Pre-RNA processing PIH1/Nop17-domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-RNA processing PIH1/Nop17, putative

Species:

Leishmania major

UniProt:

E9AFR0_LEIMA

TriTrypDb:

LmjF.35.4330 , LMJLV39_350051400 , LMJSD75_350050800

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AFR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFR0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	358	362	PF00656	0.521
CLV_NRD_NRD_1	181	183	PF00675	0.362
CLV_NRD_NRD_1	349	351	PF00675	0.364
CLV_NRD_NRD_1	411	413	PF00675	0.282
CLV_NRD_NRD_1	468	470	PF00675	0.571
CLV_NRD_NRD_1	480	482	PF00675	0.443
CLV_NRD_NRD_1	520	522	PF00675	0.521
CLV_NRD_NRD_1	557	559	PF00675	0.679
CLV_PCSK_KEX2_1	181	183	PF00082	0.381
CLV_PCSK_KEX2_1	311	313	PF00082	0.631
CLV_PCSK_KEX2_1	349	351	PF00082	0.335
CLV_PCSK_KEX2_1	468	470	PF00082	0.608
CLV_PCSK_KEX2_1	480	482	PF00082	0.624
CLV_PCSK_KEX2_1	50	52	PF00082	0.568
CLV_PCSK_KEX2_1	520	522	PF00082	0.561
CLV_PCSK_KEX2_1	599	601	PF00082	0.730
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.640
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.637
CLV_PCSK_PC1ET2_1	599	601	PF00082	0.730
CLV_PCSK_PC7_1	345	351	PF00082	0.362
CLV_PCSK_SKI1_1	438	442	PF00082	0.622
CLV_PCSK_SKI1_1	629	633	PF00082	0.545
CLV_PCSK_SKI1_1	68	72	PF00082	0.334
DEG_APCC_DBOX_1	507	515	PF00400	0.515
DEG_APCC_KENBOX_2	319	323	PF00400	0.480
DEG_Nend_UBRbox_3	1	3	PF02207	0.656
DEG_SIAH_1	579	587	PF03145	0.549
DEG_SPOP_SBC_1	570	574	PF00917	0.604
DOC_CYCLIN_RxL_1	626	635	PF00134	0.554
DOC_MAPK_gen_1	157	166	PF00069	0.465
DOC_MAPK_gen_1	409	419	PF00069	0.511
DOC_MAPK_MEF2A_6	412	421	PF00069	0.495
DOC_MAPK_RevD_3	334	350	PF00069	0.562
DOC_PP1_RVXF_1	204	211	PF00149	0.562
DOC_PP2B_LxvP_1	331	334	PF13499	0.534
DOC_PP4_FxxP_1	87	90	PF00568	0.558
DOC_USP7_MATH_1	242	246	PF00917	0.743
DOC_USP7_MATH_1	273	277	PF00917	0.725
DOC_USP7_MATH_1	369	373	PF00917	0.558
DOC_USP7_MATH_1	489	493	PF00917	0.545
DOC_USP7_MATH_1	570	574	PF00917	0.739
DOC_USP7_MATH_1	594	598	PF00917	0.764
DOC_USP7_MATH_1	602	606	PF00917	0.670
DOC_USP7_UBL2_3	211	215	PF12436	0.530
DOC_USP7_UBL2_3	409	413	PF12436	0.482
DOC_WW_Pin1_4	281	286	PF00397	0.706
DOC_WW_Pin1_4	387	392	PF00397	0.562
DOC_WW_Pin1_4	582	587	PF00397	0.756
LIG_14-3-3_CanoR_1	140	150	PF00244	0.562
LIG_14-3-3_CanoR_1	206	211	PF00244	0.508
LIG_14-3-3_CanoR_1	222	227	PF00244	0.510
LIG_14-3-3_CanoR_1	412	417	PF00244	0.496
LIG_14-3-3_CanoR_1	480	484	PF00244	0.484
LIG_Clathr_ClatBox_1	631	635	PF01394	0.565
LIG_DLG_GKlike_1	412	419	PF00625	0.586
LIG_FHA_1	285	291	PF00498	0.700
LIG_FHA_1	328	334	PF00498	0.555
LIG_FHA_1	412	418	PF00498	0.562
LIG_FHA_1	579	585	PF00498	0.705
LIG_FHA_2	336	342	PF00498	0.513
LIG_FHA_2	432	438	PF00498	0.626
LIG_FHA_2	439	445	PF00498	0.566
LIG_FHA_2	614	620	PF00498	0.676
LIG_IBAR_NPY_1	316	318	PF08397	0.479
LIG_KLC1_Yacidic_2	352	357	PF13176	0.513
LIG_LIR_Apic_2	136	142	PF02991	0.482
LIG_LIR_Gen_1	14	24	PF02991	0.615
LIG_LIR_Gen_1	390	400	PF02991	0.564
LIG_LIR_Nem_3	14	19	PF02991	0.619
LIG_LIR_Nem_3	177	183	PF02991	0.482
LIG_LIR_Nem_3	203	208	PF02991	0.544
LIG_LIR_Nem_3	325	329	PF02991	0.419
LIG_LIR_Nem_3	390	395	PF02991	0.564
LIG_Pex14_2	16	20	PF04695	0.461
LIG_PTB_Apo_2	10	17	PF02174	0.484
LIG_PTB_Apo_2	204	211	PF02174	0.496
LIG_PTB_Apo_2	313	320	PF02174	0.511
LIG_SH2_CRK	139	143	PF00017	0.562
LIG_SH2_CRK	162	166	PF00017	0.482
LIG_SH2_SRC	332	335	PF00017	0.530
LIG_SH2_STAP1	162	166	PF00017	0.482
LIG_SH2_STAP1	305	309	PF00017	0.582
LIG_SH2_STAT5	318	321	PF00017	0.486
LIG_SH2_STAT5	326	329	PF00017	0.471
LIG_SH2_STAT5	332	335	PF00017	0.471
LIG_SH2_STAT5	355	358	PF00017	0.482
LIG_SH2_STAT5	410	413	PF00017	0.562
LIG_SH2_STAT5	483	486	PF00017	0.474
LIG_SH2_STAT5	546	549	PF00017	0.459
LIG_SH2_STAT5	630	633	PF00017	0.543
LIG_SH3_3	118	124	PF00018	0.538
LIG_SH3_3	262	268	PF00018	0.703
LIG_SH3_3	420	426	PF00018	0.482
LIG_TRAF2_1	454	457	PF00917	0.548
LIG_TYR_ITIM	346	351	PF00017	0.246
LIG_UBA3_1	416	420	PF00899	0.378
LIG_UBA3_1	543	550	PF00899	0.525
MOD_CK1_1	196	202	PF00069	0.408
MOD_CK1_1	250	256	PF00069	0.741
MOD_CK1_1	276	282	PF00069	0.678
MOD_CK1_1	387	393	PF00069	0.354
MOD_CK1_1	571	577	PF00069	0.754
MOD_CK2_1	275	281	PF00069	0.631
MOD_CK2_1	335	341	PF00069	0.335
MOD_CK2_1	39	45	PF00069	0.703
MOD_CK2_1	438	444	PF00069	0.601
MOD_CK2_1	479	485	PF00069	0.502
MOD_CK2_1	571	577	PF00069	0.728
MOD_CK2_1	613	619	PF00069	0.700
MOD_GlcNHglycan	127	130	PF01048	0.344
MOD_GlcNHglycan	244	247	PF01048	0.714
MOD_GlcNHglycan	275	278	PF01048	0.722
MOD_GlcNHglycan	371	374	PF01048	0.468
MOD_GlcNHglycan	386	389	PF01048	0.222
MOD_GlcNHglycan	487	490	PF01048	0.580
MOD_GlcNHglycan	491	494	PF01048	0.608
MOD_GlcNHglycan	560	563	PF01048	0.745
MOD_GSK3_1	238	245	PF00069	0.670
MOD_GSK3_1	273	280	PF00069	0.700
MOD_GSK3_1	387	394	PF00069	0.443
MOD_GSK3_1	485	492	PF00069	0.604
MOD_GSK3_1	566	573	PF00069	0.769
MOD_GSK3_1	578	585	PF00069	0.683
MOD_LATS_1	310	316	PF00433	0.654
MOD_N-GLC_1	125	130	PF02516	0.285
MOD_N-GLC_1	206	211	PF02516	0.368
MOD_N-GLC_1	485	490	PF02516	0.580
MOD_N-GLC_2	109	111	PF02516	0.335
MOD_NEK2_1	327	332	PF00069	0.397
MOD_NEK2_1	39	44	PF00069	0.672
MOD_NEK2_1	612	617	PF00069	0.662
MOD_NEK2_2	335	340	PF00069	0.480
MOD_PIKK_1	222	228	PF00454	0.430
MOD_PIKK_1	247	253	PF00454	0.749
MOD_PIKK_1	602	608	PF00454	0.744
MOD_PIKK_1	613	619	PF00454	0.647
MOD_PK_1	524	530	PF00069	0.527
MOD_PKA_1	311	317	PF00069	0.468
MOD_PKA_1	412	418	PF00069	0.480
MOD_PKA_1	558	564	PF00069	0.706
MOD_PKA_2	221	227	PF00069	0.335
MOD_PKA_2	311	317	PF00069	0.554
MOD_PKA_2	411	417	PF00069	0.335
MOD_PKA_2	479	485	PF00069	0.487
MOD_PKB_1	220	228	PF00069	0.331
MOD_PKB_1	556	564	PF00069	0.692
MOD_Plk_1	206	212	PF00069	0.368
MOD_Plk_1	485	491	PF00069	0.588
MOD_Plk_2-3	479	485	PF00069	0.506
MOD_Plk_2-3	549	555	PF00069	0.647
MOD_Plk_4	295	301	PF00069	0.358
MOD_Plk_4	322	328	PF00069	0.246
MOD_Plk_4	412	418	PF00069	0.480
MOD_ProDKin_1	281	287	PF00069	0.706
MOD_ProDKin_1	387	393	PF00069	0.447
MOD_ProDKin_1	582	588	PF00069	0.758
MOD_SUMO_for_1	290	293	PF00179	0.720
MOD_SUMO_for_1	49	52	PF00179	0.641
MOD_SUMO_for_1	563	566	PF00179	0.724
MOD_SUMO_rev_2	402	411	PF00179	0.408
TRG_DiLeu_BaEn_2	178	184	PF01217	0.378
TRG_ENDOCYTIC_2	162	165	PF00928	0.335
TRG_ENDOCYTIC_2	326	329	PF00928	0.246
TRG_ENDOCYTIC_2	348	351	PF00928	0.246
TRG_ER_diArg_1	180	182	PF00400	0.447
TRG_ER_diArg_1	220	223	PF00400	0.335
TRG_ER_diArg_1	348	350	PF00400	0.468
TRG_ER_diArg_1	520	523	PF00400	0.565
TRG_ER_diArg_1	555	558	PF00400	0.720

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6F3	Leptomonas seymouri	62%	100%
A0A1X0P509	Trypanosomatidae	47%	100%
A0A3Q8IIQ5	Leishmania donovani	94%	100%
A0A422NU93	Trypanosoma rangeli	47%	100%
A4HNA2	Leishmania braziliensis	80%	100%
A4IBX3	Leishmania infantum	93%	100%
C9ZYN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9B6W3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BT79	Trypanosoma cruzi	47%	100%