Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AFP9_LEIMA

TriTrypDb:

LmjF.35.4220 , LMJLV39_350050200 , LMJSD75_350049600

Length:

602

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFP9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.667
CLV_NRD_NRD_1	273	275	PF00675	0.710
CLV_NRD_NRD_1	36	38	PF00675	0.743
CLV_NRD_NRD_1	581	583	PF00675	0.756
CLV_NRD_NRD_1	594	596	PF00675	0.569
CLV_PCSK_KEX2_1	216	218	PF00082	0.789
CLV_PCSK_KEX2_1	36	38	PF00082	0.743
CLV_PCSK_KEX2_1	589	591	PF00082	0.731
CLV_PCSK_KEX2_1	593	595	PF00082	0.707
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.789
CLV_PCSK_PC1ET2_1	589	591	PF00082	0.661
CLV_PCSK_PC7_1	590	596	PF00082	0.709
CLV_PCSK_SKI1_1	216	220	PF00082	0.801
CLV_PCSK_SKI1_1	24	28	PF00082	0.682
CLV_PCSK_SKI1_1	388	392	PF00082	0.714
CLV_PCSK_SKI1_1	542	546	PF00082	0.605
DEG_SPOP_SBC_1	321	325	PF00917	0.660
DEG_SPOP_SBC_1	436	440	PF00917	0.694
DOC_CYCLIN_yCln2_LP_2	250	256	PF00134	0.742
DOC_MAPK_MEF2A_6	75	84	PF00069	0.665
DOC_PP2B_LxvP_1	250	253	PF13499	0.744
DOC_PP2B_LxvP_1	94	97	PF13499	0.590
DOC_USP7_MATH_1	111	115	PF00917	0.827
DOC_USP7_MATH_1	122	126	PF00917	0.675
DOC_USP7_MATH_1	135	139	PF00917	0.554
DOC_USP7_MATH_1	206	210	PF00917	0.702
DOC_USP7_MATH_1	226	230	PF00917	0.784
DOC_USP7_MATH_1	231	235	PF00917	0.714
DOC_USP7_MATH_1	254	258	PF00917	0.759
DOC_USP7_MATH_1	321	325	PF00917	0.763
DOC_USP7_MATH_1	330	334	PF00917	0.629
DOC_USP7_MATH_1	343	347	PF00917	0.598
DOC_USP7_MATH_1	361	365	PF00917	0.840
DOC_USP7_MATH_1	374	378	PF00917	0.633
DOC_USP7_MATH_1	397	401	PF00917	0.757
DOC_USP7_MATH_1	432	436	PF00917	0.686
DOC_USP7_MATH_1	546	550	PF00917	0.640
DOC_USP7_MATH_1	551	555	PF00917	0.651
DOC_USP7_UBL2_3	30	34	PF12436	0.671
DOC_WW_Pin1_4	120	125	PF00397	0.734
DOC_WW_Pin1_4	278	283	PF00397	0.743
DOC_WW_Pin1_4	49	54	PF00397	0.751
DOC_WW_Pin1_4	92	97	PF00397	0.719
LIG_14-3-3_CanoR_1	161	169	PF00244	0.712
LIG_14-3-3_CanoR_1	220	228	PF00244	0.705
LIG_14-3-3_CanoR_1	274	284	PF00244	0.727
LIG_14-3-3_CanoR_1	303	309	PF00244	0.620
LIG_14-3-3_CanoR_1	312	321	PF00244	0.601
LIG_14-3-3_CanoR_1	363	370	PF00244	0.774
LIG_14-3-3_CanoR_1	382	391	PF00244	0.533
LIG_14-3-3_CanoR_1	523	528	PF00244	0.708
LIG_14-3-3_CanoR_1	89	97	PF00244	0.658
LIG_BIR_II_1	1	5	PF00653	0.731
LIG_FHA_1	196	202	PF00498	0.616
LIG_FHA_1	425	431	PF00498	0.733
LIG_FHA_1	481	487	PF00498	0.753
LIG_FHA_1	539	545	PF00498	0.561
LIG_FHA_2	233	239	PF00498	0.759
LIG_FHA_2	595	601	PF00498	0.724
LIG_LIR_Apic_2	19	23	PF02991	0.631
LIG_LIR_Gen_1	439	449	PF02991	0.723
LIG_LIR_Gen_1	597	602	PF02991	0.728
LIG_LIR_Nem_3	403	409	PF02991	0.718
LIG_LIR_Nem_3	439	445	PF02991	0.725
LIG_LIR_Nem_3	448	452	PF02991	0.599
LIG_LIR_Nem_3	597	602	PF02991	0.728
LIG_NRBOX	500	506	PF00104	0.592
LIG_PCNA_yPIPBox_3	496	505	PF02747	0.581
LIG_PDZ_Class_3	597	602	PF00595	0.728
LIG_SH2_CRK	442	446	PF00017	0.728
LIG_SH2_SRC	20	23	PF00017	0.687
LIG_SH2_SRC	404	407	PF00017	0.665
LIG_SH2_SRC	452	455	PF00017	0.628
LIG_SH2_STAT5	20	23	PF00017	0.687
LIG_SH3_2	211	216	PF14604	0.733
LIG_SH3_2	358	363	PF14604	0.581
LIG_SH3_3	175	181	PF00018	0.720
LIG_SH3_3	208	214	PF00018	0.736
LIG_SH3_3	299	305	PF00018	0.709
LIG_SH3_3	315	321	PF00018	0.538
LIG_SH3_3	324	330	PF00018	0.609
LIG_SH3_3	350	356	PF00018	0.761
LIG_SH3_3	484	490	PF00018	0.806
LIG_SH3_3	505	511	PF00018	0.684
LIG_SH3_3	98	104	PF00018	0.738
LIG_WW_3	509	513	PF00397	0.677
MOD_CDK_SPK_2	49	54	PF00069	0.757
MOD_CK1_1	138	144	PF00069	0.631
MOD_CK1_1	163	169	PF00069	0.733
MOD_CK1_1	194	200	PF00069	0.749
MOD_CK1_1	209	215	PF00069	0.595
MOD_CK1_1	224	230	PF00069	0.662
MOD_CK1_1	234	240	PF00069	0.691
MOD_CK1_1	278	284	PF00069	0.742
MOD_CK1_1	291	297	PF00069	0.679
MOD_CK1_1	307	313	PF00069	0.631
MOD_CK1_1	365	371	PF00069	0.681
MOD_CK1_1	378	384	PF00069	0.703
MOD_CK1_1	420	426	PF00069	0.677
MOD_CK1_1	435	441	PF00069	0.684
MOD_CK1_1	474	480	PF00069	0.730
MOD_CK1_1	516	522	PF00069	0.764
MOD_CK1_1	570	576	PF00069	0.590
MOD_CK1_1	88	94	PF00069	0.758
MOD_CK2_1	232	238	PF00069	0.759
MOD_CK2_1	239	245	PF00069	0.671
MOD_CK2_1	392	398	PF00069	0.681
MOD_CK2_1	546	552	PF00069	0.674
MOD_GlcNHglycan	109	112	PF01048	0.770
MOD_GlcNHglycan	135	138	PF01048	0.690
MOD_GlcNHglycan	140	143	PF01048	0.641
MOD_GlcNHglycan	157	160	PF01048	0.768
MOD_GlcNHglycan	189	192	PF01048	0.698
MOD_GlcNHglycan	223	226	PF01048	0.751
MOD_GlcNHglycan	229	232	PF01048	0.735
MOD_GlcNHglycan	24	27	PF01048	0.466
MOD_GlcNHglycan	250	253	PF01048	0.734
MOD_GlcNHglycan	277	280	PF01048	0.762
MOD_GlcNHglycan	299	302	PF01048	0.833
MOD_GlcNHglycan	338	341	PF01048	0.685
MOD_GlcNHglycan	364	367	PF01048	0.688
MOD_GlcNHglycan	400	403	PF01048	0.719
MOD_GlcNHglycan	434	437	PF01048	0.667
MOD_GlcNHglycan	469	472	PF01048	0.793
MOD_GlcNHglycan	473	476	PF01048	0.777
MOD_GlcNHglycan	49	52	PF01048	0.634
MOD_GlcNHglycan	492	495	PF01048	0.730
MOD_GlcNHglycan	501	504	PF01048	0.653
MOD_GlcNHglycan	515	518	PF01048	0.644
MOD_GlcNHglycan	8	11	PF01048	0.780
MOD_GSK3_1	107	114	PF00069	0.713
MOD_GSK3_1	116	123	PF00069	0.627
MOD_GSK3_1	181	188	PF00069	0.806
MOD_GSK3_1	191	198	PF00069	0.691
MOD_GSK3_1	220	227	PF00069	0.759
MOD_GSK3_1	234	241	PF00069	0.584
MOD_GSK3_1	269	276	PF00069	0.587
MOD_GSK3_1	293	300	PF00069	0.816
MOD_GSK3_1	361	368	PF00069	0.750
MOD_GSK3_1	372	379	PF00069	0.634
MOD_GSK3_1	382	389	PF00069	0.644
MOD_GSK3_1	420	427	PF00069	0.787
MOD_GSK3_1	428	435	PF00069	0.653
MOD_GSK3_1	436	443	PF00069	0.574
MOD_GSK3_1	45	52	PF00069	0.720
MOD_GSK3_1	455	462	PF00069	0.518
MOD_GSK3_1	467	474	PF00069	0.763
MOD_GSK3_1	490	497	PF00069	0.592
MOD_GSK3_1	513	520	PF00069	0.733
MOD_GSK3_1	521	528	PF00069	0.703
MOD_GSK3_1	85	92	PF00069	0.730
MOD_N-GLC_1	111	116	PF02516	0.686
MOD_N-GLC_1	206	211	PF02516	0.595
MOD_NEK2_1	195	200	PF00069	0.592
MOD_NEK2_1	219	224	PF00069	0.755
MOD_NEK2_1	273	278	PF00069	0.592
MOD_NEK2_1	424	429	PF00069	0.752
MOD_NEK2_1	538	543	PF00069	0.692
MOD_NEK2_1	545	550	PF00069	0.658
MOD_NEK2_2	191	196	PF00069	0.628
MOD_NEK2_2	239	244	PF00069	0.700
MOD_NEK2_2	330	335	PF00069	0.684
MOD_NEK2_2	366	371	PF00069	0.596
MOD_PIKK_1	116	122	PF00454	0.679
MOD_PIKK_1	382	388	PF00454	0.592
MOD_PIKK_1	424	430	PF00454	0.751
MOD_PK_1	376	382	PF00069	0.704
MOD_PKA_1	44	50	PF00069	0.645
MOD_PKA_1	594	600	PF00069	0.726
MOD_PKA_2	144	150	PF00069	0.808
MOD_PKA_2	154	160	PF00069	0.673
MOD_PKA_2	219	225	PF00069	0.770
MOD_PKA_2	273	279	PF00069	0.588
MOD_PKA_2	297	303	PF00069	0.759
MOD_PKA_2	344	350	PF00069	0.806
MOD_PKA_2	362	368	PF00069	0.775
MOD_PKA_2	375	381	PF00069	0.616
MOD_PKA_2	445	451	PF00069	0.683
MOD_PKA_2	479	485	PF00069	0.804
MOD_PKA_2	594	600	PF00069	0.669
MOD_PKA_2	88	94	PF00069	0.656
MOD_PKB_1	267	275	PF00069	0.675
MOD_Plk_1	239	245	PF00069	0.714
MOD_Plk_1	412	418	PF00069	0.576
MOD_Plk_1	440	446	PF00069	0.725
MOD_Plk_1	45	51	PF00069	0.670
MOD_Plk_4	440	446	PF00069	0.665
MOD_ProDKin_1	120	126	PF00069	0.735
MOD_ProDKin_1	278	284	PF00069	0.743
MOD_ProDKin_1	49	55	PF00069	0.751
MOD_ProDKin_1	92	98	PF00069	0.722
MOD_SUMO_for_1	393	396	PF00179	0.737
MOD_SUMO_for_1	559	562	PF00179	0.768
MOD_SUMO_rev_2	561	570	PF00179	0.592
TRG_ENDOCYTIC_2	406	409	PF00928	0.719
TRG_ENDOCYTIC_2	442	445	PF00928	0.728
TRG_ER_diArg_1	267	270	PF00400	0.643
TRG_ER_diArg_1	35	37	PF00400	0.743
TRG_ER_diArg_1	592	595	PF00400	0.734

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJF9	Leishmania donovani	85%	100%
A4HN92	Leishmania braziliensis	53%	100%
A4IBW2	Leishmania infantum	85%	100%
E9B6V2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%