Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFQ7_LEIMA

TriTrypDb:

LmjF.35.4300 , LMJLV39_350051100 , LMJSD75_350050500

Length:

249

Annotations

LeishMANIAdb annotations

A very conserved protein restricted to Kinetoplastids, protentially involved in coiled-coil interactions

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFQ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	159	161	PF00675	0.354
CLV_NRD_NRD_1	181	183	PF00675	0.321
CLV_NRD_NRD_1	230	232	PF00675	0.344
CLV_NRD_NRD_1	25	27	PF00675	0.676
CLV_NRD_NRD_1	76	78	PF00675	0.614
CLV_PCSK_KEX2_1	180	182	PF00082	0.323
CLV_PCSK_KEX2_1	2	4	PF00082	0.648
CLV_PCSK_KEX2_1	230	232	PF00082	0.363
CLV_PCSK_KEX2_1	246	248	PF00082	0.336
CLV_PCSK_KEX2_1	25	27	PF00082	0.676
CLV_PCSK_KEX2_1	75	77	PF00082	0.613
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.347
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.722
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.336
CLV_PCSK_PC7_1	226	232	PF00082	0.356
CLV_PCSK_SKI1_1	150	154	PF00082	0.321
CLV_PCSK_SKI1_1	181	185	PF00082	0.390
CLV_Separin_Metazoa	157	161	PF03568	0.554
CLV_Separin_Metazoa	72	76	PF03568	0.436
DEG_APCC_DBOX_1	149	157	PF00400	0.523
DEG_Nend_UBRbox_1	1	4	PF02207	0.473
DOC_MAPK_gen_1	160	167	PF00069	0.543
DOC_MAPK_gen_1	180	186	PF00069	0.550
DOC_MAPK_gen_1	75	82	PF00069	0.423
DOC_MAPK_MEF2A_6	109	116	PF00069	0.298
DOC_USP7_MATH_1	185	189	PF00917	0.553
DOC_USP7_MATH_1	64	68	PF00917	0.546
LIG_14-3-3_CanoR_1	230	236	PF00244	0.554
LIG_FHA_1	119	125	PF00498	0.390
LIG_FHA_1	147	153	PF00498	0.539
LIG_FHA_1	211	217	PF00498	0.619
LIG_FHA_1	84	90	PF00498	0.430
LIG_FHA_1	92	98	PF00498	0.373
LIG_FHA_2	66	72	PF00498	0.554
LIG_LIR_Nem_3	99	104	PF02991	0.349
LIG_Pex14_2	103	107	PF04695	0.330
LIG_SH2_PTP2	90	93	PF00017	0.382
LIG_SH2_SRC	90	93	PF00017	0.382
LIG_SH2_STAT3	174	177	PF00017	0.533
LIG_SH2_STAT5	235	238	PF00017	0.516
LIG_SH2_STAT5	90	93	PF00017	0.372
LIG_SUMO_SIM_anti_2	154	160	PF11976	0.549
LIG_SUMO_SIM_par_1	78	83	PF11976	0.461
LIG_TRAF2_1	69	72	PF00917	0.486
LIG_UBA3_1	152	161	PF00899	0.624
LIG_WW_3	72	76	PF00397	0.508
MOD_CK1_1	83	89	PF00069	0.430
MOD_CK2_1	151	157	PF00069	0.541
MOD_CK2_1	186	192	PF00069	0.553
MOD_CK2_1	65	71	PF00069	0.503
MOD_GlcNHglycan	16	19	PF01048	0.697
MOD_GSK3_1	127	134	PF00069	0.632
MOD_N-GLC_1	83	88	PF02516	0.618
MOD_NEK2_1	118	123	PF00069	0.290
MOD_NEK2_1	82	87	PF00069	0.415
MOD_PIKK_1	118	124	PF00454	0.286
MOD_PIKK_1	133	139	PF00454	0.686
MOD_PIKK_1	229	235	PF00454	0.550
MOD_PK_1	3	9	PF00069	0.420
MOD_PKA_2	127	133	PF00069	0.630
MOD_PKA_2	207	213	PF00069	0.610
MOD_PKA_2	229	235	PF00069	0.562
MOD_Plk_2-3	151	157	PF00069	0.536
MOD_Plk_2-3	192	198	PF00069	0.644
MOD_Plk_4	3	9	PF00069	0.506
MOD_Plk_4	96	102	PF00069	0.358
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.538
TRG_ENDOCYTIC_2	101	104	PF00928	0.365
TRG_ER_diArg_1	74	77	PF00400	0.517
TRG_ER_diLys_1	244	249	PF00400	0.538
TRG_Pf-PMV_PEXEL_1	150	155	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	194	199	PF00026	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5X4	Leptomonas seymouri	78%	98%
A0A0S4KGJ1	Bodo saltans	65%	100%
A0A1X0P6H7	Trypanosomatidae	83%	95%
A0A3Q8IIE6	Leishmania donovani	96%	100%
A0A422NU86	Trypanosoma rangeli	74%	98%
A4HN99	Leishmania braziliensis	84%	100%
A4IBX0	Leishmania infantum	97%	100%
C9ZYN8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	87%	98%
E9B6W0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5DUI0	Trypanosoma cruzi	81%	100%