.306
LIG_FHA_1	306	312	PF00498	0.251
LIG_FHA_1	35	41	PF00498	0.299
LIG_FHA_1	359	365	PF00498	0.238
LIG_FHA_1	396	402	PF00498	0.505
LIG_FHA_1	44	50	PF00498	0.325
LIG_FHA_1	449	455	PF00498	0.332
LIG_FHA_2	483	489	PF00498	0.587
LIG_FHA_2	500	506	PF00498	0.637
LIG_LIR_Apic_2	257	261	PF02991	0.278
LIG_LIR_Apic_2	344	350	PF02991	0.469
LIG_LIR_Apic_2	403	409	PF02991	0.421
LIG_LIR_Gen_1	109	117	PF02991	0.260
LIG_LIR_Gen_1	209	220	PF02991	0.469
LIG_LIR_Gen_1	281	291	PF02991	0.270
LIG_LIR_Gen_1	369	376	PF02991	0.278
LIG_LIR_Gen_1	390	400	PF02991	0.327
LIG_LIR_Gen_1	424	432	PF02991	0.294
LIG_LIR_Gen_1	455	462	PF02991	0.385
LIG_LIR_Nem_3	109	113	PF02991	0.259
LIG_LIR_Nem_3	115	121	PF02991	0.271
LIG_LIR_Nem_3	128	133	PF02991	0.235
LIG_LIR_Nem_3	209	215	PF02991	0.436
LIG_LIR_Nem_3	281	287	PF02991	0.258
LIG_LIR_Nem_3	369	373	PF02991	0.223
LIG_LIR_Nem_3	390	395	PF02991	0.345
LIG_LIR_Nem_3	424	428	PF02991	0.302
LIG_LIR_Nem_3	455	459	PF02991	0.275
LIG_LIR_Nem_3	481	486	PF02991	0.613
LIG_LIR_Nem_3	491	497	PF02991	0.577
LIG_LYPXL_S_1	129	133	PF13949	0.449
LIG_LYPXL_yS_3	130	133	PF13949	0.241
LIG_NRBOX	65	71	PF00104	0.197
LIG_PDZ_Class_2	512	517	PF00595	0.566
LIG_Pex14_1	212	216	PF04695	0.365
LIG_Pex14_1	279	283	PF04695	0.229
LIG_Pex14_1	339	343	PF04695	0.448
LIG_Pex14_2	142	146	PF04695	0.401
LIG_Pex14_2	186	190	PF04695	0.256
LIG_Pex14_2	332	336	PF04695	0.492
LIG_PTB_Apo_2	124	131	PF02174	0.228
LIG_PTB_Apo_2	237	244	PF02174	0.464
LIG_PTB_Phospho_1	124	130	PF10480	0.241
LIG_REV1ctd_RIR_1	333	342	PF16727	0.516
LIG_REV1ctd_RIR_1	459	467	PF16727	0.505
LIG_SH2_CRK	347	351	PF00017	0.446
LIG_SH2_CRK	406	410	PF00017	0.419
LIG_SH2_CRK	442	446	PF00017	0.393
LIG_SH2_CRK	483	487	PF00017	0.590
LIG_SH2_NCK_1	475	479	PF00017	0.623
LIG_SH2_PTP2	258	261	PF00017	0.288
LIG_SH2_PTP2	456	459	PF00017	0.401
LIG_SH2_SRC	258	261	PF00017	0.278
LIG_SH2_SRC	475	478	PF00017	0.597
LIG_SH2_STAP1	343	347	PF00017	0.503
LIG_SH2_STAP1	381	385	PF00017	0.285
LIG_SH2_STAP1	442	446	PF00017	0.415
LIG_SH2_STAP1	45	49	PF00017	0.300
LIG_SH2_STAT5	137	140	PF00017	0.236
LIG_SH2_STAT5	205	208	PF00017	0.429
LIG_SH2_STAT5	258	261	PF00017	0.269
LIG_SH2_STAT5	45	48	PF00017	0.279
LIG_SH2_STAT5	456	459	PF00017	0.278
LIG_SH3_3	233	239	PF00018	0.422
LIG_SH3_3	25	31	PF00018	0.702
LIG_SUMO_SIM_anti_2	36	42	PF11976	0.248
LIG_SUMO_SIM_anti_2	443	449	PF11976	0.358
LIG_SUMO_SIM_anti_2	67	72	PF11976	0.387
LIG_SUMO_SIM_par_1	384	391	PF11976	0.385
LIG_TYR_ITIM	440	445	PF00017	0.363
LIG_TYR_ITIM	454	459	PF00017	0.217
LIG_UBA3_1	385	394	PF00899	0.305
LIG_WRC_WIRS_1	332	337	PF05994	0.504
LIG_WRC_WIRS_1	389	394	PF05994	0.369
LIG_WW_3	506	510	PF00397	0.673
MOD_CDK_SPK_2	19	24	PF00069	0.602
MOD_CDK_SPxxK_3	12	19	PF00069	0.558
MOD_CK1_1	109	115	PF00069	0.391
MOD_CK1_1	272	278	PF00069	0.285
MOD_CK1_1	334	340	PF00069	0.475
MOD_CK1_1	455	461	PF00069	0.331
MOD_CK2_1	467	473	PF00069	0.558
MOD_CK2_1	482	488	PF00069	0.558
MOD_DYRK1A_RPxSP_1	12	16	PF00069	0.609
MOD_GlcNHglycan	12	15	PF01048	0.430
MOD_GlcNHglycan	148	151	PF01048	0.292
MOD_GlcNHglycan	223	226	PF01048	0.258
MOD_GlcNHglycan	227	230	PF01048	0.258
MOD_GlcNHglycan	266	269	PF01048	0.422
MOD_GlcNHglycan	425	428	PF01048	0.318
MOD_GlcNHglycan	49	52	PF01048	0.290
MOD_GSK3_1	1	8	PF00069	0.665
MOD_GSK3_1	112	119	PF00069	0.263
MOD_GSK3_1	121	128	PF00069	0.244
MOD_GSK3_1	221	228	PF00069	0.418
MOD_GSK3_1	311	318	PF00069	0.270
MOD_GSK3_1	358	365	PF00069	0.292
MOD_GSK3_1	43	50	PF00069	0.268
MOD_GSK3_1	448	455	PF00069	0.356
MOD_GSK3_1	478	485	PF00069	0.635
MOD_N-GLC_1	221	226	PF02516	0.250
MOD_N-GLC_1	356	361	PF02516	0.265
MOD_NEK2_1	179	184	PF00069	0.253
MOD_NEK2_1	296	301	PF00069	0.297
MOD_NEK2_1	311	316	PF00069	0.244
MOD_NEK2_1	355	360	PF00069	0.313
MOD_NEK2_1	366	371	PF00069	0.299
MOD_NEK2_1	395	400	PF00069	0.478
MOD_NEK2_1	432	437	PF00069	0.338
MOD_NEK2_1	441	446	PF00069	0.294
MOD_NEK2_1	467	472	PF00069	0.569
MOD_NEK2_1	55	60	PF00069	0.225
MOD_NEK2_1	6	11	PF00069	0.641
MOD_NEK2_2	137	142	PF00069	0.401
MOD_OFUCOSY	85	91	PF10250	0.232
MOD_PIKK_1	395	401	PF00454	0.521
MOD_PKA_1	201	207	PF00069	0.385
MOD_PKA_2	18	24	PF00069	0.544
MOD_PKA_2	201	207	PF00069	0.488
MOD_PKA_2	395	401	PF00069	0.492
MOD_PKA_2	499	505	PF00069	0.592
MOD_Plk_1	125	131	PF00069	0.216
MOD_Plk_1	356	362	PF00069	0.273
MOD_Plk_1	478	484	PF00069	0.544
MOD_Plk_1	55	61	PF00069	0.194
MOD_Plk_4	106	112	PF00069	0.278
MOD_Plk_4	125	131	PF00069	0.205
MOD_Plk_4	137	143	PF00069	0.288
MOD_Plk_4	166	172	PF00069	0.339
MOD_Plk_4	239	245	PF00069	0.425
MOD_Plk_4	254	260	PF00069	0.215
MOD_Plk_4	296	302	PF00069	0.314
MOD_Plk_4	311	317	PF00069	0.240
MOD_Plk_4	331	337	PF00069	0.394
MOD_Plk_4	36	42	PF00069	0.249
MOD_Plk_4	369	375	PF00069	0.264
MOD_Plk_4	388	394	PF00069	0.161
MOD_Plk_4	441	447	PF00069	0.295
MOD_Plk_4	452	458	PF00069	0.269
MOD_Plk_4	467	473	PF00069	0.497
MOD_Plk_4	482	488	PF00069	0.569
MOD_Plk_4	499	505	PF00069	0.641
MOD_Plk_4	64	70	PF00069	0.270
MOD_ProDKin_1	1	7	PF00069	0.667
MOD_ProDKin_1	12	18	PF00069	0.506
MOD_ProDKin_1	19	25	PF00069	0.425
MOD_ProDKin_1	291	297	PF00069	0.321
MOD_ProDKin_1	346	352	PF00069	0.417
TRG_DiLeu_BaLyEn_6	381	386	PF01217	0.321
TRG_DiLeu_BaLyEn_6	397	402	PF01217	0.464
TRG_DiLeu_BaLyEn_6	492	497	PF01217	0.512
TRG_DiLeu_BaLyEn_6	61	66	PF01217	0.266
TRG_ENDOCYTIC_2	130	133	PF00928	0.235
TRG_ENDOCYTIC_2	442	445	PF00928	0.349
TRG_ENDOCYTIC_2	456	459	PF00928	0.270
TRG_ENDOCYTIC_2	483	486	PF00928	0.574
TRG_ER_FFAT_1	470	481	PF00635	0.524
TRG_Pf-PMV_PEXEL_1	495	499	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2T0	Leptomonas seymouri	36%	89%
A0A0N1PGN1	Leptomonas seymouri	81%	99%
A0A0S4IJF6	Bodo saltans	27%	89%
A0A0S4ISA5	Bodo saltans	27%	89%
A0A0S4JBT0	Bodo saltans	27%	100%
A0A1X0NNQ0	Trypanosomatidae	35%	82%
A0A1X0NV66	Trypanosomatidae	34%	99%
A0A1X0P501	Trypanosomatidae	67%	95%
A0A3R7M6P3	Trypanosoma rangeli	34%	84%
A0A3R7N0T9	Trypanosoma rangeli	36%	100%
A0A3S5IRV3	Trypanosoma rangeli	66%	100%
A0A3S7WRN2	Leishmania donovani	35%	100%
A0A3S7XA01	Leishmania donovani	97%	100%
A2X8M8	Oryza sativa subsp. indica	30%	97%
A4H6H7	Leishmania braziliensis	35%	100%
A4H7J1	Leishmania braziliensis	35%	69%
A4HNB0	Leishmania braziliensis	83%	100%
A4HUW5	Leishmania infantum	35%	100%
A4IBY1	Leishmania infantum	97%	100%
C9ZYM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
D0A7J0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ANJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B6X1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
P37034	Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)	26%	100%
Q4QH28	Leishmania major	36%	100%
Q6Z8D0	Oryza sativa subsp. japonica	30%	97%
Q9C6S4	Arabidopsis thaliana	30%	100%
Q9C6S5	Arabidopsis thaliana	30%	100%
Q9FFL1	Arabidopsis thaliana	31%	100%
Q9LH39	Arabidopsis thaliana	31%	100%
Q9LHN7	Arabidopsis thaliana	30%	100%
V5BCQ1	Trypanosoma cruzi	70%	100%
V5DDZ5	Trypanosoma cruzi	34%	82%