LeishMANIAdb
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zf-3CxxC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
zf-3CxxC domain-containing protein
Gene product:
Zinc-binding domain containing protein, putative
Species:
Leishmania major
UniProt:
E9AFR4_LEIMA
TriTrypDb:
LmjF.35.4370 , LMJLV39_350051800 , LMJSD75_350051200
Length:
114

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFR4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFR4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 97 99 PF00675 0.596
CLV_PCSK_KEX2_1 24 26 PF00082 0.365
CLV_PCSK_KEX2_1 88 90 PF00082 0.641
CLV_PCSK_PC1ET2_1 24 26 PF00082 0.348
CLV_PCSK_PC1ET2_1 88 90 PF00082 0.676
CLV_PCSK_SKI1_1 98 102 PF00082 0.542
DEG_Nend_Nbox_1 1 3 PF02207 0.553
DOC_CKS1_1 16 21 PF01111 0.479
DOC_MAPK_MEF2A_6 3 10 PF00069 0.463
DOC_MAPK_NFAT4_5 3 11 PF00069 0.464
DOC_PP1_RVXF_1 11 18 PF00149 0.505
DOC_PP4_FxxP_1 17 20 PF00568 0.483
DOC_USP7_UBL2_3 24 28 PF12436 0.348
DOC_WW_Pin1_4 15 20 PF00397 0.489
DOC_WW_Pin1_4 80 85 PF00397 0.565
LIG_14-3-3_CanoR_1 3 7 PF00244 0.622
LIG_DCNL_PONY_1 1 4 PF03556 0.593
LIG_FHA_1 47 53 PF00498 0.504
LIG_NRBOX 3 9 PF00104 0.486
LIG_SH2_STAT5 69 72 PF00017 0.444
LIG_SH3_3 67 73 PF00018 0.618
MOD_CK1_1 37 43 PF00069 0.456
MOD_CK1_1 57 63 PF00069 0.463
MOD_CK1_1 93 99 PF00069 0.572
MOD_CK2_1 91 97 PF00069 0.654
MOD_DYRK1A_RPxSP_1 80 84 PF00069 0.552
MOD_GSK3_1 57 64 PF00069 0.470
MOD_GSK3_1 89 96 PF00069 0.623
MOD_NEK2_1 100 105 PF00069 0.549
MOD_NEK2_1 2 7 PF00069 0.575
MOD_NEK2_2 73 78 PF00069 0.549
MOD_PIKK_1 46 52 PF00454 0.448
MOD_PKA_2 2 8 PF00069 0.673
MOD_Plk_1 73 79 PF00069 0.552
MOD_Plk_4 2 8 PF00069 0.553
MOD_Plk_4 34 40 PF00069 0.499
MOD_Plk_4 73 79 PF00069 0.517
MOD_ProDKin_1 15 21 PF00069 0.482
MOD_ProDKin_1 80 86 PF00069 0.567
MOD_SUMO_rev_2 92 100 PF00179 0.601
TRG_ER_diArg_1 10 13 PF00400 0.499

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3J4 Leptomonas seymouri 78% 99%
A0A0S4JPM7 Bodo saltans 64% 100%
A0A3Q8IJH3 Leishmania donovani 96% 100%
A4HNA6 Leishmania braziliensis 93% 100%
A4IBX7 Leishmania infantum 96% 100%
C9ZYN0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 73% 100%
E9B6W7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS