SAS-6_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Spindle assembly abnormal protein 6 homolog

Species:

Leishmania major

UniProt:

E9AFQ5_LEIMA

TriTrypDb:

LmjF.35.4280 , LMJLV39_350050800 , LMJSD75_350050200

Length:

816

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005814	centriole	5	2
GO:0005815	microtubule organizing center	2	2
GO:0036064	ciliary basal body	3	2
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AFQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFQ5

PDB structure(s): 4ckm_A , 4ckm_B , 4ckm_C , 4ckn_A , 4ckn_B , 4ckn_C , 4ckn_D , 4ckp_A , 4ckp_B , 4ckp_C , 4ckp_D , 4ckp_E , 4ckp_F

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0007017	microtubule-based process	2	2
GO:0007099	centriole replication	3	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022402	cell cycle process	2	2
GO:0022607	cellular component assembly	4	2
GO:0031023	microtubule organizing center organization	3	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0098534	centriole assembly	4	2
GO:0140694	non-membrane-bounded organelle assembly	6	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.497
CLV_C14_Caspase3-7	698	702	PF00656	0.644
CLV_NRD_NRD_1	32	34	PF00675	0.671
CLV_NRD_NRD_1	322	324	PF00675	0.537
CLV_NRD_NRD_1	553	555	PF00675	0.673
CLV_NRD_NRD_1	570	572	PF00675	0.665
CLV_NRD_NRD_1	749	751	PF00675	0.628
CLV_NRD_NRD_1	75	77	PF00675	0.766
CLV_PCSK_KEX2_1	276	278	PF00082	0.413
CLV_PCSK_KEX2_1	31	33	PF00082	0.671
CLV_PCSK_KEX2_1	553	555	PF00082	0.673
CLV_PCSK_KEX2_1	75	77	PF00082	0.713
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.380
CLV_PCSK_PC7_1	27	33	PF00082	0.666
CLV_PCSK_SKI1_1	171	175	PF00082	0.480
CLV_PCSK_SKI1_1	525	529	PF00082	0.502
CLV_PCSK_SKI1_1	791	795	PF00082	0.542
CLV_Separin_Metazoa	568	572	PF03568	0.607
DEG_APCC_DBOX_1	114	122	PF00400	0.634
DEG_APCC_DBOX_1	170	178	PF00400	0.469
DEG_APCC_DBOX_1	245	253	PF00400	0.453
DEG_Nend_Nbox_1	1	3	PF02207	0.702
DOC_ANK_TNKS_1	220	227	PF00023	0.492
DOC_ANK_TNKS_1	74	81	PF00023	0.656
DOC_CYCLIN_RxL_1	766	777	PF00134	0.623
DOC_MAPK_gen_1	323	331	PF00069	0.529
DOC_MAPK_gen_1	587	596	PF00069	0.514
DOC_MAPK_MEF2A_6	200	209	PF00069	0.440
DOC_MAPK_MEF2A_6	258	267	PF00069	0.440
DOC_MAPK_NFAT4_5	200	208	PF00069	0.440
DOC_PP4_FxxP_1	23	26	PF00568	0.647
DOC_USP7_MATH_1	100	104	PF00917	0.629
DOC_USP7_MATH_1	124	128	PF00917	0.729
DOC_USP7_MATH_1	358	362	PF00917	0.598
DOC_USP7_MATH_1	467	471	PF00917	0.579
DOC_USP7_MATH_1	621	625	PF00917	0.680
DOC_USP7_MATH_1	630	634	PF00917	0.715
DOC_USP7_MATH_1	699	703	PF00917	0.730
DOC_USP7_MATH_1	717	721	PF00917	0.648
DOC_USP7_MATH_1	722	726	PF00917	0.723
DOC_USP7_MATH_1	744	748	PF00917	0.703
DOC_USP7_MATH_1	759	763	PF00917	0.680
DOC_USP7_MATH_1	789	793	PF00917	0.610
DOC_USP7_MATH_1	810	814	PF00917	0.576
DOC_USP7_UBL2_3	508	512	PF12436	0.639
DOC_WD40_RPTOR_TOS_1	187	193	PF00400	0.453
DOC_WW_Pin1_4	120	125	PF00397	0.658
DOC_WW_Pin1_4	715	720	PF00397	0.691
DOC_WW_Pin1_4	774	779	PF00397	0.577
LIG_14-3-3_CanoR_1	112	121	PF00244	0.798
LIG_14-3-3_CanoR_1	176	180	PF00244	0.440
LIG_14-3-3_CanoR_1	291	299	PF00244	0.357
LIG_14-3-3_CanoR_1	319	323	PF00244	0.614
LIG_14-3-3_CanoR_1	397	405	PF00244	0.521
LIG_14-3-3_CanoR_1	53	60	PF00244	0.770
LIG_14-3-3_CanoR_1	571	580	PF00244	0.628
LIG_14-3-3_CanoR_1	670	674	PF00244	0.734
LIG_14-3-3_CanoR_1	728	737	PF00244	0.715
LIG_14-3-3_CanoR_1	743	747	PF00244	0.796
LIG_14-3-3_CanoR_1	750	754	PF00244	0.747
LIG_14-3-3_CanoR_1	802	811	PF00244	0.687
LIG_Actin_WH2_2	253	271	PF00022	0.453
LIG_Actin_WH2_2	304	321	PF00022	0.512
LIG_Actin_WH2_2	366	383	PF00022	0.565
LIG_Actin_WH2_2	398	415	PF00022	0.445
LIG_Actin_WH2_2	448	464	PF00022	0.573
LIG_AP2alpha_2	182	184	PF02296	0.440
LIG_BRCT_BRCA1_1	19	23	PF00533	0.646
LIG_BRCT_BRCA1_1	812	816	PF00533	0.537
LIG_CaM_IQ_9	563	579	PF13499	0.554
LIG_Clathr_ClatBox_1	186	190	PF01394	0.453
LIG_FHA_1	136	142	PF00498	0.602
LIG_FHA_1	168	174	PF00498	0.503
LIG_FHA_1	246	252	PF00498	0.440
LIG_FHA_1	299	305	PF00498	0.417
LIG_FHA_1	375	381	PF00498	0.570
LIG_FHA_1	396	402	PF00498	0.608
LIG_FHA_1	416	422	PF00498	0.564
LIG_FHA_1	561	567	PF00498	0.622
LIG_FHA_1	605	611	PF00498	0.724
LIG_FHA_1	652	658	PF00498	0.568
LIG_FHA_1	732	738	PF00498	0.718
LIG_FHA_2	131	137	PF00498	0.451
LIG_FHA_2	332	338	PF00498	0.484
LIG_FHA_2	381	387	PF00498	0.568
LIG_FHA_2	426	432	PF00498	0.593
LIG_FHA_2	454	460	PF00498	0.627
LIG_FHA_2	559	565	PF00498	0.529
LIG_FHA_2	696	702	PF00498	0.754
LIG_Integrin_isoDGR_2	611	613	PF01839	0.572
LIG_LIR_Apic_2	20	26	PF02991	0.711
LIG_LIR_Gen_1	193	203	PF02991	0.492
LIG_LIR_Gen_1	451	461	PF02991	0.577
LIG_LIR_Gen_1	486	493	PF02991	0.478
LIG_LIR_Gen_1	50	59	PF02991	0.693
LIG_LIR_Nem_3	181	187	PF02991	0.470
LIG_LIR_Nem_3	193	199	PF02991	0.469
LIG_LIR_Nem_3	208	212	PF02991	0.469
LIG_LIR_Nem_3	254	260	PF02991	0.442
LIG_LIR_Nem_3	281	286	PF02991	0.366
LIG_LIR_Nem_3	451	457	PF02991	0.574
LIG_LIR_Nem_3	486	491	PF02991	0.476
LIG_LIR_Nem_3	50	54	PF02991	0.734
LIG_LIR_Nem_3	784	788	PF02991	0.714
LIG_MLH1_MIPbox_1	812	816	PF16413	0.537
LIG_PCNA_PIPBox_1	475	484	PF02747	0.529
LIG_Pex14_2	646	650	PF04695	0.575
LIG_SH2_PTP2	454	457	PF00017	0.571
LIG_SH2_PTP2	488	491	PF00017	0.478
LIG_SH2_STAP1	230	234	PF00017	0.471
LIG_SH2_STAP1	286	290	PF00017	0.428
LIG_SH2_STAT3	482	485	PF00017	0.486
LIG_SH2_STAT5	158	161	PF00017	0.454
LIG_SH2_STAT5	215	218	PF00017	0.467
LIG_SH2_STAT5	278	281	PF00017	0.351
LIG_SH2_STAT5	454	457	PF00017	0.571
LIG_SH2_STAT5	488	491	PF00017	0.478
LIG_SH3_1	144	150	PF00018	0.491
LIG_SH3_3	102	108	PF00018	0.618
LIG_SH3_3	144	150	PF00018	0.521
LIG_SH3_3	177	183	PF00018	0.453
LIG_SH3_3	761	767	PF00018	0.522
LIG_SUMO_SIM_anti_2	170	176	PF11976	0.464
LIG_SUMO_SIM_anti_2	188	195	PF11976	0.358
LIG_SUMO_SIM_anti_2	261	267	PF11976	0.440
LIG_SUMO_SIM_par_1	136	143	PF11976	0.609
LIG_SUMO_SIM_par_1	417	423	PF11976	0.633
LIG_TRAF2_1	127	130	PF00917	0.590
LIG_TRAF2_1	325	328	PF00917	0.465
LIG_TRAF2_1	372	375	PF00917	0.554
LIG_TRAF2_1	470	473	PF00917	0.602
LIG_TRAF2_1	724	727	PF00917	0.707
LIG_TYR_ITIM	452	457	PF00017	0.572
LIG_WRC_WIRS_1	790	795	PF05994	0.676
MOD_CDK_SPK_2	120	125	PF00069	0.658
MOD_CK1_1	10	16	PF00069	0.710
MOD_CK1_1	18	24	PF00069	0.721
MOD_CK1_1	293	299	PF00069	0.510
MOD_CK1_1	407	413	PF00069	0.529
MOD_CK1_1	420	426	PF00069	0.491
MOD_CK1_1	651	657	PF00069	0.645
MOD_CK1_1	669	675	PF00069	0.726
MOD_CK1_1	731	737	PF00069	0.693
MOD_CK1_1	745	751	PF00069	0.578
MOD_CK1_1	777	783	PF00069	0.688
MOD_CK2_1	124	130	PF00069	0.624
MOD_CK2_1	225	231	PF00069	0.520
MOD_CK2_1	331	337	PF00069	0.480
MOD_CK2_1	380	386	PF00069	0.567
MOD_CK2_1	396	402	PF00069	0.424
MOD_CK2_1	425	431	PF00069	0.487
MOD_CK2_1	445	451	PF00069	0.454
MOD_CK2_1	453	459	PF00069	0.515
MOD_CK2_1	467	473	PF00069	0.466
MOD_CK2_1	558	564	PF00069	0.423
MOD_CK2_1	721	727	PF00069	0.699
MOD_GlcNHglycan	102	105	PF01048	0.612
MOD_GlcNHglycan	126	129	PF01048	0.708
MOD_GlcNHglycan	227	230	PF01048	0.386
MOD_GlcNHglycan	237	240	PF01048	0.335
MOD_GlcNHglycan	413	416	PF01048	0.534
MOD_GlcNHglycan	619	622	PF01048	0.610
MOD_GlcNHglycan	632	635	PF01048	0.560
MOD_GlcNHglycan	649	653	PF01048	0.741
MOD_GlcNHglycan	701	704	PF01048	0.679
MOD_GlcNHglycan	730	733	PF01048	0.770
MOD_GlcNHglycan	755	758	PF01048	0.752
MOD_GlcNHglycan	761	764	PF01048	0.706
MOD_GlcNHglycan	812	815	PF01048	0.582
MOD_GSK3_1	120	127	PF00069	0.784
MOD_GSK3_1	130	137	PF00069	0.383
MOD_GSK3_1	241	248	PF00069	0.461
MOD_GSK3_1	252	259	PF00069	0.458
MOD_GSK3_1	286	293	PF00069	0.567
MOD_GSK3_1	391	398	PF00069	0.544
MOD_GSK3_1	407	414	PF00069	0.389
MOD_GSK3_1	441	448	PF00069	0.510
MOD_GSK3_1	463	470	PF00069	0.641
MOD_GSK3_1	54	61	PF00069	0.796
MOD_GSK3_1	6	13	PF00069	0.707
MOD_GSK3_1	617	624	PF00069	0.662
MOD_GSK3_1	636	643	PF00069	0.517
MOD_GSK3_1	651	658	PF00069	0.681
MOD_GSK3_1	662	669	PF00069	0.654
MOD_GSK3_1	691	698	PF00069	0.620
MOD_GSK3_1	717	724	PF00069	0.681
MOD_GSK3_1	727	734	PF00069	0.636
MOD_GSK3_1	745	752	PF00069	0.692
MOD_GSK3_1	777	784	PF00069	0.514
MOD_GSK3_1	797	804	PF00069	0.594
MOD_N-GLC_1	7	12	PF02516	0.701
MOD_NEK2_1	1	6	PF00069	0.715
MOD_NEK2_1	134	139	PF00069	0.470
MOD_NEK2_1	140	145	PF00069	0.522
MOD_NEK2_1	318	323	PF00069	0.463
MOD_NEK2_1	380	385	PF00069	0.544
MOD_NEK2_1	391	396	PF00069	0.459
MOD_NEK2_1	461	466	PF00069	0.550
MOD_NEK2_1	54	59	PF00069	0.660
MOD_NEK2_1	580	585	PF00069	0.596
MOD_NEK2_1	604	609	PF00069	0.558
MOD_NEK2_1	673	678	PF00069	0.621
MOD_NEK2_1	721	726	PF00069	0.672
MOD_NEK2_2	286	291	PF00069	0.512
MOD_NEK2_2	789	794	PF00069	0.606
MOD_PIKK_1	396	402	PF00454	0.568
MOD_PIKK_1	407	413	PF00454	0.407
MOD_PIKK_1	537	543	PF00454	0.480
MOD_PIKK_1	594	600	PF00454	0.523
MOD_PIKK_1	651	657	PF00454	0.576
MOD_PIKK_1	722	728	PF00454	0.708
MOD_PIKK_1	797	803	PF00454	0.628
MOD_PIKK_1	90	96	PF00454	0.659
MOD_PKA_1	571	577	PF00069	0.523
MOD_PKA_2	175	181	PF00069	0.431
MOD_PKA_2	245	251	PF00069	0.468
MOD_PKA_2	290	296	PF00069	0.574
MOD_PKA_2	318	324	PF00069	0.530
MOD_PKA_2	358	364	PF00069	0.435
MOD_PKA_2	380	386	PF00069	0.584
MOD_PKA_2	396	402	PF00069	0.439
MOD_PKA_2	461	467	PF00069	0.629
MOD_PKA_2	52	58	PF00069	0.775
MOD_PKA_2	669	675	PF00069	0.734
MOD_PKA_2	707	713	PF00069	0.602
MOD_PKA_2	727	733	PF00069	0.807
MOD_PKA_2	742	748	PF00069	0.667
MOD_PKA_2	749	755	PF00069	0.753
MOD_PKA_2	801	807	PF00069	0.598
MOD_PKB_1	460	468	PF00069	0.577
MOD_Plk_1	135	141	PF00069	0.593
MOD_Plk_1	230	236	PF00069	0.520
MOD_Plk_1	286	292	PF00069	0.514
MOD_Plk_1	7	13	PF00069	0.697
MOD_Plk_2-3	130	136	PF00069	0.357
MOD_Plk_2-3	256	262	PF00069	0.440
MOD_Plk_2-3	425	431	PF00069	0.592
MOD_Plk_4	130	136	PF00069	0.433
MOD_Plk_4	18	24	PF00069	0.607
MOD_Plk_4	230	236	PF00069	0.531
MOD_Plk_4	540	546	PF00069	0.611
MOD_Plk_4	669	675	PF00069	0.731
MOD_Plk_4	7	13	PF00069	0.735
MOD_Plk_4	701	707	PF00069	0.722
MOD_Plk_4	789	795	PF00069	0.583
MOD_ProDKin_1	120	126	PF00069	0.657
MOD_ProDKin_1	715	721	PF00069	0.696
MOD_ProDKin_1	774	780	PF00069	0.576
MOD_SUMO_for_1	439	442	PF00179	0.631
MOD_SUMO_rev_2	253	260	PF00179	0.535
MOD_SUMO_rev_2	360	366	PF00179	0.555
MOD_SUMO_rev_2	370	377	PF00179	0.560
MOD_SUMO_rev_2	399	406	PF00179	0.634
MOD_SUMO_rev_2	470	476	PF00179	0.641
MOD_SUMO_rev_2	588	597	PF00179	0.520
TRG_DiLeu_BaEn_1	130	135	PF01217	0.465
TRG_DiLeu_BaEn_1	261	266	PF01217	0.440
TRG_DiLeu_BaEn_1	337	342	PF01217	0.480
TRG_DiLeu_BaEn_3	326	332	PF01217	0.547
TRG_ENDOCYTIC_2	196	199	PF00928	0.440
TRG_ENDOCYTIC_2	454	457	PF00928	0.571
TRG_ENDOCYTIC_2	488	491	PF00928	0.478
TRG_ENDOCYTIC_2	51	54	PF00928	0.603
TRG_ER_diArg_1	31	33	PF00400	0.671
TRG_Pf-PMV_PEXEL_1	221	225	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	378	382	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	490	494	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWL2	Leptomonas seymouri	57%	96%
A0A1X0NEU3	Trypanosomatidae	46%	100%
A0A3S7X9W8	Leishmania donovani	92%	100%
A0A422NU91	Trypanosoma rangeli	40%	100%
A4HN97	Leishmania braziliensis	79%	100%
A4IBW8	Leishmania infantum	93%	100%
C9ZYP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B6V8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5C2P0	Trypanosoma cruzi	46%	100%