DUF4408 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AFQ6_LEIMA

TriTrypDb:

LmjF.35.4290 , LMJLV39_350050900 , LMJSD75_350050300

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AFQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFQ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	313	315	PF00675	0.499
CLV_NRD_NRD_1	60	62	PF00675	0.416
CLV_NRD_NRD_1	73	75	PF00675	0.447
CLV_PCSK_FUR_1	57	61	PF00082	0.459
CLV_PCSK_KEX2_1	271	273	PF00082	0.471
CLV_PCSK_KEX2_1	283	285	PF00082	0.475
CLV_PCSK_KEX2_1	313	315	PF00082	0.486
CLV_PCSK_KEX2_1	59	61	PF00082	0.410
CLV_PCSK_KEX2_1	72	74	PF00082	0.439
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.452
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.440
CLV_PCSK_PC7_1	68	74	PF00082	0.486
CLV_PCSK_SKI1_1	12	16	PF00082	0.688
CLV_PCSK_SKI1_1	161	165	PF00082	0.520
CLV_PCSK_SKI1_1	283	287	PF00082	0.439
CLV_PCSK_SKI1_1	80	84	PF00082	0.509
DEG_APCC_DBOX_1	20	28	PF00400	0.334
DEG_Nend_UBRbox_2	1	3	PF02207	0.493
DEG_SPOP_SBC_1	96	100	PF00917	0.799
DOC_CYCLIN_RxL_1	281	291	PF00134	0.727
DOC_CYCLIN_yClb1_LxF_4	220	225	PF00134	0.735
DOC_CYCLIN_yCln2_LP_2	138	144	PF00134	0.760
DOC_MAPK_MEF2A_6	184	192	PF00069	0.824
DOC_PP1_RVXF_1	220	226	PF00149	0.738
DOC_PP2B_LxvP_1	138	141	PF13499	0.729
DOC_PP2B_LxvP_1	188	191	PF13499	0.775
DOC_PP4_FxxP_1	225	228	PF00568	0.746
DOC_SPAK_OSR1_1	237	241	PF12202	0.701
DOC_USP7_MATH_1	191	195	PF00917	0.735
DOC_USP7_MATH_1	209	213	PF00917	0.788
DOC_USP7_MATH_1	293	297	PF00917	0.714
DOC_USP7_MATH_1	301	305	PF00917	0.753
DOC_USP7_MATH_1	46	50	PF00917	0.688
DOC_USP7_MATH_1	7	11	PF00917	0.538
DOC_USP7_MATH_1	76	80	PF00917	0.591
DOC_USP7_MATH_1	84	88	PF00917	0.602
DOC_USP7_MATH_2	103	109	PF00917	0.766
DOC_WW_Pin1_4	148	153	PF00397	0.744
DOC_WW_Pin1_4	201	206	PF00397	0.729
DOC_WW_Pin1_4	224	229	PF00397	0.717
LIG_14-3-3_CanoR_1	117	124	PF00244	0.654
LIG_14-3-3_CanoR_1	259	267	PF00244	0.680
LIG_Actin_WH2_2	216	233	PF00022	0.630
LIG_CSL_BTD_1	134	137	PF09270	0.743
LIG_FHA_1	153	159	PF00498	0.731
LIG_FHA_1	173	179	PF00498	0.770
LIG_FHA_1	214	220	PF00498	0.693
LIG_FHA_1	287	293	PF00498	0.743
LIG_FHA_1	319	325	PF00498	0.817
LIG_FHA_2	194	200	PF00498	0.728
LIG_FHA_2	231	237	PF00498	0.673
LIG_FHA_2	88	94	PF00498	0.723
LIG_LIR_Gen_1	13	20	PF02991	0.468
LIG_LIR_Nem_3	13	18	PF02991	0.471
LIG_LIR_Nem_3	133	139	PF02991	0.658
LIG_MYND_1	137	141	PF01753	0.744
LIG_NRBOX	13	19	PF00104	0.426
LIG_NRBOX	23	29	PF00104	0.402
LIG_PALB2_WD40_1	131	139	PF16756	0.738
LIG_PCNA_yPIPBox_3	266	280	PF02747	0.721
LIG_Rb_LxCxE_1	49	63	PF01857	0.653
LIG_SH2_PTP2	149	152	PF00017	0.646
LIG_SH2_STAT5	126	129	PF00017	0.724
LIG_SH2_STAT5	149	152	PF00017	0.646
LIG_SH3_3	138	144	PF00018	0.716
LIG_SH3_3	147	153	PF00018	0.662
LIG_SUMO_SIM_anti_2	25	31	PF11976	0.419
LIG_TRAF2_1	169	172	PF00917	0.642
LIG_TYR_ITIM	29	34	PF00017	0.513
LIG_WW_3	151	155	PF00397	0.590
MOD_CDC14_SPxK_1	151	154	PF00782	0.707
MOD_CDK_SPxK_1	148	154	PF00069	0.709
MOD_CDK_SPxxK_3	224	231	PF00069	0.539
MOD_CK1_1	107	113	PF00069	0.719
MOD_CK1_1	194	200	PF00069	0.640
MOD_CK1_1	201	207	PF00069	0.638
MOD_CK1_1	214	220	PF00069	0.410
MOD_CK1_1	241	247	PF00069	0.665
MOD_CK1_1	251	257	PF00069	0.534
MOD_CK1_1	6	12	PF00069	0.608
MOD_CK1_1	87	93	PF00069	0.674
MOD_CK2_1	125	131	PF00069	0.698
MOD_CK2_1	166	172	PF00069	0.709
MOD_CK2_1	230	236	PF00069	0.746
MOD_CK2_1	258	264	PF00069	0.574
MOD_CK2_1	87	93	PF00069	0.643
MOD_GlcNHglycan	213	216	PF01048	0.600
MOD_GlcNHglycan	260	263	PF01048	0.428
MOD_GlcNHglycan	5	8	PF01048	0.683
MOD_GlcNHglycan	9	12	PF01048	0.600
MOD_GSK3_1	107	114	PF00069	0.672
MOD_GSK3_1	148	155	PF00069	0.710
MOD_GSK3_1	180	187	PF00069	0.700
MOD_GSK3_1	191	198	PF00069	0.614
MOD_GSK3_1	200	207	PF00069	0.475
MOD_GSK3_1	209	216	PF00069	0.558
MOD_GSK3_1	238	245	PF00069	0.773
MOD_GSK3_1	247	254	PF00069	0.648
MOD_GSK3_1	3	10	PF00069	0.705
MOD_GSK3_1	318	325	PF00069	0.791
MOD_GSK3_1	76	83	PF00069	0.675
MOD_GSK3_1	97	104	PF00069	0.755
MOD_N-GLC_1	166	171	PF02516	0.698
MOD_N-GLC_1	180	185	PF02516	0.777
MOD_N-GLC_1	247	252	PF02516	0.687
MOD_N-GLC_1	3	8	PF02516	0.656
MOD_N-GLC_1	96	101	PF02516	0.695
MOD_N-GLC_2	255	257	PF02516	0.739
MOD_NEK2_1	200	205	PF00069	0.650
MOD_NEK2_1	230	235	PF00069	0.675
MOD_NEK2_1	238	243	PF00069	0.674
MOD_NEK2_1	288	293	PF00069	0.663
MOD_NEK2_2	174	179	PF00069	0.620
MOD_PKA_2	116	122	PF00069	0.623
MOD_PKA_2	241	247	PF00069	0.653
MOD_PKA_2	251	257	PF00069	0.535
MOD_PKA_2	258	264	PF00069	0.461
MOD_Plk_1	130	136	PF00069	0.568
MOD_Plk_1	238	244	PF00069	0.712
MOD_Plk_1	3	9	PF00069	0.613
MOD_Plk_4	131	137	PF00069	0.566
MOD_Plk_4	184	190	PF00069	0.769
MOD_Plk_4	46	52	PF00069	0.489
MOD_ProDKin_1	148	154	PF00069	0.688
MOD_ProDKin_1	201	207	PF00069	0.668
MOD_ProDKin_1	224	230	PF00069	0.651
MOD_SUMO_rev_2	227	233	PF00179	0.580
TRG_DiLeu_BaEn_1	25	30	PF01217	0.513
TRG_DiLeu_BaLyEn_6	134	139	PF01217	0.691
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.616
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.662
TRG_ENDOCYTIC_2	31	34	PF00928	0.513
TRG_ER_diArg_1	312	314	PF00400	0.545
TRG_ER_diArg_1	59	61	PF00400	0.503
TRG_ER_diArg_1	72	74	PF00400	0.551
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK89	Leptomonas seymouri	35%	100%
A0A3S7X9U4	Leishmania donovani	85%	100%
A4HN98	Leishmania braziliensis	58%	100%
A4IBW9	Leishmania infantum	85%	100%
E9B6V9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%