LisH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFR5_LEIMA

TriTrypDb:

LmjF.35.4380 , LMJLV39_350051900 , LMJSD75_350051300 , LMJSD75_350051400

Length:

495

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFR5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFR5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.682
CLV_NRD_NRD_1	154	156	PF00675	0.725
CLV_NRD_NRD_1	208	210	PF00675	0.746
CLV_NRD_NRD_1	262	264	PF00675	0.735
CLV_NRD_NRD_1	41	43	PF00675	0.672
CLV_NRD_NRD_1	70	72	PF00675	0.680
CLV_PCSK_KEX2_1	126	128	PF00082	0.703
CLV_PCSK_KEX2_1	180	182	PF00082	0.763
CLV_PCSK_KEX2_1	234	236	PF00082	0.754
CLV_PCSK_KEX2_1	288	290	PF00082	0.709
CLV_PCSK_KEX2_1	317	319	PF00082	0.747
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.703
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.763
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.754
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.709
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.747
CLV_PCSK_SKI1_1	122	126	PF00082	0.649
CLV_PCSK_SKI1_1	135	139	PF00082	0.647
CLV_PCSK_SKI1_1	176	180	PF00082	0.677
CLV_PCSK_SKI1_1	230	234	PF00082	0.623
CLV_PCSK_SKI1_1	284	288	PF00082	0.654
CLV_PCSK_SKI1_1	36	40	PF00082	0.576
CLV_Separin_Metazoa	260	264	PF03568	0.714
CLV_Separin_Metazoa	68	72	PF03568	0.716
DEG_SPOP_SBC_1	110	114	PF00917	0.698
DEG_SPOP_SBC_1	164	168	PF00917	0.754
DEG_SPOP_SBC_1	218	222	PF00917	0.763
DEG_SPOP_SBC_1	272	276	PF00917	0.701
DOC_CKS1_1	476	481	PF01111	0.817
DOC_MAPK_MEF2A_6	468	476	PF00069	0.741
DOC_PP2B_LxvP_1	3	6	PF13499	0.588
DOC_USP7_MATH_1	110	114	PF00917	0.698
DOC_USP7_MATH_1	164	168	PF00917	0.754
DOC_USP7_MATH_1	218	222	PF00917	0.763
DOC_USP7_MATH_1	272	276	PF00917	0.701
DOC_USP7_MATH_1	339	343	PF00917	0.757
DOC_USP7_MATH_1	59	63	PF00917	0.810
DOC_USP7_UBL2_3	102	106	PF12436	0.636
DOC_USP7_UBL2_3	122	126	PF12436	0.712
DOC_USP7_UBL2_3	135	139	PF12436	0.664
DOC_USP7_UBL2_3	156	160	PF12436	0.730
DOC_USP7_UBL2_3	176	180	PF12436	0.776
DOC_USP7_UBL2_3	185	189	PF12436	0.697
DOC_USP7_UBL2_3	210	214	PF12436	0.735
DOC_USP7_UBL2_3	230	234	PF12436	0.846
DOC_USP7_UBL2_3	239	243	PF12436	0.724
DOC_USP7_UBL2_3	264	268	PF12436	0.748
DOC_USP7_UBL2_3	284	288	PF12436	0.769
DOC_USP7_UBL2_3	72	76	PF12436	0.704
DOC_USP7_UBL2_3	77	81	PF12436	0.657
DOC_WW_Pin1_4	126	131	PF00397	0.696
DOC_WW_Pin1_4	180	185	PF00397	0.754
DOC_WW_Pin1_4	234	239	PF00397	0.748
DOC_WW_Pin1_4	288	293	PF00397	0.705
DOC_WW_Pin1_4	475	480	PF00397	0.723
DOC_WW_Pin1_4	76	81	PF00397	0.738
LIG_14-3-3_CanoR_1	22	30	PF00244	0.559
LIG_14-3-3_CanoR_1	484	489	PF00244	0.658
LIG_BIR_II_1	1	5	PF00653	0.635
LIG_FHA_1	44	50	PF00498	0.595
LIG_FHA_1	476	482	PF00498	0.815
LIG_SH2_NCK_1	23	27	PF00017	0.629
LIG_SH2_STAP1	23	27	PF00017	0.629
LIG_SH2_STAT5	15	18	PF00017	0.495
LIG_SH2_STAT5	23	26	PF00017	0.529
LIG_SH3_3	117	123	PF00018	0.788
LIG_SH3_3	151	157	PF00018	0.809
LIG_SH3_3	171	177	PF00018	0.801
LIG_SH3_3	205	211	PF00018	0.817
LIG_SH3_3	225	231	PF00018	0.827
LIG_SH3_3	259	265	PF00018	0.813
LIG_SH3_3	279	285	PF00018	0.791
LIG_SH3_3	67	73	PF00018	0.661
LIG_SH3_3	97	103	PF00018	0.783
LIG_SH3_4	102	109	PF00018	0.595
LIG_SH3_4	122	129	PF00018	0.699
LIG_SH3_4	156	163	PF00018	0.767
LIG_SH3_4	176	183	PF00018	0.817
LIG_SH3_4	185	192	PF00018	0.704
LIG_SH3_4	210	217	PF00018	0.777
LIG_SH3_4	230	237	PF00018	0.752
LIG_SH3_4	239	246	PF00018	0.642
LIG_SH3_4	264	271	PF00018	0.828
LIG_SH3_4	284	291	PF00018	0.705
LIG_SH3_4	72	79	PF00018	0.828
LIG_TRAF2_1	114	117	PF00917	0.697
LIG_TRAF2_1	168	171	PF00917	0.694
LIG_TRAF2_1	222	225	PF00917	0.700
LIG_TRAF2_1	276	279	PF00917	0.647
LIG_TRAF2_1	29	32	PF00917	0.565
MOD_CDK_SPK_2	126	131	PF00069	0.696
MOD_CDK_SPK_2	180	185	PF00069	0.754
MOD_CDK_SPK_2	234	239	PF00069	0.748
MOD_CDK_SPK_2	288	293	PF00069	0.705
MOD_CDK_SPK_2	76	81	PF00069	0.738
MOD_CK1_1	21	27	PF00069	0.528
MOD_CK1_1	342	348	PF00069	0.753
MOD_CK1_1	47	53	PF00069	0.661
MOD_CK1_1	477	483	PF00069	0.729
MOD_CK1_1	62	68	PF00069	0.530
MOD_CK2_1	110	116	PF00069	0.697
MOD_CK2_1	164	170	PF00069	0.751
MOD_CK2_1	218	224	PF00069	0.759
MOD_CK2_1	272	278	PF00069	0.699
MOD_CK2_1	303	309	PF00069	0.617
MOD_CK2_1	332	338	PF00069	0.768
MOD_CK2_1	62	68	PF00069	0.670
MOD_GlcNHglycan	24	27	PF01048	0.548
MOD_GlcNHglycan	46	49	PF01048	0.582
MOD_GSK3_1	122	129	PF00069	0.683
MOD_GSK3_1	176	183	PF00069	0.746
MOD_GSK3_1	18	25	PF00069	0.583
MOD_GSK3_1	230	237	PF00069	0.725
MOD_GSK3_1	284	291	PF00069	0.689
MOD_GSK3_1	334	341	PF00069	0.847
MOD_GSK3_1	43	50	PF00069	0.659
MOD_GSK3_1	480	487	PF00069	0.805
MOD_N-GLC_1	342	347	PF02516	0.802
MOD_N-GLC_1	484	489	PF02516	0.711
MOD_NEK2_1	18	23	PF00069	0.501
MOD_PK_1	484	490	PF00069	0.642
MOD_PKA_2	21	27	PF00069	0.523
MOD_Plk_1	484	490	PF00069	0.712
MOD_Plk_2-3	111	117	PF00069	0.691
MOD_Plk_2-3	145	151	PF00069	0.690
MOD_Plk_2-3	165	171	PF00069	0.714
MOD_Plk_2-3	199	205	PF00069	0.738
MOD_Plk_2-3	219	225	PF00069	0.759
MOD_Plk_2-3	253	259	PF00069	0.727
MOD_Plk_2-3	273	279	PF00069	0.695
MOD_Plk_2-3	303	309	PF00069	0.738
MOD_Plk_2-3	91	97	PF00069	0.734
MOD_ProDKin_1	126	132	PF00069	0.695
MOD_ProDKin_1	180	186	PF00069	0.752
MOD_ProDKin_1	234	240	PF00069	0.749
MOD_ProDKin_1	288	294	PF00069	0.701
MOD_ProDKin_1	475	481	PF00069	0.721
MOD_ProDKin_1	76	82	PF00069	0.738
MOD_SUMO_for_1	6	9	PF00179	0.531
TRG_ENDOCYTIC_2	15	18	PF00928	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X9Y7	Leishmania donovani	66%	77%
A4HNA7	Leishmania braziliensis	57%	94%
A4IBX8	Leishmania infantum	71%	87%
C9ZYM9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	89%
E9B6W8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	90%