HAD-like domain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

HAD-like domain

Gene product:

HAD hydrolase, TIGR01456 family/HAD hydrolase, family IIA, putative

Species:

Leishmania major

UniProt:

E9AFQ9_LEIMA

TriTrypDb:

LmjF.35.4320 , LMJLV39_350051300 , LMJSD75_350050700

Length:

549

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AFQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFQ9

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	2
GO:0006644	phospholipid metabolic process	4	2
GO:0006650	glycerophospholipid metabolic process	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0008610	lipid biosynthetic process	4	2
GO:0008654	phospholipid biosynthetic process	5	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0019637	organophosphate metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0045017	glycerolipid biosynthetic process	4	2
GO:0046474	glycerophospholipid biosynthetic process	5	2
GO:0046486	glycerolipid metabolic process	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0090407	organophosphate biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.551
CLV_NRD_NRD_1	20	22	PF00675	0.510
CLV_NRD_NRD_1	212	214	PF00675	0.254
CLV_NRD_NRD_1	290	292	PF00675	0.484
CLV_NRD_NRD_1	482	484	PF00675	0.465
CLV_NRD_NRD_1	51	53	PF00675	0.561
CLV_NRD_NRD_1	76	78	PF00675	0.600
CLV_NRD_NRD_1	92	94	PF00675	0.391
CLV_PCSK_KEX2_1	13	15	PF00082	0.546
CLV_PCSK_KEX2_1	20	22	PF00082	0.497
CLV_PCSK_KEX2_1	290	292	PF00082	0.442
CLV_PCSK_KEX2_1	315	317	PF00082	0.489
CLV_PCSK_KEX2_1	426	428	PF00082	0.286
CLV_PCSK_KEX2_1	482	484	PF00082	0.465
CLV_PCSK_KEX2_1	51	53	PF00082	0.529
CLV_PCSK_KEX2_1	76	78	PF00082	0.717
CLV_PCSK_KEX2_1	92	94	PF00082	0.391
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.530
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.302
CLV_PCSK_PC7_1	9	15	PF00082	0.615
CLV_PCSK_SKI1_1	118	122	PF00082	0.461
CLV_PCSK_SKI1_1	393	397	PF00082	0.369
CLV_PCSK_SKI1_1	426	430	PF00082	0.328
CLV_PCSK_SKI1_1	443	447	PF00082	0.269
CLV_PCSK_SKI1_1	515	519	PF00082	0.359
CLV_PCSK_SKI1_1	9	13	PF00082	0.554
CLV_PCSK_SKI1_1	93	97	PF00082	0.566
DEG_APCC_DBOX_1	392	400	PF00400	0.372
DEG_Nend_UBRbox_1	1	4	PF02207	0.627
DEG_ODPH_VHL_1	263	275	PF01847	0.445
DEG_SPOP_SBC_1	171	175	PF00917	0.701
DOC_CKS1_1	365	370	PF01111	0.474
DOC_CYCLIN_RxL_1	512	522	PF00134	0.363
DOC_CYCLIN_RxL_1	6	15	PF00134	0.526
DOC_CYCLIN_yCln2_LP_2	218	224	PF00134	0.437
DOC_MAPK_gen_1	213	220	PF00069	0.445
DOC_MAPK_MEF2A_6	213	222	PF00069	0.447
DOC_PP2B_LxvP_1	218	221	PF13499	0.437
DOC_PP2B_LxvP_1	262	265	PF13499	0.448
DOC_PP2B_LxvP_1	350	353	PF13499	0.401
DOC_PP4_FxxP_1	22	25	PF00568	0.480
DOC_USP7_MATH_1	125	129	PF00917	0.567
DOC_USP7_MATH_1	134	138	PF00917	0.679
DOC_USP7_MATH_1	169	173	PF00917	0.693
DOC_USP7_MATH_1	359	363	PF00917	0.441
DOC_USP7_UBL2_3	156	160	PF12436	0.571
DOC_WW_Pin1_4	12	17	PF00397	0.688
DOC_WW_Pin1_4	130	135	PF00397	0.620
DOC_WW_Pin1_4	139	144	PF00397	0.509
DOC_WW_Pin1_4	167	172	PF00397	0.697
DOC_WW_Pin1_4	255	260	PF00397	0.442
DOC_WW_Pin1_4	364	369	PF00397	0.447
DOC_WW_Pin1_4	499	504	PF00397	0.359
DOC_WW_Pin1_4	68	73	PF00397	0.536
DOC_WW_Pin1_4	98	103	PF00397	0.650
LIG_14-3-3_CanoR_1	2	7	PF00244	0.655
LIG_14-3-3_CanoR_1	213	219	PF00244	0.539
LIG_14-3-3_CanoR_1	290	298	PF00244	0.433
LIG_14-3-3_CanoR_1	482	488	PF00244	0.440
LIG_EH1_1	511	519	PF00400	0.441
LIG_eIF4E_1	199	205	PF01652	0.480
LIG_FHA_1	215	221	PF00498	0.539
LIG_FHA_1	482	488	PF00498	0.506
LIG_FHA_2	161	167	PF00498	0.450
LIG_FHA_2	30	36	PF00498	0.593
LIG_FHA_2	343	349	PF00498	0.369
LIG_KLC1_Yacidic_2	162	166	PF13176	0.456
LIG_LIR_Apic_2	162	167	PF02991	0.555
LIG_LIR_Apic_2	502	508	PF02991	0.356
LIG_LIR_Gen_1	337	347	PF02991	0.379
LIG_LIR_Gen_1	398	408	PF02991	0.391
LIG_LIR_LC3C_4	270	275	PF02991	0.491
LIG_LIR_Nem_3	321	327	PF02991	0.356
LIG_LIR_Nem_3	337	343	PF02991	0.313
LIG_LIR_Nem_3	34	40	PF02991	0.494
LIG_LIR_Nem_3	398	403	PF02991	0.389
LIG_LIR_Nem_3	5	11	PF02991	0.610
LIG_LYPXL_SIV_4	368	376	PF13949	0.472
LIG_LYPXL_SIV_4	420	428	PF13949	0.368
LIG_NRBOX	239	245	PF00104	0.539
LIG_NRBOX	346	352	PF00104	0.367
LIG_Pex14_2	22	26	PF04695	0.481
LIG_Pex14_2	442	446	PF04695	0.302
LIG_Pex14_2	490	494	PF04695	0.398
LIG_SH2_CRK	413	417	PF00017	0.289
LIG_SH2_CRK	8	12	PF00017	0.671
LIG_SH2_NCK_1	400	404	PF00017	0.509
LIG_SH2_PTP2	164	167	PF00017	0.578
LIG_SH2_PTP2	505	508	PF00017	0.360
LIG_SH2_SRC	164	167	PF00017	0.554
LIG_SH2_STAP1	161	165	PF00017	0.539
LIG_SH2_STAT5	105	108	PF00017	0.486
LIG_SH2_STAT5	164	167	PF00017	0.578
LIG_SH2_STAT5	18	21	PF00017	0.591
LIG_SH2_STAT5	360	363	PF00017	0.423
LIG_SH2_STAT5	369	372	PF00017	0.290
LIG_SH2_STAT5	505	508	PF00017	0.360
LIG_SH3_3	177	183	PF00018	0.600
LIG_SH3_3	272	278	PF00018	0.462
LIG_SH3_3	319	325	PF00018	0.376
LIG_SUMO_SIM_anti_2	269	276	PF11976	0.542
LIG_SUMO_SIM_anti_2	345	351	PF11976	0.370
LIG_SUMO_SIM_par_1	483	489	PF11976	0.464
LIG_TRAF2_1	32	35	PF00917	0.621
LIG_TRAF2_1	71	74	PF00917	0.560
MOD_CDC14_SPxK_1	258	261	PF00782	0.539
MOD_CDK_SPxK_1	255	261	PF00069	0.504
MOD_CDK_SPxK_1	98	104	PF00069	0.648
MOD_CK1_1	128	134	PF00069	0.721
MOD_CK1_1	137	143	PF00069	0.658
MOD_CK1_1	170	176	PF00069	0.708
MOD_CK1_1	364	370	PF00069	0.289
MOD_CK1_1	497	503	PF00069	0.374
MOD_CK2_1	132	138	PF00069	0.746
MOD_CK2_1	160	166	PF00069	0.466
MOD_CK2_1	29	35	PF00069	0.519
MOD_CK2_1	331	337	PF00069	0.469
MOD_CK2_1	395	401	PF00069	0.493
MOD_CK2_1	68	74	PF00069	0.558
MOD_GlcNHglycan	127	130	PF01048	0.653
MOD_GlcNHglycan	174	177	PF01048	0.705
MOD_GlcNHglycan	227	230	PF01048	0.272
MOD_GlcNHglycan	238	243	PF01048	0.230
MOD_GlcNHglycan	247	251	PF01048	0.164
MOD_GlcNHglycan	293	296	PF01048	0.412
MOD_GlcNHglycan	327	330	PF01048	0.428
MOD_GlcNHglycan	361	364	PF01048	0.499
MOD_GlcNHglycan	430	434	PF01048	0.370
MOD_GlcNHglycan	472	475	PF01048	0.274
MOD_GSK3_1	128	135	PF00069	0.659
MOD_GSK3_1	137	144	PF00069	0.657
MOD_GSK3_1	167	174	PF00069	0.701
MOD_GSK3_1	225	232	PF00069	0.590
MOD_GSK3_1	359	366	PF00069	0.413
MOD_GSK3_1	395	402	PF00069	0.498
MOD_N-GLC_1	125	130	PF02516	0.716
MOD_NEK2_1	1	6	PF00069	0.614
MOD_NEK2_1	106	111	PF00069	0.519
MOD_NEK2_1	184	189	PF00069	0.349
MOD_NEK2_1	225	230	PF00069	0.428
MOD_NEK2_1	395	400	PF00069	0.447
MOD_NEK2_1	41	46	PF00069	0.551
MOD_NEK2_1	465	470	PF00069	0.368
MOD_NEK2_1	525	530	PF00069	0.620
MOD_PIKK_1	128	134	PF00454	0.582
MOD_PIKK_1	361	367	PF00454	0.306
MOD_PK_1	483	489	PF00069	0.590
MOD_PKA_1	213	219	PF00069	0.527
MOD_PKA_2	1	7	PF00069	0.578
MOD_PKA_2	481	487	PF00069	0.469
MOD_Plk_1	137	143	PF00069	0.685
MOD_Plk_1	238	244	PF00069	0.480
MOD_Plk_1	66	72	PF00069	0.459
MOD_Plk_2-3	342	348	PF00069	0.384
MOD_Plk_4	160	166	PF00069	0.463
MOD_Plk_4	2	8	PF00069	0.631
MOD_Plk_4	318	324	PF00069	0.293
MOD_Plk_4	342	348	PF00069	0.377
MOD_Plk_4	395	401	PF00069	0.493
MOD_ProDKin_1	12	18	PF00069	0.688
MOD_ProDKin_1	130	136	PF00069	0.623
MOD_ProDKin_1	139	145	PF00069	0.504
MOD_ProDKin_1	167	173	PF00069	0.699
MOD_ProDKin_1	255	261	PF00069	0.442
MOD_ProDKin_1	364	370	PF00069	0.442
MOD_ProDKin_1	499	505	PF00069	0.358
MOD_ProDKin_1	68	74	PF00069	0.534
MOD_ProDKin_1	98	104	PF00069	0.648
MOD_SUMO_rev_2	151	158	PF00179	0.610
MOD_SUMO_rev_2	27	33	PF00179	0.490
TRG_DiLeu_BaEn_1	239	244	PF01217	0.462
TRG_DiLeu_BaEn_1	269	274	PF01217	0.491
TRG_DiLeu_BaEn_3	90	96	PF01217	0.595
TRG_DiLeu_BaEn_4	73	79	PF01217	0.645
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.569
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.539
TRG_ENDOCYTIC_2	400	403	PF00928	0.514
TRG_ENDOCYTIC_2	8	11	PF00928	0.674
TRG_ER_diArg_1	12	14	PF00400	0.551
TRG_ER_diArg_1	20	22	PF00400	0.487
TRG_ER_diArg_1	289	291	PF00400	0.488
TRG_ER_diArg_1	76	78	PF00400	0.600
TRG_Pf-PMV_PEXEL_1	261	266	PF00026	0.339
TRG_Pf-PMV_PEXEL_1	426	430	PF00026	0.302
TRG_Pf-PMV_PEXEL_1	483	488	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5I3	Leptomonas seymouri	73%	100%
A0A0S4JPF8	Bodo saltans	53%	100%
A0A1X0P5B2	Trypanosomatidae	59%	100%
A0A3Q8IMX2	Leishmania donovani	95%	100%
A0A3R7L7A5	Trypanosoma rangeli	60%	100%
A4HNA1	Leishmania braziliensis	84%	100%
A4IBX2	Leishmania infantum	95%	100%
C9ZYN6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9B6W2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BCR1	Trypanosoma cruzi	60%	100%