LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AFQ1_LEIMA
TriTrypDb:
LmjF.35.4240 , LMJLV39_350050400 * , LMJSD75_350049800 *
Length:
298

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFQ1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFQ1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 267 269 PF00675 0.417
CLV_PCSK_KEX2_1 267 269 PF00082 0.431
CLV_PCSK_KEX2_1 286 288 PF00082 0.492
CLV_PCSK_PC1ET2_1 286 288 PF00082 0.451
CLV_PCSK_SKI1_1 133 137 PF00082 0.350
CLV_PCSK_SKI1_1 177 181 PF00082 0.737
CLV_PCSK_SKI1_1 257 261 PF00082 0.478
CLV_Separin_Metazoa 238 242 PF03568 0.459
DEG_APCC_DBOX_1 60 68 PF00400 0.451
DEG_SCF_FBW7_2 231 238 PF00400 0.429
DEG_SPOP_SBC_1 155 159 PF00917 0.673
DOC_CKS1_1 232 237 PF01111 0.425
DOC_CYCLIN_yCln2_LP_2 114 120 PF00134 0.506
DOC_MAPK_MEF2A_6 206 214 PF00069 0.448
DOC_MAPK_MEF2A_6 3 12 PF00069 0.606
DOC_PP2B_LxvP_1 210 213 PF13499 0.394
DOC_PP4_FxxP_1 5 8 PF00568 0.590
DOC_USP7_MATH_1 175 179 PF00917 0.693
DOC_USP7_MATH_1 201 205 PF00917 0.640
DOC_USP7_MATH_1 290 294 PF00917 0.489
DOC_WW_Pin1_4 168 173 PF00397 0.576
DOC_WW_Pin1_4 231 236 PF00397 0.348
LIG_14-3-3_CanoR_1 226 232 PF00244 0.397
LIG_14-3-3_CanoR_1 29 35 PF00244 0.501
LIG_14-3-3_CanoR_1 36 40 PF00244 0.424
LIG_14-3-3_CanoR_1 7 13 PF00244 0.546
LIG_CSL_BTD_1 42 45 PF09270 0.316
LIG_deltaCOP1_diTrp_1 40 46 PF00928 0.440
LIG_FHA_1 149 155 PF00498 0.683
LIG_FHA_1 192 198 PF00498 0.759
LIG_FHA_1 207 213 PF00498 0.424
LIG_FHA_1 277 283 PF00498 0.481
LIG_FHA_1 73 79 PF00498 0.342
LIG_FHA_1 83 89 PF00498 0.337
LIG_FHA_2 102 108 PF00498 0.459
LIG_FHA_2 214 220 PF00498 0.459
LIG_FHA_2 243 249 PF00498 0.315
LIG_FXI_DFP_1 182 186 PF00024 0.468
LIG_LIR_Gen_1 89 99 PF02991 0.301
LIG_LIR_LC3C_4 208 212 PF02991 0.468
LIG_LIR_Nem_3 124 129 PF02991 0.517
LIG_LIR_Nem_3 184 188 PF02991 0.455
LIG_LIR_Nem_3 40 46 PF02991 0.402
LIG_LIR_Nem_3 89 95 PF02991 0.300
LIG_LIR_Nem_3 97 102 PF02991 0.318
LIG_SH2_SRC 217 220 PF00017 0.486
LIG_SH2_STAT5 123 126 PF00017 0.384
LIG_SH2_STAT5 127 130 PF00017 0.313
LIG_SH2_STAT5 217 220 PF00017 0.486
LIG_SH3_1 241 247 PF00018 0.415
LIG_SH3_3 241 247 PF00018 0.500
MOD_CK1_1 141 147 PF00069 0.565
MOD_CK1_1 205 211 PF00069 0.594
MOD_CK1_1 225 231 PF00069 0.331
MOD_CK2_1 101 107 PF00069 0.288
MOD_CK2_1 18 24 PF00069 0.514
MOD_CK2_1 196 202 PF00069 0.620
MOD_CK2_1 213 219 PF00069 0.407
MOD_CK2_1 242 248 PF00069 0.510
MOD_GlcNHglycan 12 15 PF01048 0.634
MOD_GlcNHglycan 140 143 PF01048 0.654
MOD_GlcNHglycan 151 154 PF01048 0.573
MOD_GlcNHglycan 177 180 PF01048 0.699
MOD_GlcNHglycan 282 285 PF01048 0.420
MOD_GlcNHglycan 292 295 PF01048 0.418
MOD_GlcNHglycan 96 99 PF01048 0.460
MOD_GSK3_1 102 109 PF00069 0.498
MOD_GSK3_1 140 147 PF00069 0.593
MOD_GSK3_1 154 161 PF00069 0.654
MOD_GSK3_1 171 178 PF00069 0.650
MOD_GSK3_1 201 208 PF00069 0.584
MOD_GSK3_1 276 283 PF00069 0.501
MOD_N-GLC_1 121 126 PF02516 0.464
MOD_NEK2_1 129 134 PF00069 0.365
MOD_NEK2_1 145 150 PF00069 0.509
MOD_NEK2_1 239 244 PF00069 0.462
MOD_NEK2_1 282 287 PF00069 0.454
MOD_NEK2_1 91 96 PF00069 0.310
MOD_OFUCOSY 69 76 PF10250 0.439
MOD_PIKK_1 44 50 PF00454 0.552
MOD_PKA_2 145 151 PF00069 0.733
MOD_PKA_2 225 231 PF00069 0.453
MOD_PKA_2 242 248 PF00069 0.321
MOD_PKA_2 28 34 PF00069 0.512
MOD_PKA_2 35 41 PF00069 0.425
MOD_Plk_1 222 228 PF00069 0.522
MOD_Plk_4 206 212 PF00069 0.480
MOD_Plk_4 213 219 PF00069 0.435
MOD_Plk_4 277 283 PF00069 0.412
MOD_Plk_4 91 97 PF00069 0.439
MOD_ProDKin_1 168 174 PF00069 0.575
MOD_ProDKin_1 231 237 PF00069 0.349
MOD_SUMO_for_1 271 274 PF00179 0.500
TRG_ENDOCYTIC_2 126 129 PF00928 0.459
TRG_ENDOCYTIC_2 20 23 PF00928 0.512
TRG_ER_diArg_1 240 243 PF00400 0.409
TRG_ER_diArg_1 266 268 PF00400 0.424
TRG_Pf-PMV_PEXEL_1 86 90 PF00026 0.386

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HY73 Leptomonas seymouri 50% 100%
A0A0S4JF57 Bodo saltans 35% 100%
A0A1X0P581 Trypanosomatidae 36% 100%
A0A3R7NNI3 Trypanosoma rangeli 37% 100%
A0A3S7X9V8 Leishmania donovani 92% 100%
A4HN94 Leishmania braziliensis 71% 98%
A4IBW4 Leishmania infantum 92% 100%
C9ZYP7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9B6V4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
V5BCR5 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS