SAC domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

synaptojanin (N-terminal domain), putative

Species:

Leishmania major

UniProt:

E9AFQ0_LEIMA

TriTrypDb:

LmjF.35.4230 , LMJLV39_350050300 , LMJSD75_350049700

Length:

1010

Annotations

LeishMANIAdb annotations

Carries a conserved SAC1-type phosphatidylinositol phosphatase domain. Other eukaryotic homologs have no TM domains

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	6
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	6

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Expansion

Sequence features

E9AFQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFQ0

Function

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Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	2
GO:0006644	phospholipid metabolic process	4	2
GO:0006650	glycerophospholipid metabolic process	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016311	dephosphorylation	5	2
GO:0019637	organophosphate metabolic process	3	2
GO:0030258	lipid modification	4	2

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity	7	2
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0043812	phosphatidylinositol-4-phosphate phosphatase activity	8	2
GO:0052744	phosphatidylinositol monophosphate phosphatase activity	7	2
GO:0052866	phosphatidylinositol phosphate phosphatase activity	6	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.519
CLV_C14_Caspase3-7	206	210	PF00656	0.427
CLV_C14_Caspase3-7	659	663	PF00656	0.703
CLV_C14_Caspase3-7	761	765	PF00656	0.719
CLV_C14_Caspase3-7	832	836	PF00656	0.646
CLV_NRD_NRD_1	147	149	PF00675	0.279
CLV_NRD_NRD_1	369	371	PF00675	0.312
CLV_NRD_NRD_1	420	422	PF00675	0.278
CLV_NRD_NRD_1	425	427	PF00675	0.254
CLV_NRD_NRD_1	43	45	PF00675	0.358

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5I0	Leptomonas seymouri	54%	100%
A0A3S7X9T5	Leishmania donovani	91%	100%
A4HN93	Leishmania braziliensis	77%	100%
A4IBW3	Leishmania infantum	91%	100%
E9B6V3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%

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