TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TAX-1

Species:

Leishmania major

UniProt:

E9AFR6_LEIMA

TriTrypDb:

LmjF.35.4390 , LMJLV39_350052000 , LMJSD75_350051500

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AFR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFR6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004427	inorganic diphosphate phosphatase activity	6	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	262	264	PF00675	0.456
CLV_PCSK_KEX2_1	147	149	PF00082	0.504
CLV_PCSK_KEX2_1	262	264	PF00082	0.431
CLV_PCSK_KEX2_1	313	315	PF00082	0.586
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.504
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.586
CLV_PCSK_PC7_1	309	315	PF00082	0.564
CLV_PCSK_SKI1_1	143	147	PF00082	0.464
CLV_PCSK_SKI1_1	213	217	PF00082	0.477
CLV_PCSK_SKI1_1	344	348	PF00082	0.445
CLV_PCSK_SKI1_1	99	103	PF00082	0.399
DEG_SCF_FBW7_1	6	12	PF00400	0.509
DOC_CKS1_1	6	11	PF01111	0.508
DOC_CKS1_1	63	68	PF01111	0.539
DOC_CYCLIN_yCln2_LP_2	132	138	PF00134	0.322
DOC_MAPK_gen_1	123	132	PF00069	0.484
DOC_MAPK_gen_1	262	270	PF00069	0.438
DOC_MAPK_HePTP_8	162	174	PF00069	0.491
DOC_MAPK_MEF2A_6	112	120	PF00069	0.503
DOC_MAPK_MEF2A_6	165	174	PF00069	0.462
DOC_MAPK_MEF2A_6	262	270	PF00069	0.438
DOC_MAPK_MEF2A_6	324	333	PF00069	0.339
DOC_PP4_FxxP_1	124	127	PF00568	0.477
DOC_PP4_FxxP_1	356	359	PF00568	0.526
DOC_USP7_MATH_1	187	191	PF00917	0.489
DOC_USP7_MATH_1	230	234	PF00917	0.440
DOC_USP7_MATH_1	298	302	PF00917	0.386
DOC_USP7_MATH_1	318	322	PF00917	0.504
DOC_USP7_UBL2_3	143	147	PF12436	0.498
DOC_WW_Pin1_4	273	278	PF00397	0.592
DOC_WW_Pin1_4	5	10	PF00397	0.657
DOC_WW_Pin1_4	62	67	PF00397	0.523
LIG_14-3-3_CanoR_1	201	205	PF00244	0.449
LIG_14-3-3_CanoR_1	213	222	PF00244	0.327
LIG_14-3-3_CanoR_1	271	277	PF00244	0.423
LIG_14-3-3_CanoR_1	314	323	PF00244	0.443
LIG_14-3-3_CanoR_1	350	359	PF00244	0.441
LIG_BIR_II_1	1	5	PF00653	0.620
LIG_BRCT_BRCA1_1	1	5	PF00533	0.463
LIG_BRCT_BRCA1_1	352	356	PF00533	0.436
LIG_deltaCOP1_diTrp_1	368	374	PF00928	0.385
LIG_FHA_1	169	175	PF00498	0.400
LIG_FHA_1	201	207	PF00498	0.321
LIG_FHA_2	334	340	PF00498	0.505
LIG_FHA_2	379	385	PF00498	0.652
LIG_FHA_2	397	403	PF00498	0.639
LIG_FHA_2	6	12	PF00498	0.547
LIG_LIR_Apic_2	122	127	PF02991	0.479
LIG_LIR_Apic_2	353	359	PF02991	0.527
LIG_LIR_Gen_1	203	212	PF02991	0.339
LIG_LIR_Gen_1	217	227	PF02991	0.363
LIG_LIR_Gen_1	246	257	PF02991	0.450
LIG_LIR_Gen_1	53	63	PF02991	0.380
LIG_LIR_Nem_3	2	6	PF02991	0.706
LIG_LIR_Nem_3	203	208	PF02991	0.334
LIG_LIR_Nem_3	217	222	PF02991	0.358
LIG_LIR_Nem_3	246	252	PF02991	0.442
LIG_LIR_Nem_3	48	52	PF02991	0.425
LIG_LIR_Nem_3	53	59	PF02991	0.352
LIG_LYPXL_yS_3	3	6	PF13949	0.480
LIG_Pex14_1	370	374	PF04695	0.380
LIG_SH2_CRK	241	245	PF00017	0.329
LIG_SH2_GRB2like	378	381	PF00017	0.524
LIG_SH2_PTP2	161	164	PF00017	0.477
LIG_SH2_STAP1	249	253	PF00017	0.490
LIG_SH2_STAT5	136	139	PF00017	0.338
LIG_SH2_STAT5	161	164	PF00017	0.469
LIG_SH2_STAT5	205	208	PF00017	0.345
LIG_SH2_STAT5	221	224	PF00017	0.251
LIG_SH3_3	356	362	PF00018	0.535
LIG_SUMO_SIM_anti_2	57	65	PF11976	0.532
LIG_TRAF2_1	277	280	PF00917	0.591
LIG_TRAF2_1	94	97	PF00917	0.469
LIG_TYR_ITIM	247	252	PF00017	0.415
LIG_WRC_WIRS_1	216	221	PF05994	0.335
MOD_CK1_1	200	206	PF00069	0.456
MOD_CK1_1	273	279	PF00069	0.488
MOD_CK1_1	28	34	PF00069	0.591
MOD_CK2_1	187	193	PF00069	0.480
MOD_CK2_1	333	339	PF00069	0.454
MOD_CK2_1	378	384	PF00069	0.601
MOD_CK2_1	389	395	PF00069	0.464
MOD_GlcNHglycan	27	30	PF01048	0.521
MOD_GlcNHglycan	316	319	PF01048	0.509
MOD_GlcNHglycan	390	394	PF01048	0.577
MOD_GlcNHglycan	84	87	PF01048	0.475
MOD_GSK3_1	14	21	PF00069	0.686
MOD_GSK3_1	200	207	PF00069	0.339
MOD_GSK3_1	314	321	PF00069	0.444
MOD_GSK3_1	374	381	PF00069	0.489
MOD_GSK3_1	389	396	PF00069	0.596
MOD_GSK3_1	5	12	PF00069	0.708
MOD_GSK3_1	71	78	PF00069	0.577
MOD_N-GLC_1	25	30	PF02516	0.485
MOD_N-GLC_1	45	50	PF02516	0.572
MOD_NEK2_1	137	142	PF00069	0.332
MOD_NEK2_1	394	399	PF00069	0.471
MOD_PIKK_1	350	356	PF00454	0.416
MOD_PIKK_1	37	43	PF00454	0.552
MOD_PKA_2	200	206	PF00069	0.417
MOD_PKA_2	270	276	PF00069	0.424
MOD_PKA_2	75	81	PF00069	0.546
MOD_PKB_1	80	88	PF00069	0.531
MOD_Plk_1	168	174	PF00069	0.440
MOD_Plk_1	37	43	PF00069	0.599
MOD_Plk_1	374	380	PF00069	0.527
MOD_Plk_1	389	395	PF00069	0.620
MOD_Plk_1	45	51	PF00069	0.436
MOD_Plk_4	200	206	PF00069	0.324
MOD_ProDKin_1	273	279	PF00069	0.590
MOD_ProDKin_1	5	11	PF00069	0.658
MOD_ProDKin_1	62	68	PF00069	0.532
TRG_DiLeu_BaEn_1	58	63	PF01217	0.377
TRG_DiLeu_BaEn_1	97	102	PF01217	0.414
TRG_ENDOCYTIC_2	136	139	PF00928	0.338
TRG_ENDOCYTIC_2	161	164	PF00928	0.477
TRG_ENDOCYTIC_2	205	208	PF00928	0.344
TRG_ENDOCYTIC_2	221	224	PF00928	0.256
TRG_ENDOCYTIC_2	241	244	PF00928	0.334
TRG_ENDOCYTIC_2	249	252	PF00928	0.341
TRG_ENDOCYTIC_2	3	6	PF00928	0.558
TRG_ER_diArg_1	118	121	PF00400	0.455
TRG_ER_diArg_1	80	83	PF00400	0.509
TRG_Pf-PMV_PEXEL_1	99	104	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P968	Leptomonas seymouri	75%	100%
A0A0S4JSR6	Bodo saltans	45%	70%
A0A1X0P6F9	Trypanosomatidae	57%	100%
A0A3R7KSW5	Trypanosoma rangeli	54%	100%
A0A3S7X9V3	Leishmania donovani	94%	100%
A4HNA8	Leishmania braziliensis	80%	100%
A4IBX9	Leishmania infantum	94%	100%
C9ZYM8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9B6W9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q9H0C1	Homo sapiens	27%	100%
V5BXU3	Trypanosoma cruzi	54%	100%