DUF4408 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AFQ6_LEIMA

TriTrypDb:

LmjF.35.4290 , LMJLV39_350050900 , LMJSD75_350050300

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

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Expansion

Sequence features

E9AFQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFQ6

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	313	315	PF00675	0.499
CLV_NRD_NRD_1	60	62	PF00675	0.416
CLV_NRD_NRD_1	73	75	PF00675	0.447
CLV_PCSK_FUR_1	57	61	PF00082	0.459
CLV_PCSK_KEX2_1	271	273	PF00082	0.471
CLV_PCSK_KEX2_1	283	285	PF00082	0.475
CLV_PCSK_KEX2_1	313	315	PF00082	0.486
CLV_PCSK_KEX2_1	59	61	PF00082	0.410
CLV_PCSK_KEX2_1	72	74	PF00082	0.439
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.452

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK89	Leptomonas seymouri	35%	100%
A0A3S7X9U4	Leishmania donovani	85%	100%
A4HN98	Leishmania braziliensis	58%	100%
A4IBW9	Leishmania infantum	85%	100%
E9B6V9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%

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