FYVE-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

predicted zinc finger protein

Species:

Leishmania major

UniProt:

E9AFQ3_LEIMA

TriTrypDb:

LmjF.35.4260 , LMJLV39_350050600 , LMJSD75_350050000

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFQ3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.489
CLV_C14_Caspase3-7	244	248	PF00656	0.706
CLV_NRD_NRD_1	136	138	PF00675	0.487
CLV_NRD_NRD_1	142	144	PF00675	0.493
CLV_NRD_NRD_1	183	185	PF00675	0.512
CLV_NRD_NRD_1	189	191	PF00675	0.487
CLV_NRD_NRD_1	192	194	PF00675	0.490
CLV_NRD_NRD_1	306	308	PF00675	0.520
CLV_NRD_NRD_1	85	87	PF00675	0.465
CLV_NRD_NRD_1	92	94	PF00675	0.453
CLV_PCSK_FUR_1	140	144	PF00082	0.488
CLV_PCSK_FUR_1	190	194	PF00082	0.529
CLV_PCSK_KEX2_1	136	138	PF00082	0.496
CLV_PCSK_KEX2_1	140	142	PF00082	0.488
CLV_PCSK_KEX2_1	189	191	PF00082	0.514
CLV_PCSK_KEX2_1	192	194	PF00082	0.524
CLV_PCSK_KEX2_1	306	308	PF00082	0.454
CLV_PCSK_KEX2_1	353	355	PF00082	0.383
CLV_PCSK_KEX2_1	92	94	PF00082	0.489
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.520
CLV_PCSK_PC1ET2_1	353	355	PF00082	0.383
CLV_PCSK_PC7_1	136	142	PF00082	0.486
CLV_PCSK_SKI1_1	260	264	PF00082	0.622
CLV_PCSK_SKI1_1	310	314	PF00082	0.443
CLV_PCSK_SKI1_1	37	41	PF00082	0.498
CLV_PCSK_SKI1_1	80	84	PF00082	0.453
DOC_CKS1_1	362	367	PF01111	0.360
DOC_MAPK_gen_1	306	314	PF00069	0.444
DOC_PP2B_LxvP_1	16	19	PF13499	0.531
DOC_PP2B_LxvP_1	266	269	PF13499	0.644
DOC_PP4_FxxP_1	292	295	PF00568	0.455
DOC_USP7_MATH_1	270	274	PF00917	0.623
DOC_USP7_MATH_1	348	352	PF00917	0.383
DOC_USP7_UBL2_3	185	189	PF12436	0.546
DOC_USP7_UBL2_3	217	221	PF12436	0.563
DOC_USP7_UBL2_3	309	313	PF12436	0.476
DOC_USP7_UBL2_3	57	61	PF12436	0.417
DOC_WW_Pin1_4	279	284	PF00397	0.473
DOC_WW_Pin1_4	361	366	PF00397	0.360
DOC_WW_Pin1_4	4	9	PF00397	0.689
LIG_14-3-3_CanoR_1	34	40	PF00244	0.518
LIG_14-3-3_CterR_2	374	377	PF00244	0.508
LIG_Actin_WH2_2	250	265	PF00022	0.654
LIG_BIR_II_1	1	5	PF00653	0.655
LIG_deltaCOP1_diTrp_1	228	232	PF00928	0.665
LIG_FHA_2	288	294	PF00498	0.444
LIG_LIR_Apic_2	290	295	PF02991	0.458
LIG_LIR_Apic_2	298	302	PF02991	0.433
LIG_LIR_Apic_2	359	365	PF02991	0.383
LIG_LIR_Gen_1	22	32	PF02991	0.462
LIG_LIR_Gen_1	228	237	PF02991	0.674
LIG_LIR_Gen_1	52	60	PF02991	0.439
LIG_LIR_Gen_1	73	83	PF02991	0.434
LIG_LIR_Nem_3	22	28	PF02991	0.483
LIG_LIR_Nem_3	228	232	PF02991	0.547
LIG_LIR_Nem_3	305	311	PF02991	0.405
LIG_LIR_Nem_3	52	56	PF02991	0.442
LIG_LIR_Nem_3	73	79	PF02991	0.447
LIG_SH2_CRK	308	312	PF00017	0.509
LIG_SH2_CRK	362	366	PF00017	0.383
LIG_SH2_PTP2	53	56	PF00017	0.497
LIG_SH2_STAP1	63	67	PF00017	0.531
LIG_SH2_STAT5	53	56	PF00017	0.497
LIG_SH3_3	311	317	PF00018	0.323
LIG_SH3_3	5	11	PF00018	0.647
LIG_TRAF2_1	106	109	PF00917	0.514
LIG_TRAF2_1	128	131	PF00917	0.569
LIG_TRAF2_1	153	156	PF00917	0.501
LIG_TRAF2_1	165	168	PF00917	0.512
LIG_TRAF2_1	169	172	PF00917	0.519
LIG_TRAF2_1	176	179	PF00917	0.504
LIG_TYR_ITIM	51	56	PF00017	0.495
LIG_UBA3_1	35	40	PF00899	0.456
MOD_CDK_SPK_2	4	9	PF00069	0.637
MOD_CDK_SPxK_1	361	367	PF00069	0.360
MOD_CK1_1	3	9	PF00069	0.734
MOD_CK2_1	125	131	PF00069	0.406
MOD_GlcNHglycan	127	130	PF01048	0.403
MOD_GlcNHglycan	80	83	PF01048	0.485
MOD_GSK3_1	275	282	PF00069	0.567
MOD_GSK3_1	61	68	PF00069	0.524
MOD_N-GLC_1	348	353	PF02516	0.383
MOD_NEK2_1	1	6	PF00069	0.622
MOD_NEK2_1	232	237	PF00069	0.688
MOD_NEK2_1	262	267	PF00069	0.720
MOD_NEK2_1	277	282	PF00069	0.480
MOD_NEK2_1	35	40	PF00069	0.456
MOD_NEK2_2	19	24	PF00069	0.664
MOD_PKA_2	125	131	PF00069	0.406
MOD_PKA_2	19	25	PF00069	0.589
MOD_PKA_2	332	338	PF00069	0.383
MOD_PKB_1	211	219	PF00069	0.456
MOD_Plk_2-3	52	58	PF00069	0.440
MOD_ProDKin_1	279	285	PF00069	0.461
MOD_ProDKin_1	361	367	PF00069	0.360
MOD_ProDKin_1	4	10	PF00069	0.688
MOD_SUMO_rev_2	258	265	PF00179	0.624
TRG_DiLeu_BaEn_1	46	51	PF01217	0.426
TRG_DiLeu_BaEn_4	202	208	PF01217	0.498
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.416
TRG_ENDOCYTIC_2	308	311	PF00928	0.532
TRG_ENDOCYTIC_2	370	373	PF00928	0.429
TRG_ENDOCYTIC_2	53	56	PF00928	0.462
TRG_ENDOCYTIC_2	63	66	PF00928	0.430
TRG_ER_diArg_1	140	143	PF00400	0.510
TRG_ER_diArg_1	190	193	PF00400	0.507
TRG_ER_diArg_1	306	308	PF00400	0.520
TRG_ER_diArg_1	373	376	PF00400	0.479
TRG_NES_CRM1_1	46	58	PF08389	0.433
TRG_NLS_MonoCore_2	188	193	PF00514	0.497
TRG_NLS_MonoExtC_3	188	193	PF00514	0.497
TRG_NLS_MonoExtN_4	188	193	PF00514	0.501
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	354	358	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	37	42	PF00026	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3I7	Leptomonas seymouri	79%	95%
A0A0S4JE94	Bodo saltans	55%	100%
A0A3S5H806	Leishmania donovani	96%	100%
A4IBW6	Leishmania infantum	96%	100%
E9AIX0	Leishmania braziliensis	87%	100%
E9B6V6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%